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Q9Y696

- CLIC4_HUMAN

UniProt

Q9Y696 - CLIC4_HUMAN

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Protein

Chloride intracellular channel protein 4

Gene

CLIC4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).6 Publications

GO - Molecular functioni

  1. chloride channel activity Source: ProtInc
  2. voltage-gated chloride channel activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. branching morphogenesis of an epithelial tube Source: Ensembl
  3. cell differentiation Source: UniProtKB
  4. cellular response to calcium ion Source: UniProtKB
  5. chloride transmembrane transport Source: GOC
  6. chloride transport Source: UniProtKB
  7. endothelial cell morphogenesis Source: Ensembl
  8. establishment or maintenance of apical/basal cell polarity Source: UniProtKB
  9. fertilization Source: Ensembl
  10. keratinocyte differentiation Source: UniProtKB
  11. multicellular organism growth Source: Ensembl
  12. negative regulation of cell migration Source: UniProtKB
  13. regulation of cytoskeleton organization Source: UniProtKB
  14. retina vasculature morphogenesis in camera-type eye Source: Ensembl
  15. vacuolar acidification Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Protein family/group databases

TCDBi1.A.12.1.6. the intracellular chloride channel (clic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel protein 4
Alternative name(s):
Intracellular chloride ion channel protein p64H1
Gene namesi
Name:CLIC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:13518. CLIC4.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Cytoplasmic vesicle membrane Curated; Single-pass membrane protein Curated. Nucleus matrix. Cell membrane Curated; Single-pass membrane protein Curated. Mitochondrion. Cell junction
Note: Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.

GO - Cellular componenti

  1. actin cytoskeleton Source: UniProtKB
  2. apical part of cell Source: UniProtKB
  3. cell-cell junction Source: UniProtKB
  4. cell surface Source: UniProtKB
  5. centrosome Source: UniProtKB
  6. chloride channel complex Source: UniProtKB-KW
  7. cytoplasm Source: UniProtKB
  8. cytoplasmic vesicle Source: UniProtKB-KW
  9. cytosol Source: UniProtKB
  10. extracellular vesicular exosome Source: UniProt
  11. intracellular Source: LIFEdb
  12. microvillus Source: UniProtKB
  13. midbody Source: UniProtKB
  14. mitochondrion Source: UniProtKB
  15. nuclear matrix Source: UniProtKB
  16. perinuclear region of cytoplasm Source: UniProtKB
  17. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Membrane, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26591.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 253252Chloride intracellular channel protein 4PRO_0000144210Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications
Modified residuei4 – 41Phosphoserine1 Publication
Modified residuei130 – 1301N6-acetyllysine1 Publication
Modified residuei236 – 2361PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Y696.
PaxDbiQ9Y696.
PeptideAtlasiQ9Y696.
PRIDEiQ9Y696.

2D gel databases

OGPiQ9Y696.
REPRODUCTION-2DPAGEIPI00001960.

PTM databases

PhosphoSiteiQ9Y696.

Expressioni

Tissue specificityi

Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.3 Publications

Inductioni

Up-regulated by calcium ions in differentiating keratinocytes. Up-regulated in myofibroblasts.2 Publications

Gene expression databases

BgeeiQ9Y696.
CleanExiHS_CLIC4.
ExpressionAtlasiQ9Y696. baseline and differential.
GenevestigatoriQ9Y696.

Organism-specific databases

HPAiHPA008019.

Interactioni

Subunit structurei

Component of a multimeric complex consisting of several cytoskeletal proteins, including actin, ezrin, alpha-actinin, gelsolin, IQGAP1 and CLIC5A. Binds directly to brain dynamin I in a complex containing actin, tubulin and 14-3-3 isoforms. Monomer. Interacts with HRH3. Interacts with AKAP9.4 Publications

Protein-protein interaction databases

BioGridi117431. 14 interactions.
IntActiQ9Y696. 3 interactions.
MINTiMINT-3087884.
STRINGi9606.ENSP00000363500.

Structurei

Secondary structure

1
253
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi19 – 257
Beta strandi29 – 324
Helixi36 – 4813
Beta strandi53 – 575
Helixi64 – 696
Beta strandi77 – 804
Beta strandi83 – 853
Helixi88 – 9811
Turni101 – 1033
Helixi112 – 1154
Turni116 – 1205
Helixi121 – 13010
Helixi134 – 1363
Helixi137 – 15620
Beta strandi181 – 1833
Helixi186 – 20621
Helixi215 – 22511
Helixi228 – 2314
Helixi237 – 2437
Turni244 – 2474

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2AHEX-ray1.80A1-251[»]
2D2ZX-ray2.20A/B/C1-253[»]
3OQSX-ray2.00B198-207[»]
ProteinModelPortaliQ9Y696.
SMRiQ9Y696. Positions 6-253.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y696.

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 5721Helical; Note=After insertion into the membraneSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini104 – 244141GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 101100Required for insertion into the membraneCuratedAdd
BLAST

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.1 Publication

Sequence similaritiesi

Belongs to the chloride channel CLIC family.Curated
Contains 1 GST C-terminal domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG282171.
GeneTreeiENSGT00550000074477.
HOGENOMiHOG000231548.
HOVERGENiHBG050994.
InParanoidiQ9Y696.
KOiK05024.
OMAiIDHNSIE.
OrthoDBiEOG7X3QR3.
PhylomeDBiQ9Y696.
TreeFamiTF315438.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR002946. Int_Cl_channel.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
PRINTSiPR01263. INTCLCHANNEL.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00862. O-ClC. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y696-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALSMPLNGL KEEDKEPLIE LFVKAGSDGE SIGNCPFSQR LFMILWLKGV
60 70 80 90 100
VFSVTTVDLK RKPADLQNLA PGTHPPFITF NSEVKTDVNK IEEFLEEVLC
110 120 130 140 150
PPKYLKLSPK HPESNTAGMD IFAKFSAYIK NSRPEANEAL ERGLLKTLQK
160 170 180 190 200
LDEYLNSPLP DEIDENSMED IKFSTRKFLD GNEMTLADCN LLPKLHIVKV
210 220 230 240 250
VAKKYRNFDI PKEMTGIWRY LTNAYSRDEF TNTCPSDKEV EIAYSDVAKR

LTK
Length:253
Mass (Da):28,772
Last modified:January 23, 2007 - v4
Checksum:i3DD21A33C66626A5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141D → Y in AAD26136. (PubMed:10191309)Curated
Sequence conflicti133 – 1342RP → SA in AAD38446. (PubMed:10070163)Curated
Sequence conflicti133 – 1342RP → SA in AAD26136. (PubMed:10191309)Curated
Sequence conflicti225 – 2251Y → S in AAD26136. (PubMed:10191309)Curated
Sequence conflicti233 – 2331T → A in AAD26136. (PubMed:10191309)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097330 mRNA. Translation: AAD38446.1.
AF109196 mRNA. Translation: AAD26136.1.
AL117424 mRNA. Translation: CAB55916.1.
BC012444 mRNA. Translation: AAH12444.1.
CCDSiCCDS256.1.
PIRiT17226.
RefSeqiNP_039234.1. NM_013943.2.
UniGeneiHs.440544.

Genome annotation databases

EnsembliENST00000374379; ENSP00000363500; ENSG00000169504.
ENST00000488683; ENSP00000436538; ENSG00000169504.
GeneIDi25932.
KEGGihsa:25932.
UCSCiuc001bjo.2. human.

Polymorphism databases

DMDMi20141285.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097330 mRNA. Translation: AAD38446.1 .
AF109196 mRNA. Translation: AAD26136.1 .
AL117424 mRNA. Translation: CAB55916.1 .
BC012444 mRNA. Translation: AAH12444.1 .
CCDSi CCDS256.1.
PIRi T17226.
RefSeqi NP_039234.1. NM_013943.2.
UniGenei Hs.440544.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2AHE X-ray 1.80 A 1-251 [» ]
2D2Z X-ray 2.20 A/B/C 1-253 [» ]
3OQS X-ray 2.00 B 198-207 [» ]
ProteinModelPortali Q9Y696.
SMRi Q9Y696. Positions 6-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117431. 14 interactions.
IntActi Q9Y696. 3 interactions.
MINTi MINT-3087884.
STRINGi 9606.ENSP00000363500.

Protein family/group databases

TCDBi 1.A.12.1.6. the intracellular chloride channel (clic) family.

PTM databases

PhosphoSitei Q9Y696.

Polymorphism databases

DMDMi 20141285.

2D gel databases

OGPi Q9Y696.
REPRODUCTION-2DPAGE IPI00001960.

Proteomic databases

MaxQBi Q9Y696.
PaxDbi Q9Y696.
PeptideAtlasi Q9Y696.
PRIDEi Q9Y696.

Protocols and materials databases

DNASUi 25932.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000374379 ; ENSP00000363500 ; ENSG00000169504 .
ENST00000488683 ; ENSP00000436538 ; ENSG00000169504 .
GeneIDi 25932.
KEGGi hsa:25932.
UCSCi uc001bjo.2. human.

