Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y6A2

- CP46A_HUMAN

UniProt

Q9Y6A2 - CP46A_HUMAN

Protein

Cholesterol 24-hydroxylase

Gene

CYP46A1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole.2 Publications

    Catalytic activityi

    Cholesterol + NADPH + O2 = (24S)-24-hydroxycholesterol + NADP+ + H2O.1 Publication

    Cofactori

    Heme group.3 Publications

    Kineticsi

    1. KM=2.2 µM for 24(S)-hydroxycholesterol1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi437 – 4371Iron (heme axial ligand)

    GO - Molecular functioni

    1. cholesterol 24-hydroxylase activity Source: UniProtKB
    2. heme binding Source: UniProtKB
    3. iron ion binding Source: InterPro
    4. steroid hydroxylase activity Source: ProtInc

    GO - Biological processi

    1. bile acid biosynthetic process Source: Reactome
    2. bile acid metabolic process Source: Reactome
    3. cholesterol catabolic process Source: UniProtKB
    4. nervous system development Source: ProtInc
    5. small molecule metabolic process Source: Reactome
    6. sterol metabolic process Source: Reactome
    7. xenobiotic metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism

    Keywords - Ligandi

    Heme, Iron, Metal-binding, NADP

    Enzyme and pathway databases

    BRENDAi1.14.13.98. 2681.
    ReactomeiREACT_11053. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
    REACT_13812. Endogenous sterols.
    SABIO-RKQ9Y6A2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cholesterol 24-hydroxylase (EC:1.14.13.98)
    Short name:
    CH24H
    Alternative name(s):
    Cytochrome P450 46A1
    Gene namesi
    Name:CYP46A1
    Synonyms:CYP46
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:2641. CYP46A1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: ProtInc
    2. endoplasmic reticulum membrane Source: Reactome
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27117.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Cholesterol 24-hydroxylasePRO_0000051994Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y6A2.
    PRIDEiQ9Y6A2.

    PTM databases

    PhosphoSiteiQ9Y6A2.

    Expressioni

    Tissue specificityi

    Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age.

    Gene expression databases

    ArrayExpressiQ9Y6A2.
    BgeeiQ9Y6A2.
    CleanExiHS_CYP46A1.
    GenevestigatoriQ9Y6A2.

    Organism-specific databases

    HPAiHPA040702.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000261835.

    Structurei

    Secondary structure

    1
    500
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi60 – 7112
    Beta strandi73 – 797
    Beta strandi82 – 876
    Helixi90 – 978
    Helixi106 – 1138
    Beta strandi118 – 1214
    Turni125 – 1273
    Helixi131 – 14111
    Helixi142 – 1454
    Helixi147 – 1515
    Helixi154 – 17017
    Beta strandi173 – 1764
    Helixi180 – 19718
    Helixi203 – 2053
    Helixi209 – 22719
    Helixi230 – 2323
    Helixi234 – 2363
    Helixi237 – 26630
    Helixi275 – 2828
    Turni283 – 2853
    Beta strandi287 – 2893
    Helixi290 – 30213
    Helixi305 – 31814
    Helixi322 – 33514
    Turni336 – 3383
    Helixi344 – 3496
    Helixi351 – 36313
    Beta strandi370 – 3745
    Beta strandi378 – 3803
    Beta strandi383 – 3853
    Beta strandi387 – 3937
    Helixi395 – 3995
    Turni402 – 4043
    Beta strandi405 – 4073
    Helixi413 – 4164
    Beta strandi424 – 4263
    Helixi433 – 4353
    Helixi440 – 45718
    Beta strandi458 – 4625
    Beta strandi470 – 48011
    Beta strandi483 – 4886

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2Q9FX-ray1.90A51-500[»]
    2Q9GX-ray2.40A51-500[»]
    3MDMX-ray1.60A51-500[»]
    3MDRX-ray2.00A/B51-500[»]
    3MDTX-ray2.30A/B51-500[»]
    3MDVX-ray2.40A/B51-500[»]
    4ENHX-ray2.50A51-500[»]
    4FIAX-ray2.10A51-500[»]
    4J14X-ray2.50A51-500[»]
    ProteinModelPortaliQ9Y6A2.
    SMRiQ9Y6A2. Positions 57-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y6A2.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei3 – 2321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi493 – 4997Poly-Pro

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000290190.
    HOVERGENiHBG102502.
    InParanoidiQ9Y6A2.
    KOiK07440.
    OMAiRPRGWQP.
    PhylomeDBiQ9Y6A2.
    TreeFamiTF352037.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y6A2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSPGLLLLGS AVLLAFGLCC TFVHRARSRY EHIPGPPRPS FLLGHLPCFW    50
    KKDEVGGRVL QDVFLDWAKK YGPVVRVNVF HKTSVIVTSP ESVKKFLMST 100
    KYNKDSKMYR ALQTVFGERL FGQGLVSECN YERWHKQRRV IDLAFSRSSL 150
    VSLMETFNEK AEQLVEILEA KADGQTPVSM QDMLTYTAMD ILAKAAFGME 200
    TSMLLGAQKP LSQAVKLMLE GITASRNTLA KFLPGKRKQL REVRESIRFL 250
    RQVGRDWVQR RREALKRGEE VPADILTQIL KAEEGAQDDE GLLDNFVTFF 300
    IAGHETSANH LAFTVMELSR QPEIVARLQA EVDEVIGSKR YLDFEDLGRL 350
    QYLSQVLKES LRLYPPAWGT FRLLEEETLI DGVRVPGNTP LLFSTYVMGR 400
    MDTYFEDPLT FNPDRFGPGA PKPRFTYFPF SLGHRSCIGQ QFAQMEVKVV 450
    MAKLLQRLEF RLVPGQRFGL QEQATLKPLD PVLCTLRPRG WQPAPPPPPC 500
    Length:500
    Mass (Da):56,821
    Last modified:November 1, 1999 - v1
    Checksum:iAB9307749D9E5FDA
    GO
    Isoform 2 (identifier: Q9Y6A2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-97: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:403
    Mass (Da):45,976
    Checksum:iE47E531F99EAA940
    GO
    Isoform 3 (identifier: Q9Y6A2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-153: Missing.
         383-392: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:337
    Mass (Da):38,315
    Checksum:i43E23CB22A230FD7
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 153153Missing in isoform 3. 1 PublicationVSP_053858Add
    BLAST
    Alternative sequencei1 – 9797Missing in isoform 2. 1 PublicationVSP_053859Add
    BLAST
    Alternative sequencei383 – 39210Missing in isoform 3. 1 PublicationVSP_053860

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF094480 mRNA. Translation: AAD41244.1.
    AK090886 mRNA. Translation: BAC03539.1.
    AK295216 mRNA. Translation: BAG58210.1.
    AL136000 Genomic DNA. No translation available.
    AL160313 Genomic DNA. No translation available.
    BC022539 mRNA. Translation: AAH22539.1.
    CCDSiCCDS9954.1. [Q9Y6A2-1]
    RefSeqiNP_006659.1. NM_006668.1. [Q9Y6A2-1]
    UniGeneiHs.25121.

    Genome annotation databases

    EnsembliENST00000261835; ENSP00000261835; ENSG00000036530. [Q9Y6A2-1]
    ENST00000554176; ENSP00000450553; ENSG00000036530. [Q9Y6A2-3]
    GeneIDi10858.
    KEGGihsa:10858.
    UCSCiuc001ygo.3. human. [Q9Y6A2-1]

