Q9Y694 (S22A7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier family 22 member 7

Alternative name(s):
Novel liver transporter
Organic anion transporter 2
Short name=hOAT2

Gene names

Name:	SLC22A7
Synonyms:	NLT, OAT2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. Ref.9 Ref.10 Ref.11 Ref.12 Ref.13
Subcellular location	Basolateral cell membrane; Multi-pass membrane protein. Note: Apical side of the renal tubule. Ref.10 Ref.11
Tissue specificity	Expressed in liver and kidney. Ref.9 Ref.11 Ref.13
Sequence similarities	Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]
Biophysicochemical properties	Kinetic parameters: KM=713 nM for prostaglandin E2 Ref.11 Ref.12 KM=440 µM for tetracycline

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to stilbenoid Inferred from electronic annotation. Source: Ensembl
Cellular_component	basolateral plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral component of plasma membrane Traceable author statement PubMed 9650585. Source: ProtInc
Molecular_function	sodium-independent organic anion transmembrane transporter activity Traceable author statement PubMed 9650585. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y694-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y694-2)

The sequence of this isoform differs from the canonical sequence as follows:
     132-133: Missing.

Isoform 3 (identifier: Q9Y694-3)

The sequence of this isoform differs from the canonical sequence as follows:
     132-133: Missing.
     531-548: SAPTSLQEEEMPMKQVQN → RCVHRTVSVYV

Isoform 4 (identifier: Q9Y694-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-317: PVCEDSFSQE → MLQPHLLPYQ

