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Q9Y694

- S22A7_HUMAN

UniProt

Q9Y694 - S22A7_HUMAN

Protein

Solute carrier family 22 member 7

Gene

SLC22A7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate.5 Publications

    Kineticsi

    1. KM=713 nM for prostaglandin E22 Publications
    2. KM=440 µM for tetracycline2 Publications

    GO - Molecular functioni

    1. sodium-independent organic anion transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. organic anion transport Source: ProtInc
    2. response to stilbenoid Source: Ensembl
    3. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_22310. Organic anion transport.

    Protein family/group databases

    TCDBi2.A.1.19.25. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 22 member 7
    Alternative name(s):
    Novel liver transporter
    Organic anion transporter 2
    Short name:
    hOAT2
    Gene namesi
    Name:SLC22A7
    Synonyms:NLT, OAT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:10971. SLC22A7.

    Subcellular locationi

    Basolateral cell membrane 2 Publications; Multi-pass membrane protein 2 Publications
    Note: Apical side of the renal tubule.

    GO - Cellular componenti

    1. basolateral plasma membrane Source: UniProtKB-SubCell
    2. integral component of plasma membrane Source: ProtInc
    3. membrane Source: ProtInc
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35848.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 548548Solute carrier family 22 member 7PRO_0000317481Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi91 – 911N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y694.
    PRIDEiQ9Y694.

    PTM databases

    PhosphoSiteiQ9Y694.

    Expressioni

    Tissue specificityi

    Expressed in liver and kidney.3 Publications

    Gene expression databases

    ArrayExpressiQ9Y694.
    BgeeiQ9Y694.
    CleanExiHS_SLC22A7.
    GenevestigatoriQ9Y694.

    Organism-specific databases

    HPAiHPA030220.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000361666.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y694.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei234 – 25421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei346 – 36621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei376 – 39722HelicalSequence AnalysisAdd
    BLAST
    Transmembranei404 – 42320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei466 – 48621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei493 – 51321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000234569.
    HOVERGENiHBG108433.
    KOiK08204.
    OMAiPMKQVQN.
    OrthoDBiEOG7C8GH9.
    PhylomeDBiQ9Y694.
    TreeFamiTF315847.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004749. Orgcat_transp.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00898. 2A0119. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y694-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGFEELLEQV GGFGPFQLRN VALLALPRVL LPLHFLLPIF LAAVPAHRCA    50
    LPGAPANFSH QDVWLEAHLP REPDGTLSSC LRFAYPQALP NTTLGEERQS 100
    RGELEDEPAT VPCSQGWEYD HSEFSSTIAT ESQWDLVCEQ KGLNRAASTF 150
    FFAGVLVGAV AFGYLSDRFG RRRLLLVAYV STLVLGLASA ASVSYVMFAI 200
    TRTLTGSALA GFTIIVMPLE LEWLDVEHRT VAGVLSSTFW TGGVMLLALV 250
    GYLIRDWRWL LLAVTLPCAP GILSLWWVPE SARWLLTQGH VKEAHRYLLH 300
    CARLNGRPVC EDSFSQEAVS KVAAGERVVR RPSYLDLFRT PRLRHISLCC 350
    VVVWFGVNFS YYGLSLDVSG LGLNVYQTQL LFGAVELPSK LLVYLSVRYA 400
    GRRLTQAGTL LGTALAFGTR LLVSSDMKSW STVLAVMGKA FSEAAFTTAY 450
    LFTSELYPTV LRQTGMGLTA LVGRLGGSLA PLAALLDGVW LSLPKLTYGG 500
    IALLAAGTAL LLPETRQAQL PETIQDVERK SAPTSLQEEE MPMKQVQN 548
    Length:548
    Mass (Da):60,026
    Last modified:November 1, 1999 - v1
    Checksum:i5BA4C3FCC3C57533
    GO
    Isoform 2 (identifier: Q9Y694-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-133: Missing.

