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Protein

Transforming acidic coiled-coil-containing protein 3

Gene

TACC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476).By similarity3 Publications

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • cell proliferation Source: GO_Central
  • cerebral cortex development Source: GO_Central
  • metaphase/anaphase transition of mitotic cell cycle Source: UniProtKB
  • microtubule cytoskeleton organization Source: GO_Central
  • microtubule cytoskeleton organization involved in mitosis Source: UniProtKB
  • regulation of mitotic spindle organization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000013810-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming acidic coiled-coil-containing protein 3
Alternative name(s):
ERIC-1
Gene namesi
Name:TACC3
Synonyms:ERIC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:11524. TACC3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi558S → A: Disrupts localization to mitotic spindle and impairs recruitment of clathrin to mitotic spindle. 1 Publication1
Mutagenesisi566 – 567LL → AA: Impairs localization to mitotic spindle. 1 Publication2

Organism-specific databases

DisGeNETi10460.
MalaCardsiTACC3.
OpenTargetsiENSG00000013810.
Orphaneti251579. Giant cell glioblastoma.
251576. Gliosarcoma.
PharmGKBiPA36301.

Polymorphism and mutation databases

BioMutaiTACC3.
DMDMi13431939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001799902 – 838Transforming acidic coiled-coil-containing protein 3Add BLAST837

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei25PhosphoserineCombined sources1
Modified residuei39PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei177PhosphoserineCombined sources1
Modified residuei250PhosphoserineCombined sources1
Modified residuei317PhosphoserineCombined sources1
Modified residuei402PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei558Phosphoserine; by AURKACombined sources1 Publication1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y6A5.
MaxQBiQ9Y6A5.
PaxDbiQ9Y6A5.
PeptideAtlasiQ9Y6A5.
PRIDEiQ9Y6A5.

PTM databases

iPTMnetiQ9Y6A5.
PhosphoSitePlusiQ9Y6A5.

Expressioni

Inductioni

Up-regulated in various cancer cell lines.

Gene expression databases

BgeeiENSG00000013810.
CleanExiHS_TACC3.
ExpressionAtlasiQ9Y6A5. baseline and differential.
GenevisibleiQ9Y6A5. HS.

Organism-specific databases

HPAiCAB010111.
HPA005781.
HPA006050.
HPA022039.

Interactioni

Subunit structurei

Interacts with microtubules. Interacts with CKAP5 independently of clathrin. Interacts with CKAP5 and clathrin forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; TACC3 (phosphorylated at Ser-558 by AURKA) and CLTC are proposed to form a composite microtubule interaction surface (PubMed:21297582, PubMed:23918938, PubMed:25596274). Interacts with CCDC100/CEP120. The coiled coil C-terminal region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2 (By similarity). Interacts with GCN5L2 and PCAF (PubMed:14767476).By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ASPSCR1Q9BZE93EBI-2554984,EBI-1993677
CIB3Q96Q775EBI-2554984,EBI-10292696
CKAP5Q140087EBI-2554984,EBI-310585
CLTAP094963EBI-2554984,EBI-1171169
KIZQ2M2Z55EBI-2554984,EBI-2554344
SNX20Q7Z6143EBI-2554984,EBI-744896
TBC1D22BQ9NU195EBI-2554984,EBI-8787464
VPS37CA5D8V63EBI-2554984,EBI-2559305

Protein-protein interaction databases

BioGridi115723. 77 interactors.
IntActiQ9Y6A5. 56 interactors.
MINTiMINT-8144915.
STRINGi9606.ENSP00000326550.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6A5.
SMRiQ9Y6A5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni522 – 577Necessary but not sufficient for spindle localization1 PublicationAdd BLAST56
Regioni594 – 838Necessary but not sufficient for spindle localization1 PublicationAdd BLAST245

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili637 – 837Sequence analysisAdd BLAST201

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi155 – 160Poly-Ser6

Sequence similaritiesi

Belongs to the TACC family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIVK. Eukaryota.
ENOG410YMFS. LUCA.
GeneTreeiENSGT00530000063855.
HOGENOMiHOG000294059.
HOVERGENiHBG044999.
InParanoidiQ9Y6A5.
KOiK14283.
OMAiSMHGANE.
OrthoDBiEOG091G072Z.
PhylomeDBiQ9Y6A5.
TreeFamiTF333149.

Family and domain databases

InterProiIPR007707. TACC.
[Graphical view]
PfamiPF05010. TACC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y6A5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQVLNDKN VSNEKNTENC DFLFSPPEVT GRSSVLRVSQ KENVPPKNLA
60 70 80 90 100
KAMKVTFQTP LRDPQTHRIL SPSMASKLEA PFTQDDTLGL ENSHPVWTQK
110 120 130 140 150
ENQQLIKEVD AKTTHGILQK PVEADTDLLG DASPAFGSGS SSESGPGALA
160 170 180 190 200
DLDCSSSSQS PGSSENQMVS PGKVSGSPEQ AVEENLSSYS LDRRVTPASE
210 220 230 240 250
TLEDPCRTES QHKAETPHGA EEECKAETPH GAEEECRHGG VCAPAAVATS
260 270 280 290 300
PPGAIPKEAC GGAPLQGLPG EALGCPAGVG TPVPADGTQT LTCAHTSAPE
310 320 330 340 350
STAPTNHLVA GRAMTLSPQE EVAAGQMASS SRSGPVKLEF DVSDGATSKR
360 370 380 390 400
APPPRRLGER SGLKPPLRKA AVRQQKAPQE VEEDDGRSGA GEDPPMPASR
410 420 430 440 450
GSYHLDWDKM DDPNFIPFGG DTKSGCSEAQ PPESPETRLG QPAAEQLHAG
460 470 480 490 500
PATEEPGPCL SQQLHSASAE DTPVVQLAAE TPTAESKERA LNSASTSLPT
510 520 530 540 550
SCPGSEPVPT HQQGQPALEL KEESFRDPAE VLGTGAEVDY LEQFGTSSFK
560 570 580 590 600
ESALRKQSLY LKFDPLLRDS PGRPVPVATE TSSMHGANET PSGRPREAKL
610 620 630 640 650
VEFDFLGALD IPVPGPPPGV PAPGGPPLST GPIVDLLQYS QKDLDAVVKA
660 670 680 690 700
TQEENRELRS RCEELHGKNL ELGKIMDRFE EVVYQAMEEV QKQKELSKAE
710 720 730 740 750
IQKVLKEKDQ LTTDLNSMEK SFSDLFKRFE KQKEVIEGYR KNEESLKKCV
760 770 780 790 800
EDYLARITQE GQRYQALKAH AEEKLQLANE EIAQVRSKAQ AEALALQASL
810 820 830
RKEQMRIQSL EKTVEQKTKE NEELTRICDD LISKMEKI
Length:838
Mass (Da):90,360
Last modified:November 1, 1999 - v1
Checksum:i07F056678096775E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti342V → L in CAB53009 (PubMed:11298601).Curated1
Sequence conflicti406D → G in CAB53009 (PubMed:11298601).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053714143E → K.Corresponds to variant rs34205238dbSNPEnsembl.1
Natural variantiVAR_053715275C → Y.2 PublicationsCorresponds to variant rs17132047dbSNPEnsembl.1
Natural variantiVAR_053716287G → S.2 PublicationsCorresponds to variant rs1063743dbSNPEnsembl.1
Natural variantiVAR_053717514G → E.2 PublicationsCorresponds to variant rs17680881dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093543 mRNA. Translation: AAD25964.1.
AJ243997 mRNA. Translation: CAB53009.1.
BC106071 mRNA. Translation: AAI06072.1.
BC111771 mRNA. Translation: AAI11772.1.
CCDSiCCDS3352.1.
RefSeqiNP_006333.1. NM_006342.2.
XP_016863142.1. XM_017007653.1.
UniGeneiHs.104019.

Genome annotation databases

EnsembliENST00000313288; ENSP00000326550; ENSG00000013810.
GeneIDi10460.
KEGGihsa:10460.
UCSCiuc003gdo.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093543 mRNA. Translation: AAD25964.1.
AJ243997 mRNA. Translation: CAB53009.1.
BC106071 mRNA. Translation: AAI06072.1.
BC111771 mRNA. Translation: AAI11772.1.
CCDSiCCDS3352.1.
RefSeqiNP_006333.1. NM_006342.2.
XP_016863142.1. XM_017007653.1.
UniGeneiHs.104019.

3D structure databases

ProteinModelPortaliQ9Y6A5.
SMRiQ9Y6A5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115723. 77 interactors.
IntActiQ9Y6A5. 56 interactors.
MINTiMINT-8144915.
STRINGi9606.ENSP00000326550.

PTM databases

iPTMnetiQ9Y6A5.
PhosphoSitePlusiQ9Y6A5.

Polymorphism and mutation databases

BioMutaiTACC3.
DMDMi13431939.

Proteomic databases

EPDiQ9Y6A5.
MaxQBiQ9Y6A5.
PaxDbiQ9Y6A5.
PeptideAtlasiQ9Y6A5.
PRIDEiQ9Y6A5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313288; ENSP00000326550; ENSG00000013810.
GeneIDi10460.
KEGGihsa:10460.
UCSCiuc003gdo.4. human.

Organism-specific databases

CTDi10460.
DisGeNETi10460.
GeneCardsiTACC3.
HGNCiHGNC:11524. TACC3.
HPAiCAB010111.
HPA005781.
HPA006050.
HPA022039.
MalaCardsiTACC3.
MIMi605303. gene.
neXtProtiNX_Q9Y6A5.
OpenTargetsiENSG00000013810.
Orphaneti251579. Giant cell glioblastoma.
251576. Gliosarcoma.
PharmGKBiPA36301.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIVK. Eukaryota.
ENOG410YMFS. LUCA.
GeneTreeiENSGT00530000063855.
HOGENOMiHOG000294059.
HOVERGENiHBG044999.
InParanoidiQ9Y6A5.
KOiK14283.
OMAiSMHGANE.
OrthoDBiEOG091G072Z.
PhylomeDBiQ9Y6A5.
TreeFamiTF333149.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000013810-MONOMER.

Miscellaneous databases

GeneWikiiTACC3.
GenomeRNAii10460.
PROiQ9Y6A5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000013810.
CleanExiHS_TACC3.
ExpressionAtlasiQ9Y6A5. baseline and differential.
GenevisibleiQ9Y6A5. HS.

Family and domain databases

InterProiIPR007707. TACC.
[Graphical view]
PfamiPF05010. TACC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTACC3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6A5
Secondary accession number(s): Q2NKK4, Q3KQS5, Q9UMQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.