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 548	548	Solute carrier family 22 member 7		PRO_0000317481
Regions
	Transmembrane	21 – 41	21	Helical; Potential
	Transmembrane	146 – 166	21	Helical; Potential
	Transmembrane	180 – 200	21	Helical; Potential
	Transmembrane	204 – 224	21	Helical; Potential
	Transmembrane	234 – 254	21	Helical; Potential
	Transmembrane	259 – 279	21	Helical; Potential
	Transmembrane	346 – 366	21	Helical; Potential
	Transmembrane	376 – 397	22	Helical; Potential
	Transmembrane	404 – 423	20	Helical; Potential
	Transmembrane	432 – 452	21	Helical; Potential
	Transmembrane	466 – 486	21	Helical; Potential
	Transmembrane	493 – 513	21	Helical; Potential
Amino acid modifications
	Glycosylation	91	1	N-linked (GlcNAc...) Ref.14
Natural variations
	Alternative sequence	1 – 307	307	Missing in isoform 4.		VSP_030991
	Alternative sequence	132 – 133	2	Missing in isoform 2 and isoform 3.		VSP_030992
	Alternative sequence	308 – 317	10	PVCEDSFSQE → MLQPHLLPYQ in isoform 4.		VSP_030993
	Alternative sequence	531 – 548	18	SAPTS…KQVQN → RCVHRTVSVYV in isoform 3.		VSP_030994
	Natural variant	303	1	R → K. Ref.5 Corresponds to variant rs70953684 [ dbSNP | Ensembl ].		VAR_047875
	Natural variant	327	1	R → W. Ref.5 Corresponds to variant rs36040909 [ dbSNP | Ensembl ].		VAR_047876
	Natural variant	507	1	G → V. Ref.5 Corresponds to variant rs70953693 [ dbSNP | Ensembl ].		VAR_047877
Experimental info
	Sequence conflict	304	1	L → P in AAG43523. Ref.2
	Sequence conflict	413	1	T → A in AAG43523. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 5BA4C3FCC3C57533	FASTA	548	60,026
	10 20 30 40 50 60 MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA LPGAPANFSH 70 80 90 100 110 120 QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS RGELEDEPAT VPCSQGWEYD 130 140 150 160 170 180 HSEFSSTIAT ESQWDLVCEQ KGLNRAASTF FFAGVLVGAV AFGYLSDRFG RRRLLLVAYV 190 200 210 220 230 240 STLVLGLASA ASVSYVMFAI TRTLTGSALA GFTIIVMPLE LEWLDVEHRT VAGVLSSTFW 250 260 270 280 290 300 TGGVMLLALV GYLIRDWRWL LLAVTLPCAP GILSLWWVPE SARWLLTQGH VKEAHRYLLH 310 320 330 340 350 360 CARLNGRPVC EDSFSQEAVS KVAAGERVVR RPSYLDLFRT PRLRHISLCC VVVWFGVNFS 370 380 390 400 410 420 YYGLSLDVSG LGLNVYQTQL LFGAVELPSK LLVYLSVRYA GRRLTQAGTL LGTALAFGTR 430 440 450 460 470 480 LLVSSDMKSW STVLAVMGKA FSEAAFTTAY LFTSELYPTV LRQTGMGLTA LVGRLGGSLA 490 500 510 520 530 540 PLAALLDGVW LSLPKLTYGG IALLAAGTAL LLPETRQAQL PETIQDVERK SAPTSLQEEE MPMKQVQN
	Isoform 2 [UniParc]. Checksum: 6A87AA1BD6FEA15C	FASTA	546	59,810
	10 20 30 40 50 60 MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA LPGAPANFSH 70 80 90 100 110 120 QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS RGELEDEPAT VPCSQGWEYD 130 140 150 160 170 180 HSEFSSTIAT EWDLVCEQKG LNRAASTFFF AGVLVGAVAF GYLSDRFGRR RLLLVAYVST 190 200 210 220 230 240 LVLGLASAAS VSYVMFAITR TLTGSALAGF TIIVMPLELE WLDVEHRTVA GVLSSTFWTG 250 260 270 280 290 300 GVMLLALVGY LIRDWRWLLL AVTLPCAPGI LSLWWVPESA RWLLTQGHVK EAHRYLLHCA 310 320 330 340 350 360 RLNGRPVCED SFSQEAVSKV AAGERVVRRP SYLDLFRTPR LRHISLCCVV VWFGVNFSYY 370 380 390 400 410 420 GLSLDVSGLG LNVYQTQLLF GAVELPSKLL VYLSVRYAGR RLTQAGTLLG TALAFGTRLL 430 440 450 460 470 480 VSSDMKSWST VLAVMGKAFS EAAFTTAYLF TSELYPTVLR QTGMGLTALV GRLGGSLAPL 490 500 510 520 530 540 AALLDGVWLS LPKLTYGGIA LLAAGTALLL PETRQAQLPE TIQDVERKSA PTSLQEEEMP MKQVQN
	Isoform 3 [UniParc]. Checksum: F3D6F799778EFE63	FASTA	539	59,082
	10 20 30 40 50 60 MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA LPGAPANFSH 70 80 90 100 110 120 QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS RGELEDEPAT VPCSQGWEYD 130 140 150 160 170 180 HSEFSSTIAT EWDLVCEQKG LNRAASTFFF AGVLVGAVAF GYLSDRFGRR RLLLVAYVST 190 200 210 220 230 240 LVLGLASAAS VSYVMFAITR TLTGSALAGF TIIVMPLELE WLDVEHRTVA GVLSSTFWTG 250 260 270 280 290 300 GVMLLALVGY LIRDWRWLLL AVTLPCAPGI LSLWWVPESA RWLLTQGHVK EAHRYLLHCA 310 320 330 340 350 360 RLNGRPVCED SFSQEAVSKV AAGERVVRRP SYLDLFRTPR LRHISLCCVV VWFGVNFSYY 370 380 390 400 410 420 GLSLDVSGLG LNVYQTQLLF GAVELPSKLL VYLSVRYAGR RLTQAGTLLG TALAFGTRLL 430 440 450 460 470 480 VSSDMKSWST VLAVMGKAFS EAAFTTAYLF TSELYPTVLR QTGMGLTALV GRLGGSLAPL 490 500 510 520 530 AALLDGVWLS LPKLTYGGIA LLAAGTALLL PETRQAQLPE TIQDVERKRC VHRTVSVYV
	Isoform 4 [UniParc]. Checksum: 8AF6769F5CAC8439	FASTA	241	26,213
	10 20 30 40 50 60 MLQPHLLPYQ AVSKVAAGER VVRRPSYLDL FRTPRLRHIS LCCVVVWFGV NFSYYGLSLD 70 80 90 100 110 120 VSGLGLNVYQ TQLLFGAVEL PSKLLVYLSV RYAGRRLTQA GTLLGTALAF GTRLLVSSDM 130 140 150 160 170 180 KSWSTVLAVM GKAFSEAAFT TAYLFTSELY PTVLRQTGMG LTALVGRLGG SLAPLAALLD 190 200 210 220 230 240 GVWLSLPKLT YGGIALLAAG TALLLPETRQ AQLPETIQDV ERKSAPTSLQ EEEMPMKQVQ N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of a human liver-specific transporter, NLT." Kim R.B., Leake B.L., Cvetkovic M. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Liver.
[2]	"Identification of a human organic anion transporter 2 homolog." Reid G., Bahn A., Ebbinghaus C., Wolff N.A., Burckhardt G. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Kidney.
[3]	"Cloning, characterization and localization of human organic anion transporter 2." Kobayashi Y., Ohshiro N., Sekine T., Endoh H., Yamamoto T. Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Kidney.
[5]	NIEHS SNPs program Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-303; TRP-327 AND VAL-507.
[6]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Colon.
[9]	"Isolation of a family of organic anion transporters from human liver and kidney." Sun W., Wu R.R., van Poelje P.D., Erion M.D. Biochem. Biophys. Res. Commun. 283:417-422(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[10]	"Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors." Enomoto A., Takeda M., Shimoda M., Narikawa S., Kobayashi Y., Kobayashi Y., Yamamoto T., Sekine T., Cha S.H., Niwa T., Endou H. J. Pharmacol. Exp. Ther. 301:797-802(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[11]	"Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins." Kimura H., Takeda M., Narikawa S., Enomoto A., Ichida K., Endou H. J. Pharmacol. Exp. Ther. 301:293-298(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION.
[12]	"Human organic anion transporters mediate the transport of tetracycline." Babu E., Takeda M., Narikawa S., Kobayashi Y., Yamamoto T., Cha S.H., Sekine T., Sakthisekaran D., Endou H. Jpn. J. Pharmacol. 88:69-76(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
[13]	"Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7])." Kobayashi Y., Ohshiro N., Sakai R., Ohbayashi M., Kohyama N., Yamamoto T. J. Pharm. Pharmacol. 57:573-578(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, TISSUE SPECIFICITY.
[14]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-91, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Web resources