    Show »
    Length:546
    Mass (Da):59,810
    Checksum:i6A87AA1BD6FEA15C
    GO
    Isoform 3 (identifier: Q9Y694-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         132-133: Missing.
         531-548: SAPTSLQEEEMPMKQVQN → RCVHRTVSVYV

    Show »
    Length:539
    Mass (Da):59,082
    Checksum:iF3D6F799778EFE63
    GO
    Isoform 4 (identifier: Q9Y694-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-307: Missing.
         308-317: PVCEDSFSQE → MLQPHLLPYQ

    Show »
    Length:241
    Mass (Da):26,213
    Checksum:i8AF6769F5CAC8439
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti304 – 3041L → P in AAG43523. 1 PublicationCurated
    Sequence conflicti413 – 4131T → A in AAG43523. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti303 – 3031R → K.1 Publication
    Corresponds to variant rs70953684 [ dbSNP | Ensembl ].
    VAR_047875
    Natural varianti327 – 3271R → W.1 Publication
    Corresponds to variant rs36040909 [ dbSNP | Ensembl ].
    VAR_047876
    Natural varianti507 – 5071G → V.1 Publication
    Corresponds to variant rs70953693 [ dbSNP | Ensembl ].
    VAR_047877

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 307307Missing in isoform 4. CuratedVSP_030991Add
    BLAST
    Alternative sequencei132 – 1332Missing in isoform 2 and isoform 3. 2 PublicationsVSP_030992
    Alternative sequencei308 – 31710PVCEDSFSQE → MLQPHLLPYQ in isoform 4. CuratedVSP_030993
    Alternative sequencei531 – 54818SAPTS…KQVQN → RCVHRTVSVYV in isoform 3. 2 PublicationsVSP_030994Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097518 mRNA. Translation: AAD37091.1.
    AF210455 mRNA. Translation: AAG43523.1.
    AY050498 mRNA. Translation: AAL12496.1.
    AK290796 mRNA. Translation: BAF83485.1.
    AK290806 mRNA. Translation: BAF83495.1.
    EU562669 Genomic DNA. Translation: ACB21045.1.
    AL583834 Genomic DNA. Translation: CAI14466.1.
    AL583834 Genomic DNA. Translation: CAI14462.1.
    AL583834 Genomic DNA. Translation: CAI14463.1.
    AL583834 Genomic DNA. Translation: CAI14464.1.
    CH471081 Genomic DNA. Translation: EAX04172.1.
    CH471081 Genomic DNA. Translation: EAX04175.1.
    BC033805 mRNA. Translation: AAH33805.1.
    CCDSiCCDS4892.1. [Q9Y694-2]
    CCDS4893.2. [Q9Y694-1]
    RefSeqiNP_006663.2. NM_006672.3. [Q9Y694-2]
    NP_696961.2. NM_153320.2. [Q9Y694-1]
    UniGeneiHs.485438.

    Genome annotation databases

    EnsembliENST00000372574; ENSP00000361655; ENSG00000137204. [Q9Y694-3]
    ENST00000372585; ENSP00000361666; ENSG00000137204. [Q9Y694-1]
    ENST00000372589; ENSP00000361670; ENSG00000137204. [Q9Y694-2]
    GeneIDi10864.
    KEGGihsa:10864.
    UCSCiuc003ous.3. human. [Q9Y694-3]
    uc003out.3. human. [Q9Y694-1]

    Polymorphism databases

    DMDMi74753520.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF097518 mRNA. Translation: AAD37091.1 .
    AF210455 mRNA. Translation: AAG43523.1 .
    AY050498 mRNA. Translation: AAL12496.1 .
    AK290796 mRNA. Translation: BAF83485.1 .
    AK290806 mRNA. Translation: BAF83495.1 .
    EU562669 Genomic DNA. Translation: ACB21045.1 .
    AL583834 Genomic DNA. Translation: CAI14466.1 .
    AL583834 Genomic DNA. Translation: CAI14462.1 .
    AL583834 Genomic DNA. Translation: CAI14463.1 .
    AL583834 Genomic DNA. Translation: CAI14464.1 .
    CH471081 Genomic DNA. Translation: EAX04172.1 .
    CH471081 Genomic DNA. Translation: EAX04175.1 .
    BC033805 mRNA. Translation: AAH33805.1 .
    CCDSi CCDS4892.1. [Q9Y694-2 ]
    CCDS4893.2. [Q9Y694-1 ]
    RefSeqi NP_006663.2. NM_006672.3. [Q9Y694-2 ]
    NP_696961.2. NM_153320.2. [Q9Y694-1 ]
    UniGenei Hs.485438.

