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UniProtKB - Q9Y694 (S22A7_HUMAN)

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Protein

Solute carrier family 22 member 7

Gene

SLC22A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.5 Publications

Kineticsi

  1. KM=713 nM for prostaglandin E22 Publications
  2. KM=440 µM for tetracycline2 Publications

    GO - Molecular functioni

    Complete GO annotation...

    GO - Biological processi

    • organic anion transport Source: ProtInc
    • sodium-independent organic anion transport Source: GO_Central
    Complete GO annotation...

    Keywordsi

    Biological processIon transport, Transport

    Enzyme and pathway databases

    ReactomeiR-HSA-561048. Organic anion transport.

    Protein family/group databases

    TCDBi2.A.1.19.25. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 7
    Alternative name(s):
    Novel liver transporter
    Organic anion transporter 2
    Short name:
    hOAT2
    Gene namesi
    Name:SLC22A7
    Synonyms:NLT, OAT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    Proteomesi
    • UP000005640 Componenti: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:10971. SLC22A7.

    Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
    Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
    Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
    Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
    Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
    Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
    Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
    Transmembranei376 – 397HelicalSequence analysisAdd BLAST22
    Transmembranei404 – 423HelicalSequence analysisAdd BLAST20
    Transmembranei432 – 452HelicalSequence analysisAdd BLAST21
    Transmembranei466 – 486HelicalSequence analysisAdd BLAST21
    Transmembranei493 – 513HelicalSequence analysisAdd BLAST21

    GO - Cellular componenti

    • basolateral plasma membrane Source: UniProtKB-SubCell
    • integral component of plasma membrane Source: ProtInc
    • membrane Source: ProtInc
    • plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    DisGeNETi10864.
    OpenTargetsiENSG00000137204.
    PharmGKBiPA35848.

    Chemistry databases

    ChEMBLiCHEMBL1955711.
    DrugBankiDB00945. Acetylsalicylic acid.
    DB00437. Allopurinol.
    DB00345. Aminohippuric acid.
    DB00887. Bumetanide.
    DB00456. Cefalotin.
    DB01326. Cefamandole.
    DB01329. Cefoperazone.
    DB00493. Cefotaxime.
    DB02659. Cholic Acid.
    DB00501. Cimetidine.
    DB01211. Clarithromycin.
    DB02527. Cyclic Adenosine Monophosphate.
    DB01160. Dinoprost Tromethamine.
    DB00917. Dinoprostone.
    DB01248. Docetaxel.
    DB00584. Enalapril.
    DB00544. Fluorouracil.
    DB01004. Ganciclovir.
    DB03553. Glutaric Acid.
    DB01016. Glyburide.
    DB00328. Indomethacin.
    DB01009. Ketoprofen.
    DB00563. Methotrexate.
    DB01017. Minocycline.
    DB01303. Oxtriphylline.
    DB00595. Oxytetracycline.
    DB00175. Pravastatin.
    DB01032. Probenecid.
    DB01045. Rifampicin.
    DB00936. Salicylic acid.
    DB00624. Testosterone.
    DB00759. Tetracycline.
    DB00277. Theophylline.
    DB00313. Valproic Acid.
    DB00943. Zalcitabine.
    DB00495. Zidovudine.

    Polymorphism and mutation databases

    BioMutaiSLC22A7.
    DMDMi74753520.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00003174811 – 548Solute carrier family 22 member 7Add BLAST548

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Glycosylationi91N-linked (GlcNAc...) asparagine1 Publication1

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y694.
    PeptideAtlasiQ9Y694.
    PRIDEiQ9Y694.

    PTM databases

    iPTMnetiQ9Y694.
    PhosphoSitePlusiQ9Y694.

    Expressioni

    Tissue specificityi

    Expressed in liver and kidney.3 Publications

    Gene expression databases

    BgeeiENSG00000137204.
    CleanExiHS_SLC22A7.
    ExpressionAtlasiQ9Y694. baseline and differential.
    GenevisibleiQ9Y694. HS.

    Organism-specific databases

    HPAiHPA030220.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9Y694. 2 interactors.
    STRINGi9606.ENSP00000361666.

    Chemistry databases

    BindingDBiQ9Y694.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y694.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiKOG0255. Eukaryota.
    COG0477. LUCA.
    GeneTreeiENSGT00760000118852.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    InParanoidiQ9Y694.
    KOiK08204.
    OMAiWLDVEHR.
    OrthoDBiEOG091G07GO.
    PhylomeDBiQ9Y694.
    TreeFamiTF315847.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiView protein in InterPro
    IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR004749. Orgcat_transp/SVOP.
    PfamiView protein in Pfam
    PF07690. MFS_1. 1 hit.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00898. 2A0119. 1 hit.
    PROSITEiView protein in PROSITE
    PS50850. MFS. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q9Y694-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA 
            60         70         80         90        100
    LPGAPANFSH QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS 
           110        120        130        140        150
    RGELEDEPAT VPCSQGWEYD HSEFSSTIAT ESQWDLVCEQ KGLNRAASTF 
           160        170        180        190        200
    FFAGVLVGAV AFGYLSDRFG RRRLLLVAYV STLVLGLASA ASVSYVMFAI 
           210        220        230        240        250
    TRTLTGSALA GFTIIVMPLE LEWLDVEHRT VAGVLSSTFW TGGVMLLALV 
           260        270        280        290        300
    GYLIRDWRWL LLAVTLPCAP GILSLWWVPE SARWLLTQGH VKEAHRYLLH 
           310        320        330        340        350
    CARLNGRPVC EDSFSQEAVS KVAAGERVVR RPSYLDLFRT PRLRHISLCC 
           360        370        380        390        400
    VVVWFGVNFS YYGLSLDVSG LGLNVYQTQL LFGAVELPSK LLVYLSVRYA 
           410        420        430        440        450
    GRRLTQAGTL LGTALAFGTR LLVSSDMKSW STVLAVMGKA FSEAAFTTAY 
           460        470        480        490        500
    LFTSELYPTV LRQTGMGLTA LVGRLGGSLA PLAALLDGVW LSLPKLTYGG 
           510        520        530        540 
    IALLAAGTAL LLPETRQAQL PETIQDVERK SAPTSLQEEE MPMKQVQN
    Length:548
    Mass (Da):60,026
    Last modified:November 1, 1999 - v1
    Checksum:i5BA4C3FCC3C57533
    GO
    Isoform 2 (identifier: Q9Y694-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-133: Missing.

    Show »
    Length:546
    Mass (Da):59,810
    Checksum:i6A87AA1BD6FEA15C
    GO
    Isoform 3 (identifier: Q9Y694-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-133: Missing.
         531-548: SAPTSLQEEEMPMKQVQN → RCVHRTVSVYV

    Show »
    Length:539
    Mass (Da):59,082
    Checksum:iF3D6F799778EFE63
    GO
    Isoform 4 (identifier: Q9Y694-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-307: Missing.
         308-317: PVCEDSFSQE → MLQPHLLPYQ

    Show »
    Length:241
    Mass (Da):26,213
    Checksum:i8AF6769F5CAC8439
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti304L → P in AAG43523 (Ref. 2) Curated1
    Sequence conflicti413T → A in AAG43523 (Ref. 2) Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_047875303R → K1 PublicationCorresponds to variant dbSNP:rs70953684Ensembl.1
    Natural variantiVAR_047876327R → W1 PublicationCorresponds to variant dbSNP:rs36040909Ensembl.1
    Natural variantiVAR_047877507G → V1 PublicationCorresponds to variant dbSNP:rs70953693Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0309911 – 307Missing in isoform 4. CuratedAdd BLAST307
    Alternative sequenceiVSP_030992132 – 133Missing in isoform 2 and isoform 3. 2 Publications2
    Alternative sequenceiVSP_030993308 – 317PVCEDSFSQE → MLQPHLLPYQ in isoform 4. Curated10
    Alternative sequenceiVSP_030994531 – 548SAPTS…KQVQN → RCVHRTVSVYV in isoform 3. 2 PublicationsAdd BLAST18

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF097518 mRNA. Translation: AAD37091.1.
    AF210455 mRNA. Translation: AAG43523.1.
    AY050498 mRNA. Translation: AAL12496.1.
    AK290796 mRNA. Translation: BAF83485.1.
    AK290806 mRNA. Translation: BAF83495.1.
    EU562669 Genomic DNA. Translation: ACB21045.1.
    AL583834 Genomic DNA. Translation: CAI14466.1.
    AL583834 Genomic DNA. Translation: CAI14462.1.
    AL583834 Genomic DNA. Translation: CAI14463.1.
    AL583834 Genomic DNA. Translation: CAI14464.1.
    CH471081 Genomic DNA. Translation: EAX04172.1.
    CH471081 Genomic DNA. Translation: EAX04175.1.
    BC033805 mRNA. Translation: AAH33805.1.
    CCDSiCCDS4892.1. [Q9Y694-2]
    CCDS4893.2. [Q9Y694-1]
    RefSeqiNP_006663.2. NM_006672.3. [Q9Y694-2]
    NP_696961.2. NM_153320.2. [Q9Y694-1]
    UniGeneiHs.485438.

    Genome annotation databases

    EnsembliENST00000372574; ENSP00000361655; ENSG00000137204. [Q9Y694-3]
    ENST00000372585; ENSP00000361666; ENSG00000137204. [Q9Y694-1]
    ENST00000372589; ENSP00000361670; ENSG00000137204. [Q9Y694-2]
    GeneIDi10864.
    KEGGihsa:10864.
    UCSCiuc003ous.4. human. [Q9Y694-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AF097518 mRNA. Translation: AAD37091.1.
    AF210455 mRNA. Translation: AAG43523.1.
    AY050498 mRNA. Translation: AAL12496.1.
    AK290796 mRNA. Translation: BAF83485.1.
    AK290806 mRNA. Translation: BAF83495.1.
    EU562669 Genomic DNA. Translation: ACB21045.1.
    AL583834 Genomic DNA. Translation: CAI14466.1.
    AL583834 Genomic DNA. Translation: CAI14462.1.
    AL583834 Genomic DNA. Translation: CAI14463.1.
    AL583834 Genomic DNA. Translation: CAI14464.1.
    CH471081 Genomic DNA. Translation: EAX04172.1.
    CH471081 Genomic DNA. Translation: EAX04175.1.
    BC033805 mRNA. Translation: AAH33805.1.
    CCDSiCCDS4892.1. [Q9Y694-2]
    CCDS4893.2. [Q9Y694-1]
    RefSeqiNP_006663.2. NM_006672.3. [Q9Y694-2]
    NP_696961.2. NM_153320.2. [Q9Y694-1]
    UniGeneiHs.485438.

