Reviewed, UniProtKB/Swiss-Prot Q9Y680 (FKBP7_HUMAN)

Names and origin

Protein names

Recommended name:
    FK506-binding protein 7
    EC=5.2.1.8
Alternative name(s):
    Peptidyl-prolyl cis-trans isomerase
      Short name=PPIase
      Short name=Rotamase
    FKBP-23

Gene names

Name:	FKBP7
Synonyms:	FKBP23
ORF Names:	UNQ670/PRO1304

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	PPIases accelerate the folding of proteins during protein synthesis.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subcellular location	Endoplasmic reticulum lumenBy similarity.
Post-translational modification	Glycosylated By similarity.
Miscellaneous	Binds calcium By similarity.
Sequence similarities	Contains 2 EF-hand domains. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal
Ligand	Calcium
Molecular function	Isomerase Rotamase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y680-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y680-2)

The sequence of this isoform differs from the canonical sequence as follows:
     125-161: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 259	236	FK506-binding protein 7		PRO_0000025513
Regions
	Domain	53 – 182	130	PPIase FKBP-type
	Domain	182 – 217	36	EF-hand 1
	Domain	226 – 259	34	EF-hand 2
	Calcium binding	195 – 206	12	1 Potential
	Calcium binding	239 – 250	12	2 Potential
	Motif	256 – 259	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	45	1	N-linked (GlcNAc...) Potential
	Glycosylation	158	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	125 – 161	37	Missing in isoform 2.		VSP_005187
Experimental info
	Sequence conflict	124	1	Y → H Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 886A1F3F5ACB9E78	FASTA	259	30,009
	10 20 30 40 50 60 MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE STEEVKIEVL HRPENCSKTS KKGDLLNAHY 70 80 90 100 110 120 DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM TDMCPGEKRK VVIPPSFAYG 130 140 150 160 170 180 KEGYGSLEEV FLLQNILVSC HRTTLHVLKC MYLLVLNNNT CAEGKIPPDA TLIFEIELYA 190 200 210 220 230 240 VTKGPRSIET FKQIDMDNDR QLSKAEINLY LQREFEKDEK PRDKSYQDAV LEDIFKKNDH 250 DGDGFISPKE YNVYQHDEL
	Isoform 2 [UniParc]. Checksum: 362957BAD3C5C2A6		222	25,794
	10 20 30 40 50 60 MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE STEEVKIEVL HRPENCSKTS KKGDLLNAHY 70 80 90 100 110 120 DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM TDMCPGEKRK VVIPPSFAYG 130 140 150 160 170 180 KEGYAEGKIP PDATLIFEIE LYAVTKGPRS IETFKQIDMD NDRQLSKAEI NLYLQREFEK 190 200 210 220 DEKPRDKSYQ DAVLEDIFKK NDHDGDGFIS PKEYNVYQHD EL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human FK506-binding protein (FKBP23)-isoform gene." Guan Z., Zhang Q., Dai M., Song H., Mao Y., Wu X., Mao M., Fu G., Luo M., Chen J., Hu R. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Pituitary tumor.
[2]	"Human FK506-binding protein mRNA, complete cds." Han Z., Song H., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Pituitary.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Lung.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF100751 mRNA. Translation: AAD43015.1. AF092137 mRNA. Translation: AAD40379.1. AY359015 mRNA. Translation: AAQ89374.1. BT007122 mRNA. Translation: AAP35786.1. BC009711 mRNA. Translation: AAH09711.1.
UniGene	Hs.410378
3D structure databases
HSSP	HSSP built from PDB template 1N1A based on UniProtKB Q02790.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000079150. Homo sapiens. [Contig view]
KEGG	hsa:51661.
Organism-specific databases
H-InvDB	HIX0002629.
HGNC	HGNC:3723. FKBP7.
HPA	HPA008707.
MIM	607062. gene.
PharmGKB	PA28164.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q9Y680.
HOVERGEN	Q9Y680.
Gene expression databases
ArrayExpress	Q9Y680.
CleanEx	HS_FKBP7.
GermOnline	ENSG00000079150. Homo sapiens.
Family and domain databases
InterPro	IPR002048. EF_hand_Ca_bd. IPR000886. ER_targeting_sequence. IPR001179. PPIase_FKBP. [Graphical view]
PANTHER	PTHR10516. PPIase_FKBP. 1 hit.
Pfam	PF00036. efhand. 2 hits. PF00254. FKBP_C. 1 hit. [Graphical view]
SMART	SM00054. EFh. 2 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. PS00014. ER_TARGET. 1 hit. PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...
Other Resources
LinkHub	Q9Y680.
NextBio	55642.
SOURCE	Search...

Entry information

Entry name

FKBP7_HUMAN

Accession

Primary (citable) accession number: Q9Y680
Secondary accession number(s): Q86U65, Q96DA4, Q9Y6B0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	November 1, 1999
Last modified:	November 4, 2008
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)