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Protein

Peptidyl-prolyl cis-trans isomerase FKBP7

Gene

FKBP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi195 – 2061PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi239 – 2502PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS01313-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP7 (EC:5.2.1.8)
Short name:
PPIase FKBP7
Alternative name(s):
23 kDa FK506-binding protein
Short name:
23 kDa FKBP
Short name:
FKBP-23
FK506-binding protein 7
Short name:
FKBP-7
Rotamase
Gene namesi
Name:FKBP7
Synonyms:FKBP23
ORF Names:UNQ670/PRO1304
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:3723. FKBP7.

Subcellular locationi

  • Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi51661.
OpenTargetsiENSG00000079150.
PharmGKBiPA28164.

Polymorphism and mutation databases

BioMutaiFKBP7.
DMDMi23396602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002551324 – 259Peptidyl-prolyl cis-trans isomerase FKBP7Add BLAST236

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...)Sequence analysis1
Glycosylationi158N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y680.
PeptideAtlasiQ9Y680.
PRIDEiQ9Y680.

PTM databases

iPTMnetiQ9Y680.
PhosphoSitePlusiQ9Y680.

Expressioni

Gene expression databases

BgeeiENSG00000079150.
CleanExiHS_FKBP7.
ExpressionAtlasiQ9Y680. baseline and differential.
GenevisibleiQ9Y680. HS.

Organism-specific databases

HPAiHPA008707.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PEX19P408553EBI-3918971,EBI-594747
SGTAO437653EBI-3918971,EBI-347996

Protein-protein interaction databases

BioGridi119666. 27 interactors.
IntActiQ9Y680. 7 interactors.
MINTiMINT-4723228.

Structurei

3D structure databases

ProteinModelPortaliQ9Y680.
SMRiQ9Y680.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 182PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST130
Domaini182 – 217EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini226 – 259EF-hand 2PROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi256 – 259Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation
Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00530000062784.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiQ9Y680.
KOiK09573.
OMAiHRPENCS.
OrthoDBiEOG091G02W1.
PhylomeDBiQ9Y680.
TreeFamiTF105296.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y680-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE STEEVKIEVL HRPENCSKTS
60 70 80 90 100
KKGDLLNAHY DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM
110 120 130 140 150
TDMCPGEKRK VVIPPSFAYG KEGYGSLEEV FLLQNILVSC HRTTLHVLKC
160 170 180 190 200
MYLLVLNNNT CAEGKIPPDA TLIFEIELYA VTKGPRSIET FKQIDMDNDR
210 220 230 240 250
QLSKAEINLY LQREFEKDEK PRDKSYQDAV LEDIFKKNDH DGDGFISPKE

YNVYQHDEL
Length:259
Mass (Da):30,009
Last modified:November 1, 1999 - v1
Checksum:i886A1F3F5ACB9E78
GO
Isoform 2 (identifier: Q9Y680-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-161: Missing.

Show »
Length:222
Mass (Da):25,794
Checksum:i362957BAD3C5C2A6
GO
Isoform 3 (identifier: Q9Y680-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-162: Missing.

Show »
Length:221
Mass (Da):25,723
Checksum:i7A00D79506D301BF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124Y → H in AAD40379 (PubMed:10931946).Curated1
Sequence conflicti237K → M in AAQ57208 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041018125 – 162Missing in isoform 3. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_005187125 – 161Missing in isoform 2. 5 PublicationsAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092137 mRNA. Translation: AAD40379.1.
AF100751 mRNA. Translation: AAD43015.1.
AY359015 mRNA. Translation: AAQ89374.1.
AK292145 mRNA. Translation: BAF84834.1.
BT007122 mRNA. Translation: AAP35786.1.
AY353086 mRNA. Translation: AAQ57208.1.
AC009948 Genomic DNA. Translation: AAX88883.1.
BC009711 mRNA. Translation: AAH09711.1.
CCDSiCCDS2280.1. [Q9Y680-2]
CCDS46462.1. [Q9Y680-3]
RefSeqiNP_001128684.1. NM_001135212.1. [Q9Y680-3]
NP_851939.1. NM_181342.2. [Q9Y680-2]
UniGeneiHs.410378.

Genome annotation databases

EnsembliENST00000424785; ENSP00000413152; ENSG00000079150. [Q9Y680-2]
ENST00000434643; ENSP00000415486; ENSG00000079150. [Q9Y680-3]
GeneIDi51661.
KEGGihsa:51661.
UCSCiuc002umk.4. human. [Q9Y680-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092137 mRNA. Translation: AAD40379.1.
AF100751 mRNA. Translation: AAD43015.1.
AY359015 mRNA. Translation: AAQ89374.1.
AK292145 mRNA. Translation: BAF84834.1.
BT007122 mRNA. Translation: AAP35786.1.
AY353086 mRNA. Translation: AAQ57208.1.
AC009948 Genomic DNA. Translation: AAX88883.1.
BC009711 mRNA. Translation: AAH09711.1.
CCDSiCCDS2280.1. [Q9Y680-2]
CCDS46462.1. [Q9Y680-3]
RefSeqiNP_001128684.1. NM_001135212.1. [Q9Y680-3]
NP_851939.1. NM_181342.2. [Q9Y680-2]
UniGeneiHs.410378.

3D structure databases

ProteinModelPortaliQ9Y680.
SMRiQ9Y680.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119666. 27 interactors.
IntActiQ9Y680. 7 interactors.
MINTiMINT-4723228.

PTM databases

iPTMnetiQ9Y680.
PhosphoSitePlusiQ9Y680.

Polymorphism and mutation databases

BioMutaiFKBP7.
DMDMi23396602.

Proteomic databases

EPDiQ9Y680.
PeptideAtlasiQ9Y680.
PRIDEiQ9Y680.

Protocols and materials databases

DNASUi51661.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000424785; ENSP00000413152; ENSG00000079150. [Q9Y680-2]
ENST00000434643; ENSP00000415486; ENSG00000079150. [Q9Y680-3]
GeneIDi51661.
KEGGihsa:51661.
UCSCiuc002umk.4. human. [Q9Y680-1]

Organism-specific databases

CTDi51661.
DisGeNETi51661.
GeneCardsiFKBP7.
H-InvDBHIX0002629.
HGNCiHGNC:3723. FKBP7.
HPAiHPA008707.
MIMi607062. gene.
neXtProtiNX_Q9Y680.
OpenTargetsiENSG00000079150.
PharmGKBiPA28164.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000062784.
HOGENOMiHOG000154887.
HOVERGENiHBG051623.
InParanoidiQ9Y680.
KOiK09573.
OMAiHRPENCS.
OrthoDBiEOG091G02W1.
PhylomeDBiQ9Y680.
TreeFamiTF105296.

Enzyme and pathway databases

BioCyciZFISH:HS01313-MONOMER.

Miscellaneous databases

GenomeRNAii51661.
PROiQ9Y680.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000079150.
CleanExiHS_FKBP7.
ExpressionAtlasiQ9Y680. baseline and differential.
GenevisibleiQ9Y680. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR023566. PPIase_FKBP.
IPR001179. PPIase_FKBP_dom.
[Graphical view]
PANTHERiPTHR10516. PTHR10516. 2 hits.
PfamiPF13499. EF-hand_7. 1 hit.
PF00254. FKBP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
PS00014. ER_TARGET. 1 hit.
PS50059. FKBP_PPIASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFKBP7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y680
Secondary accession number(s): Q4ZG70
, Q6V3B2, Q86U65, Q96DA4, Q9Y6B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 156 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds calcium.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.