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Q9Y696

- CLIC4_HUMAN

UniProt

Q9Y696 - CLIC4_HUMAN

Protein

Chloride intracellular channel protein 4

Gene

CLIC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).6 Publications

    GO - Molecular functioni

    1. chloride channel activity Source: ProtInc
    2. protein binding Source: UniProtKB
    3. voltage-gated chloride channel activity Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. branching morphogenesis of an epithelial tube Source: Ensembl
    3. cell differentiation Source: UniProtKB
    4. cellular response to calcium ion Source: UniProtKB
    5. chloride transmembrane transport Source: GOC
    6. chloride transport Source: UniProtKB
    7. endothelial cell morphogenesis Source: Ensembl
    8. establishment or maintenance of apical/basal cell polarity Source: UniProtKB
    9. fertilization Source: Ensembl
    10. keratinocyte differentiation Source: UniProtKB
    11. multicellular organism growth Source: Ensembl
    12. negative regulation of cell migration Source: UniProtKB
    13. regulation of cytoskeleton organization Source: UniProtKB
    14. retina vasculature morphogenesis in camera-type eye Source: Ensembl
    15. vacuolar acidification Source: Ensembl

    Keywords - Molecular functioni

    Chloride channel, Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Transport

    Keywords - Ligandi

    Chloride

    Protein family/group databases

    TCDBi1.A.12.1.6. the intracellular chloride channel (clic) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chloride intracellular channel protein 4
    Alternative name(s):
    Intracellular chloride ion channel protein p64H1
    Gene namesi
    Name:CLIC4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:13518. CLIC4.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasmic vesicle membrane Curated; Single-pass membrane protein Curated. Nucleus matrix. Cell membrane Curated; Single-pass membrane protein Curated. Mitochondrion. Cell junction
    Note: Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.

    GO - Cellular componenti

    1. actin cytoskeleton Source: UniProtKB
    2. apical part of cell Source: UniProtKB
    3. cell-cell junction Source: UniProtKB
    4. cell surface Source: UniProtKB
    5. centrosome Source: UniProtKB
    6. chloride channel complex Source: UniProtKB-KW
    7. cytoplasm Source: UniProtKB
    8. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    9. cytosol Source: UniProtKB
    10. extracellular vesicular exosome Source: UniProt
    11. intracellular Source: LIFEdb
    12. microvillus Source: UniProtKB
    13. midbody Source: UniProtKB
    14. mitochondrion Source: UniProtKB
    15. nuclear matrix Source: UniProtKB
    16. perinuclear region of cytoplasm Source: UniProtKB
    17. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Mitochondrion, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26591.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 253252Chloride intracellular channel protein 4PRO_0000144210Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei4 – 41Phosphoserine1 Publication
    Modified residuei130 – 1301N6-acetyllysine1 Publication
    Modified residuei236 – 2361PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y696.
    PaxDbiQ9Y696.
    PeptideAtlasiQ9Y696.
    PRIDEiQ9Y696.

    2D gel databases

    OGPiQ9Y696.
    REPRODUCTION-2DPAGEIPI00001960.

    PTM databases

    PhosphoSiteiQ9Y696.

    Expressioni

    Tissue specificityi

    Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.3 Publications

    Inductioni

    Up-regulated by calcium ions in differentiating keratinocytes. Up-regulated in myofibroblasts.2 Publications

    Gene expression databases

    ArrayExpressiQ9Y696.
    BgeeiQ9Y696.
    CleanExiHS_CLIC4.
    GenevestigatoriQ9Y696.

    Organism-specific databases

    HPAiHPA008019.

    Interactioni

    Subunit structurei

    Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, IQGAP1 and CLIC5A. Binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. Monomer. Interacts with HRH3. Interacts with AKAP9.4 Publications

    Protein-protein interaction databases

    BioGridi117431. 9 interactions.
    IntActiQ9Y696. 3 interactions.
    MINTiMINT-3087884.
    STRINGi9606.ENSP00000363500.

