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Q9Y678

- COPG1_HUMAN

UniProt

Q9Y678 - COPG1_HUMAN

Protein

Coatomer subunit gamma-1

Gene

COPG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. COPI coating of Golgi vesicle Source: Reactome
    2. establishment of Golgi localization Source: BHF-UCL
    3. intracellular protein transport Source: InterPro
    4. membrane organization Source: Reactome
    5. organelle transport along microtubule Source: BHF-UCL
    6. retrograde vesicle-mediated transport, Golgi to ER Source: Reactome

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_11096. COPI Mediated Transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coatomer subunit gamma-1
    Alternative name(s):
    Gamma-1-coat protein
    Short name:
    Gamma-1-COP
    Gene namesi
    Name:COPG1
    Synonyms:COPG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:2236. COPG1.

    Subcellular locationi

    Cytoplasm 1 Publication. Golgi apparatus membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication. Cytoplasmic vesicleCOPI-coated vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
    Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. Predominantly located in the cis-Golgi apparatus.By similarity

    GO - Cellular componenti

    1. COPI vesicle coat Source: UniProtKB
    2. cytosol Source: Reactome
    3. Golgi membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi776 – 7761W → S: Loss of interaction with ZNF289/ARFGAP2. 1 Publication

    Organism-specific databases

    PharmGKBiPA26752.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 874874Coatomer subunit gamma-1PRO_0000193858Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y678.
    PaxDbiQ9Y678.
    PeptideAtlasiQ9Y678.
    PRIDEiQ9Y678.

    PTM databases

    PhosphoSiteiQ9Y678.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y678.
    BgeeiQ9Y678.
    CleanExiHS_COPG.
    GenevestigatoriQ9Y678.

    Organism-specific databases

    HPAiHPA037867.

    Interactioni

    Subunit structurei

    Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Interacts with ZNF289/ARFGAP2 through its C-terminal appendage domain. Interacts with EGFR upon EGF treatment; interaction is essential for regulation of EGF-dependent nuclear transport of EGFR by retrograde trafficking from the Golgi to the ER. Interacts with COPB1. Interacts with TMED10 (via C-terminus). Interacts with TMED2, TMED3, TMED7 and TMED9.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GBF1Q925382EBI-1049127,EBI-359050
    NUDCD1Q96RS62EBI-1049127,EBI-2512429
    SACM1LQ9NTJ53EBI-1049127,EBI-3917235

    Protein-protein interaction databases

    BioGridi116496. 46 interactions.
    DIPiDIP-29872N.
    IntActiQ9Y678. 19 interactions.
    MINTiMINT-4657598.
    STRINGi9606.ENSP00000325002.

    Structurei

    Secondary structure

    1
    874
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi609 – 61810
    Helixi621 – 6233
    Beta strandi644 – 65411
    Beta strandi656 – 66712
    Beta strandi672 – 68615
    Beta strandi688 – 6936
    Beta strandi695 – 6984
    Beta strandi704 – 7118
    Beta strandi714 – 7163
    Beta strandi722 – 73514
    Turni737 – 7393
    Beta strandi747 – 7526
    Beta strandi756 – 7583
    Helixi760 – 7634
    Beta strandi764 – 7663
    Helixi772 – 7798
    Beta strandi785 – 7917
    Helixi797 – 80812
    Turni814 – 8174
    Beta strandi824 – 83411
    Turni835 – 8373
    Beta strandi838 – 86225
    Helixi863 – 87210

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1R4XX-ray1.90A608-874[»]
    ProteinModelPortaliQ9Y678.
    SMRiQ9Y678. Positions 20-311, 608-873.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y678.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati64 – 10138HEAT 1Add
    BLAST
    Repeati283 – 32038HEAT 2Add
    BLAST
    Repeati322 – 35534HEAT 3Add
    BLAST
    Repeati356 – 39237HEAT 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni609 – 874266Interaction with ZNF289/ARFGAP2Add
    BLAST

