Q9Y680 (FKBP7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP7
Short name=PPIase FKBP7
EC=5.2.1.8

Alternative name(s):
23 kDa FK506-binding protein
Short name=23 kDa FKBP
Short name=FKBP-23
FK506-binding protein 7
Short name=FKBP-7
Rotamase

Gene names

Name:	FKBP7
Synonyms:	FKBP23
ORF Names:	UNQ670/PRO1304

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins during protein synthesis.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subcellular location	Endoplasmic reticulum lumen By similarity.
Post-translational modification	Glycosylated By similarity.
Miscellaneous	Binds calcium By similarity.
Sequence similarities	Contains 2 EF-hand domains. Contains 1 PPIase FKBP-type domain.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal
Ligand	Calcium Metal-binding
Molecular function	Isomerase Rotamase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	endoplasmic reticulum Inferred from direct assay. Source: HPA endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	FK506 binding Inferred from Biological aspect of Ancestor. Source: RefGenome calcium ion binding Inferred from electronic annotation. Source: Compara peptidyl-prolyl cis-trans isomerase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y680-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y680-2)

The sequence of this isoform differs from the canonical sequence as follows:
     125-161: Missing.

Isoform 3 (identifier: Q9Y680-3)

The sequence of this isoform differs from the canonical sequence as follows:
     125-162: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 259	236	Peptidyl-prolyl cis-trans isomerase FKBP7		PRO_0000025513
Regions
	Domain	53 – 182	130	PPIase FKBP-type
	Domain	182 – 217	36	EF-hand 1
	Domain	226 – 259	34	EF-hand 2
	Calcium binding	195 – 206	12	1 Potential
	Calcium binding	239 – 250	12	2 Potential
	Motif	256 – 259	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	45	1	N-linked (GlcNAc...) Potential
	Glycosylation	158	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	125 – 162	38	Missing in isoform 3.		VSP_041018
	Alternative sequence	125 – 161	37	Missing in isoform 2.		VSP_005187
Experimental info
	Sequence conflict	124	1	Y → H in AAD40379. Ref.1
	Sequence conflict	237	1	K → M in AAQ57208. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 886A1F3F5ACB9E78	FASTA	259	30,009
	10 20 30 40 50 60 MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE STEEVKIEVL HRPENCSKTS KKGDLLNAHY 70 80 90 100 110 120 DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM TDMCPGEKRK VVIPPSFAYG 130 140 150 160 170 180 KEGYGSLEEV FLLQNILVSC HRTTLHVLKC MYLLVLNNNT CAEGKIPPDA TLIFEIELYA 190 200 210 220 230 240 VTKGPRSIET FKQIDMDNDR QLSKAEINLY LQREFEKDEK PRDKSYQDAV LEDIFKKNDH 250 DGDGFISPKE YNVYQHDEL
	Isoform 2 [UniParc]. Checksum: 362957BAD3C5C2A6	FASTA	222	25,794
	10 20 30 40 50 60 MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE STEEVKIEVL HRPENCSKTS KKGDLLNAHY 70 80 90 100 110 120 DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM TDMCPGEKRK VVIPPSFAYG 130 140 150 160 170 180 KEGYAEGKIP PDATLIFEIE LYAVTKGPRS IETFKQIDMD NDRQLSKAEI NLYLQREFEK 190 200 210 220 DEKPRDKSYQ DAVLEDIFKK NDHDGDGFIS PKEYNVYQHD EL
	Isoform 3 [UniParc]. Checksum: 7A00D79506D301BF	FASTA	221	25,723
	10 20 30 40 50 60 MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE STEEVKIEVL HRPENCSKTS KKGDLLNAHY 70 80 90 100 110 120 DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM TDMCPGEKRK VVIPPSFAYG 130 140 150 160 170 180 KEGYEGKIPP DATLIFEIEL YAVTKGPRSI ETFKQIDMDN DRQLSKAEIN LYLQREFEKD 190 200 210 220 EKPRDKSYQD AVLEDIFKKN DHDGDGFISP KEYNVYQHDE L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Pituitary and Pituitary tumor.
[2]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Synovial cell.
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[5]	Li H., Zhong G., Yu R., Shen C., Zhou G., Li M., Xiao W., Lin L., Yang S. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[6]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Lung.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF092137 mRNA. Translation: AAD40379.1. AF100751 mRNA. Translation: AAD43015.1. AY359015 mRNA. Translation: AAQ89374.1. AK292145 mRNA. Translation: BAF84834.1. BT007122 mRNA. Translation: AAP35786.1. AY353086 mRNA. Translation: AAQ57208.1. AC009948 Genomic DNA. Translation: AAX88883.1. BC009711 mRNA. Translation: AAH09711.1.
IPI	IPI00001914. IPI00218686. IPI01009357.
RefSeq	NP_001128684.1. NM_001135212.1. NP_851939.1. NM_181342.2.
UniGene	Hs.410378.
3D structure databases
ProteinModelPortal	Q9Y680.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y680. 1 interaction.
STRING	9606.ENSP00000413152.
PTM databases
PhosphoSite	Q9Y680.
Polymorphism databases
DMDM	23396602.
Proteomic databases
PaxDb	Q9Y680.
PRIDE	Q9Y680.
Protocols and materials databases
DNASU	51661.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000424785; ENSP00000413152; ENSG00000079150. ENST00000434643; ENSP00000415486; ENSG00000079150.
GeneID	51661.
KEGG	hsa:51661.
UCSC	uc002umk.3. human. uc002umm.3. human.
Organism-specific databases
CTD	51661.
GeneCards	GC02M179328.
H-InvDB	HIX0002629.
HGNC	HGNC:3723. FKBP7.
HPA	HPA008707.
MIM	607062. gene.
neXtProt	NX_Q9Y680.
PharmGKB	PA28164.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0545.
HOGENOM	HOG000154887.
HOVERGEN	HBG051623.
InParanoid	Q9Y680.
KO	K09573.
OrthoDB	EOG4G7BZZ.
Gene expression databases
ArrayExpress	Q9Y680.
Bgee	Q9Y680.
CleanEx	HS_FKBP7.
Genevestigator	Q9Y680.
GermOnline	ENSG00000079150. Homo sapiens.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR023566. PPIase_FKBP. IPR001179. PPIase_FKBP_dom. [Graphical view]
PANTHER	PTHR10516. PTHR10516. 1 hit.
Pfam	PF13499. EF_hand_5. 1 hit. PF00254. FKBP_C. 1 hit. [Graphical view]
SMART	SM00054. EFh. 2 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. PS00014. ER_TARGET. 1 hit. PS50059. FKBP_PPIASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51661.
NextBio	55642.
SOURCE	Search...

Entry information

Entry name

FKBP7_HUMAN

Accession

Primary (citable) accession number: Q9Y680
Secondary accession number(s): Q4ZG70 , Q6V3B2, Q86U65, Q96DA4, Q9Y6B0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2002
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 123 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.