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Protein

Glucocorticoid modulatory element-binding protein 1

Gene

GMEB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi113Zinc1
Binding sitei139DNA1
Binding sitei143DNA1
Binding sitei146DNA1
Binding sitei157DNA1
Metal bindingi170Zinc1
Metal bindingi174Zinc1
Metal bindingi178Zinc1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Glucocorticoid modulatory element-binding protein 1
Short name:
GMEB-1
Alternative name(s):
DNA-binding protein p96PIF
Parvovirus initiation factor p96
Short name:
PIF p96
Gene namesi
Name:GMEB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162419.12
HGNCiHGNC:4370 GMEB1
MIMi604409 gene
neXtProtiNX_Q9Y692

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162419
PharmGKBiPA28755

Polymorphism and mutation databases

BioMutaiGMEB1
DMDMi22001627

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000740892 – 573Glucocorticoid modulatory element-binding protein 1Add BLAST572

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y692
PaxDbiQ9Y692
PeptideAtlasiQ9Y692
PRIDEiQ9Y692
ProteomicsDBi86625
86626 [Q9Y692-2]

PTM databases

iPTMnetiQ9Y692
PhosphoSitePlusiQ9Y692

Expressioni

Gene expression databases

BgeeiENSG00000162419
CleanExiHS_GMEB1
ExpressionAtlasiQ9Y692 baseline and differential
GenevisibleiQ9Y692 HS

Organism-specific databases

HPAiHPA044811
HPA052975

Interactioni

Subunit structurei

Homodimer, and heterodimer of GMEB1 and GMEB2. GMEB1 and GMEB2 form the parvovirus initiator complex (PIF). Interacts with the glucocorticoid receptor (NR3C1) and NCOA2/TIF2 (By similarity). May interact with HSP27 and CREB-binding protein (CBP).By similarity

Protein-protein interaction databases

BioGridi115930, 19 interactors
IntActiQ9Y692, 15 interactors
MINTiQ9Y692
STRINGi9606.ENSP00000294409

Structurei

Secondary structure

1573
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi92 – 99Combined sources8
Beta strandi102 – 107Combined sources6
Helixi108 – 110Combined sources3
Beta strandi121 – 123Combined sources3
Beta strandi126 – 128Combined sources3
Helixi130 – 136Combined sources7
Helixi140 – 142Combined sources3
Helixi145 – 148Combined sources4
Beta strandi149 – 151Combined sources3
Helixi156 – 161Combined sources6
Turni168 – 172Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OQJX-ray1.55A/B89-182[»]
ProteinModelPortaliQ9Y692
SMRiQ9Y692
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y692

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 166SANDPROSITE-ProRule annotationAdd BLAST85

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili321 – 367Sequence analysisAdd BLAST47

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4333 Eukaryota
ENOG410ZMTP LUCA
GeneTreeiENSGT00410000025596
HOGENOMiHOG000231857
HOVERGENiHBG051742
InParanoidiQ9Y692
OMAiCPITCGD
OrthoDBiEOG091G07Q9
PhylomeDBiQ9Y692
TreeFamiTF317090

Family and domain databases

Gene3Di3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR024830 GMEB1/2
IPR010919 SAND-like_dom_sf
IPR000770 SAND_dom
PANTHERiPTHR10417 PTHR10417, 1 hit
PfamiView protein in Pfam
PF01342 SAND, 1 hit
SMARTiView protein in SMART
SM00258 SAND, 1 hit
SUPFAMiSSF63763 SSF63763, 1 hit
PROSITEiView protein in PROSITE
PS50864 SAND, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y692-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANAEVSVPV GDVVVVPTEG NEGENPEDTK TQVILQLQPV QQGLFIDGHF
60 70 80 90 100
YNRIYEAGSE NNTAVVAVET HTIHKIEEGI DTGTIEANED MEIAYPITCG
110 120 130 140 150
ESKAILLWKK FVCPGINVKC VKFNDQLISP KHFVHLAGKS TLKDWKRAIR
160 170 180 190 200
LGGIMLRKMM DSGQIDFYQH DKVCSNTCRS TKFDLLISSA RAPVPGQQTS
210 220 230 240 250
VVQTPTSADG SITQIAISEE SMEEAGLEWN SALTAAVTMA TEEGVKKDSE
260 270 280 290 300
EISEDTLMFW KGIADVGLME EVVCNIQKEI EELLRGVQQR LIQAPFQVTD
310 320 330 340 350
AAVLNNVAHT FGLMDTVKKV LDNRRNQVEQ GEEQFLYTLT DLERQLEEQK
360 370 380 390 400
KQGQDHRLKS QTVQNVVLMP VSTPKPPKRP RLQRPASTTV LSPSPPVQQP
410 420 430 440 450
QFTVISPITI TPVGQSFSMG NIPVATLSQG SSPVTVHTLP SGPQLFRYAT
460 470 480 490 500
VVSSAKSSSP DTVTIHPSSS LALLSSTAMQ DGSTLGNMTT MVSPVELVAM
510 520 530 540 550
ESGLTSAIQA VESTSEDGQT IIEIDPAPDP EAEDTEGKAV ILETELRTEE
560 570
KVVAEMEEHQ HQVHNVEIVV LED
Length:573
Mass (Da):62,591
Last modified:July 26, 2002 - v2
Checksum:i8175B0730F1550B8
GO
Isoform 2 (identifier: Q9Y692-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-53: Missing.

Show »
Length:563
Mass (Da):61,327
Checksum:iDFDF1EA16BAFB055
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti401Q → E in AAD39355 (PubMed:10386584).Curated1
Sequence conflicti463V → M in BAA91410 (PubMed:14702039).Curated1
Sequence conflicti548T → I in BAA91410 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05189414V → A. Corresponds to variant dbSNP:rs11557120Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00597044 – 53Missing in isoform 2. 4 Publications10

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF099013 mRNA Translation: AAD39355.1
AF173868 mRNA Translation: AAD51352.1
AF203694 mRNA Translation: AAG01189.1
AK000892 mRNA Translation: BAA91410.1
AL645729 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07677.1
BC001473 mRNA Translation: AAH01473.1
CCDSiCCDS327.1 [Q9Y692-1]
CCDS328.1 [Q9Y692-2]
RefSeqiNP_001306603.1, NM_001319674.1 [Q9Y692-2]
NP_006573.2, NM_006582.3 [Q9Y692-1]
NP_077808.1, NM_024482.2 [Q9Y692-2]
XP_011538820.1, XM_011540518.2 [Q9Y692-1]
XP_011538821.1, XM_011540519.2 [Q9Y692-1]
XP_011538823.1, XM_011540521.2 [Q9Y692-2]
XP_016855576.1, XM_017000087.1 [Q9Y692-1]
UniGeneiHs.632373

Genome annotation databases

EnsembliENST00000294409; ENSP00000294409; ENSG00000162419 [Q9Y692-1]
ENST00000361872; ENSP00000355186; ENSG00000162419 [Q9Y692-2]
ENST00000373816; ENSP00000362922; ENSG00000162419 [Q9Y692-2]
GeneIDi10691
KEGGihsa:10691
UCSCiuc001bqz.4 human [Q9Y692-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGMEB1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y692
Secondary accession number(s): B1AT48, Q9NWH1, Q9UKD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 26, 2002
Last modified: June 20, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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