    Sequence similaritiesi

    Belongs to the COPG family.Curated
    Contains 4 HEAT repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5240.
    HOGENOMiHOG000184434.
    HOVERGENiHBG004368.
    InParanoidiQ9Y678.
    KOiK17267.
    OMAiEFHGLGP.
    OrthoDBiEOG75XGK5.
    PhylomeDBiQ9Y678.
    TreeFamiTF300324.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    2.60.40.1480. 1 hit.
    3.30.310.30. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    IPR017106. Coatomer_gsu.
    IPR013040. Coatomer_gsu_app_Ig-like-sub.
    [Graphical view]
    PANTHERiPTHR10261. PTHR10261. 1 hit.
    PfamiPF01602. Adaptin_N. 1 hit.
    PF08752. COP-gamma_platf. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037093. Coatomer_gamma_subunit. 1 hit.
    SUPFAMiSSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Y678-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKKFDKKDE ESGGGSNPFQ HLEKSAVLQE ARVFNETPIN PRKCAHILTK    50
    ILYLINQGEH LGTTEATEAF FAMTKLFQSN DPTLRRMCYL TIKEMSCIAE 100
    DVIIVTSSLT KDMTGKEDNY RGPAVRALCQ ITDSTMLQAI ERYMKQAIVD 150
    KVPSVSSSAL VSSLHLLKCS FDVVKRWVNE AQEAASSDNI MVQYHALGLL 200
    YHVRKNDRLA VNKMISKVTR HGLKSPFAYC MMIRVASKQL EEEDGSRDSP 250
    LFDFIESCLR NKHEMVVYEA ASAIVNLPGC SAKELAPAVS VLQLFCSSPK 300
    AALRYAAVRT LNKVAMKHPS AVTACNLDLE NLVTDSNRSI ATLAITTLLK 350
    TGSESSIDRL MKQISSFMSE ISDEFKVVVV QAISALCQKY PRKHAVLMNF 400
    LFTMLREEGG FEYKRAIVDC IISIIEENSE SKETGLSHLC EFIEDCEFTV 450
    LATRILHLLG QEGPKTTNPS KYIRFIYNRV VLEHEEVRAG AVSALAKFGA 500
    QNEEMLPSIL VLLKRCVMDD DNEVRDRATF YLNVLEQKQK ALNAGYILNG 550
    LTVSIPGLER ALQQYTLEPS EKPFDLKSVP LATAPMAEQR TESTPITAVK 600
    QPEKVAATRQ EIFQEQLAAV PEFRGLGPLF KSSPEPVALT ESETEYVIRC 650
    TKHTFTNHMV FQFDCTNTLN DQTLENVTVQ MEPTEAYEVL CYVPARSLPY 700
    NQPGTCYTLV ALPKEDPTAV ACTFSCMMKF TVKDCDPTTG ETDDEGYEDE 750
    YVLEDLEVTV ADHIQKVMKL NFEAAWDEVG DEFEKEETFT LSTIKTLEEA 800
    VGNIVKFLGM HPCERSDKVP DNKNTHTLLL AGVFRGGHDI LVRSRLLLLD 850
    TVTMQVTARS LEELPVDIIL ASVG 874
    Length:874
    Mass (Da):97,718
    Last modified:November 1, 1999 - v1
    Checksum:iA2FAB492C598EC98
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti622 – 6221E → V in BAG50968. (PubMed:14702039)Curated
    Sequence conflicti786 – 7861E → G in BAG50968. (PubMed:14702039)Curated
    Sequence conflicti842 – 8421V → M in BAG50968. (PubMed:14702039)Curated
    Sequence conflicti854 – 8541M → T in BAF84382. (PubMed:14702039)Curated
    Sequence conflicti854 – 8541M → T in BAG50968. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti681 – 6811M → T.
    Corresponds to variant rs15648 [ dbSNP | Ensembl ].
    VAR_054039

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB047846 mRNA. Translation: BAB17657.1.
    AF100756 mRNA. Translation: AAD43020.1.
    AK001724 mRNA. Translation: BAG50968.1.
    AK291693 mRNA. Translation: BAF84382.1.
    CH471052 Genomic DNA. Translation: EAW79267.1.
    BC066650 mRNA. Translation: AAH66650.1.
    CCDSiCCDS33851.1.
    RefSeqiNP_057212.1. NM_016128.3.
    UniGeneiHs.518250.

    Genome annotation databases

    EnsembliENST00000314797; ENSP00000325002; ENSG00000181789.
    GeneIDi22820.
    KEGGihsa:22820.
    UCSCiuc003els.3. human.

    Polymorphism databases

    DMDMi12229771.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB047846 mRNA. Translation: BAB17657.1 .
    AF100756 mRNA. Translation: AAD43020.1 .
    AK001724 mRNA. Translation: BAG50968.1 .
    AK291693 mRNA. Translation: BAF84382.1 .
    CH471052 Genomic DNA. Translation: EAW79267.1 .
    BC066650 mRNA. Translation: AAH66650.1 .
    CCDSi CCDS33851.1.
    RefSeqi NP_057212.1. NM_016128.3.
    UniGenei Hs.518250.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1R4X X-ray 1.90 A 608-874 [» ]
    ProteinModelPortali Q9Y678.
    SMRi Q9Y678. Positions 20-311, 608-873.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116496. 46 interactions.
    DIPi DIP-29872N.
    IntActi Q9Y678. 19 interactions.
    MINTi MINT-4657598.
    STRINGi 9606.ENSP00000325002.

    PTM databases

    PhosphoSitei Q9Y678.

    Polymorphism databases

    DMDMi 12229771.

    Proteomic databases

    MaxQBi Q9Y678.
    PaxDbi Q9Y678.
    PeptideAtlasi Q9Y678.
    PRIDEi Q9Y678.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314797 ; ENSP00000325002 ; ENSG00000181789 .
    GeneIDi 22820.
    KEGGi hsa:22820.
    UCSCi uc003els.3. human.

    Organism-specific databases

    CTDi 22820.
    GeneCardsi GC03P128970.
    HGNCi HGNC:2236. COPG1.
    HPAi HPA037867.
    MIMi 615525. gene.
    neXtProti NX_Q9Y678.
    PharmGKBi PA26752.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5240.
    HOGENOMi HOG000184434.
    HOVERGENi HBG004368.
    InParanoidi Q9Y678.
    KOi K17267.
    OMAi EFHGLGP.
    OrthoDBi EOG75XGK5.
    PhylomeDBi Q9Y678.
    TreeFami TF300324.

    Enzyme and pathway databases

    Reactomei REACT_11096. COPI Mediated Transport.

    Miscellaneous databases

    ChiTaRSi COPG1. human.
    EvolutionaryTracei Q9Y678.
    GeneWikii COPG.
    GenomeRNAii 22820.
    NextBioi 43212.
    PROi Q9Y678.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y678.
    Bgeei Q9Y678.
    CleanExi HS_COPG.
    Genevestigatori Q9Y678.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    2.60.40.1480. 1 hit.
    3.30.310.30. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR002553. Clathrin/coatomer_adapt-like_N.
    IPR015873. Clathrin_a/coatomer_app_sub_C.
    IPR009028. Coatomer/calthrin_app_sub_C.
    IPR013041. Coatomer/clathrin_app_Ig-like.
    IPR017106. Coatomer_gsu.
    IPR013040. Coatomer_gsu_app_Ig-like-sub.
    [Graphical view ]
    PANTHERi PTHR10261. PTHR10261. 1 hit.
    Pfami PF01602. Adaptin_N. 1 hit.
    PF08752. COP-gamma_platf. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037093. Coatomer_gamma_subunit. 1 hit.
    SUPFAMi SSF48371. SSF48371. 1 hit.
    SSF49348. SSF49348. 1 hit.
    SSF55711. SSF55711. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of novel isoforms of COP I subunits."
      Futatsumori M., Kasai K., Takatsu H., Shin H.-W., Nakayama K.
      J. Biochem. 128:793-801(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH COPB1 AND TMED10, SUBCELLULAR LOCATION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta and Teratocarcinoma.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    6. "COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport."
      Wang Y.N., Wang H., Yamaguchi H., Lee H.J., Lee H.H., Hung M.C.
      Biochem. Biophys. Res. Commun. 399:498-504(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH EGFR.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Gamma-COP appendage domain -- structure and function."
      Watson P.J., Frigerio G., Collins B.M., Duden R., Owen D.J.
      Traffic 5:79-88(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 608-874, INTERACTION WITH ZNF289, MUTAGENESIS OF TRP-776.

    Entry informationi

    Entry nameiCOPG1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y678
    Secondary accession number(s): A8K6M8, B3KMF6, Q54AC4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3