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Protein

Calcium-activated potassium channel subunit beta-2

Gene

KCNMB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.2 Publications

GO - Molecular functioni

  • calcium-activated potassium channel activity Source: UniProtKB
  • ion channel inhibitor activity Source: ProtInc
  • potassium channel regulator activity Source: ProtInc

GO - Biological processi

  • action potential Source: UniProtKB
  • chemical synaptic transmission Source: GO_Central
  • detection of calcium ion Source: UniProtKB
  • neuronal action potential Source: UniProtKB
  • potassium ion transport Source: UniProtKB
  • regulation of vasoconstriction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1296052. Ca2+ activated K+ channels.
R-HSA-418457. cGMP effects.

Protein family/group databases

TCDBi8.A.14.1.3. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-2
Alternative name(s):
BK channel subunit beta-2
Short name:
BKbeta2
Short name:
Hbeta2
Calcium-activated potassium channel, subfamily M subunit beta-2
Charybdotoxin receptor subunit beta-2
Hbeta3
K(VCA)beta-2
Maxi K channel subunit beta-2
Slo-beta-2
Gene namesi
Name:KCNMB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:6286. KCNMB2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46CytoplasmicSequence analysisAdd BLAST46
Transmembranei47 – 67Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini68 – 194ExtracellularSequence analysisAdd BLAST127
Transmembranei195 – 215Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • voltage-gated potassium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2 – 4FIW → GGG: Abolishes inactivation of KCNMA1 channel. 1 Publication3

Organism-specific databases

DisGeNETi10242.
OpenTargetsiENSG00000197584.
ENSG00000275163.
PharmGKBiPA30066.

Chemistry databases

DrugBankiDB01110. Miconazole.
DB00721. Procaine.

Polymorphism and mutation databases

DMDMi46396054.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870511 – 235Calcium-activated potassium channel subunit beta-2Add BLAST235

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y691.
PeptideAtlasiQ9Y691.
PRIDEiQ9Y691.

PTM databases

iPTMnetiQ9Y691.
PhosphoSitePlusiQ9Y691.

Expressioni

Tissue specificityi

Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.3 Publications

Gene expression databases

BgeeiENSG00000197584.
CleanExiHS_KCNMB2.
ExpressionAtlasiQ9Y691. baseline and differential.
GenevisibleiQ9Y691. HS.

Organism-specific databases

HPAiCAB022649.

Interactioni

Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer.1 Publication

Protein-protein interaction databases

BioGridi115536. 1 interactor.
IntActiQ9Y691. 1 interactor.
MINTiMINT-8381989.
STRINGi9606.ENSP00000351068.

Structurei

Secondary structure

1235
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi12 – 15Combined sources4
Helixi22 – 29Combined sources8
Turni30 – 32Combined sources3
Beta strandi33 – 35Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JO6NMR-A1-45[»]
ProteinModelPortaliQ9Y691.
SMRiQ9Y691.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y691.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 45Ball and chainAdd BLAST45

Domaini

The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus.2 Publications

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEU4. Eukaryota.
ENOG4111FIG. LUCA.
GeneTreeiENSGT00390000015997.
HOVERGENiHBG052223.
InParanoidiQ9Y691.
KOiK04938.
OMAiKMFIWTS.
OrthoDBiEOG091G0MVO.
PhylomeDBiQ9Y691.
TreeFamiTF328589.

Family and domain databases

Gene3Di4.10.81.20. 1 hit.
InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
IPR015382. KCNMB2_ball_chain_dom.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
PF09303. KcnmB2_inactiv. 1 hit.
[Graphical view]
PRINTSiPR01450. BKCHANNELB.

Sequencei

Sequence statusi: Complete.

