UniProtKB - Q9Y694 (S22A7_HUMAN)
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Protein
Solute carrier family 22 member 7
Gene
SLC22A7
Organism
Homo sapiens (Human)
Status
Functioni
Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.5 Publications
Kineticsi
- KM=713 nM for prostaglandin E22 Publications
- KM=440 µM for tetracycline2 Publications
GO - Molecular functioni
- anion:anion antiporter activity Source: Reactome
- inorganic anion exchanger activity Source: GO_Central
- sodium-independent organic anion transmembrane transporter activity Source: GO_Central
GO - Biological processi
- organic anion transport Source: ProtInc
- sodium-independent organic anion transport Source: GO_Central
Keywordsi
Biological process | Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-HSA-561048. Organic anion transport. |
Protein family/group databases
TCDBi | 2.A.1.19.25. the major facilitator superfamily (mfs). |
Names & Taxonomyi
Protein namesi | Recommended name: Solute carrier family 22 member 7Alternative name(s): Novel liver transporter Organic anion transporter 2 Short name: hOAT2 |
Gene namesi | Name:SLC22A7 Synonyms:NLT, OAT2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000137204.14. |
HGNCi | HGNC:10971. SLC22A7. |
MIMi | 604995. gene. |
neXtProti | NX_Q9Y694. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 21 – 41 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 146 – 166 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 180 – 200 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 204 – 224 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 234 – 254 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 259 – 279 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 346 – 366 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 376 – 397 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 404 – 423 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 432 – 452 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 466 – 486 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 493 – 513 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10864. |
OpenTargetsi | ENSG00000137204. |
PharmGKBi | PA35848. |
Chemistry databases
ChEMBLi | CHEMBL1955711. |
DrugBanki | DB00945. Acetylsalicylic acid. DB00437. Allopurinol. DB00345. Aminohippuric acid. DB00887. Bumetanide. DB00456. Cefalotin. DB01326. Cefamandole. DB01329. Cefoperazone. DB00493. Cefotaxime. DB02659. Cholic Acid. DB00501. Cimetidine. DB01211. Clarithromycin. DB02527. Cyclic Adenosine Monophosphate. DB01160. Dinoprost Tromethamine. DB00917. Dinoprostone. DB01248. Docetaxel. DB00584. Enalapril. DB00544. Fluorouracil. DB01004. Ganciclovir. DB03553. Glutaric Acid. DB01016. Glyburide. DB00328. Indomethacin. DB01009. Ketoprofen. DB00563. Methotrexate. DB01017. Minocycline. DB01303. Oxtriphylline. DB00595. Oxytetracycline. DB00175. Pravastatin. DB01032. Probenecid. DB01045. Rifampicin. DB00936. Salicylic acid. DB00624. Testosterone. DB00759. Tetracycline. DB00277. Theophylline. DB00313. Valproic Acid. DB00943. Zalcitabine. DB00495. Zidovudine. |
Polymorphism and mutation databases
BioMutai | SLC22A7. |
DMDMi | 74753520. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317481 | 1 – 548 | Solute carrier family 22 member 7Add BLAST | 548 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 91 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q9Y694. |
PeptideAtlasi | Q9Y694. |
PRIDEi | Q9Y694. |
PTM databases
iPTMneti | Q9Y694. |
PhosphoSitePlusi | Q9Y694. |
Expressioni
Tissue specificityi
Expressed in liver and kidney.3 Publications
Gene expression databases
Bgeei | ENSG00000137204. |
CleanExi | HS_SLC22A7. |
ExpressionAtlasi | Q9Y694. baseline and differential. |
Genevisiblei | Q9Y694. HS. |
Organism-specific databases
HPAi | HPA030220. |
Interactioni
Protein-protein interaction databases
