Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y694 - S22A7_HUMAN

UniProt

Q9Y694 - S22A7_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Solute carrier family 22 member 7

Gene

SLC22A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.5 Publications

Kineticsi

  1. KM=713 nM for prostaglandin E22 Publications
  2. KM=440 µM for tetracycline2 Publications

GO - Molecular functioni

  1. sodium-independent organic anion transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. organic anion transport Source: ProtInc
  2. response to stilbenoid Source: Ensembl
  3. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_22310. Organic anion transport.

Protein family/group databases

TCDBi2.A.1.19.25. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 7
Alternative name(s):
Novel liver transporter
Organic anion transporter 2
Short name:
hOAT2
Gene namesi
Name:SLC22A7
Synonyms:NLT, OAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:10971. SLC22A7.

Subcellular locationi

Basolateral cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
Note: Apical side of the renal tubule.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121HelicalSequence AnalysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence AnalysisAdd
BLAST
Transmembranei180 – 20021HelicalSequence AnalysisAdd
BLAST
Transmembranei204 – 22421HelicalSequence AnalysisAdd
BLAST
Transmembranei234 – 25421HelicalSequence AnalysisAdd
BLAST
Transmembranei259 – 27921HelicalSequence AnalysisAdd
BLAST
Transmembranei346 – 36621HelicalSequence AnalysisAdd
BLAST
Transmembranei376 – 39722HelicalSequence AnalysisAdd
BLAST
Transmembranei404 – 42320HelicalSequence AnalysisAdd
BLAST
Transmembranei432 – 45221HelicalSequence AnalysisAdd
BLAST
Transmembranei466 – 48621HelicalSequence AnalysisAdd
BLAST
Transmembranei493 – 51321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. basolateral plasma membrane Source: UniProtKB-SubCell
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: ProtInc
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35848.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548Solute carrier family 22 member 7PRO_0000317481Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y694.
PRIDEiQ9Y694.

PTM databases

PhosphoSiteiQ9Y694.

Expressioni

Tissue specificityi

Expressed in liver and kidney.3 Publications

Gene expression databases

BgeeiQ9Y694.
CleanExiHS_SLC22A7.
ExpressionAtlasiQ9Y694. baseline and differential.
GenevestigatoriQ9Y694.

Organism-specific databases

HPAiHPA030220.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000361666.

Structurei

3D structure databases

ProteinModelPortaliQ9Y694.
SMRiQ9Y694. Positions 154-458.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ9Y694.
KOiK08204.
OMAiHCARLNG.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ9Y694.
TreeFamiTF315847.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004749. Orgcat_transp.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y694-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA 
        60         70         80         90        100
LPGAPANFSH QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS 
       110        120        130        140        150
RGELEDEPAT VPCSQGWEYD HSEFSSTIAT ESQWDLVCEQ KGLNRAASTF 
       160        170        180        190        200
FFAGVLVGAV AFGYLSDRFG RRRLLLVAYV STLVLGLASA ASVSYVMFAI 
       210        220        230        240        250
TRTLTGSALA GFTIIVMPLE LEWLDVEHRT VAGVLSSTFW TGGVMLLALV 
       260        270        280        290        300
GYLIRDWRWL LLAVTLPCAP GILSLWWVPE SARWLLTQGH VKEAHRYLLH 
       310        320        330        340        350
CARLNGRPVC EDSFSQEAVS KVAAGERVVR RPSYLDLFRT PRLRHISLCC 
       360        370        380        390        400
VVVWFGVNFS YYGLSLDVSG LGLNVYQTQL LFGAVELPSK LLVYLSVRYA 
       410        420        430        440        450
GRRLTQAGTL LGTALAFGTR LLVSSDMKSW STVLAVMGKA FSEAAFTTAY 
       460        470        480        490        500
LFTSELYPTV LRQTGMGLTA LVGRLGGSLA PLAALLDGVW LSLPKLTYGG 
       510        520        530        540 
IALLAAGTAL LLPETRQAQL PETIQDVERK SAPTSLQEEE MPMKQVQN
Length:548
Mass (Da):60,026
Last modified:November 1, 1999 - v1
Checksum:i5BA4C3FCC3C57533
GO
Isoform 2 (identifier: Q9Y694-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-133: Missing.