    Polymorphism databases

    DMDMi12585217.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF094480 mRNA. Translation: AAD41244.1 .
    AK090886 mRNA. Translation: BAC03539.1 .
    AK295216 mRNA. Translation: BAG58210.1 .
    AL136000 Genomic DNA. No translation available.
    AL160313 Genomic DNA. No translation available.
    BC022539 mRNA. Translation: AAH22539.1 .
    CCDSi CCDS9954.1. [Q9Y6A2-1 ]
    RefSeqi NP_006659.1. NM_006668.1. [Q9Y6A2-1 ]
    UniGenei Hs.25121.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2Q9F X-ray 1.90 A 51-500 [» ]
    2Q9G X-ray 2.40 A 51-500 [» ]
    3MDM X-ray 1.60 A 51-500 [» ]
    3MDR X-ray 2.00 A/B 51-500 [» ]
    3MDT X-ray 2.30 A/B 51-500 [» ]
    3MDV X-ray 2.40 A/B 51-500 [» ]
    4ENH X-ray 2.50 A 51-500 [» ]
    4FIA X-ray 2.10 A 51-500 [» ]
    4J14 X-ray 2.50 A 51-500 [» ]
    ProteinModelPortali Q9Y6A2.
    SMRi Q9Y6A2. Positions 57-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000261835.

    PTM databases

    PhosphoSitei Q9Y6A2.

    Polymorphism databases

    DMDMi 12585217.

    Proteomic databases

    PaxDbi Q9Y6A2.
    PRIDEi Q9Y6A2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261835 ; ENSP00000261835 ; ENSG00000036530 . [Q9Y6A2-1 ]
    ENST00000554176 ; ENSP00000450553 ; ENSG00000036530 . [Q9Y6A2-3 ]
    GeneIDi 10858.
    KEGGi hsa:10858.
    UCSCi uc001ygo.3. human. [Q9Y6A2-1 ]

    Organism-specific databases

    CTDi 10858.
    GeneCardsi GC14P100150.
    HGNCi HGNC:2641. CYP46A1.
    HPAi HPA040702.
    MIMi 604087. gene.
    neXtProti NX_Q9Y6A2.
    PharmGKBi PA27117.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000290190.
    HOVERGENi HBG102502.
    InParanoidi Q9Y6A2.
    KOi K07440.
    OMAi RPRGWQP.
    PhylomeDBi Q9Y6A2.
    TreeFami TF352037.

    Enzyme and pathway databases

    BRENDAi 1.14.13.98. 2681.
    Reactomei REACT_11053. Synthesis of bile acids and bile salts via 24-hydroxycholesterol.
    REACT_13812. Endogenous sterols.
    SABIO-RK Q9Y6A2.

    Miscellaneous databases

    ChiTaRSi CYP46A1. human.
    EvolutionaryTracei Q9Y6A2.
    GeneWikii CYP46A1.
    GenomeRNAii 10858.
    NextBioi 35472068.
    PROi Q9Y6A2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y6A2.
    Bgeei Q9Y6A2.
    CleanExi HS_CYP46A1.
    Genevestigatori Q9Y6A2.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain."
      Lund E.G., Guileyardo J.M., Russell D.W.
      Proc. Natl. Acad. Sci. U.S.A. 96:7238-7243(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Amygdala and Caudate nucleus.
    3. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain."
      Mast N., Norcross R., Andersson U., Shou M., Nakayama K., Bjoerkhem I., Pikuleva I.A.
      Biochemistry 42:14284-14292(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, BIOPHYSICOCHEMICAL PROPERTIES.
    6. "Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain."
      Mast N., White M.A., Bjorkhem I., Johnson E.F., Stout C.D., Pikuleva I.A.
      Proc. Natl. Acad. Sci. U.S.A. 105:9546-9551(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 51-500 IN COMPLEX WITH HEME AND CHOLESTEROL 3-SULFATE, FUNCTION, CATALYTIC ACTIVITY, COFACTOR.
    7. "Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain."
      Mast N., Charvet C., Pikuleva I.A., Stout C.D.
      J. Biol. Chem. 285:31783-31795(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 51-500 IN COMPLEXES WITH HEME AND INHIBITORS, FUNCTION, COFACTOR.
    8. "Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response."
      Mast N., Zheng W., Stout C.D., Pikuleva I.A.
      J. Biol. Chem. 288:4613-4624(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 51-500 IN COMPLEXES WITH HEME AND THE INHIBITOR BICALUTAMIDE, COFACTOR.

    Entry informationi

    Entry nameiCP46A_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y6A2
    Secondary accession number(s): B4DHP8, E7EQG9, Q8N2B0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3