Reviewed, UniProtKB/Swiss-Prot Q9Y693 (LHFP_HUMAN)

Names and origin

Protein names

Recommended name:
    Lipoma HMGIC fusion partner

Gene names

Name:

LHFP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	200 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane proteinPotential.
Tissue specificity	Pancreas, kidney, skeletal muscle, liver, lung brain, heart, colon, small intestine, uterus, testis, prostate, thymus, spleen and placenta.
Involvement in disease	A chromosomal aberration involving LHFP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(12;13)(q13-q15;q12) with HMGA2 is shown in lipomas.
Sequence similarities	Belongs to the LHFP family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Chromosomal rearrangement
Domain	Signal Transmembrane
Gene Ontology (GO)
Molecular function	DNA binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 200	179	Lipoma HMGIC fusion partner		PRO_0000244756
Regions
	Transmembrane	84 – 104	21	Potential
	Transmembrane	123 – 143	21	Potential
	Transmembrane	166 – 186	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9Y693-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 49D1161602966423	FASTA	200	21,598
	10 20 30 40 50 60 MASSLTCTGV IWALLSFLCA ATSCVGFFMP YWLWGSQLGK PVSFGTFRRC SYPVHDESRQ 70 80 90 100 110 120 MMVMVEECGR YASFQGIPSA EWRICTIVTG LGCGLLLLVA LTALMGCCVS DLISRTVGRV 130 140 150 160 170 180 AGGIQFLGGL LIGAGCALYP LGWDSEEVRQ TCGYTSGQFD LGKCEIGWAY YCTGAGATAA 190 200 MLLCTWLACF SGKKQKHYPY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes." Petit M.M.R., Schoenmakers E.F.P.M., Huysmans C., Geurts J.M.W., Mandahl N., Van de Ven W.J.M. Genomics 57:438-441(1999) [PubMed: 10329012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DISEASE.
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-200. Tissue: Dermoid cancer.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF098807 mRNA. Translation: AAD31386.1. AL138685, AL158194, AL136358 Genomic DNA. Translation: CAH71055.1. AL136358, AL158194, AL138685 Genomic DNA. Translation: CAC39629.2. AL158194, AL136358 Genomic DNA. Translation: CAH73751.1. BC017824 mRNA. Translation: AAH17824.1. AK223369 mRNA. Translation: BAD97089.1.
RefSeq	NP_005771.1.
UniGene	Hs.507798 Hs.648603
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000183722. Homo sapiens. [Contig view]
GeneID	10186.
KEGG	hsa:10186.
Organism-specific databases
HGNC	HGNC:6586. LHFP.
MIM	606710. gene.
PharmGKB	PA30358.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q9Y693.
HOVERGEN	Q9Y693.
Gene expression databases
ArrayExpress	Q9Y693.
CleanEx	HS_LHFP.
GermOnline	ENSG00000183722. Homo sapiens.
Family and domain databases
BLOCKS	Search...
ProtoNet	Search...
Other Resources
NextBio	38550.
SOURCE	Search...

Entry information

Entry name

LHFP_HUMAN

Accession

Primary (citable) accession number: Q9Y693
Secondary accession number(s): Q53FC0, Q96SH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	November 1, 1999
Last modified:	November 4, 2008
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)