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Protein

Peptidyl-prolyl cis-trans isomerase FKBP7

Gene

FKBP7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins during protein synthesis.

Miscellaneous

Binds calcium.By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi158 – 1691PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi202 – 2132PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Rotamase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase FKBP7 (EC:5.2.1.8)
Short name:
PPIase FKBP7
Alternative name(s):
23 kDa FK506-binding protein
Short name:
23 kDa FKBP
Short name:
FKBP-23
FK506-binding protein 7
Short name:
FKBP-7
Rotamase
Gene namesi
Name:FKBP7
Synonyms:FKBP23
ORF Names:UNQ670/PRO1304
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000079150.17
HGNCiHGNC:3723 FKBP7
MIMi607062 gene
neXtProtiNX_Q9Y680

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000079150
PharmGKBiPA28164

Polymorphism and mutation databases

BioMutaiFKBP7
DMDMi23396602

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000002551324 – 222Peptidyl-prolyl cis-trans isomerase FKBP7Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi45N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y680
PeptideAtlasiQ9Y680
PRIDEiQ9Y680

PTM databases

iPTMnetiQ9Y680
PhosphoSitePlusiQ9Y680

Expressioni

Gene expression databases

BgeeiENSG00000079150
CleanExiHS_FKBP7
ExpressionAtlasiQ9Y680 baseline and differential
GenevisibleiQ9Y680 HS

Organism-specific databases

HPAiHPA008707

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119666, 33 interactors
IntActiQ9Y680, 8 interactors
MINTiQ9Y680

Structurei

3D structure databases

ProteinModelPortaliQ9Y680
SMRiQ9Y680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 145PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST93
Domaini145 – 180EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini189 – 222EF-hand 2PROSITE-ProRule annotationAdd BLAST34

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi219 – 222Retention in the endoplasmic reticulumPROSITE-ProRule annotation4

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00530000062784
HOGENOMiHOG000154887
HOVERGENiHBG051623
InParanoidiQ9Y680
KOiK09573
OMAiHRPENCS
OrthoDBiEOG091G02W1
PhylomeDBiQ9Y680
TreeFamiTF105296

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR023566 PPIase_FKBP
IPR001179 PPIase_FKBP_dom
PANTHERiPTHR10516 PTHR10516, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF00254 FKBP_C, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS00014 ER_TARGET, 1 hit
PS50059 FKBP_PPIASE, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q9Y680-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKTMHFLFR FIVFFYLWGL FTAQRQKKEE STEEVKIEVL HRPENCSKTS
60 70 80 90 100
KKGDLLNAHY DGYLAKDGSK FYCSRTQNEG HPKWFVLGVG QVIKGLDIAM
110 120 130 140 150
TDMCPGEKRK VVIPPSFAYG KEGYAEGKIP PDATLIFEIE LYAVTKGPRS
160 170 180 190 200
IETFKQIDMD NDRQLSKAEI NLYLQREFEK DEKPRDKSYQ DAVLEDIFKK
210 220
NDHDGDGFIS PKEYNVYQHD EL
Length:222
Mass (Da):25,794
Last modified:March 28, 2018 - v2
Checksum:i362957BAD3C5C2A6
GO
Isoform 3 (identifier: Q9Y680-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-125: Missing.

Show »
Length:221
Mass (Da):25,723
Checksum:i7A00D79506D301BF
GO
Isoform 1 (identifier: Q9Y680-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     125-127: AEG → GST
     128-222: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:127
Mass (Da):14,562
Checksum:iC613FC1F00F4B8B9
GO

Sequence cautioni

The sequence AAD43015 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124Y → H in AAD40379 (PubMed:10931946).Curated1
Sequence conflicti200K → M in AAQ57208 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059387125 – 127AEG → GST in isoform 1. 1 Publication3
Alternative sequenceiVSP_041018125Missing in isoform 3. 1 Publication1
Alternative sequenceiVSP_059388128 – 222Missing in isoform 1. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092137 mRNA Translation: AAD40379.1
AF100751 mRNA Translation: AAD43015.1 Frameshift.
AY359015 mRNA Translation: AAQ89374.1
AK292145 mRNA Translation: BAF84834.1
BT007122 mRNA Translation: AAP35786.1
AY353086 mRNA Translation: AAQ57208.1
AC009948 Genomic DNA Translation: AAX88883.1
BC009711 mRNA Translation: AAH09711.1
CCDSiCCDS2280.1 [Q9Y680-2]
CCDS46462.1 [Q9Y680-3]
RefSeqiNP_001128684.1, NM_001135212.1 [Q9Y680-3]
NP_851939.1, NM_181342.2 [Q9Y680-2]
UniGeneiHs.410378

Genome annotation databases

EnsembliENST00000233092; ENSP00000233092; ENSG00000079150 [Q9Y680-1]
ENST00000424785; ENSP00000413152; ENSG00000079150 [Q9Y680-2]
ENST00000434643; ENSP00000415486; ENSG00000079150 [Q9Y680-3]
GeneIDi51661
KEGGihsa:51661
UCSCiuc002umk.4 human [Q9Y680-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFKBP7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y680
Secondary accession number(s): Q4ZG70
, Q6V3B2, Q86U65, Q96DA4, Q9Y6B0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 28, 2018
Last modified: April 25, 2018
This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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