Organism-specific databases

CTDi 25932.
GeneCardsi GC01P025071.
HGNCi HGNC:13518. CLIC4.
HPAi HPA008019.
MIMi 606536. gene.
neXtProti NX_Q9Y696.
PharmGKBi PA26591.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG282171.
GeneTreei ENSGT00550000074477.
HOGENOMi HOG000231548.
HOVERGENi HBG050994.
InParanoidi Q9Y696.
KOi K05024.
OMAi IDHNSIE.
OrthoDBi EOG7X3QR3.
PhylomeDBi Q9Y696.
TreeFami TF315438.

Miscellaneous databases

ChiTaRSi CLIC4. human.
EvolutionaryTracei Q9Y696.
GeneWikii CLIC4.
GenomeRNAii 25932.
NextBioi 47480.
PROi Q9Y696.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y696.
CleanExi HS_CLIC4.
ExpressionAtlasi Q9Y696. baseline and differential.
Genevestigatori Q9Y696.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR002946. Int_Cl_channel.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF13417. GST_N_3. 1 hit.
[Graphical view ]
PRINTSi PR01263. INTCLCHANNEL.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsi TIGR00862. O-ClC. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel p64-related Cl- channel: subcellular distribution and nephron segment-specific expression."
    Edwards J.C.
    Am. J. Physiol. 276:F398-F408(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons."
    Chuang J.Z., Milner T.A., Zhu M., Sung C.H.
    J. Neurosci. 19:2919-2928(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  5. Bienvenut W.V., Claeys D.
    Submitted (FEB-2006) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-24; 41-60; 62-85 AND 125-130, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Platelet.
  6. "Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli."
    Berryman M., Bretscher A.
    Mol. Biol. Cell 11:1509-1521(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, TISSUE SPECIFICITY.
  7. "Differential expression of a chloride intracellular channel gene, CLIC4, in transforming growth factor-beta1-mediated conversion of fibroblasts to myofibroblasts."
    Ronnov-Jessen L., Villadsen R., Edwards J.C., Petersen O.W.
    Am. J. Pathol. 161:471-480(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, FUNCTION.
  8. "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member."
    Shanks R.A., Larocca M.C., Berryman M., Edwards J.C., Urushidani T., Navarre J., Goldenring J.R.
    J. Biol. Chem. 277:40973-40980(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH AKAP9.
  9. "CLIC4 is enriched at cell-cell junctions and colocalizes with AKAP350 at the centrosome and midbody of cultured mammalian cells."
    Berryman M.A., Goldenring J.R.
    Cell Motil. Cytoskeleton 56:159-172(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. "Proteomic analysis of vascular endothelial growth factor-induced endothelial cell differentiation reveals a role for chloride intracellular channel 4 (CLIC4) in tubular morphogenesis."
    Bohman S., Matsumoto T., Suh K., Dimberg A., Jakobsson L., Yuspa S., Claesson-Welsh L.
    J. Biol. Chem. 280:42397-42404(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers."
    Suh K.S., Crutchley J.M., Koochek A., Ryscavage A., Bhat K., Tanaka T., Oshima A., Fitzgerald P., Yuspa S.H.
    Clin. Cancer Res. 13:121-131(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  12. "CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation."
    Suh K.S., Mutoh M., Mutoh T., Li L., Ryscavage A., Crutchley J.M., Dumont R.A., Cheng C., Yuspa S.H.
    J. Cell Sci. 120:2631-2640(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION, SUBCELLULAR LOCATION.
  13. "CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression."
    Maeda K., Haraguchi M., Kuramasu A., Sato T., Ariake K., Sakagami H., Kondo H., Yanai K., Fukunaga K., Yanagisawa T., Sukegawa J.
    Biochem. Biophys. Res. Commun. 369:603-608(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HRH3, FUNCTION, SUBCELLULAR LOCATION.
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Chloride intracellular channel 4 is involved in endothelial proliferation and morphogenesis in vitro."
    Tung J.J., Hobert O., Berryman M., Kitajewski J.
    Angiogenesis 12:209-220(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-130, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  18. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  19. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Crystal structure of the soluble form of the redox-regulated chloride ion channel protein CLIC4."
    Littler D.R., Assaad N.N., Harrop S.J., Brown L.J., Pankhurst G.J., Luciani P., Aguilar M.-I., Mazzanti M., Berryman M.A., Breit S.N., Curmi P.M.G.
    FEBS J. 272:4996-5007(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS), SUBUNIT, FUNCTION, SUBCELLULAR LOCATION.
  21. "Trimeric structure of the wild soluble chloride intracellular ion channel CLIC4 observed in crystals."
    Li Y., Li D., Zeng Z., Wang D.
    Biochem. Biophys. Res. Commun. 343:1272-1278(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS), DOMAIN.

Entry informationi

Entry nameiCLIC4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y696
Secondary accession number(s): Q9UFW9, Q9UQJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 139 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3