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Protein

Glucocorticoid modulatory element-binding protein 1

Gene

GMEB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi113Zinc1
Binding sitei139DNA1
Binding sitei143DNA1
Binding sitei146DNA1
Binding sitei157DNA1
Metal bindingi170Zinc1
Metal bindingi174Zinc1
Metal bindingi178Zinc1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162419-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucocorticoid modulatory element-binding protein 1
Short name:
GMEB-1
Alternative name(s):
DNA-binding protein p96PIF
Parvovirus initiation factor p96
Short name:
PIF p96
Gene namesi
Name:GMEB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4370. GMEB1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162419.
PharmGKBiPA28755.

Polymorphism and mutation databases

BioMutaiGMEB1.
DMDMi22001627.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000740892 – 573Glucocorticoid modulatory element-binding protein 1Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y692.
PaxDbiQ9Y692.
PeptideAtlasiQ9Y692.
PRIDEiQ9Y692.

PTM databases

iPTMnetiQ9Y692.
PhosphoSitePlusiQ9Y692.

Expressioni

Gene expression databases

BgeeiENSG00000162419.
CleanExiHS_GMEB1.
ExpressionAtlasiQ9Y692. baseline and differential.
GenevisibleiQ9Y692. HS.

Organism-specific databases

HPAiHPA044811.
HPA052975.

Interactioni

Subunit structurei

Homodimer, and heterodimer of GMEB1 and GMEB2. GMEB1 and GMEB2 form the parvovirus initiator complex (PIF). Interacts with the glucocorticoid receptor (NR3C1) and NCOA2/TIF2 (By similarity). May interact with HSP27 and CREB-binding protein (CBP).By similarity

Protein-protein interaction databases

BioGridi115930. 16 interactors.
IntActiQ9Y692. 15 interactors.
MINTiMINT-1181706.
STRINGi9606.ENSP00000294409.

Structurei

Secondary structure

1573
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi92 – 99Combined sources8
Beta strandi102 – 107Combined sources6
Helixi108 – 110Combined sources3
Beta strandi121 – 123Combined sources3
Beta strandi126 – 128Combined sources3
Helixi130 – 136Combined sources7
Helixi140 – 142Combined sources3
Helixi145 – 148Combined sources4
Beta strandi149 – 151Combined sources3
Helixi156 – 161Combined sources6
Turni168 – 172Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OQJX-ray1.55A/B89-182[»]
ProteinModelPortaliQ9Y692.
SMRiQ9Y692.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y692.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 166SANDPROSITE-ProRule annotationAdd BLAST85

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili321 – 367Sequence analysisAdd BLAST47

Sequence similaritiesi

Contains 1 SAND domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4333. Eukaryota.
ENOG410ZMTP. LUCA.
GeneTreeiENSGT00410000025596.
HOGENOMiHOG000231857.
HOVERGENiHBG051742.
InParanoidiQ9Y692.
OMAiAAMQDGG.
OrthoDBiEOG091G07Q9.
PhylomeDBiQ9Y692.
TreeFamiTF317090.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
InterProiIPR024830. GMEB1/2.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
[Graphical view]
PANTHERiPTHR10417. PTHR10417. 1 hit.
PfamiPF01342. SAND. 1 hit.
[Graphical view]
SMARTiSM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF63763. SSF63763. 1 hit.
PROSITEiPS50864. SAND. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y692-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANAEVSVPV GDVVVVPTEG NEGENPEDTK TQVILQLQPV QQGLFIDGHF
60 70 80 90 100
YNRIYEAGSE NNTAVVAVET HTIHKIEEGI DTGTIEANED MEIAYPITCG
110 120 130 140 150
ESKAILLWKK FVCPGINVKC VKFNDQLISP KHFVHLAGKS TLKDWKRAIR
160 170 180 190 200
LGGIMLRKMM DSGQIDFYQH DKVCSNTCRS TKFDLLISSA RAPVPGQQTS
210 220 230 240 250
VVQTPTSADG SITQIAISEE SMEEAGLEWN SALTAAVTMA TEEGVKKDSE
260 270 280 290 300
EISEDTLMFW KGIADVGLME EVVCNIQKEI EELLRGVQQR LIQAPFQVTD
310 320 330 340 350
AAVLNNVAHT FGLMDTVKKV LDNRRNQVEQ GEEQFLYTLT DLERQLEEQK
360 370 380 390 400
KQGQDHRLKS QTVQNVVLMP VSTPKPPKRP RLQRPASTTV LSPSPPVQQP
410 420 430 440 450
QFTVISPITI TPVGQSFSMG NIPVATLSQG SSPVTVHTLP SGPQLFRYAT
460 470 480 490 500
VVSSAKSSSP DTVTIHPSSS LALLSSTAMQ DGSTLGNMTT MVSPVELVAM
510 520 530 540 550
ESGLTSAIQA VESTSEDGQT IIEIDPAPDP EAEDTEGKAV ILETELRTEE
560 570
KVVAEMEEHQ HQVHNVEIVV LED
Length:573
Mass (Da):62,591
Last modified:July 26, 2002 - v2
Checksum:i8175B0730F1550B8
GO
Isoform 2 (identifier: Q9Y692-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-53: Missing.

Show »
Length:563
Mass (Da):61,327
Checksum:iDFDF1EA16BAFB055
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti401Q → E in AAD39355 (PubMed:10386584).Curated1
Sequence conflicti463V → M in BAA91410 (PubMed:14702039).Curated1
Sequence conflicti548T → I in BAA91410 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05189414V → A.Corresponds to variant rs11557120dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00597044 – 53Missing in isoform 2. 4 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF099013 mRNA. Translation: AAD39355.1.
AF173868 mRNA. Translation: AAD51352.1.
AF203694 mRNA. Translation: AAG01189.1.
AK000892 mRNA. Translation: BAA91410.1.
AL645729 Genomic DNA. Translation: CAH72427.1.
CH471059 Genomic DNA. Translation: EAX07677.1.
BC001473 mRNA. Translation: AAH01473.1.
CCDSiCCDS327.1. [Q9Y692-1]
CCDS328.1. [Q9Y692-2]
RefSeqiNP_001306603.1. NM_001319674.1. [Q9Y692-2]
NP_006573.2. NM_006582.3. [Q9Y692-1]
NP_077808.1. NM_024482.2. [Q9Y692-2]
XP_011538820.1. XM_011540518.2. [Q9Y692-1]
XP_011538821.1. XM_011540519.2. [Q9Y692-1]
XP_011538823.1. XM_011540521.2. [Q9Y692-2]
XP_016855576.1. XM_017000087.1. [Q9Y692-1]
UniGeneiHs.632373.

Genome annotation databases

EnsembliENST00000294409; ENSP00000294409; ENSG00000162419. [Q9Y692-1]
ENST00000361872; ENSP00000355186; ENSG00000162419. [Q9Y692-2]
ENST00000373816; ENSP00000362922; ENSG00000162419. [Q9Y692-2]
GeneIDi10691.
KEGGihsa:10691.
UCSCiuc001bqz.4. human. [Q9Y692-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF099013 mRNA. Translation: AAD39355.1.
AF173868 mRNA. Translation: AAD51352.1.
AF203694 mRNA. Translation: AAG01189.1.
AK000892 mRNA. Translation: BAA91410.1.
AL645729 Genomic DNA. Translation: CAH72427.1.
CH471059 Genomic DNA. Translation: EAX07677.1.
BC001473 mRNA. Translation: AAH01473.1.
CCDSiCCDS327.1. [Q9Y692-1]
CCDS328.1. [Q9Y692-2]
RefSeqiNP_001306603.1. NM_001319674.1. [Q9Y692-2]
NP_006573.2. NM_006582.3. [Q9Y692-1]
NP_077808.1. NM_024482.2. [Q9Y692-2]
XP_011538820.1. XM_011540518.2. [Q9Y692-1]
XP_011538821.1. XM_011540519.2. [Q9Y692-1]
XP_011538823.1. XM_011540521.2. [Q9Y692-2]
XP_016855576.1. XM_017000087.1. [Q9Y692-1]
UniGeneiHs.632373.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OQJX-ray1.55A/B89-182[»]
ProteinModelPortaliQ9Y692.
SMRiQ9Y692.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115930. 16 interactors.
IntActiQ9Y692. 15 interactors.
MINTiMINT-1181706.
STRINGi9606.ENSP00000294409.

PTM databases

iPTMnetiQ9Y692.
PhosphoSitePlusiQ9Y692.

Polymorphism and mutation databases

BioMutaiGMEB1.
DMDMi22001627.

Proteomic databases

EPDiQ9Y692.
PaxDbiQ9Y692.
PeptideAtlasiQ9Y692.
PRIDEiQ9Y692.

Protocols and materials databases

DNASUi10691.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000294409; ENSP00000294409; ENSG00000162419. [Q9Y692-1]
ENST00000361872; ENSP00000355186; ENSG00000162419. [Q9Y692-2]
ENST00000373816; ENSP00000362922; ENSG00000162419. [Q9Y692-2]
GeneIDi10691.
KEGGihsa:10691.
UCSCiuc001bqz.4. human. [Q9Y692-1]

Organism-specific databases

CTDi10691.
GeneCardsiGMEB1.
HGNCiHGNC:4370. GMEB1.
HPAiHPA044811.
HPA052975.
MIMi604409. gene.
neXtProtiNX_Q9Y692.
OpenTargetsiENSG00000162419.
PharmGKBiPA28755.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4333. Eukaryota.
ENOG410ZMTP. LUCA.
GeneTreeiENSGT00410000025596.
HOGENOMiHOG000231857.
HOVERGENiHBG051742.
InParanoidiQ9Y692.
OMAiAAMQDGG.
OrthoDBiEOG091G07Q9.
PhylomeDBiQ9Y692.
TreeFamiTF317090.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162419-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9Y692.
GeneWikiiGMEB1.
GenomeRNAii10691.
PROiQ9Y692.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162419.
CleanExiHS_GMEB1.
ExpressionAtlasiQ9Y692. baseline and differential.
GenevisibleiQ9Y692. HS.

Family and domain databases

Gene3Di3.10.390.10. 1 hit.
InterProiIPR024830. GMEB1/2.
IPR000770. SAND_dom.
IPR010919. SAND_dom-like.
[Graphical view]
PANTHERiPTHR10417. PTHR10417. 1 hit.
PfamiPF01342. SAND. 1 hit.
[Graphical view]
SMARTiSM00258. SAND. 1 hit.
[Graphical view]
SUPFAMiSSF63763. SSF63763. 1 hit.
PROSITEiPS50864. SAND. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGMEB1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y692
Secondary accession number(s): B1AT48, Q9NWH1, Q9UKD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 26, 2002
Last modified: November 2, 2016
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.