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Protein

ADP-ribosylation factor-like protein 5A

Gene

ARL5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lacks ADP-ribosylation enhancing activity.By similarity

Caution

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei159GTP; via amide nitrogen1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 30GTP8
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi125 – 128GTP4

GO - Molecular functioni

GO - Biological processi

  • protein localization to Golgi membrane Source: FlyBase

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 5A
Gene namesi
Name:ARL5A
Synonyms:ARFLP5, ARL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000162980.16
HGNCiHGNC:696 ARL5A
MIMi608960 gene
neXtProtiNX_Q9Y689

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi26225
OpenTargetsiENSG00000162980
PharmGKBiPA24989

Chemistry databases

DrugBankiDB04315 Guanosine-5'-Diphosphate

Polymorphism and mutation databases

BioMutaiARL5A
DMDMi12229600

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074672 – 179ADP-ribosylation factor-like protein 5AAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ9Y689
PaxDbiQ9Y689
PeptideAtlasiQ9Y689
PRIDEiQ9Y689

PTM databases

iPTMnetiQ9Y689
PhosphoSitePlusiQ9Y689

Expressioni

Gene expression databases

BgeeiENSG00000162980
CleanExiHS_ARL5A
ExpressionAtlasiQ9Y689 baseline and differential
GenevisibleiQ9Y689 HS

Organism-specific databases

HPAiHPA027002

Interactioni

Protein-protein interaction databases

BioGridi1176168 interactors.
STRINGi9606.ENSP00000295087

Structurei

Secondary structure

1179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 12Combined sources10
Beta strandi17 – 24Combined sources8
Helixi29 – 37Combined sources9
Beta strandi42 – 45Combined sources4
Beta strandi48 – 51Combined sources4
Beta strandi53 – 57Combined sources5
Beta strandi60 – 70Combined sources11
Helixi71 – 73Combined sources3
Helixi76 – 81Combined sources6
Beta strandi86 – 92Combined sources7
Turni96 – 98Combined sources3
Helixi99 – 110Combined sources12
Helixi113 – 115Combined sources3
Beta strandi119 – 125Combined sources7
Helixi135 – 141Combined sources7
Helixi144 – 146Combined sources3
Beta strandi152 – 156Combined sources5
Turni159 – 162Combined sources4
Helixi165 – 173Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z6YX-ray2.40A/B1-179[»]
1ZJ6X-ray2.00A1-179[»]
2H16X-ray2.00A/B/C/D14-177[»]
2H17X-ray1.70A15-176[»]
ProteinModelPortaliQ9Y689
SMRiQ9Y689
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y689

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00910000144027
HOGENOMiHOG000163691
HOVERGENiHBG002073
InParanoidiQ9Y689
KOiK07949
OMAiDVKGCMS
OrthoDBiEOG091G0W92
PhylomeDBiQ9Y689
TreeFamiTF105465

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y689-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGILFTRIWR LFNHQEHKVI IVGLDNAGKT TILYQFSMNE VVHTSPTIGS
60 70 80 90 100
NVEEIVINNT RFLMWDIGGQ ESLRSSWNTY YTNTEFVIVV VDSTDRERIS
110 120 130 140 150
VTREELYKML AHEDLRKAGL LIFANKQDVK ECMTVAEISQ FLKLTSIKDH
160 170
QWHIQACCAL TGEGLCQGLE WMMSRLKIR
Length:179
Mass (Da):20,728
Last modified:November 1, 1999 - v1
Checksum:i431CC65F8D8CB9D5
GO
Isoform 2 (identifier: Q9Y689-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Note: No experimental confirmation available.
Show »
Length:142
Mass (Da):16,385
Checksum:i00FEAA9777FEEED7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0410171 – 37Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087889 mRNA Translation: AAP97188.1
AF100740 mRNA Translation: AAD40383.1
AK292714 mRNA Translation: BAF85403.1
AF493891 mRNA Translation: AAM12605.1
BT009829 mRNA Translation: AAP88831.1
CR613929 mRNA No translation available.
AC097448 Genomic DNA Translation: AAX82013.1
CH471058 Genomic DNA Translation: EAX11495.1
CH471058 Genomic DNA Translation: EAX11496.1
BC001254 mRNA Translation: AAH01254.1
CCDSiCCDS2195.1 [Q9Y689-1]
CCDS46425.1 [Q9Y689-2]
RefSeqiNP_001032251.1, NM_001037174.1 [Q9Y689-2]
NP_036229.1, NM_012097.3 [Q9Y689-1]
NP_817114.2, NM_177985.2 [Q9Y689-2]
UniGeneiHs.470233

Genome annotation databases

EnsembliENST00000295087; ENSP00000295087; ENSG00000162980 [Q9Y689-1]
ENST00000428992; ENSP00000415950; ENSG00000162980 [Q9Y689-2]
ENST00000446896; ENSP00000394626; ENSG00000162980 [Q9Y689-2]
GeneIDi26225
KEGGihsa:26225
UCSCiuc002txw.2 human [Q9Y689-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARL5A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y689
Secondary accession number(s): Q580I5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 165 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome