ADP-ribosylation factor-like protein 5A

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Reviewed, UniProtKB/Swiss-Prot Q9Y689 (ARL5A_HUMAN)

Last modified June 16, 2009. Version 86. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
ADP-ribosylation factor-like protein 5A

Gene names

Name:	ARL5A
Synonyms:	ARFLP5, ARL5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Lacks ADP-ribosylation enhancing activity By similarity.
Sequence similarities	Belongs to the small GTPase superfamily. Arf family.

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Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Myristate
Technical term	3D-structure
Gene Ontology (GO)
Biological process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed Potential

Chain

2 – 179

178

ADP-ribosylation factor-like protein 5A

PRO_0000207467

Regions

Nucleotide binding

23 – 30

GTP

Nucleotide binding

66 – 70

GTP By similarity

Nucleotide binding

125 – 128

GTP

Sites

Binding site

159

GTP; via amide nitrogen

Amino acid modifications

Lipidation

N-myristoyl glycine Potential

Secondary structure

179

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9Y689-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 431CC65F8D8CB9D5
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FASTA

179

20,728

        10         20         30         40         50         60 
MGILFTRIWR LFNHQEHKVI IVGLDNAGKT TILYQFSMNE VVHTSPTIGS NVEEIVINNT 

        70         80         90        100        110        120 
RFLMWDIGGQ ESLRSSWNTY YTNTEFVIVV VDSTDRERIS VTREELYKML AHEDLRKAGL 

       130        140        150        160        170 
LIFANKQDVK ECMTVAEISQ FLKLTSIKDH QWHIQACCAL TGEGLCQGLE WMMSRLKIR

« Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and characterization of nine novel human small GTPases showing variable expressions in liver cancer tissues." He H., Dai F.Y., Yu L., She X., Zhao Y., Jiang J., Chen X., Zhao S.Y. Gene Expr. 10:231-242(2002) [PubMed: 12450215] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
[3]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[6]	"2.0 A crystal structure of human ARL5-GDP3'P, a novel member of the small GTP-binding proteins." Wang Z.-X., Shi L., Liu J.-F., An X.-M., Chang W.-R., Liang D.-C. Biochem. Biophys. Res. Commun. 332:640-645(2005) [PubMed: 15896705] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH GTP ANALOG.
[7]	"Structure of human ADP-ribosylation factor-like 5 (ARL5)." Structural genomics consortium (SGC) Submitted (JUN-2006) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 15-176.

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Cross-references

Sequence databases

AF087889 mRNA. Translation: AAP97188.1.
AF100740 mRNA. Translation: AAD40383.1.
AF493891 mRNA. Translation: AAM12605.1.
BT009829 mRNA. Translation: AAP88831.1.
BC001254 mRNA. Translation: AAH01254.1.

IPI

IPI00412787.

RefSeq

NP_036229.1.

UniGene

Hs.470233

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1Z6Y	X-ray	2.40	A/B	1-179	[»]
1ZJ6	X-ray	2.00	A	1-179	[»]
2H16	X-ray	2.00	A/B/C/D	14-177	[»]
2H17	X-ray	1.70	A	15-176	[»]

ModBase

Search...

Proteomic databases

PRIDE

Q9Y689.

Genome annotation databases

Ensembl

ENSG00000162980. Homo sapiens. [Contig view]

GeneID

26225.

Organism-specific databases

GeneCards

GC02M152365.

H-InvDB

HIX0002506.

HGNC

HGNC:696. ARL5A.

MIM

608960. gene.

PharmGKB

PA24989.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q9Y689.

HOVERGEN

Q9Y689.

OMA

Q9Y689. THAVIVV.

Gene expression databases

ArrayExpress

Q9Y689.

Bgee

Q9Y689.

CleanEx

HS_ARL5A.

GermOnline

ENSG00000162980. Homo sapiens.

Family and domain databases

InterPro

IPR006688. ARF.
IPR006689. ARF/SAR.
IPR005225. Small_GTP_bd.
[Graphical view]

PANTHER

PTHR11711. ARF/SAR. 1 hit.

Pfam

PF00025. Arf. 1 hit.
[Graphical view]

PRINTS

PR00328. SAR1GTPBP.

SMART

SM00177. ARF. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00231. small_GTP. 1 hit.

PROSITE

PS51417. ARF. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

48373.

SOURCE

Search...

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Entry information

Entry name

ARL5A_HUMAN

Accession

Primary (citable) accession number: Q9Y689

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	June 16, 2009
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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