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Protein

Lipoma HMGIC fusion partner

Gene

LHFP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Protein family/group databases

TCDBi1.A.82.1.6. the lhfpl tetraspan protein (ltsp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoma HMGIC fusion partner
Gene namesi
Name:LHFP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000183722.7.
HGNCiHGNC:6586. LHFP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving LHFP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(12;13)(q13-q15;q12) with HMGA2 is shown in lipomas.1 Publication

Organism-specific databases

DisGeNETi10186.
OpenTargetsiENSG00000183722.
PharmGKBiPA30358.

Polymorphism and mutation databases

BioMutaiLHFP.
DMDMi74753519.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000024475622 – 200Lipoma HMGIC fusion partnerAdd BLAST179

Proteomic databases

MaxQBiQ9Y693.
PaxDbiQ9Y693.
PeptideAtlasiQ9Y693.
PRIDEiQ9Y693.

PTM databases

iPTMnetiQ9Y693.
PhosphoSitePlusiQ9Y693.
SwissPalmiQ9Y693.

Expressioni

Tissue specificityi

Pancreas, kidney, skeletal muscle, liver, lung brain, heart, colon, small intestine, uterus, testis, prostate, thymus, spleen and placenta.1 Publication

Gene expression databases

BgeeiENSG00000183722.
CleanExiHS_LHFP.
ExpressionAtlasiQ9Y693. baseline and differential.
GenevisibleiQ9Y693. HS.

Organism-specific databases

HPAiHPA058975.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000368908.

Structurei

3D structure databases

ProteinModelPortaliQ9Y693.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LHFP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4026. Eukaryota.
ENOG410XSUB. LUCA.
GeneTreeiENSGT00550000074479.
HOGENOMiHOG000007007.
HOVERGENiHBG080585.
InParanoidiQ9Y693.
OMAiSTEWRIC.
OrthoDBiEOG091G10EV.
PhylomeDBiQ9Y693.
TreeFamiTF321143.

Family and domain databases

InterProiView protein in InterPro
IPR019372. Lipome_HGMIC_fus_partner-like.
PfamiView protein in Pfam
PF10242. L_HMGIC_fpl. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y693-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSLTCTGV IWALLSFLCA ATSCVGFFMP YWLWGSQLGK PVSFGTFRRC
60 70 80 90 100
SYPVHDESRQ MMVMVEECGR YASFQGIPSA EWRICTIVTG LGCGLLLLVA
110 120 130 140 150
LTALMGCCVS DLISRTVGRV AGGIQFLGGL LIGAGCALYP LGWDSEEVRQ
160 170 180 190 200
TCGYTSGQFD LGKCEIGWAY YCTGAGATAA MLLCTWLACF SGKKQKHYPY
Length:200
Mass (Da):21,598
Last modified:November 1, 1999 - v1
Checksum:i49D1161602966423
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF098807 mRNA. Translation: AAD31386.1.
AL138685, AL158194, AL136358 Genomic DNA. Translation: CAH71055.1.
AL136358, AL158194, AL138685 Genomic DNA. Translation: CAC39629.2.
AL158194, AL136358 Genomic DNA. Translation: CAH73751.1.
CH471075 Genomic DNA. Translation: EAX08616.1.
BC017824 mRNA. Translation: AAH17824.1.
AK223369 mRNA. Translation: BAD97089.1.
AK313036 mRNA. Translation: BAG35869.1.
CCDSiCCDS9369.1.
RefSeqiNP_005771.1. NM_005780.2.
XP_011533163.1. XM_011534861.1.
UniGeneiHs.507798.

Genome annotation databases

EnsembliENST00000379589; ENSP00000368908; ENSG00000183722.
GeneIDi10186.
KEGGihsa:10186.
UCSCiuc001uxf.4. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiLHFP_HUMAN
AccessioniPrimary (citable) accession number: Q9Y693
Secondary accession number(s): B2R7M2, Q53FC0, Q96SH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1999
Last modified: September 27, 2017
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families