    Structurei

    Secondary structure

    1
    253
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi19 – 257
    Beta strandi29 – 324
    Helixi36 – 4813
    Beta strandi53 – 575
    Helixi64 – 696
    Beta strandi77 – 804
    Beta strandi83 – 853
    Helixi88 – 9811
    Turni101 – 1033
    Helixi112 – 1154
    Turni116 – 1205
    Helixi121 – 13010
    Helixi134 – 1363
    Helixi137 – 15620
    Beta strandi181 – 1833
    Helixi186 – 20621
    Helixi215 – 22511
    Helixi228 – 2314
    Helixi237 – 2437
    Turni244 – 2474

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2AHEX-ray1.80A1-251[»]
    2D2ZX-ray2.20A/B/C1-253[»]
    3OQSX-ray2.00B198-207[»]
    ProteinModelPortaliQ9Y696.
    SMRiQ9Y696. Positions 6-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y696.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 5721Helical; Note=After insertion into the membraneSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini104 – 244141GST C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 101100Required for insertion into the membraneCuratedAdd
    BLAST

    Domaini

    Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.1 Publication

    Sequence similaritiesi

    Belongs to the chloride channel CLIC family.Curated
    Contains 1 GST C-terminal domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG282171.
    HOGENOMiHOG000231548.
    HOVERGENiHBG050994.
    InParanoidiQ9Y696.
    KOiK05024.
    OMAiIDHNSIE.
    OrthoDBiEOG7X3QR3.
    PhylomeDBiQ9Y696.
    TreeFamiTF315438.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR002946. Int_Cl_channel.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF13417. GST_N_3. 1 hit.
    [Graphical view]
    PRINTSiPR01263. INTCLCHANNEL.
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    TIGRFAMsiTIGR00862. O-ClC. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y696-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSMPLNGL KEEDKEPLIE LFVKAGSDGE SIGNCPFSQR LFMILWLKGV    50
    VFSVTTVDLK RKPADLQNLA PGTHPPFITF NSEVKTDVNK IEEFLEEVLC 100
    PPKYLKLSPK HPESNTAGMD IFAKFSAYIK NSRPEANEAL ERGLLKTLQK 150
    LDEYLNSPLP DEIDENSMED IKFSTRKFLD GNEMTLADCN LLPKLHIVKV 200
    VAKKYRNFDI PKEMTGIWRY LTNAYSRDEF TNTCPSDKEV EIAYSDVAKR 250
    LTK 253
    Length:253
    Mass (Da):28,772
    Last modified:January 23, 2007 - v4
    Checksum:i3DD21A33C66626A5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti14 – 141D → Y in AAD26136. (PubMed:10191309)Curated
    Sequence conflicti133 – 1342RP → SA in AAD38446. (PubMed:10070163)Curated
    Sequence conflicti133 – 1342RP → SA in AAD26136. (PubMed:10191309)Curated
    Sequence conflicti225 – 2251Y → S in AAD26136. (PubMed:10191309)Curated
    Sequence conflicti233 – 2331T → A in AAD26136. (PubMed:10191309)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097330 mRNA. Translation: AAD38446.1.
    AF109196 mRNA. Translation: AAD26136.1.
    AL117424 mRNA. Translation: CAB55916.1.
    BC012444 mRNA. Translation: AAH12444.1.
    CCDSiCCDS256.1.
    PIRiT17226.
    RefSeqiNP_039234.1. NM_013943.2.
    UniGeneiHs.440544.

    Genome annotation databases

    EnsembliENST00000374379; ENSP00000363500; ENSG00000169504.
    ENST00000488683; ENSP00000436538; ENSG00000169504.
    GeneIDi25932.
    KEGGihsa:25932.
    UCSCiuc001bjo.2. human.

    Polymorphism databases

    DMDMi20141285.

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097330 mRNA. Translation: AAD38446.1 .
    AF109196 mRNA. Translation: AAD26136.1 .
    AL117424 mRNA. Translation: CAB55916.1 .
    BC012444 mRNA. Translation: AAH12444.1 .
    CCDSi CCDS256.1.
    PIRi T17226.
    RefSeqi NP_039234.1. NM_013943.2.
    UniGenei Hs.440544.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2AHE X-ray 1.80 A 1-251 [» ]
    2D2Z X-ray 2.20 A/B/C 1-253 [» ]
    3OQS X-ray 2.00 B 198-207 [» ]
    ProteinModelPortali Q9Y696.
    SMRi Q9Y696. Positions 6-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117431. 9 interactions.
    IntActi Q9Y696. 3 interactions.
    MINTi MINT-3087884.
    STRINGi 9606.ENSP00000363500.

    Protein family/group databases

    TCDBi 1.A.12.1.6. the intracellular chloride channel (clic) family.

    PTM databases

    PhosphoSitei Q9Y696.

    Polymorphism databases

    DMDMi 20141285.

    2D gel databases

    OGPi Q9Y696.
    REPRODUCTION-2DPAGE IPI00001960.

    Proteomic databases

    MaxQBi Q9Y696.
    PaxDbi Q9Y696.
    PeptideAtlasi Q9Y696.
    PRIDEi Q9Y696.