Q9Y691-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIWTSGRTS SSYRHDEKRN IYQKIRDHDL LDKRKTVTAL KAGEDRAILL
60 70 80 90 100
GLAMMVCSIM MYFLLGITLL RSYMQSVWTE ESQCTLLNAS ITETFNCSFS
110 120 130 140 150
CGPDCWKLSQ YPCLQVYVNL TSSGEKLLLY HTEETIKINQ KCSYIPKCGK
160 170 180 190 200
NFEESMSLVN VVMENFRKYQ HFSCYSDPEG NQKSVILTKL YSSNVLFHSL
210 220 230
FWPTCMMAGG VAIVAMVKLT QYLSLLCERI QRINR
Length:235
Mass (Da):27,130
Last modified:November 1, 1999 - v1
Checksum:i5752021DF27D8CF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF099137 mRNA. Translation: AAD23380.1.
AF209747 mRNA. Translation: AAF36562.1.
BC017825 mRNA. Translation: AAH17825.1.
CCDSiCCDS3223.1.
RefSeqiNP_001265840.1. NM_001278911.1.
NP_005823.1. NM_005832.4.
NP_852006.1. NM_181361.2.
XP_011510627.1. XM_011512325.2.
UniGeneiHs.478368.

Genome annotation databases

EnsembliENST00000358316; ENSP00000351068; ENSG00000197584.
ENST00000420517; ENSP00000408252; ENSG00000197584.
ENST00000432997; ENSP00000407592; ENSG00000197584.
ENST00000452583; ENSP00000397483; ENSG00000197584.
GeneIDi10242.
KEGGihsa:10242.
UCSCiuc003fjd.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF099137 mRNA. Translation: AAD23380.1.
AF209747 mRNA. Translation: AAF36562.1.
BC017825 mRNA. Translation: AAH17825.1.
CCDSiCCDS3223.1.
RefSeqiNP_001265840.1. NM_001278911.1.
NP_005823.1. NM_005832.4.
NP_852006.1. NM_181361.2.
XP_011510627.1. XM_011512325.2.
UniGeneiHs.478368.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JO6NMR-A1-45[»]
ProteinModelPortaliQ9Y691.
SMRiQ9Y691.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115536. 1 interactor.
IntActiQ9Y691. 1 interactor.
MINTiMINT-8381989.
STRINGi9606.ENSP00000351068.

Chemistry databases

DrugBankiDB01110. Miconazole.
DB00721. Procaine.

Protein family/group databases

TCDBi8.A.14.1.3. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family.

PTM databases

iPTMnetiQ9Y691.
PhosphoSitePlusiQ9Y691.

Polymorphism and mutation databases

DMDMi46396054.

Proteomic databases

PaxDbiQ9Y691.
PeptideAtlasiQ9Y691.
PRIDEiQ9Y691.

Protocols and materials databases

DNASUi10242.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358316; ENSP00000351068; ENSG00000197584.
ENST00000420517; ENSP00000408252; ENSG00000197584.
ENST00000432997; ENSP00000407592; ENSG00000197584.
ENST00000452583; ENSP00000397483; ENSG00000197584.
GeneIDi10242.
KEGGihsa:10242.
UCSCiuc003fjd.5. human.

Organism-specific databases

CTDi10242.
DisGeNETi10242.
GeneCardsiKCNMB2.
HGNCiHGNC:6286. KCNMB2.
HPAiCAB022649.
MIMi605214. gene.
neXtProtiNX_Q9Y691.
OpenTargetsiENSG00000197584.
ENSG00000275163.
PharmGKBiPA30066.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEU4. Eukaryota.
ENOG4111FIG. LUCA.
GeneTreeiENSGT00390000015997.
HOVERGENiHBG052223.
InParanoidiQ9Y691.
KOiK04938.
OMAiKMFIWTS.
OrthoDBiEOG091G0MVO.
PhylomeDBiQ9Y691.
TreeFamiTF328589.

Enzyme and pathway databases

ReactomeiR-HSA-1296052. Ca2+ activated K+ channels.
R-HSA-418457. cGMP effects.

Miscellaneous databases

EvolutionaryTraceiQ9Y691.
GeneWikiiKCNMB2.
GenomeRNAii10242.
PROiQ9Y691.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197584.
CleanExiHS_KCNMB2.
ExpressionAtlasiQ9Y691. baseline and differential.
GenevisibleiQ9Y691. HS.

Family and domain databases

Gene3Di4.10.81.20. 1 hit.
InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
IPR015382. KCNMB2_ball_chain_dom.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
PF09303. KcnmB2_inactiv. 1 hit.
[Graphical view]
PRINTSiPR01450. BKCHANNELB.
ProtoNetiSearch...

Entry informationi

Entry nameiKCMB2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y691
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.