Show »
Length:546
Mass (Da):59,810
Checksum:i6A87AA1BD6FEA15C
GO
Isoform 3 (identifier: Q9Y694-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     132-133: Missing.
     531-548: SAPTSLQEEEMPMKQVQN → RCVHRTVSVYV

Show »
Length:539
Mass (Da):59,082
Checksum:iF3D6F799778EFE63
GO
Isoform 4 (identifier: Q9Y694-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-307: Missing.
     308-317: PVCEDSFSQE → MLQPHLLPYQ

Show »
Length:241
Mass (Da):26,213
Checksum:i8AF6769F5CAC8439
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti304 – 3041L → P in AAG43523. 1 PublicationCurated
Sequence conflicti413 – 4131T → A in AAG43523. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti303 – 3031R → K.1 Publication
Corresponds to variant rs70953684 [ dbSNP | Ensembl ].		VAR_047875
Natural varianti327 – 3271R → W.1 Publication
Corresponds to variant rs36040909 [ dbSNP | Ensembl ].		VAR_047876
Natural varianti507 – 5071G → V.1 Publication
Corresponds to variant rs70953693 [ dbSNP | Ensembl ].		VAR_047877

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 307307Missing in isoform 4. CuratedVSP_030991Add
BLAST
Alternative sequencei132 – 1332Missing in isoform 2 and isoform 3. 2 PublicationsVSP_030992
Alternative sequencei308 – 31710PVCEDSFSQE → MLQPHLLPYQ in isoform 4. CuratedVSP_030993
Alternative sequencei531 – 54818SAPTS…KQVQN → RCVHRTVSVYV in isoform 3. 2 PublicationsVSP_030994Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097518 mRNA. Translation: AAD37091.1.
AF210455 mRNA. Translation: AAG43523.1.
AY050498 mRNA. Translation: AAL12496.1.
AK290796 mRNA. Translation: BAF83485.1.
AK290806 mRNA. Translation: BAF83495.1.
EU562669 Genomic DNA. Translation: ACB21045.1.
AL583834 Genomic DNA. Translation: CAI14466.1.
AL583834 Genomic DNA. Translation: CAI14462.1.
AL583834 Genomic DNA. Translation: CAI14463.1.
AL583834 Genomic DNA. Translation: CAI14464.1.
CH471081 Genomic DNA. Translation: EAX04172.1.
CH471081 Genomic DNA. Translation: EAX04175.1.
BC033805 mRNA. Translation: AAH33805.1.
CCDSiCCDS4892.1. [Q9Y694-2]
CCDS4893.2. [Q9Y694-1]
RefSeqiNP_006663.2. NM_006672.3. [Q9Y694-2]
NP_696961.2. NM_153320.2. [Q9Y694-1]
UniGeneiHs.485438.

Genome annotation databases

EnsembliENST00000372574; ENSP00000361655; ENSG00000137204. [Q9Y694-3]
ENST00000372585; ENSP00000361666; ENSG00000137204. [Q9Y694-1]
ENST00000372589; ENSP00000361670; ENSG00000137204. [Q9Y694-2]
GeneIDi10864.
KEGGihsa:10864.
UCSCiuc003ous.3. human. [Q9Y694-3]
uc003out.3. human. [Q9Y694-1]

Polymorphism databases

DMDMi74753520.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097518 mRNA. Translation: AAD37091.1.
AF210455 mRNA. Translation: AAG43523.1.
AY050498 mRNA. Translation: AAL12496.1.
AK290796 mRNA. Translation: BAF83485.1.
AK290806 mRNA. Translation: BAF83495.1.
EU562669 Genomic DNA. Translation: ACB21045.1.
AL583834 Genomic DNA. Translation: CAI14466.1.
AL583834 Genomic DNA. Translation: CAI14462.1.
AL583834 Genomic DNA. Translation: CAI14463.1.
AL583834 Genomic DNA. Translation: CAI14464.1.
CH471081 Genomic DNA. Translation: EAX04172.1.
CH471081 Genomic DNA. Translation: EAX04175.1.
BC033805 mRNA. Translation: AAH33805.1.
CCDSiCCDS4892.1. [Q9Y694-2]
CCDS4893.2. [Q9Y694-1]
RefSeqiNP_006663.2. NM_006672.3. [Q9Y694-2]
NP_696961.2. NM_153320.2. [Q9Y694-1]
UniGeneiHs.485438.

3D structure databases

ProteinModelPortaliQ9Y694.
SMRiQ9Y694. Positions 154-458.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000361666.