    Protocols and materials databases

    DNASUi 25932.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000374379 ; ENSP00000363500 ; ENSG00000169504 .
    ENST00000488683 ; ENSP00000436538 ; ENSG00000169504 .
    GeneIDi 25932.
    KEGGi hsa:25932.
    UCSCi uc001bjo.2. human.

    Organism-specific databases

    CTDi 25932.
    GeneCardsi GC01P025071.
    HGNCi HGNC:13518. CLIC4.
    HPAi HPA008019.
    MIMi 606536. gene.
    neXtProti NX_Q9Y696.
    PharmGKBi PA26591.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG282171.
    HOGENOMi HOG000231548.
    HOVERGENi HBG050994.
    InParanoidi Q9Y696.
    KOi K05024.
    OMAi IDHNSIE.
    OrthoDBi EOG7X3QR3.
    PhylomeDBi Q9Y696.
    TreeFami TF315438.

    Miscellaneous databases

    ChiTaRSi CLIC4. human.
    EvolutionaryTracei Q9Y696.
    GeneWikii CLIC4.
    GenomeRNAii 25932.
    NextBioi 47480.
    PROi Q9Y696.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y696.
    Bgeei Q9Y696.
    CleanExi HS_CLIC4.
    Genevestigatori Q9Y696.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR002946. Int_Cl_channel.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF13417. GST_N_3. 1 hit.
    [Graphical view ]
    PRINTSi PR01263. INTCLCHANNEL.
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    TIGRFAMsi TIGR00862. O-ClC. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel p64-related Cl- channel: subcellular distribution and nephron segment-specific expression."
      Edwards J.C.
      Am. J. Physiol. 276:F398-F408(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons."
      Chuang J.Z., Milner T.A., Zhu M., Sung C.H.
      J. Neurosci. 19:2919-2928(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    5. Bienvenut W.V., Claeys D.
      Submitted (FEB-2006) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-24; 41-60; 62-85 AND 125-130, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Platelet.
    6. "Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli."
      Berryman M., Bretscher A.
      Mol. Biol. Cell 11:1509-1521(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT, TISSUE SPECIFICITY.
    7. "Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts."
      Ronnov-Jessen L., Villadsen R., Edwards J.C., Petersen O.W.
      Am. J. Pathol. 161:471-480(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, FUNCTION.
    8. "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member."
      Shanks R.A., Larocca M.C., Berryman M., Edwards J.C., Urushidani T., Navarre J., Goldenring J.R.
      J. Biol. Chem. 277:40973-40980(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH AKAP9.
    9. "CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells."
      Berryman M.A., Goldenring J.R.
      Cell Motil. Cytoskeleton 56:159-172(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    10. "Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis."
      Bohman S., Matsumoto T., Suh K., Dimberg A., Jakobsson L., Yuspa S., Claesson-Welsh L.
      J. Biol. Chem. 280:42397-42404(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers."
      Suh K.S., Crutchley J.M., Koochek A., Ryscavage A., Bhat K., Tanaka T., Oshima A., Fitzgerald P., Yuspa S.H.
      Clin. Cancer Res. 13:121-131(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    12. "CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation."
      Suh K.S., Mutoh M., Mutoh T., Li L., Ryscavage A., Crutchley J.M., Dumont R.A., Cheng C., Yuspa S.H.
      J. Cell Sci. 120:2631-2640(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION, SUBCELLULAR LOCATION.
    13. "CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression."
      Maeda K., Haraguchi M., Kuramasu A., Sato T., Ariake K., Sakagami H., Kondo H., Yanai K., Fukunaga K., Yanagisawa T., Sukegawa J.
      Biochem. Biophys. Res. Commun. 369:603-608(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HRH3, FUNCTION, SUBCELLULAR LOCATION.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Chloride intracellular channel 4 is involved in endothelial proliferation and morphogenesis in vitro."
      Tung J.J., Hobert O., Berryman M., Kitajewski J.
      Angiogenesis 12:209-220(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4."
      Littler D.R., Assaad N.N., Harrop S.J., Brown L.J., Pankhurst G.J., Luciani P., Aguilar M.-I., Mazzanti M., Berryman M.A., Breit S.N., Curmi P.M.G.
      FEBS J. 272:4996-5007(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS), SUBUNIT, FUNCTION, SUBCELLULAR LOCATION.
    21. "Trimeric structure of the wild soluble chloride intracellular ion channel CLIC4 observed in crystals."
      Li Y., Li D., Zeng Z., Wang D.
      Biochem. Biophys. Res. Commun. 343:1272-1278(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS), DOMAIN.

    Entry informationi

    Entry nameiCLIC4_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y696
    Secondary accession number(s): Q9UFW9, Q9UQJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 138 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3