    3D structure databases

    ProteinModelPortali Q9Y694.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000361666.

    Chemistry

    ChEMBLi CHEMBL1955711.

    Protein family/group databases

    TCDBi 2.A.1.19.25. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q9Y694.

    Polymorphism databases

    DMDMi 74753520.

    Proteomic databases

    PaxDbi Q9Y694.
    PRIDEi Q9Y694.

    Protocols and materials databases

    DNASUi 10864.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372574 ; ENSP00000361655 ; ENSG00000137204 . [Q9Y694-3 ]
    ENST00000372585 ; ENSP00000361666 ; ENSG00000137204 . [Q9Y694-1 ]
    ENST00000372589 ; ENSP00000361670 ; ENSG00000137204 . [Q9Y694-2 ]
    GeneIDi 10864.
    KEGGi hsa:10864.
    UCSCi uc003ous.3. human. [Q9Y694-3 ]
    uc003out.3. human. [Q9Y694-1 ]

    Organism-specific databases

    CTDi 10864.
    GeneCardsi GC06P043263.
    HGNCi HGNC:10971. SLC22A7.
    HPAi HPA030220.
    MIMi 604995. gene.
    neXtProti NX_Q9Y694.
    PharmGKBi PA35848.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000234569.
    HOVERGENi HBG108433.
    KOi K08204.
    OMAi PMKQVQN.
    OrthoDBi EOG7C8GH9.
    PhylomeDBi Q9Y694.
    TreeFami TF315847.

    Enzyme and pathway databases

    Reactomei REACT_22310. Organic anion transport.

    Miscellaneous databases

    GeneWikii SLC22A7.
    GenomeRNAii 10864.
    NextBioi 41247.
    PROi Q9Y694.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y694.
    Bgeei Q9Y694.
    CleanExi HS_SLC22A7.
    Genevestigatori Q9Y694.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR004749. Orgcat_transp.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00898. 2A0119. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a human liver-specific transporter, NLT."
      Kim R.B., Leake B.L., Cvetkovic M.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    2. "Identification of a human organic anion transporter 2 homolog."
      Reid G., Bahn A., Ebbinghaus C., Wolff N.A., Burckhardt G.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: Kidney.
    3. "Cloning, characterization and localization of human organic anion transporter 2."
      Kobayashi Y., Ohshiro N., Sekine T., Endoh H., Yamamoto T.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Kidney.
    5. NIEHS SNPs program
      Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS LYS-303; TRP-327 AND VAL-507.
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon.
    9. "Isolation of a family of organic anion transporters from human liver and kidney."
      Sun W., Wu R.R., van Poelje P.D., Erion M.D.
      Biochem. Biophys. Res. Commun. 283:417-422(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    10. "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors."
      Enomoto A., Takeda M., Shimoda M., Narikawa S., Kobayashi Y., Kobayashi Y., Yamamoto T., Sekine T., Cha S.H., Niwa T., Endou H.
      J. Pharmacol. Exp. Ther. 301:797-802(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    11. "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins."
      Kimura H., Takeda M., Narikawa S., Enomoto A., Ichida K., Endou H.
      J. Pharmacol. Exp. Ther. 301:293-298(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION.
    12. Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES.
    13. "Transport mechanism and substrate specificity of human organic anion transporter 2 (hOat2 [SLC22A7])."
      Kobayashi Y., Ohshiro N., Sakai R., Ohbayashi M., Kohyama N., Yamamoto T.
      J. Pharm. Pharmacol. 57:573-578(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-91.
      Tissue: Liver.

    Entry informationi

    Entry nameiS22A7_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y694
    Secondary accession number(s): B2CZX6
    , Q5T046, Q5T048, Q5T050, Q9H2W5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 123 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3