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Protein

ADP-ribosylation factor-like protein 5A

Gene

ARL5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Lacks ADP-ribosylation enhancing activity.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei159GTP; via amide nitrogen1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 30GTP8
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi125 – 128GTP4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 5A
Gene namesi
Name:ARL5A
Synonyms:ARFLP5, ARL5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:696. ARL5A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi26225.
OpenTargetsiENSG00000162980.
PharmGKBiPA24989.

Polymorphism and mutation databases

BioMutaiARL5A.
DMDMi12229600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002074672 – 179ADP-ribosylation factor-like protein 5AAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ9Y689.
PaxDbiQ9Y689.
PeptideAtlasiQ9Y689.
PRIDEiQ9Y689.

PTM databases

iPTMnetiQ9Y689.
PhosphoSitePlusiQ9Y689.

Expressioni

Gene expression databases

BgeeiENSG00000162980.
CleanExiHS_ARL5A.
ExpressionAtlasiQ9Y689. baseline and differential.
GenevisibleiQ9Y689. HS.

Organism-specific databases

HPAiHPA027002.

Interactioni

Protein-protein interaction databases

BioGridi117616. 6 interactors.
STRINGi9606.ENSP00000295087.

Structurei

Secondary structure

1179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 12Combined sources10
Beta strandi17 – 24Combined sources8
Helixi29 – 37Combined sources9
Beta strandi42 – 45Combined sources4
Beta strandi48 – 51Combined sources4
Beta strandi53 – 57Combined sources5
Beta strandi60 – 70Combined sources11
Helixi71 – 73Combined sources3
Helixi76 – 81Combined sources6
Beta strandi86 – 92Combined sources7
Turni96 – 98Combined sources3
Helixi99 – 110Combined sources12
Helixi113 – 115Combined sources3
Beta strandi119 – 125Combined sources7
Helixi135 – 141Combined sources7
Helixi144 – 146Combined sources3
Beta strandi152 – 156Combined sources5
Turni159 – 162Combined sources4
Helixi165 – 173Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z6YX-ray2.40A/B1-179[»]
1ZJ6X-ray2.00A1-179[»]
2H16X-ray2.00A/B/C/D14-177[»]
2H17X-ray1.70A15-176[»]
ProteinModelPortaliQ9Y689.
SMRiQ9Y689.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y689.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133732.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ9Y689.
KOiK07949.
OMAiDVKGCMS.
OrthoDBiEOG091G0W92.
PhylomeDBiQ9Y689.
TreeFamiTF105465.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y689-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGILFTRIWR LFNHQEHKVI IVGLDNAGKT TILYQFSMNE VVHTSPTIGS
60 70 80 90 100
NVEEIVINNT RFLMWDIGGQ ESLRSSWNTY YTNTEFVIVV VDSTDRERIS
110 120 130 140 150
VTREELYKML AHEDLRKAGL LIFANKQDVK ECMTVAEISQ FLKLTSIKDH
160 170
QWHIQACCAL TGEGLCQGLE WMMSRLKIR
Length:179
Mass (Da):20,728
Last modified:November 1, 1999 - v1
Checksum:i431CC65F8D8CB9D5
GO
Isoform 2 (identifier: Q9Y689-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Note: No experimental confirmation available.
Show »
Length:142
Mass (Da):16,385
Checksum:i00FEAA9777FEEED7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0410171 – 37Missing in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087889 mRNA. Translation: AAP97188.1.
AF100740 mRNA. Translation: AAD40383.1.
AK292714 mRNA. Translation: BAF85403.1.
AF493891 mRNA. Translation: AAM12605.1.
BT009829 mRNA. Translation: AAP88831.1.
CR613929 mRNA. No translation available.
AC097448 Genomic DNA. Translation: AAX82013.1.
CH471058 Genomic DNA. Translation: EAX11495.1.
CH471058 Genomic DNA. Translation: EAX11496.1.
BC001254 mRNA. Translation: AAH01254.1.
CCDSiCCDS2195.1. [Q9Y689-1]
CCDS46425.1. [Q9Y689-2]
RefSeqiNP_001032251.1. NM_001037174.1. [Q9Y689-2]
NP_036229.1. NM_012097.3. [Q9Y689-1]
NP_817114.2. NM_177985.2. [Q9Y689-2]
UniGeneiHs.470233.

