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Protein

Cilia- and flagella-associated protein 20

Gene

CFAP20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia (PubMed:24414207). Required for axonemal microtubules polyglutamylation (PubMed:24414207).1 Publication

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

  • cilium assembly Source: UniProtKB
  • multicellular organism development Source: ProtInc
  • positive regulation of cell motility Source: UniProtKB
  • positive regulation of feeding behavior Source: UniProtKB
  • protein polyglutamylation Source: UniProtKB
  • regulation of cilium beat frequency involved in ciliary motility Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 20
Alternative name(s):
Basal body up-regulated protein 22
Transcription factor IIB
Gene namesi
Name:CFAP20
Synonyms:BUG22, C16orf80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29523. CFAP20.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • ciliary basal body Source: UniProtKB
  • cilium Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • nucleus Source: HPA

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29105.
OpenTargetsiENSG00000070761.
PharmGKBiPA162378384.

Polymorphism and mutation databases

BioMutaiC16orf80.
DMDMi74753521.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002963981 – 193Cilia- and flagella-associated protein 20Add BLAST193

Proteomic databases

EPDiQ9Y6A4.
MaxQBiQ9Y6A4.
PaxDbiQ9Y6A4.
PeptideAtlasiQ9Y6A4.
PRIDEiQ9Y6A4.

PTM databases

iPTMnetiQ9Y6A4.
PhosphoSitePlusiQ9Y6A4.

Expressioni

Gene expression databases

BgeeiENSG00000070761.
CleanExiHS_C16orf80.
ExpressionAtlasiQ9Y6A4. baseline and differential.
GenevisibleiQ9Y6A4. HS.

Organism-specific databases

HPAiHPA018195.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CLASRPQ8N2M83EBI-1046872,EBI-751069

Protein-protein interaction databases

BioGridi118873. 23 interactors.
IntActiQ9Y6A4. 26 interactors.
MINTiMINT-1683561.
STRINGi9606.ENSP00000262498.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6A4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CFAP20 family.Curated

Phylogenomic databases

eggNOGiKOG3213. Eukaryota.
ENOG410XS39. LUCA.
GeneTreeiENSGT00390000004554.
HOGENOMiHOG000257095.
HOVERGENiHBG102938.
InParanoidiQ9Y6A4.
OMAiHNTFQSG.
OrthoDBiEOG091G0NXL.
PhylomeDBiQ9Y6A4.
TreeFamiTF313405.

Family and domain databases

InterProiView protein in InterPro
IPR007714. CFA20/WDR90/C3orf67.
PANTHERiPTHR12458. PTHR12458. 1 hit.
PfamiView protein in Pfam
PF05018. DUF667. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y6A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIE
60 70 80 90 100
GTNVSTTYIT CPADPKKTLG IKLPFLVMII KNLKKYFTFE VQVLDDKNVR
110 120 130 140 150
RRFRASNYQS TTRVKPFICT MPMRLDDGWN QIQFNLLDFT RRAYGTNYIE
160 170 180 190
TLRVQIHANC RIRRVYFSDR LYSEDELPAE FKLYLPVQNK AKQ
Length:193
Mass (Da):22,774
Last modified:November 1, 1999 - v1
Checksum:i82ECDB0D2515BF77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087845 mRNA. Translation: AAP97158.1.
AF093680 mRNA. Translation: AAD40382.1.
AC009107 Genomic DNA. No translation available.
AC026771 Genomic DNA. No translation available.
BC005152 mRNA. Translation: AAH05152.1.
CCDSiCCDS10793.1.
RefSeqiNP_037374.1. NM_013242.2.
UniGeneiHs.532755.

Genome annotation databases

EnsembliENST00000262498; ENSP00000262498; ENSG00000070761.
GeneIDi29105.
KEGGihsa:29105.
UCSCiuc002enb.2. human.

Similar proteinsi

Entry informationi

Entry nameiCFA20_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: November 1, 1999
Last modified: August 30, 2017
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries