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Protein

Solute carrier family 22 member 7

Gene

SLC22A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.5 Publications

Kineticsi

  1. KM=713 nM for prostaglandin E22 Publications
  2. KM=440 µM for tetracycline2 Publications

    GO - Molecular functioni

    • sodium-independent organic anion transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    • organic anion transport Source: ProtInc
    • response to stilbenoid Source: Ensembl
    • transmembrane transport Source: Reactome
    Complete GO annotation...

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22310. Organic anion transport.

    Protein family/group databases

    TCDBi2.A.1.19.25. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 7
    Alternative name(s):
    Novel liver transporter
    Organic anion transporter 2
    Short name:
    hOAT2
    Gene namesi
    Name:SLC22A7
    Synonyms:NLT, OAT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640 Componenti: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:10971. SLC22A7.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei376 – 39722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei404 – 42320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei466 – 48621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei493 – 51321HelicalSequence AnalysisAdd
    BLAST

    GO - Cellular componenti

    • basolateral plasma membrane Source: UniProtKB-SubCell
    • integral component of plasma membrane Source: ProtInc
    • membrane Source: ProtInc
    • plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35848.

    Chemistry

    DrugBankiDB00945. Acetylsalicylic acid.
    DB00437. Allopurinol.
    DB00345. Aminohippurate.
    DB00887. Bumetanide.
    DB00456. Cefalotin.
    DB01326. Cefamandole.
    DB01329. Cefoperazone.
    DB00493. Cefotaxime.
    DB02659. Cholic Acid.
    DB00501. Cimetidine.
    DB01211. Clarithromycin.
    DB01160. Dinoprost Tromethamine.
    DB00917. Dinoprostone.
    DB01248. Docetaxel.
    DB00584. Enalapril.
    DB00199. Erythromycin.
    DB00544. Fluorouracil.
    DB01004. Ganciclovir.
    DB01016. Glyburide.
    DB00328. Indomethacin.
    DB01009. Ketoprofen.
    DB00563. Methotrexate.
    DB01017. Minocycline.
    DB01303. Oxtriphylline.
    DB00595. Oxytetracycline.
    DB00175. Pravastatin.
    DB01032. Probenecid.
    DB01045. Rifampicin.
    DB00936. Salicylic acid.
    DB00624. Testosterone.
    DB00759. Tetracycline.
    DB00277. Theophylline.
    DB00313. Valproic Acid.
    DB00943. Zalcitabine.
    DB00495. Zidovudine.

    Polymorphism and mutation databases

    BioMutaiSLC22A7.
    DMDMi74753520.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 548548Solute carrier family 22 member 7PRO_0000317481Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi91 – 911N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y694.
    PRIDEiQ9Y694.

    PTM databases

    PhosphoSiteiQ9Y694.

    Expressioni

    Tissue specificityi

    Expressed in liver and kidney.3 Publications

    Gene expression databases

    BgeeiQ9Y694.
    CleanExiHS_SLC22A7.
    ExpressionAtlasiQ9Y694. baseline and differential.
    GenevisibleiQ9Y694. HS.

    Organism-specific databases

    HPAiHPA030220.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9Y694. 2 interactions.
    STRINGi9606.ENSP00000361666.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y694.
    SMRiQ9Y694. Positions 154-458.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00760000118852.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    InParanoidiQ9Y694.
    KOiK08204.
    OMAiHCARLNG.
    OrthoDBiEOG7C8GH9.
    PhylomeDBiQ9Y694.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR004749. Orgcat_transp.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00898. 2A0119. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

    Isoform 1 (identifier: Q9Y694-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA
    60 70 80 90 100
    LPGAPANFSH QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS
    110 120 130 140 150
    RGELEDEPAT VPCSQGWEYD HSEFSSTIAT ESQWDLVCEQ KGLNRAASTF
    160 170 180 190 200
    FFAGVLVGAV AFGYLSDRFG RRRLLLVAYV STLVLGLASA ASVSYVMFAI
    210 220 230 240 250
    TRTLTGSALA GFTIIVMPLE LEWLDVEHRT VAGVLSSTFW TGGVMLLALV
    260 270 280 290 300
    GYLIRDWRWL LLAVTLPCAP GILSLWWVPE SARWLLTQGH VKEAHRYLLH
    310 320 330 340 350
    CARLNGRPVC EDSFSQEAVS KVAAGERVVR RPSYLDLFRT PRLRHISLCC
    360 370 380 390 400
    VVVWFGVNFS YYGLSLDVSG LGLNVYQTQL LFGAVELPSK LLVYLSVRYA
    410 420 430 440 450
    GRRLTQAGTL LGTALAFGTR LLVSSDMKSW STVLAVMGKA FSEAAFTTAY
    460 470 480 490 500
    LFTSELYPTV LRQTGMGLTA LVGRLGGSLA PLAALLDGVW LSLPKLTYGG
    510 520 530 540
    IALLAAGTAL LLPETRQAQL PETIQDVERK SAPTSLQEEE MPMKQVQN
    Length:548
    Mass (Da):60,026
    Last modified:November 1, 1999 - v1
    Checksum:i5BA4C3FCC3C57533
    GO
    Isoform 2 (identifier: Q9Y694-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-133: Missing.

    Show »
    Length:546
    Mass (Da):59,810
    Checksum:i6A87AA1BD6FEA15C
    GO
    Isoform 3 (identifier: Q9Y694-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-133: Missing.
         531-548: SAPTSLQEEEMPMKQVQN → RCVHRTVSVYV

    Show »
    Length:539
    Mass (Da):59,082
    Checksum:iF3D6F799778EFE63
    GO
    Isoform 4 (identifier: Q9Y694-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-307: Missing.
         308-317: PVCEDSFSQE → MLQPHLLPYQ

    Show »
    Length:241
    Mass (Da):26,213
    Checksum:i8AF6769F5CAC8439
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti304 – 3041L → P in AAG43523 (Ref. 2) Curated
    Sequence conflicti413 – 4131T → A in AAG43523 (Ref. 2) Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti303 – 3031R → K.1 Publication
    Corresponds to variant rs70953684 [ dbSNP | Ensembl ].
    VAR_047875
    Natural varianti327 – 3271R → W.1 Publication
    Corresponds to variant rs36040909 [ dbSNP | Ensembl ].
    VAR_047876
    Natural varianti507 – 5071G → V.1 Publication
    Corresponds to variant rs70953693 [ dbSNP | Ensembl ].
    VAR_047877

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 307307Missing in isoform 4. CuratedVSP_030991Add
    BLAST
    Alternative sequencei132 – 1332Missing in isoform 2 and isoform 3. 2 PublicationsVSP_030992
    Alternative sequencei308 – 31710PVCEDSFSQE → MLQPHLLPYQ in isoform 4. CuratedVSP_030993
    Alternative sequencei531 – 54818SAPTS…KQVQN → RCVHRTVSVYV in isoform 3. 2 PublicationsVSP_030994Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF097518 mRNA. Translation: AAD37091.1.
    AF210455 mRNA. Translation: AAG43523.1.
    AY050498 mRNA. Translation: AAL12496.1.
    AK290796 mRNA. Translation: BAF83485.1.
    AK290806 mRNA. Translation: BAF83495.1.
    EU562669 Genomic DNA. Translation: ACB21045.1.
    AL583834 Genomic DNA. Translation: CAI14466.1.
    AL583834 Genomic DNA. Translation: CAI14462.1.
    AL583834 Genomic DNA. Translation: CAI14463.1.
    AL583834 Genomic DNA. Translation: CAI14464.1.
    CH471081 Genomic DNA. Translation: EAX04172.1.
    CH471081 Genomic DNA. Translation: EAX04175.1.
    BC033805 mRNA. Translation: AAH33805.1.
    CCDSiCCDS4892.1. [Q9Y694-2]
    CCDS4893.2. [Q9Y694-1]
    RefSeqiNP_006663.2. NM_006672.3. [Q9Y694-2]
    NP_696961.2. NM_153320.2. [Q9Y694-1]
    UniGeneiHs.485438.

    Genome annotation databases

    EnsembliENST00000372574; ENSP00000361655; ENSG00000137204. [Q9Y694-3]
    ENST00000372585; ENSP00000361666; ENSG00000137204. [Q9Y694-1]
    ENST00000372589; ENSP00000361670; ENSG00000137204. [Q9Y694-2]
    GeneIDi10864.
    KEGGihsa:10864.
    UCSCiuc003ous.3. human. [Q9Y694-3]
    uc003out.3. human. [Q9Y694-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF097518 mRNA. Translation: AAD37091.1.
    AF210455 mRNA. Translation: AAG43523.1.
    AY050498 mRNA. Translation: AAL12496.1.
    AK290796 mRNA. Translation: BAF83485.1.
    AK290806 mRNA. Translation: BAF83495.1.
    EU562669 Genomic DNA. Translation: ACB21045.1.
    AL583834 Genomic DNA. Translation: CAI14466.1.
    AL583834 Genomic DNA. Translation: CAI14462.1.
    AL583834 Genomic DNA. Translation: CAI14463.1.
    AL583834 Genomic DNA. Translation: CAI14464.1.
    CH471081 Genomic DNA. Translation: EAX04172.1.
    CH471081 Genomic DNA. Translation: EAX04175.1.
    BC033805 mRNA. Translation: AAH33805.1.
    CCDSiCCDS4892.1. [Q9Y694-2]
    CCDS4893.2. [Q9Y694-1]
    RefSeqiNP_006663.2. NM_006672.3. [Q9Y694-2]
    NP_696961.2. NM_153320.2. [Q9Y694-1]
    UniGeneiHs.485438.

    3D structure databases

    ProteinModelPortaliQ9Y694.
    SMRiQ9Y694. Positions 154-458.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    IntActiQ9Y694. 2 interactions.
    STRINGi9606.ENSP00000361666.