    3D structure databases

    ProteinModelPortaliQ9Y694.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiQ9Y694. 2 interactors.
    STRINGi9606.ENSP00000361666.

    Chemistry databases

    BindingDBiQ9Y694.
    ChEMBLiCHEMBL1955711.
    DrugBankiDB00945. Acetylsalicylic acid.
    DB00437. Allopurinol.
    DB00345. Aminohippuric acid.
    DB00887. Bumetanide.
    DB00456. Cefalotin.
    DB01326. Cefamandole.
    DB01329. Cefoperazone.
    DB00493. Cefotaxime.
    DB02659. Cholic Acid.
    DB00501. Cimetidine.
    DB01211. Clarithromycin.
    DB02527. Cyclic Adenosine Monophosphate.
    DB01160. Dinoprost Tromethamine.
    DB00917. Dinoprostone.
    DB01248. Docetaxel.
    DB00584. Enalapril.
    DB00544. Fluorouracil.
    DB01004. Ganciclovir.
    DB03553. Glutaric Acid.
    DB01016. Glyburide.
    DB00328. Indomethacin.
    DB01009. Ketoprofen.
    DB00563. Methotrexate.
    DB01017. Minocycline.
    DB01303. Oxtriphylline.
    DB00595. Oxytetracycline.
    DB00175. Pravastatin.
    DB01032. Probenecid.
    DB01045. Rifampicin.
    DB00936. Salicylic acid.
    DB00624. Testosterone.
    DB00759. Tetracycline.
    DB00277. Theophylline.
    DB00313. Valproic Acid.
    DB00943. Zalcitabine.
    DB00495. Zidovudine.

    Protein family/group databases

    TCDBi2.A.1.19.25. the major facilitator superfamily (mfs).

    PTM databases

    iPTMnetiQ9Y694.
    PhosphoSitePlusiQ9Y694.

    Polymorphism and mutation databases

    BioMutaiSLC22A7.
    DMDMi74753520.

    Proteomic databases

    PaxDbiQ9Y694.
    PeptideAtlasiQ9Y694.
    PRIDEiQ9Y694.

    Protocols and materials databases

    DNASUi10864.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000372574; ENSP00000361655; ENSG00000137204. [Q9Y694-3]
    ENST00000372585; ENSP00000361666; ENSG00000137204. [Q9Y694-1]
    ENST00000372589; ENSP00000361670; ENSG00000137204. [Q9Y694-2]
    GeneIDi10864.
    KEGGihsa:10864.
    UCSCiuc003ous.4. human. [Q9Y694-1]

    Organism-specific databases

    CTDi10864.
    DisGeNETi10864.
    GeneCardsiSLC22A7.
    HGNCiHGNC:10971. SLC22A7.
    HPAiHPA030220.
    MIMi604995. gene.
    neXtProtiNX_Q9Y694.
    OpenTargetsiENSG00000137204.
    PharmGKBiPA35848.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG0255. Eukaryota.
    COG0477. LUCA.
    GeneTreeiENSGT00760000118852.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    InParanoidiQ9Y694.
    KOiK08204.
    OMAiWLDVEHR.
    OrthoDBiEOG091G07GO.
    PhylomeDBiQ9Y694.
    TreeFamiTF315847.

    Enzyme and pathway databases

    ReactomeiR-HSA-561048. Organic anion transport.

    Miscellaneous databases

    GeneWikiiSLC22A7.
    GenomeRNAii10864.
    PROiPR:Q9Y694.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000137204.
    CleanExiHS_SLC22A7.
    ExpressionAtlasiQ9Y694. baseline and differential.
    GenevisibleiQ9Y694. HS.

    Family and domain databases

    CDDicd06174. MFS. 1 hit.
    InterProiView protein in InterPro
    IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR004749. Orgcat_transp/SVOP.
    PfamiView protein in Pfam
    PF07690. MFS_1. 1 hit.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00898. 2A0119. 1 hit.
    PROSITEiView protein in PROSITE
    PS50850. MFS. 1 hit.
    ProtoNetiSearch...

    Entry informationi

    Entry nameiS22A7_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y694
    Secondary accession number(s): B2CZX6
    , Q5T046, Q5T048, Q5T050, Q9H2W5
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 1, 1999
    Last modified: June 7, 2017
    This is version 146 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.