NIEHS-SNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF097518 mRNA. Translation: AAD37091.1. AF210455 mRNA. Translation: AAG43523.1. AY050498 mRNA. Translation: AAL12496.1. AK290796 mRNA. Translation: BAF83485.1. AK290806 mRNA. Translation: BAF83495.1. EU562669 Genomic DNA. Translation: ACB21045.1. AL583834 Genomic DNA. Translation: CAI14466.1. AL583834 Genomic DNA. Translation: CAI14462.1. AL583834 Genomic DNA. Translation: CAI14463.1. AL583834 Genomic DNA. Translation: CAI14464.1. CH471081 Genomic DNA. Translation: EAX04172.1. CH471081 Genomic DNA. Translation: EAX04175.1. BC033805 mRNA. Translation: AAH33805.1.
RefSeq	NP_006663.2. NM_006672.3. NP_696961.2. NM_153320.2.
UniGene	Hs.485438.
3D structure databases
ProteinModelPortal	Q9Y694.
SMR	Q9Y694. Positions 154-458.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000361666.
Chemistry
ChEMBL	CHEMBL1955711.
Protein family/group databases
TCDB	2.A.1.19.25. the major facilitator superfamily (mfs).
PTM databases
PhosphoSite	Q9Y694.
Polymorphism databases
DMDM	74753520.
Proteomic databases
PaxDb	Q9Y694.
PRIDE	Q9Y694.
Protocols and materials databases
DNASU	10864.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000372574; ENSP00000361655; ENSG00000137204. ENST00000372585; ENSP00000361666; ENSG00000137204. ENST00000372589; ENSP00000361670; ENSG00000137204.
GeneID	10864.
KEGG	hsa:10864.
UCSC	uc003out.3. human.
Organism-specific databases
CTD	10864.
GeneCards	GC06P043263.
HGNC	HGNC:10971. SLC22A7.
HPA	HPA030220.
MIM	604995. gene.
neXtProt	NX_Q9Y694.
PharmGKB	PA35848.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0477.
HOGENOM	HOG000234569.
HOVERGEN	HBG108433.
KO	K08204.
OMA	PMKQVQN.
OrthoDB	EOG7C8GH9.
PhylomeDB	Q9Y694.
TreeFam	TF315847.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q9Y694.
Bgee	Q9Y694.
CleanEx	HS_SLC22A7.
Genevestigator	Q9Y694.
Family and domain databases
InterPro	IPR011701. MFS. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR004749. Orgcat_transp. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
SUPFAM	SSF103473. SSF103473. 1 hit.
TIGRFAMs	TIGR00898. 2A0119. 1 hit.
PROSITE	PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GeneWiki	SLC22A7.
GenomeRNAi	10864.
NextBio	41247.
PRO	Q9Y694.
SOURCE	Search...

Entry information

Entry name

S22A7_HUMAN

Accession

Primary (citable) accession number: Q9Y694
Secondary accession number(s): B2CZX6 , Q5T046, Q5T048, Q5T050, Q9H2W5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	November 1, 1999
Last modified:	February 19, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.