ID FKBP7_HUMAN Reviewed; 259 AA. AC Q9Y680; Q4ZG70; Q6V3B2; Q86U65; Q96DA4; Q9Y6B0; DT 19-SEP-2002, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1999, sequence version 1. DT 25-JAN-2012, entry version 110. DE RecName: Full=Peptidyl-prolyl cis-trans isomerase FKBP7; DE Short=PPIase FKBP7; DE EC=5.2.1.8; DE AltName: Full=23 kDa FK506-binding protein; DE Short=23 kDa FKBP; DE Short=FKBP-23; DE AltName: Full=FK506-binding protein 7; DE Short=FKBP-7; DE AltName: Full=Rotamase; DE Flags: Precursor; GN Name=FKBP7; Synonyms=FKBP23; ORFNames=UNQ670/PRO1304; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Pituitary, and Pituitary tumor; RX MEDLINE=20402571; PubMed=10931946; DOI=10.1073/pnas.160270997; RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., RA Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., RA Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., RA Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.; RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal RT axis and full-length cDNA cloning."; RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RX MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Synovial cell; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RA Li H., Zhong G., Yu R., Shen C., Zhou G., Li M., Xiao W., Lin L., RA Yang S.; RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). RC TISSUE=Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: PPIases accelerate the folding of proteins during CC protein synthesis. CC -!- CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline CC (omega=0). CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q9Y680-1; Sequence=Displayed; CC Name=2; CC IsoId=Q9Y680-2; Sequence=VSP_005187; CC Name=3; CC IsoId=Q9Y680-3; Sequence=VSP_041018; CC -!- PTM: Glycosylated (By similarity). CC -!- MISCELLANEOUS: Binds calcium (By similarity). CC -!- SIMILARITY: Contains 2 EF-hand domains. CC -!- SIMILARITY: Contains 1 PPIase FKBP-type domain. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF092137; AAD40379.1; -; mRNA. DR EMBL; AF100751; AAD43015.1; -; mRNA. DR EMBL; AY359015; AAQ89374.1; -; mRNA. DR EMBL; AK292145; BAF84834.1; -; mRNA. DR EMBL; BT007122; AAP35786.1; -; mRNA. DR EMBL; AY353086; AAQ57208.1; -; mRNA. DR EMBL; AC009948; AAX88883.1; -; Genomic_DNA. DR EMBL; BC009711; AAH09711.1; -; mRNA. DR IPI; IPI00001914; -. DR IPI; IPI00218686; -. DR IPI; IPI01009357; -. DR RefSeq; NP_001128684.1; NM_001135212.1. DR RefSeq; NP_851939.1; NM_181342.2. DR UniGene; Hs.410378; -. DR ProteinModelPortal; Q9Y680; -. DR SMR; Q9Y680; 45-183, 189-252. DR IntAct; Q9Y680; 1. DR DMDM; 23396602; -. DR PRIDE; Q9Y680; -. DR Ensembl; ENST00000350591; ENSP00000335194; ENSG00000079150. DR Ensembl; ENST00000434643; ENSP00000415486; ENSG00000079150. DR GeneID; 51661; -. DR KEGG; hsa:51661; -. DR UCSC; uc002umk.1; human. DR CTD; 51661; -. DR GeneCards; GC02M179328; -. DR H-InvDB; HIX0002629; -. DR HGNC; HGNC:3723; FKBP7. DR HPA; HPA008707; -. DR MIM; 607062; gene. DR neXtProt; NX_Q9Y680; -. DR PharmGKB; PA28164; -. DR GeneTree; ENSGT00530000062784; -. DR HOGENOM; HBG731200; -. DR HOVERGEN; HBG051623; -. DR InParanoid; Q9Y680; -. DR PhylomeDB; Q9Y680; -. DR NextBio; 55642; -. DR ArrayExpress; Q9Y680; -. DR Bgee; Q9Y680; -. DR CleanEx; HS_FKBP7; -. DR Genevestigator; Q9Y680; -. DR GermOnline; ENSG00000079150; Homo sapiens. DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IBA:RefGenome. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0005528; F:FK506 binding; IBA:RefGenome. DR GO; GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome. DR GO; GO:0006457; P:protein folding; IEA:UniProtKB-KW. DR InterPro; IPR011992; EF-hand-like_dom. DR InterPro; IPR018247; EF_Hand_1_Ca_BS. DR InterPro; IPR018249; EF_HAND_2. DR InterPro; IPR002048; EF_hand_Ca-bd. DR InterPro; IPR023566; PPIase_FKBP. DR InterPro; IPR001179; PPIase_FKBP_dom. DR Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1. DR KO; K09573; -. DR PANTHER; PTHR10516; PPIase_FKBP; 1. DR Pfam; PF00254; FKBP_C; 1. DR SMART; SM00054; EFh; 2. DR PROSITE; PS00018; EF_HAND_1; 2. DR PROSITE; PS50222; EF_HAND_2; 2. DR PROSITE; PS00014; ER_TARGET; 1. DR PROSITE; PS50059; FKBP_PPIASE; 1. PE 1: Evidence at protein level; KW Alternative splicing; Calcium; Complete proteome; KW Endoplasmic reticulum; Glycoprotein; Isomerase; Reference proteome; KW Repeat; Rotamase; Signal. FT SIGNAL 1 23 Potential. FT CHAIN 24 259 Peptidyl-prolyl cis-trans isomerase FT FKBP7. FT /FTId=PRO_0000025513. FT DOMAIN 53 182 PPIase FKBP-type. FT DOMAIN 182 217 EF-hand 1. FT DOMAIN 226 259 EF-hand 2. FT CA_BIND 195 206 1 (Potential). FT CA_BIND 239 250 2 (Potential). FT MOTIF 256 259 Prevents secretion from ER (Potential). FT CARBOHYD 45 45 N-linked (GlcNAc...) (Potential). FT CARBOHYD 158 158 N-linked (GlcNAc...) (Potential). FT VAR_SEQ 125 162 Missing (in isoform 3). FT /FTId=VSP_041018. FT VAR_SEQ 125 161 Missing (in isoform 2). FT /FTId=VSP_005187. FT CONFLICT 124 124 Y -> H (in Ref. 1; AAD40379). FT CONFLICT 237 237 K -> M (in Ref. 5; AAQ57208). SQ SEQUENCE 259 AA; 30009 MW; 886A1F3F5ACB9E78 CRC64; MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE STEEVKIEVL HRPENCSKTS KKGDLLNAHY DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM TDMCPGEKRK VVIPPSFAYG KEGYGSLEEV FLLQNILVSC HRTTLHVLKC MYLLVLNNNT CAEGKIPPDA TLIFEIELYA VTKGPRSIET FKQIDMDNDR QLSKAEINLY LQREFEKDEK PRDKSYQDAV LEDIFKKNDH DGDGFISPKE YNVYQHDEL //