Chemistry

BindingDBiQ9Y694.
ChEMBLiCHEMBL1955711.
DrugBankiDB00945. Acetylsalicylic acid.
DB00437. Allopurinol.
DB00345. Aminohippurate.
DB00887. Bumetanide.
DB00456. Cefalotin.
DB01326. Cefamandole.
DB01329. Cefoperazone.
DB00493. Cefotaxime.
DB00501. Cimetidine.
DB01211. Clarithromycin.
DB01160. Dinoprost Tromethamine.
DB00917. Dinoprostone.
DB01248. Docetaxel.
DB00584. Enalapril.
DB00199. Erythromycin.
DB00544. Fluorouracil.
DB01004. Ganciclovir.
DB01016. Glyburide.
DB00328. Indomethacin.
DB01009. Ketoprofen.
DB00563. Methotrexate.
DB01017. Minocycline.
DB01303. Oxtriphylline.
DB00595. Oxytetracycline.
DB00175. Pravastatin.
DB01032. Probenecid.
DB01045. Rifampicin.
DB00936. Salicylic acid.
DB00624. Testosterone.
DB00759. Tetracycline.
DB00277. Theophylline.
DB00313. Valproic Acid.
DB00943. Zalcitabine.
DB00495. Zidovudine.

Protein family/group databases

TCDBi2.A.1.19.25. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiQ9Y694.

Polymorphism databases

DMDMi74753520.

Proteomic databases

PaxDbiQ9Y694.
PRIDEiQ9Y694.

Protocols and materials databases

DNASUi10864.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372574; ENSP00000361655; ENSG00000137204. [Q9Y694-3]
ENST00000372585; ENSP00000361666; ENSG00000137204. [Q9Y694-1]
ENST00000372589; ENSP00000361670; ENSG00000137204. [Q9Y694-2]
GeneIDi10864.
KEGGihsa:10864.
UCSCiuc003ous.3. human. [Q9Y694-3]
uc003out.3. human. [Q9Y694-1]

Organism-specific databases

CTDi10864.
GeneCardsiGC06P043263.
HGNCiHGNC:10971. SLC22A7.
HPAiHPA030220.
MIMi604995. gene.
neXtProtiNX_Q9Y694.
PharmGKBiPA35848.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118852.
HOGENOMiHOG000234569.
HOVERGENiHBG108433.
InParanoidiQ9Y694.
KOiK08204.
OMAiHCARLNG.
OrthoDBiEOG7C8GH9.
PhylomeDBiQ9Y694.
TreeFamiTF315847.

Enzyme and pathway databases

ReactomeiREACT_22310. Organic anion transport.

Miscellaneous databases

GeneWikiiSLC22A7.
GenomeRNAii10864.
NextBioi41247.
PROiQ9Y694.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y694.
CleanExiHS_SLC22A7.
ExpressionAtlasiQ9Y694. baseline and differential.
GenevestigatoriQ9Y694.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR004749. Orgcat_transp.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00898. 2A0119. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of a human liver-specific transporter, NLT."
    Kim R.B., Leake B.L., Cvetkovic M.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Liver.
  2. "Identification of a human organic anion transporter 2 homolog."
    Reid G., Bahn A., Ebbinghaus C., Wolff N.A., Burckhardt G.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: Kidney.
  3. "Cloning, characterization and localization of human organic anion transporter 2."
    Kobayashi Y., Ohshiro N., Sekine T., Endoh H., Yamamoto T.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Kidney.
  5. NIEHS SNPs program
    Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-303; TRP-327 AND VAL-507.
  6. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Colon.
  9. "Isolation of a family of organic anion transporters from human liver and kidney."
    Sun W., Wu R.R., van Poelje P.D., Erion M.D.
    Biochem. Biophys. Res. Commun. 283:417-422(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  10. "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors."
    Enomoto A., Takeda M., Shimoda M., Narikawa S., Kobayashi Y., Kobayashi Y., Yamamoto T., Sekine T., Cha S.H., Niwa T., Endou H.
    J. Pharmacol. Exp. Ther. 301:797-802(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  11. "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins."
    Kimura H., Takeda M., Narikawa S., Enomoto A., Ichida K., Endou H.
    J. Pharmacol. Exp. Ther. 301:293-298(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION.
  12. Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
  13. "Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7])."
    Kobayashi Y., Ohshiro N., Sakai R., Ohbayashi M., Kohyama N., Yamamoto T.
    J. Pharm. Pharmacol. 57:573-578(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-91.
    Tissue: Liver.
+Additional computationally mapped references.

Entry informationi

Entry nameiS22A7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y694
Secondary accession number(s): B2CZX6
, Q5T046, Q5T048, Q5T050, Q9H2W5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 1, 1999
Last modified: January 7, 2015
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.