Reviewed,
UniProtKB/Swiss-Prot Q9Y693 (LHFP_HUMAN)
Last modified
November 4, 2008.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Lipoma HMGIC fusion partner | ||
| Gene names |
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| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 200 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Membrane; Multi-pass membrane proteinPotential. |
| Tissue specificity | Pancreas, kidney, skeletal muscle, liver, lung brain, heart, colon, small intestine, uterus, testis, prostate, thymus, spleen and placenta. |
| Involvement in disease | A chromosomal aberration involving LHFP is associated with a subclass of benign mesenchymal tumors known as lipomas. Translocation t(12;13)(q13-q15;q12) with HMGA2 is shown in lipomas. |
| Sequence similarities | Belongs to the LHFP family. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Chromosomal rearrangement |
| Domain | Signal Transmembrane |
Gene Ontology (GO) | |
| Molecular function | DNA binding Ref.1 Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "LHFP, a novel translocation partner gene of HMGIC in a lipoma, is a member of a new family of LHFP-like genes." Petit M.M.R., Schoenmakers E.F.P.M., Huysmans C., Geurts J.M.W., Mandahl N., Van de Ven W.J.M. Genomics 57:438-441(1999) [PubMed: 10329012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DISEASE. |
| [2] | "The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. Ross M.T.Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung. |
| [4] | Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-200. Tissue: Dermoid cancer. |
Cross-references
Sequence databases | |
|---|---|
| AF098807 mRNA. Translation: AAD31386.1. AL138685, AL158194, AL136358 Genomic DNA. Translation: CAH71055.1. AL136358, AL158194, AL138685 Genomic DNA. Translation: CAC39629.2. AL158194, AL136358 Genomic DNA. Translation: CAH73751.1. BC017824 mRNA. Translation: AAH17824.1. AK223369 mRNA. Translation: BAD97089.1. | |
| RefSeq | NP_005771.1. |
| UniGene | Hs.507798 Hs.648603 |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000183722. Homo sapiens. [Contig view] |
| GeneID | 10186. |
| KEGG | hsa:10186. |
Organism-specific databases | |
| HGNC | HGNC:6586. LHFP. |
| MIM | 606710. gene. |
| PharmGKB | PA30358. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q9Y693. |
| HOVERGEN | Q9Y693. |
Gene expression databases | |
| ArrayExpress | Q9Y693. |
| CleanEx | HS_LHFP. |
| GermOnline | ENSG00000183722. Homo sapiens. |
Family and domain databases | |
| BLOCKS | Search... |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 38550. |
| SOURCE | Search... |
Entry information
| Entry name | LHFP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y693 Secondary accession number(s): Q53FC0, Q96SH5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 13 Human chromosome 13: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