IntActi | Q9Y694. 2 interactors. |
STRINGi | 9606.ENSP00000361666. |
Chemistry databases
BindingDBi | Q9Y694. |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0255. Eukaryota. COG0477. LUCA. |
GeneTreei | ENSGT00760000118852. |
HOGENOMi | HOG000234569. |
HOVERGENi | HBG108433. |
InParanoidi | Q9Y694. |
KOi | K08204. |
OMAi | LLPMHFL. |
OrthoDBi | EOG091G07GO. |
PhylomeDBi | Q9Y694. |
TreeFami | TF315847. |
Family and domain databases
CDDi | cd06174. MFS. 1 hit. |
InterProi | View protein in InterPro IPR011701. MFS. IPR020846. MFS_dom. IPR036259. MFS_trans_sf. IPR004749. Orgcat_transp/SVOP. |
Pfami | View protein in Pfam PF07690. MFS_1. 1 hit. |
SUPFAMi | SSF103473. SSF103473. 1 hit. |
TIGRFAMsi | TIGR00898. 2A0119. 1 hit. |
PROSITEi | View protein in PROSITE PS50850. MFS. 1 hit. |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y694-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA
60 70 80 90 100
LPGAPANFSH QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS
110 120 130 140 150
RGELEDEPAT VPCSQGWEYD HSEFSSTIAT ESQWDLVCEQ KGLNRAASTF
160 170 180 190 200
FFAGVLVGAV AFGYLSDRFG RRRLLLVAYV STLVLGLASA ASVSYVMFAI
210 220 230 240 250
TRTLTGSALA GFTIIVMPLE LEWLDVEHRT VAGVLSSTFW TGGVMLLALV
260 270 280 290 300
GYLIRDWRWL LLAVTLPCAP GILSLWWVPE SARWLLTQGH VKEAHRYLLH
310 320 330 340 350
CARLNGRPVC EDSFSQEAVS KVAAGERVVR RPSYLDLFRT PRLRHISLCC
360 370 380 390 400
VVVWFGVNFS YYGLSLDVSG LGLNVYQTQL LFGAVELPSK LLVYLSVRYA
410 420 430 440 450
GRRLTQAGTL LGTALAFGTR LLVSSDMKSW STVLAVMGKA FSEAAFTTAY
460 470 480 490 500
LFTSELYPTV LRQTGMGLTA LVGRLGGSLA PLAALLDGVW LSLPKLTYGG
510 520 530 540
IALLAAGTAL LLPETRQAQL PETIQDVERK SAPTSLQEEE MPMKQVQN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 304 | L → P in AAG43523 (Ref. 2) Curated | 1 | |
Sequence conflicti | 413 | T → A in AAG43523 (Ref. 2) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047875 | 303 | R → K1 PublicationCorresponds to variant dbSNP:rs70953684Ensembl. | 1 | |
Natural variantiVAR_047876 | 327 | R → W1 PublicationCorresponds to variant dbSNP:rs36040909Ensembl. | 1 | |
Natural variantiVAR_047877 | 507 | G → V1 PublicationCorresponds to variant dbSNP:rs70953693Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_030991 | 1 – 307 | Missing in isoform 4. CuratedAdd BLAST | 307 | |
Alternative sequenceiVSP_030992 | 132 – 133 | Missing in isoform 2 and isoform 3. 2 Publications | 2 | |
Alternative sequenceiVSP_030993 | 308 – 317 | PVCEDSFSQE → MLQPHLLPYQ in isoform 4. Curated | 10 | |
Alternative sequenceiVSP_030994 | 531 – 548 | SAPTS…KQVQN → RCVHRTVSVYV in isoform 3. 2 PublicationsAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF097518 mRNA. Translation: AAD37091.1. AF210455 mRNA. Translation: AAG43523.1. AY050498 mRNA. Translation: AAL12496.1. AK290796 mRNA. Translation: BAF83485.1. AK290806 mRNA. Translation: BAF83495.1. EU562669 Genomic DNA. Translation: ACB21045.1. AL583834 Genomic DNA. No translation available. CH471081 Genomic DNA. Translation: EAX04172.1. CH471081 Genomic DNA. Translation: EAX04175.1. BC033805 mRNA. Translation: AAH33805.1. |
CCDSi | CCDS4892.1. [Q9Y694-2] CCDS4893.2. [Q9Y694-1] |
RefSeqi | NP_006663.2. NM_006672.3. [Q9Y694-2] NP_696961.2. NM_153320.2. [Q9Y694-1] |
UniGenei | Hs.485438. |
Genome annotation databases
Ensembli | ENST00000372574; ENSP00000361655; ENSG00000137204. [Q9Y694-3] ENST00000372585; ENSP00000361666; ENSG00000137204. [Q9Y694-1] ENST00000372589; ENSP00000361670; ENSG00000137204. [Q9Y694-2] |
GeneIDi | 10864. |
KEGGi | hsa:10864. |
UCSCi | uc003ous.4. human. [Q9Y694-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | S22A7_HUMAN | |
Accessioni | Q9Y694Primary (citable) accession number: Q9Y694 Secondary accession number(s): B2CZX6 Q9H2W5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | November 1, 1999 | |
Last modified: | March 28, 2018 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |