Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y678

- COPG1_HUMAN

UniProt

Q9Y678 - COPG1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Coatomer subunit gamma-1

Gene

COPG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity).By similarity

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. COPI coating of Golgi vesicle Source: Reactome
  2. establishment of Golgi localization Source: BHF-UCL
  3. intracellular protein transport Source: InterPro
  4. membrane organization Source: Reactome
  5. organelle transport along microtubule Source: BHF-UCL
  6. retrograde vesicle-mediated transport, Golgi to ER Source: Reactome
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_11096. COPI Mediated Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit gamma-1
Alternative name(s):
Gamma-1-coat protein
Short name:
Gamma-1-COP
Gene namesi
Name:COPG1
Synonyms:COPG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:2236. COPG1.

Subcellular locationi

Cytoplasm 1 Publication. Golgi apparatus membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmic vesicleCOPI-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Predominantly located in the cis-Golgi apparatus.By similarity

GO - Cellular componenti

  1. COPI vesicle coat Source: UniProtKB
  2. cytosol Source: Reactome
  3. Golgi membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi776 – 7761W → S: Loss of interaction with ZNF289/ARFGAP2. 1 Publication

Organism-specific databases

PharmGKBiPA26752.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Coatomer subunit gamma-1PRO_0000193858Add
BLAST

Proteomic databases

MaxQBiQ9Y678.
PaxDbiQ9Y678.
PeptideAtlasiQ9Y678.
PRIDEiQ9Y678.

PTM databases

PhosphoSiteiQ9Y678.

Expressioni

Gene expression databases

BgeeiQ9Y678.
CleanExiHS_COPG.
ExpressionAtlasiQ9Y678. baseline and differential.
GenevestigatoriQ9Y678.

Organism-specific databases

HPAiHPA037867.

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with ZNF289/ARFGAP2 through its C-terminal appendage domain. Interacts with EGFR upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with COPB1. Interacts with TMED10 (via C-terminus). Interacts with TMED2, TMED3, TMED7 and TMED9.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GBF1Q925382EBI-1049127,EBI-359050
NUDCD1Q96RS62EBI-1049127,EBI-2512429
SACM1LQ9NTJ53EBI-1049127,EBI-3917235

Protein-protein interaction databases

BioGridi116496. 51 interactions.
DIPiDIP-29872N.
IntActiQ9Y678. 19 interactions.
MINTiMINT-4657598.
STRINGi9606.ENSP00000325002.

Structurei

Secondary structure

1
874
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi609 – 61810
Helixi621 – 6233
Beta strandi644 – 65411
Beta strandi656 – 66712
Beta strandi672 – 68615
Beta strandi688 – 6936
Beta strandi695 – 6984
Beta strandi704 – 7118
Beta strandi714 – 7163
Beta strandi722 – 73514
Turni737 – 7393
Beta strandi747 – 7526
Beta strandi756 – 7583
Helixi760 – 7634
Beta strandi764 – 7663
Helixi772 – 7798
Beta strandi785 – 7917
Helixi797 – 80812
Turni814 – 8174
Beta strandi824 – 83411
Turni835 – 8373
Beta strandi838 – 86225
Helixi863 – 87210

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1R4XX-ray1.90A608-874[»]
ProteinModelPortaliQ9Y678.
SMRiQ9Y678. Positions 608-873.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y678.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati64 – 10138HEAT 1Add
BLAST
Repeati283 – 32038HEAT 2Add
BLAST
Repeati322 – 35534HEAT 3Add
BLAST
Repeati356 – 39237HEAT 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni609 – 874266Interaction with ZNF289/ARFGAP2Add
BLAST

Sequence similaritiesi

Belongs to the COPG family.Curated
Contains 4 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5240.
GeneTreeiENSGT00390000016313.
HOGENOMiHOG000184434.
HOVERGENiHBG004368.
InParanoidiQ9Y678.
KOiK17267.
OMAiEFHGLGP.
OrthoDBiEOG75XGK5.
PhylomeDBiQ9Y678.
TreeFamiTF300324.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
2.60.40.1480. 1 hit.
3.30.310.30. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR017106. Coatomer_gsu.
IPR013040. Coatomer_gsu_app_Ig-like-sub.
[Graphical view]
PANTHERiPTHR10261. PTHR10261. 1 hit.
PfamiPF01602. Adaptin_N. 1 hit.
PF08752. COP-gamma_platf. 1 hit.
[Graphical view]
PIRSFiPIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y678-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLKKFDKKDE ESGGGSNPFQ HLEKSAVLQE ARVFNETPIN PRKCAHILTK
60 70 80 90 100
ILYLINQGEH LGTTEATEAF FAMTKLFQSN DPTLRRMCYL TIKEMSCIAE
110 120 130 140 150
DVIIVTSSLT KDMTGKEDNY RGPAVRALCQ ITDSTMLQAI ERYMKQAIVD
160 170 180 190 200
KVPSVSSSAL VSSLHLLKCS FDVVKRWVNE AQEAASSDNI MVQYHALGLL
210 220 230 240 250
YHVRKNDRLA VNKMISKVTR HGLKSPFAYC MMIRVASKQL EEEDGSRDSP
260 270 280 290 300
LFDFIESCLR NKHEMVVYEA ASAIVNLPGC SAKELAPAVS VLQLFCSSPK
310 320 330 340 350
AALRYAAVRT LNKVAMKHPS AVTACNLDLE NLVTDSNRSI ATLAITTLLK
360 370 380 390 400
TGSESSIDRL MKQISSFMSE ISDEFKVVVV QAISALCQKY PRKHAVLMNF
410 420 430 440 450
LFTMLREEGG FEYKRAIVDC IISIIEENSE SKETGLSHLC EFIEDCEFTV
460 470 480 490 500
LATRILHLLG QEGPKTTNPS KYIRFIYNRV VLEHEEVRAG AVSALAKFGA
510 520 530 540 550
QNEEMLPSIL VLLKRCVMDD DNEVRDRATF YLNVLEQKQK ALNAGYILNG
560 570 580 590 600
LTVSIPGLER ALQQYTLEPS EKPFDLKSVP LATAPMAEQR TESTPITAVK
610 620 630 640 650
QPEKVAATRQ EIFQEQLAAV PEFRGLGPLF KSSPEPVALT ESETEYVIRC
660 670 680 690 700
TKHTFTNHMV FQFDCTNTLN DQTLENVTVQ MEPTEAYEVL CYVPARSLPY
710 720 730 740 750
NQPGTCYTLV ALPKEDPTAV ACTFSCMMKF TVKDCDPTTG ETDDEGYEDE
760 770 780 790 800
YVLEDLEVTV ADHIQKVMKL NFEAAWDEVG DEFEKEETFT LSTIKTLEEA
810 820 830 840 850
VGNIVKFLGM HPCERSDKVP DNKNTHTLLL AGVFRGGHDI LVRSRLLLLD
860 870
TVTMQVTARS LEELPVDIIL ASVG
Length:874
Mass (Da):97,718
Last modified:November 1, 1999 - v1
Checksum:iA2FAB492C598EC98
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti622 – 6221E → V in BAG50968. (PubMed:14702039)Curated
Sequence conflicti786 – 7861E → G in BAG50968. (PubMed:14702039)Curated
Sequence conflicti842 – 8421V → M in BAG50968. (PubMed:14702039)Curated
Sequence conflicti854 – 8541M → T in BAF84382. (PubMed:14702039)Curated
Sequence conflicti854 – 8541M → T in BAG50968. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti681 – 6811M → T.
Corresponds to variant rs15648 [ dbSNP | Ensembl ].
VAR_054039

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB047846 mRNA. Translation: BAB17657.1.
AF100756 mRNA. Translation: AAD43020.1.
AK001724 mRNA. Translation: BAG50968.1.
AK291693 mRNA. Translation: BAF84382.1.
CH471052 Genomic DNA. Translation: EAW79267.1.
BC066650 mRNA. Translation: AAH66650.1.
CCDSiCCDS33851.1.
RefSeqiNP_057212.1. NM_016128.3.
UniGeneiHs.518250.

Genome annotation databases

EnsembliENST00000314797; ENSP00000325002; ENSG00000181789.
GeneIDi22820.
KEGGihsa:22820.
UCSCiuc003els.3. human.

Polymorphism databases

DMDMi12229771.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB047846 mRNA. Translation: BAB17657.1 .
AF100756 mRNA. Translation: AAD43020.1 .
AK001724 mRNA. Translation: BAG50968.1 .
AK291693 mRNA. Translation: BAF84382.1 .
CH471052 Genomic DNA. Translation: EAW79267.1 .
BC066650 mRNA. Translation: AAH66650.1 .
CCDSi CCDS33851.1.
RefSeqi NP_057212.1. NM_016128.3.
UniGenei Hs.518250.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1R4X X-ray 1.90 A 608-874 [» ]
ProteinModelPortali Q9Y678.
SMRi Q9Y678. Positions 608-873.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116496. 51 interactions.
DIPi DIP-29872N.
IntActi Q9Y678. 19 interactions.
MINTi MINT-4657598.
STRINGi 9606.ENSP00000325002.

PTM databases

PhosphoSitei Q9Y678.

Polymorphism databases

DMDMi 12229771.

Proteomic databases

MaxQBi Q9Y678.
PaxDbi Q9Y678.
PeptideAtlasi Q9Y678.
PRIDEi Q9Y678.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314797 ; ENSP00000325002 ; ENSG00000181789 .
GeneIDi 22820.
KEGGi hsa:22820.
UCSCi uc003els.3. human.

Organism-specific databases

CTDi 22820.
GeneCardsi GC03P129056.
HGNCi HGNC:2236. COPG1.
HPAi HPA037867.
MIMi 615525. gene.
neXtProti NX_Q9Y678.
PharmGKBi PA26752.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5240.
GeneTreei ENSGT00390000016313.
HOGENOMi HOG000184434.
HOVERGENi HBG004368.
InParanoidi Q9Y678.
KOi K17267.
OMAi EFHGLGP.
OrthoDBi EOG75XGK5.
PhylomeDBi Q9Y678.
TreeFami TF300324.

Enzyme and pathway databases

Reactomei REACT_11096. COPI Mediated Transport.

Miscellaneous databases

ChiTaRSi COPG1. human.
EvolutionaryTracei Q9Y678.
GeneWikii COPG.
GenomeRNAii 22820.
NextBioi 43212.
PROi Q9Y678.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y678.
CleanExi HS_COPG.
ExpressionAtlasi Q9Y678. baseline and differential.
Genevestigatori Q9Y678.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
2.60.40.1480. 1 hit.
3.30.310.30. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR002553. Clathrin/coatomer_adapt-like_N.
IPR015873. Clathrin_a/coatomer_app_sub_C.
IPR009028. Coatomer/calthrin_app_sub_C.
IPR013041. Coatomer/clathrin_app_Ig-like.
IPR017106. Coatomer_gsu.
IPR013040. Coatomer_gsu_app_Ig-like-sub.
[Graphical view ]
PANTHERi PTHR10261. PTHR10261. 1 hit.
Pfami PF01602. Adaptin_N. 1 hit.
PF08752. COP-gamma_platf. 1 hit.
[Graphical view ]
PIRSFi PIRSF037093. Coatomer_gamma_subunit. 1 hit.
SUPFAMi SSF48371. SSF48371. 1 hit.
SSF49348. SSF49348. 1 hit.
SSF55711. SSF55711. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of novel isoforms of COP I subunits."
    Futatsumori M., Kasai K., Takatsu H., Shin H.-W., Nakayama K.
    J. Biochem. 128:793-801(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH COPB1 AND TMED10, SUBCELLULAR LOCATION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Teratocarcinoma.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. "COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport."
    Wang Y.N., Wang H., Yamaguchi H., Lee H.J., Lee H.H., Hung M.C.
    Biochem. Biophys. Res. Commun. 399:498-504(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EGFR.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Gamma-COP appendage domain -- structure and function."
    Watson P.J., Frigerio G., Collins B.M., Duden R., Owen D.J.
    Traffic 5:79-88(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 608-874, INTERACTION WITH ZNF289, MUTAGENESIS OF TRP-776.

Entry informationi

Entry nameiCOPG1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y678
Secondary accession number(s): A8K6M8, B3KMF6, Q54AC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3