Genome annotation databases

EnsembliENST00000295087; ENSP00000295087; ENSG00000162980. [Q9Y689-1]
ENST00000428992; ENSP00000415950; ENSG00000162980. [Q9Y689-2]
ENST00000446896; ENSP00000394626; ENSG00000162980. [Q9Y689-2]
GeneIDi26225.
KEGGihsa:26225.
UCSCiuc002txw.2. human. [Q9Y689-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087889 mRNA. Translation: AAP97188.1.
AF100740 mRNA. Translation: AAD40383.1.
AK292714 mRNA. Translation: BAF85403.1.
AF493891 mRNA. Translation: AAM12605.1.
BT009829 mRNA. Translation: AAP88831.1.
CR613929 mRNA. No translation available.
AC097448 Genomic DNA. Translation: AAX82013.1.
CH471058 Genomic DNA. Translation: EAX11495.1.
CH471058 Genomic DNA. Translation: EAX11496.1.
BC001254 mRNA. Translation: AAH01254.1.
CCDSiCCDS2195.1. [Q9Y689-1]
CCDS46425.1. [Q9Y689-2]
RefSeqiNP_001032251.1. NM_001037174.1. [Q9Y689-2]
NP_036229.1. NM_012097.3. [Q9Y689-1]
NP_817114.2. NM_177985.2. [Q9Y689-2]
UniGeneiHs.470233.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z6YX-ray2.40A/B1-179[»]
1ZJ6X-ray2.00A1-179[»]
2H16X-ray2.00A/B/C/D14-177[»]
2H17X-ray1.70A15-176[»]
ProteinModelPortaliQ9Y689.
SMRiQ9Y689.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117616. 6 interactors.
STRINGi9606.ENSP00000295087.

PTM databases

iPTMnetiQ9Y689.
PhosphoSitePlusiQ9Y689.

Polymorphism and mutation databases

BioMutaiARL5A.
DMDMi12229600.

Proteomic databases

EPDiQ9Y689.
PaxDbiQ9Y689.
PeptideAtlasiQ9Y689.
PRIDEiQ9Y689.

Protocols and materials databases

DNASUi26225.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295087; ENSP00000295087; ENSG00000162980. [Q9Y689-1]
ENST00000428992; ENSP00000415950; ENSG00000162980. [Q9Y689-2]
ENST00000446896; ENSP00000394626; ENSG00000162980. [Q9Y689-2]
GeneIDi26225.
KEGGihsa:26225.
UCSCiuc002txw.2. human. [Q9Y689-1]

Organism-specific databases

CTDi26225.
DisGeNETi26225.
GeneCardsiARL5A.
HGNCiHGNC:696. ARL5A.
HPAiHPA027002.
MIMi608960. gene.
neXtProtiNX_Q9Y689.
OpenTargetsiENSG00000162980.
PharmGKBiPA24989.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0070. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133732.
HOGENOMiHOG000163691.
HOVERGENiHBG002073.
InParanoidiQ9Y689.
KOiK07949.
OMAiDVKGCMS.
OrthoDBiEOG091G0W92.
PhylomeDBiQ9Y689.
TreeFamiTF105465.

Miscellaneous databases

ChiTaRSiARL5A. human.
EvolutionaryTraceiQ9Y689.
GenomeRNAii26225.
PROiQ9Y689.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162980.
CleanExiHS_ARL5A.
ExpressionAtlasiQ9Y689. baseline and differential.
GenevisibleiQ9Y689. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARL5A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y689
Secondary accession number(s): Q580I5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.