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Protein

Cilia- and flagella-associated protein 20

Gene

CFAP20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia (PubMed:24414207). Required for axonemal microtubules polyglutamylation (PubMed:24414207).1 Publication

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  • cilium morphogenesis Source: UniProtKB
  • multicellular organism development Source: ProtInc
  • positive regulation of cell motility Source: UniProtKB
  • positive regulation of feeding behavior Source: UniProtKB
  • protein polyglutamylation Source: UniProtKB
  • regulation of cilium beat frequency involved in ciliary motility Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cilia- and flagella-associated protein 20
Alternative name(s):
Basal body up-regulated protein 22
Transcription factor IIB
Gene namesi
Name:CFAP20
Synonyms:BUG22, C16orf80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29523. CFAP20.

Subcellular locationi

GO - Cellular componenti

  • centriole Source: UniProtKB
  • ciliary basal body Source: UniProtKB
  • cilium Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • microtubule Source: UniProtKB-KW
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162378384.

Polymorphism and mutation databases

BioMutaiC16orf80.
DMDMi74753521.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 193193Cilia- and flagella-associated protein 20PRO_0000296398Add
BLAST

Proteomic databases

EPDiQ9Y6A4.
MaxQBiQ9Y6A4.
PaxDbiQ9Y6A4.
PRIDEiQ9Y6A4.

PTM databases

iPTMnetiQ9Y6A4.
PhosphoSiteiQ9Y6A4.

Expressioni

Gene expression databases

BgeeiQ9Y6A4.
CleanExiHS_C16orf80.
ExpressionAtlasiQ9Y6A4. baseline and differential.
GenevisibleiQ9Y6A4. HS.

Organism-specific databases

HPAiHPA018195.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
YWHAGP619812EBI-1046872,EBI-359832

Protein-protein interaction databases

BioGridi118873. 19 interactions.
IntActiQ9Y6A4. 8 interactions.
MINTiMINT-1683561.
STRINGi9606.ENSP00000262498.

Structurei

3D structure databases

ProteinModelPortaliQ9Y6A4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CFAP20 family.Curated

Phylogenomic databases

eggNOGiKOG3213. Eukaryota.
ENOG410XS39. LUCA.
GeneTreeiENSGT00390000004554.
HOGENOMiHOG000257095.
HOVERGENiHBG102938.
InParanoidiQ9Y6A4.
OMAiLRIQIHA.
OrthoDBiEOG7DNNX8.
PhylomeDBiQ9Y6A4.
TreeFamiTF313405.

Family and domain databases

InterProiIPR007714. CFA20/WDR90/C3orf67.
[Graphical view]
PANTHERiPTHR12458. PTHR12458. 1 hit.
PfamiPF05018. DUF667. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y6A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKNTFQSGF LSILYSIGSK PLQIWDKKVR NGHIKRITDN DIQSLVLEIE
60 70 80 90 100
GTNVSTTYIT CPADPKKTLG IKLPFLVMII KNLKKYFTFE VQVLDDKNVR
110 120 130 140 150
RRFRASNYQS TTRVKPFICT MPMRLDDGWN QIQFNLLDFT RRAYGTNYIE
160 170 180 190
TLRVQIHANC RIRRVYFSDR LYSEDELPAE FKLYLPVQNK AKQ
Length:193
Mass (Da):22,774
Last modified:November 1, 1999 - v1
Checksum:i82ECDB0D2515BF77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087845 mRNA. Translation: AAP97158.1.
AF093680 mRNA. Translation: AAD40382.1.
AC009107 Genomic DNA. No translation available.
AC026771 Genomic DNA. No translation available.
BC005152 mRNA. Translation: AAH05152.1.
CCDSiCCDS10793.1.
RefSeqiNP_037374.1. NM_013242.2.
UniGeneiHs.532755.

Genome annotation databases

EnsembliENST00000262498; ENSP00000262498; ENSG00000070761.
GeneIDi29105.
KEGGihsa:29105.
UCSCiuc002enb.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087845 mRNA. Translation: AAP97158.1.
AF093680 mRNA. Translation: AAD40382.1.
AC009107 Genomic DNA. No translation available.
AC026771 Genomic DNA. No translation available.
BC005152 mRNA. Translation: AAH05152.1.
CCDSiCCDS10793.1.
RefSeqiNP_037374.1. NM_013242.2.
UniGeneiHs.532755.

3D structure databases

ProteinModelPortaliQ9Y6A4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118873. 19 interactions.
IntActiQ9Y6A4. 8 interactions.
MINTiMINT-1683561.
STRINGi9606.ENSP00000262498.

PTM databases

iPTMnetiQ9Y6A4.
PhosphoSiteiQ9Y6A4.

Polymorphism and mutation databases

BioMutaiC16orf80.
DMDMi74753521.

Proteomic databases

EPDiQ9Y6A4.
MaxQBiQ9Y6A4.
PaxDbiQ9Y6A4.
PRIDEiQ9Y6A4.

Protocols and materials databases

DNASUi29105.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262498; ENSP00000262498; ENSG00000070761.
GeneIDi29105.
KEGGihsa:29105.
UCSCiuc002enb.2. human.

Organism-specific databases

CTDi29105.
GeneCardsiCFAP20.
HGNCiHGNC:29523. CFAP20.
HPAiHPA018195.
neXtProtiNX_Q9Y6A4.
PharmGKBiPA162378384.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3213. Eukaryota.
ENOG410XS39. LUCA.
GeneTreeiENSGT00390000004554.
HOGENOMiHOG000257095.
HOVERGENiHBG102938.
InParanoidiQ9Y6A4.
OMAiLRIQIHA.
OrthoDBiEOG7DNNX8.
PhylomeDBiQ9Y6A4.
TreeFamiTF313405.

Miscellaneous databases

ChiTaRSiC16orf80. human.
GenomeRNAii29105.
NextBioi52157.
PROiQ9Y6A4.

Gene expression databases

BgeeiQ9Y6A4.
CleanExiHS_C16orf80.
ExpressionAtlasiQ9Y6A4. baseline and differential.
GenevisibleiQ9Y6A4. HS.

Family and domain databases

InterProiIPR007714. CFA20/WDR90/C3orf67.
[Graphical view]
PANTHERiPTHR12458. PTHR12458. 1 hit.
PfamiPF05018. DUF667. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel human cDNA homologous to murine evolutionary conserved transcript."
    Zhang M., Yu L., Li N.G., Zhou Y., Zheng L.H., Zhao S.Y.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Human transcription factor IIB mRNA, complete cds."
    Peng Y., Song H., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  5. "Bug22p, a conserved centrosomal/ciliary protein also present in higher plants, is required for an effective ciliary stroke in Paramecium."
    Laligne C., Klotz C., de Loubresse N.G., Lemullois M., Hori M., Laurent F.X., Papon J.F., Louis B., Cohen J., Koll F.
    Eukaryot. Cell 9:645-655(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Bug22 influences cilium morphology and the post-translational modification of ciliary microtubules."
    Mendes Maia T., Gogendeau D., Pennetier C., Janke C., Basto R.
    Biol. Open 3:138-151(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCFA20_HUMAN
AccessioniPrimary (citable) accession number: Q9Y6A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.