Reviewed,
UniProtKB/Swiss-Prot Q9Y680 (FKBP7_HUMAN)
Last modified
November 4, 2008.
Version 73.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: FK506-binding protein 7 EC=5.2.1.8 Alternative name(s): Peptidyl-prolyl cis-trans isomerase Short name=PPIase Short name=Rotamase FKBP-23 | ||||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||||
| Taxonomic identifier | 9606 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 259 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | PPIases accelerate the folding of proteins during protein synthesis. |
| Catalytic activity | Peptidylproline (omega=180) = peptidylproline (omega=0). |
| Subcellular location | Endoplasmic reticulum lumenBy similarity. |
| Post-translational modification | Glycosylated By similarity. |
| Miscellaneous | Binds calcium By similarity. |
| Sequence similarities | Contains 2 EF-hand domains. Contains 1 PPIase FKBP-type domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum |
| Coding sequence diversity | Alternative splicing |
| Domain | Repeat Signal |
| Ligand | Calcium |
| Molecular function | Isomerase Rotamase |
| PTM | Glycoprotein |
Gene Ontology (GO) | |
| Cellular component | endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9Y680-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9Y680-2) The sequence of this isoform differs from the canonical sequence as follows: 125-161: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 23 | 23 | Potential | ||||||
| Chain | 24 – 259 | 236 | FK506-binding protein 7 | PRO_0000025513 | |||||
Regions | |||||||||
| Domain | 53 – 182 | 130 | PPIase FKBP-type | ||||||
| Domain | 182 – 217 | 36 | EF-hand 1 | ||||||
| Domain | 226 – 259 | 34 | EF-hand 2 | ||||||
| Calcium binding | 195 – 206 | 12 | 1 Potential | ||||||
| Calcium binding | 239 – 250 | 12 | 2 Potential | ||||||
| Motif | 256 – 259 | 4 | Prevents secretion from ER Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 45 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 158 | 1 | N-linked (GlcNAc...) Potential | ||||||
Natural variations | |||||||||
| Alternative sequence | 125 – 161 | 37 | Missing in isoform 2. | VSP_005187 | |||||
Experimental info | |||||||||
| Sequence conflict | 124 | 1 | Y → H Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Human FK506-binding protein (FKBP23)-isoform gene." Guan Z., Zhang Q., Dai M., Song H., Mao Y., Wu X., Mao M., Fu G., Luo M., Chen J., Hu R. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Pituitary tumor. |
| [2] | "Human FK506-binding protein mRNA, complete cds." Han Z., Song H., Dai M., Huang Q., Mao Y., Zhang Q., Mao M., Fu G., Luo M., Chen J., Hu R. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Pituitary. |
| [3] | "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M.Genome Res. 13:2265-2270(2003) [PubMed: 12975309] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). |
| [4] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Lung. |
Cross-references
Sequence databases | |
|---|---|
| AF100751 mRNA. Translation: AAD43015.1. AF092137 mRNA. Translation: AAD40379.1. AY359015 mRNA. Translation: AAQ89374.1. BT007122 mRNA. Translation: AAP35786.1. BC009711 mRNA. Translation: AAH09711.1. | |
| UniGene | Hs.410378 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1N1A based on UniProtKB Q02790. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000079150. Homo sapiens. [Contig view] |
| KEGG | hsa:51661. |
Organism-specific databases | |
| H-InvDB | HIX0002629. |
| HGNC | HGNC:3723. FKBP7. |
| HPA | HPA008707. |
| MIM | 607062. gene. |
| PharmGKB | PA28164. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | Q9Y680. |
| HOVERGEN | Q9Y680. |
Gene expression databases | |
| ArrayExpress | Q9Y680. |
| CleanEx | HS_FKBP7. |
| GermOnline | ENSG00000079150. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR002048. EF_hand_Ca_bd. IPR000886. ER_targeting_sequence. IPR001179. PPIase_FKBP. [Graphical view] |
| PANTHER | PTHR10516. PPIase_FKBP. 1 hit. |
| Pfam | PF00036. efhand. 2 hits. PF00254. FKBP_C. 1 hit. [Graphical view] |
| SMART | SM00054. EFh. 2 hits. [Graphical view] |
| PROSITE | PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. PS00014. ER_TARGET. 1 hit. PS50059. FKBP_PPIASE. 1 hit. [Graphical view] |
| BLOCKS | Search... |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | Q9Y680. |
| NextBio | 55642. |
| SOURCE | Search... |
Entry information
| Entry name | FKBP7_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y680 Secondary accession number(s): Q86U65, Q96DA4, Q9Y6B0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 2 Human chromosome 2: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

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