    Chemistry

    BindingDBiQ9Y694.
    ChEMBLiCHEMBL1955711.
    DrugBankiDB00945. Acetylsalicylic acid.
    DB00437. Allopurinol.
    DB00345. Aminohippurate.
    DB00887. Bumetanide.
    DB00456. Cefalotin.
    DB01326. Cefamandole.
    DB01329. Cefoperazone.
    DB00493. Cefotaxime.
    DB02659. Cholic Acid.
    DB00501. Cimetidine.
    DB01211. Clarithromycin.
    DB01160. Dinoprost Tromethamine.
    DB00917. Dinoprostone.
    DB01248. Docetaxel.
    DB00584. Enalapril.
    DB00199. Erythromycin.
    DB00544. Fluorouracil.
    DB01004. Ganciclovir.
    DB01016. Glyburide.
    DB00328. Indomethacin.
    DB01009. Ketoprofen.
    DB00563. Methotrexate.
    DB01017. Minocycline.
    DB01303. Oxtriphylline.
    DB00595. Oxytetracycline.
    DB00175. Pravastatin.
    DB01032. Probenecid.
    DB01045. Rifampicin.
    DB00936. Salicylic acid.
    DB00624. Testosterone.
    DB00759. Tetracycline.
    DB00277. Theophylline.
    DB00313. Valproic Acid.
    DB00943. Zalcitabine.
    DB00495. Zidovudine.

    Protein family/group databases

    TCDBi2.A.1.19.25. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSiteiQ9Y694.

    Polymorphism and mutation databases

    BioMutaiSLC22A7.
    DMDMi74753520.

    Proteomic databases

    PaxDbiQ9Y694.
    PRIDEiQ9Y694.

    Protocols and materials databases

    DNASUi10864.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000372574; ENSP00000361655; ENSG00000137204. [Q9Y694-3]
    ENST00000372585; ENSP00000361666; ENSG00000137204. [Q9Y694-1]
    ENST00000372589; ENSP00000361670; ENSG00000137204. [Q9Y694-2]
    GeneIDi10864.
    KEGGihsa:10864.
    UCSCiuc003ous.3. human. [Q9Y694-3]
    uc003out.3. human. [Q9Y694-1]

    Organism-specific databases

    CTDi10864.
    GeneCardsiGC06P043263.
    HGNCiHGNC:10971. SLC22A7.
    HPAiHPA030220.
    MIMi604995. gene.
    neXtProtiNX_Q9Y694.
    PharmGKBiPA35848.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00760000118852.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    InParanoidiQ9Y694.
    KOiK08204.
    OMAiHCARLNG.
    OrthoDBiEOG7C8GH9.
    PhylomeDBiQ9Y694.
    TreeFamiTF315847.

    Enzyme and pathway databases

    ReactomeiREACT_22310. Organic anion transport.

    Miscellaneous databases

    GeneWikiiSLC22A7.
    GenomeRNAii10864.
    NextBioi41247.
    PROiQ9Y694.
    SOURCEiSearch...

    Gene expression databases

    BgeeiQ9Y694.
    CleanExiHS_SLC22A7.
    ExpressionAtlasiQ9Y694. baseline and differential.
    GenevisibleiQ9Y694. HS.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR004749. Orgcat_transp.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00898. 2A0119. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]
    ProtoNetiSearch...

    Publicationsi

    « Hide 'large scale' publications
    1. "Molecular cloning of a human liver-specific transporter, NLT."
      Kim R.B., Leake B.L., Cvetkovic M.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    2. "Identification of a human organic anion transporter 2 homolog."
      Reid G., Bahn A., Ebbinghaus C., Wolff N.A., Burckhardt G.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Kidney.
    3. "Cloning, characterization and localization of human organic anion transporter 2."
      Kobayashi Y., Ohshiro N., Sekine T., Endoh H., Yamamoto T.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Kidney.
    5. NIEHS SNPs program
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-303; TRP-327 AND VAL-507.
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    9. "Isolation of a family of organic anion transporters from human liver and kidney."
      Sun W., Wu R.R., van Poelje P.D., Erion M.D.
      Biochem. Biophys. Res. Commun. 283:417-422(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    10. "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors."
      Enomoto A., Takeda M., Shimoda M., Narikawa S., Kobayashi Y., Kobayashi Y., Yamamoto T., Sekine T., Cha S.H., Niwa T., Endou H.
      J. Pharmacol. Exp. Ther. 301:797-802(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    11. "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins."
      Kimura H., Takeda M., Narikawa S., Enomoto A., Ichida K., Endou H.
      J. Pharmacol. Exp. Ther. 301:293-298(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION.
    12. Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    13. "Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7])."
      Kobayashi Y., Ohshiro N., Sakai R., Ohbayashi M., Kohyama N., Yamamoto T.
      J. Pharm. Pharmacol. 57:573-578(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-91.
      Tissue: Liver.

    Entry informationi

    Entry nameiS22A7_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y694
    Secondary accession number(s): B2CZX6
    , Q5T046, Q5T048, Q5T050, Q9H2W5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 1, 1999
    Last modified: June 24, 2015
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.