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Protein

Lipoma HMGIC fusion partner

Gene

LHFP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoma HMGIC fusion partner
Gene namesi
Name:LHFP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:6586. LHFP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei84 – 10421HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving LHFP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(12;13)(q13-q15;q12) with HMGA2 is shown in lipomas.

Organism-specific databases

PharmGKBiPA30358.

Polymorphism and mutation databases

BioMutaiLHFP.
DMDMi74753519.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 200179Lipoma HMGIC fusion partnerPRO_0000244756Add
BLAST

Proteomic databases

MaxQBiQ9Y693.
PaxDbiQ9Y693.
PRIDEiQ9Y693.

PTM databases

iPTMnetiQ9Y693.
SwissPalmiQ9Y693.

Expressioni

Tissue specificityi

Pancreas, kidney, skeletal muscle, liver, lung brain, heart, colon, small intestine, uterus, testis, prostate, thymus, spleen and placenta.1 Publication

Gene expression databases

BgeeiQ9Y693.
CleanExiHS_LHFP.
ExpressionAtlasiQ9Y693. baseline and differential.
GenevisibleiQ9Y693. HS.

Organism-specific databases

HPAiHPA058975.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368908.

Structurei

3D structure databases

ProteinModelPortaliQ9Y693.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LHFP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4026. Eukaryota.
ENOG410XSUB. LUCA.
GeneTreeiENSGT00550000074479.
HOGENOMiHOG000007007.
HOVERGENiHBG080585.
InParanoidiQ9Y693.
OMAiSTEWRIC.
OrthoDBiEOG7TF7BG.
PhylomeDBiQ9Y693.
TreeFamiTF321143.

Family and domain databases

InterProiIPR019372. Lipome_HGMIC_fus_partner-like.
[Graphical view]
PfamiPF10242. L_HMGIC_fpl. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y693-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSLTCTGV IWALLSFLCA ATSCVGFFMP YWLWGSQLGK PVSFGTFRRC
60 70 80 90 100
SYPVHDESRQ MMVMVEECGR YASFQGIPSA EWRICTIVTG LGCGLLLLVA
110 120 130 140 150
LTALMGCCVS DLISRTVGRV AGGIQFLGGL LIGAGCALYP LGWDSEEVRQ
160 170 180 190 200
TCGYTSGQFD LGKCEIGWAY YCTGAGATAA MLLCTWLACF SGKKQKHYPY
Length:200
Mass (Da):21,598
Last modified:November 1, 1999 - v1
Checksum:i49D1161602966423
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098807 mRNA. Translation: AAD31386.1.
AL138685, AL158194, AL136358 Genomic DNA. Translation: CAH71055.1.
AL136358, AL158194, AL138685 Genomic DNA. Translation: CAC39629.2.
AL158194, AL136358 Genomic DNA. Translation: CAH73751.1.
CH471075 Genomic DNA. Translation: EAX08616.1.
BC017824 mRNA. Translation: AAH17824.1.
AK223369 mRNA. Translation: BAD97089.1.
AK313036 mRNA. Translation: BAG35869.1.
CCDSiCCDS9369.1.
RefSeqiNP_005771.1. NM_005780.2.
XP_011533163.1. XM_011534861.1.
UniGeneiHs.507798.

Genome annotation databases

EnsembliENST00000379589; ENSP00000368908; ENSG00000183722.
GeneIDi10186.
KEGGihsa:10186.
UCSCiuc001uxf.4. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098807 mRNA. Translation: AAD31386.1.
AL138685, AL158194, AL136358 Genomic DNA. Translation: CAH71055.1.
AL136358, AL158194, AL138685 Genomic DNA. Translation: CAC39629.2.
AL158194, AL136358 Genomic DNA. Translation: CAH73751.1.
CH471075 Genomic DNA. Translation: EAX08616.1.
BC017824 mRNA. Translation: AAH17824.1.
AK223369 mRNA. Translation: BAD97089.1.
AK313036 mRNA. Translation: BAG35869.1.
CCDSiCCDS9369.1.
RefSeqiNP_005771.1. NM_005780.2.
XP_011533163.1. XM_011534861.1.
UniGeneiHs.507798.

3D structure databases

ProteinModelPortaliQ9Y693.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000368908.

PTM databases

iPTMnetiQ9Y693.
SwissPalmiQ9Y693.

Polymorphism and mutation databases

BioMutaiLHFP.
DMDMi74753519.

Proteomic databases

MaxQBiQ9Y693.
PaxDbiQ9Y693.
PRIDEiQ9Y693.

Protocols and materials databases

DNASUi10186.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379589; ENSP00000368908; ENSG00000183722.
GeneIDi10186.
KEGGihsa:10186.
UCSCiuc001uxf.4. human.

Organism-specific databases

CTDi10186.
GeneCardsiLHFP.
HGNCiHGNC:6586. LHFP.
HPAiHPA058975.
MIMi606710. gene.
neXtProtiNX_Q9Y693.
PharmGKBiPA30358.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4026. Eukaryota.
ENOG410XSUB. LUCA.
GeneTreeiENSGT00550000074479.
HOGENOMiHOG000007007.
HOVERGENiHBG080585.
InParanoidiQ9Y693.
OMAiSTEWRIC.
OrthoDBiEOG7TF7BG.
PhylomeDBiQ9Y693.
TreeFamiTF321143.

Miscellaneous databases

ChiTaRSiLHFP. human.
GeneWikiiLHFP.
GenomeRNAii10186.
PROiQ9Y693.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y693.
CleanExiHS_LHFP.
ExpressionAtlasiQ9Y693. baseline and differential.
GenevisibleiQ9Y693. HS.

Family and domain databases

InterProiIPR019372. Lipome_HGMIC_fus_partner-like.
[Graphical view]
PfamiPF10242. L_HMGIC_fpl. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes."
    Petit M.M.R., Schoenmakers E.F.P.M., Huysmans C., Geurts J.M.W., Mandahl N., Van de Ven W.J.M.
    Genomics 57:438-441(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DISEASE.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Amygdala.
  3. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-200.
    Tissue: Dermoid cancer.

Entry informationi

Entry nameiLHFP_HUMAN
AccessioniPrimary (citable) accession number: Q9Y693
Secondary accession number(s): B2R7M2, Q53FC0, Q96SH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.