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Reviewed, UniProtKB/Swiss-Prot Q9Y689 (ARL5A_HUMAN)

Last modified June 16, 2009. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    ADP-ribosylation factor-like protein 5A
Gene names
Name: ARL5A
Synonyms: ARFLP5, ARL5
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length179 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Lacks ADP-ribosylation enhancing activity By similarity.

Sequence similarities

Belongs to the small GTPase superfamily. Arf family.

Ontologies

Keywords
   LigandGTP-binding
Nucleotide-binding
   PTMLipoprotein
Myristate
   Technical term3D-structure
Gene Ontology (GO)
   Biological processsmall GTPase mediated signal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Potential
Chain2 – 179178ADP-ribosylation factor-like protein 5A
PRO_0000207467

Regions

Nucleotide binding23 – 308GTP
Nucleotide binding66 – 705GTP By similarity
Nucleotide binding125 – 1284GTP

Sites

Binding site1591GTP; via amide nitrogen

Amino acid modifications

Lipidation21N-myristoyl glycine Potential

Secondary structure

.................................... 179
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9Y689-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 431CC65F8D8CB9D5

FASTA17920,728
        10         20         30         40         50         60 
MGILFTRIWR LFNHQEHKVI IVGLDNAGKT TILYQFSMNE VVHTSPTIGS NVEEIVINNT 

        70         80         90        100        110        120 
RFLMWDIGGQ ESLRSSWNTY YTNTEFVIVV VDSTDRERIS VTREELYKML AHEDLRKAGL 

       130        140        150        160        170 
LIFANKQDVK ECMTVAEISQ FLKLTSIKDH QWHIQACCAL TGEGLCQGLE WMMSRLKIR 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues."
He H., Dai F.Y., Yu L., She X., Zhao Y., Jiang J., Chen X., Zhao S.Y.
Gene Expr. 10:231-242(2002) [PubMed: 12450215] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[3]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[6]"2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins."
Wang Z.-X., Shi L., Liu J.-F., An X.-M., Chang W.-R., Liang D.-C.
Biochem. Biophys. Res. Commun. 332:640-645(2005) [PubMed: 15896705] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH GTP ANALOG.
[7]"Structure of human ADP-ribosylation factor-like 5 (ARL5)."
Structural genomics consortium (SGC)
Submitted (JUN-2006) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 15-176.

Cross-references

Sequence databases

AF087889 mRNA. Translation: AAP97188.1.
AF100740 mRNA. Translation: AAD40383.1.
AF493891 mRNA. Translation: AAM12605.1.
BT009829 mRNA. Translation: AAP88831.1.
BC001254 mRNA. Translation: AAH01254.1.
IPIIPI00412787.
RefSeqNP_036229.1.
UniGeneHs.470233

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1Z6YX-ray2.40A/B1-179[»]
1ZJ6X-ray2.00A1-179[»]
2H16X-ray2.00A/B/C/D14-177[»]
2H17X-ray1.70A15-176[»]
ModBaseSearch...

Proteomic databases

PRIDEQ9Y689.

Genome annotation databases

EnsemblENSG00000162980. Homo sapiens. [Contig view]
GeneID26225.

Organism-specific databases

GeneCardsGC02M152365.
H-InvDBHIX0002506.
HGNCHGNC:696. ARL5A.
MIM608960. gene.
PharmGKBPA24989.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9Y689.
HOVERGENQ9Y689.
OMAQ9Y689. THAVIVV.

Gene expression databases

ArrayExpressQ9Y689.
BgeeQ9Y689.
CleanExHS_ARL5A.
GermOnlineENSG00000162980. Homo sapiens.

Family and domain databases

InterProIPR006688. ARF.
IPR006689. ARF/SAR.
IPR005225. Small_GTP_bd.
[Graphical view]
PANTHERPTHR11711. ARF/SAR. 1 hit.
PfamPF00025. Arf. 1 hit.
[Graphical view]
PRINTSPR00328. SAR1GTPBP.
SMARTSM00177. ARF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio48373.
SOURCESearch...

Entry information

Entry nameARL5A_HUMAN
AccessionPrimary (citable) accession number: Q9Y689
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: June 16, 2009
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents