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Q9Y680

- FKBP7_HUMAN

UniProt

Q9Y680 - FKBP7_HUMAN

Protein

Peptidyl-prolyl cis-trans isomerase FKBP7

Gene

FKBP7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 137 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    PPIases accelerate the folding of proteins during protein synthesis.

    Catalytic activityi

    Peptidylproline (omega=180) = peptidylproline (omega=0).

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi195 – 206121PROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi239 – 250122PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: Ensembl
    2. FK506 binding Source: RefGenome
    3. peptidyl-prolyl cis-trans isomerase activity Source: RefGenome

    GO - Biological processi

    1. chaperone-mediated protein folding Source: RefGenome
    2. protein peptidyl-prolyl isomerization Source: RefGenome

    Keywords - Molecular functioni

    Isomerase, Rotamase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidyl-prolyl cis-trans isomerase FKBP7 (EC:5.2.1.8)
    Short name:
    PPIase FKBP7
    Alternative name(s):
    23 kDa FK506-binding protein
    Short name:
    23 kDa FKBP
    Short name:
    FKBP-23
    FK506-binding protein 7
    Short name:
    FKBP-7
    Rotamase
    Gene namesi
    Name:FKBP7
    Synonyms:FKBP23
    ORF Names:UNQ670/PRO1304
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:3723. FKBP7.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    2. endoplasmic reticulum membrane Source: RefGenome

    Keywords - Cellular componenti

    Endoplasmic reticulum

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28164.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 259236Peptidyl-prolyl cis-trans isomerase FKBP7PRO_0000025513Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi45 – 451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi158 – 1581N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9Y680.
    PaxDbiQ9Y680.
    PRIDEiQ9Y680.

    PTM databases

    PhosphoSiteiQ9Y680.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y680.
    BgeeiQ9Y680.
    CleanExiHS_FKBP7.
    GenevestigatoriQ9Y680.

    Organism-specific databases

    HPAiHPA008707.

    Interactioni

    Protein-protein interaction databases

    BioGridi119666. 5 interactions.
    IntActiQ9Y680. 4 interactions.
    MINTiMINT-4723228.
    STRINGi9606.ENSP00000413152.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y680.
    SMRiQ9Y680. Positions 34-258.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini53 – 182130PPIase FKBP-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini182 – 21736EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini226 – 25934EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi256 – 2594Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 2 EF-hand domains.PROSITE-ProRule annotation
    Contains 1 PPIase FKBP-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG0545.
    HOGENOMiHOG000154887.
    HOVERGENiHBG051623.
    InParanoidiQ9Y680.
    KOiK09573.
    OMAiRPENCSK.
    OrthoDBiEOG7T1R9S.
    PhylomeDBiQ9Y680.
    TreeFamiTF105296.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view]
    PANTHERiPTHR10516. PTHR10516. 1 hit.
    PfamiPF13499. EF-hand_7. 1 hit.
    PF00254. FKBP_C. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y680-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE STEEVKIEVL HRPENCSKTS    50
    KKGDLLNAHY DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM 100
    TDMCPGEKRK VVIPPSFAYG KEGYGSLEEV FLLQNILVSC HRTTLHVLKC 150
    MYLLVLNNNT CAEGKIPPDA TLIFEIELYA VTKGPRSIET FKQIDMDNDR 200
    QLSKAEINLY LQREFEKDEK PRDKSYQDAV LEDIFKKNDH DGDGFISPKE 250
    YNVYQHDEL 259
    Length:259
    Mass (Da):30,009
    Last modified:November 1, 1999 - v1
    Checksum:i886A1F3F5ACB9E78
    GO
    Isoform 2 (identifier: Q9Y680-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         125-161: Missing.

    Show »
    Length:222
    Mass (Da):25,794
    Checksum:i362957BAD3C5C2A6
    GO
    Isoform 3 (identifier: Q9Y680-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         125-162: Missing.

    Show »
    Length:221
    Mass (Da):25,723
    Checksum:i7A00D79506D301BF
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1241Y → H in AAD40379. (PubMed:10931946)Curated
    Sequence conflicti237 – 2371K → M in AAQ57208. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei125 – 16238Missing in isoform 3. 1 PublicationVSP_041018Add
    BLAST
    Alternative sequencei125 – 16137Missing in isoform 2. 5 PublicationsVSP_005187Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092137 mRNA. Translation: AAD40379.1.
    AF100751 mRNA. Translation: AAD43015.1.
    AY359015 mRNA. Translation: AAQ89374.1.
    AK292145 mRNA. Translation: BAF84834.1.
    BT007122 mRNA. Translation: AAP35786.1.
    AY353086 mRNA. Translation: AAQ57208.1.
    AC009948 Genomic DNA. Translation: AAX88883.1.
    BC009711 mRNA. Translation: AAH09711.1.
    CCDSiCCDS2280.1. [Q9Y680-2]
    CCDS46462.1. [Q9Y680-3]
    RefSeqiNP_001128684.1. NM_001135212.1. [Q9Y680-3]
    NP_851939.1. NM_181342.2. [Q9Y680-2]
    UniGeneiHs.410378.

    Genome annotation databases

    EnsembliENST00000424785; ENSP00000413152; ENSG00000079150. [Q9Y680-2]
    ENST00000434643; ENSP00000415486; ENSG00000079150. [Q9Y680-3]
    GeneIDi51661.
    KEGGihsa:51661.
    UCSCiuc002umk.3. human. [Q9Y680-2]
    uc002umm.3. human. [Q9Y680-3]

    Polymorphism databases

    DMDMi23396602.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF092137 mRNA. Translation: AAD40379.1 .
    AF100751 mRNA. Translation: AAD43015.1 .
    AY359015 mRNA. Translation: AAQ89374.1 .
    AK292145 mRNA. Translation: BAF84834.1 .
    BT007122 mRNA. Translation: AAP35786.1 .
    AY353086 mRNA. Translation: AAQ57208.1 .
    AC009948 Genomic DNA. Translation: AAX88883.1 .
    BC009711 mRNA. Translation: AAH09711.1 .
    CCDSi CCDS2280.1. [Q9Y680-2 ]
    CCDS46462.1. [Q9Y680-3 ]
    RefSeqi NP_001128684.1. NM_001135212.1. [Q9Y680-3 ]
    NP_851939.1. NM_181342.2. [Q9Y680-2 ]
    UniGenei Hs.410378.

    3D structure databases

    ProteinModelPortali Q9Y680.
    SMRi Q9Y680. Positions 34-258.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119666. 5 interactions.
    IntActi Q9Y680. 4 interactions.
    MINTi MINT-4723228.
    STRINGi 9606.ENSP00000413152.

    PTM databases

    PhosphoSitei Q9Y680.

    Polymorphism databases

    DMDMi 23396602.

    Proteomic databases

    MaxQBi Q9Y680.
    PaxDbi Q9Y680.
    PRIDEi Q9Y680.

    Protocols and materials databases

    DNASUi 51661.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000424785 ; ENSP00000413152 ; ENSG00000079150 . [Q9Y680-2 ]
    ENST00000434643 ; ENSP00000415486 ; ENSG00000079150 . [Q9Y680-3 ]
    GeneIDi 51661.
    KEGGi hsa:51661.
    UCSCi uc002umk.3. human. [Q9Y680-2 ]
    uc002umm.3. human. [Q9Y680-3 ]

    Organism-specific databases

    CTDi 51661.
    GeneCardsi GC02M179328.
    H-InvDB HIX0002629.
    HGNCi HGNC:3723. FKBP7.
    HPAi HPA008707.
    MIMi 607062. gene.
    neXtProti NX_Q9Y680.
    PharmGKBi PA28164.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0545.
    HOGENOMi HOG000154887.
    HOVERGENi HBG051623.
    InParanoidi Q9Y680.
    KOi K09573.
    OMAi RPENCSK.
    OrthoDBi EOG7T1R9S.
    PhylomeDBi Q9Y680.
    TreeFami TF105296.

    Miscellaneous databases

    GenomeRNAii 51661.
    NextBioi 55642.
    PROi Q9Y680.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y680.
    Bgeei Q9Y680.
    CleanExi HS_FKBP7.
    Genevestigatori Q9Y680.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR023566. PPIase_FKBP.
    IPR001179. PPIase_FKBP_dom.
    [Graphical view ]
    PANTHERi PTHR10516. PTHR10516. 1 hit.
    Pfami PF13499. EF-hand_7. 1 hit.
    PF00254. FKBP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 2 hits.
    PS50222. EF_HAND_2. 2 hits.
    PS00014. ER_TARGET. 1 hit.
    PS50059. FKBP_PPIASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
      Tissue: Pituitary and Pituitary tumor.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Synovial cell.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. Li H., Zhong G., Yu R., Shen C., Zhou G., Li M., Xiao W., Lin L., Yang S.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    6. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Lung.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFKBP7_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y680
    Secondary accession number(s): Q4ZG70
    , Q6V3B2, Q86U65, Q96DA4, Q9Y6B0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 137 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Binds calcium.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3