Q9Y676 (RT18B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S18b, mitochondrial
Short name=MRP-S18-b
Short name=Mrps18-b
Short name=S18mt-b

Alternative name(s):
28S ribosomal protein S18-2, mitochondrial
Short name=MRP-S18-2

Gene names

Name:	MRPS18B
Synonyms:	C6orf14
ORF Names:	HSPC183, PTD017

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular location	Mitochondrion Ref.8.
Sequence similarities	Belongs to the ribosomal protein S18P family. Ref.8

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Non-traceable author statement Ref.8. Source: UniProtKB
Cellular_component	mitochondrial small ribosomal subunit Non-traceable author statement Ref.8. Source: UniProtKB
Molecular_function	structural constituent of ribosome Non-traceable author statement Ref.8. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NFKBIL1	Q9UBC1	1	EBI-750085,EBI-1043728

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 258		28S ribosomal protein S18b, mitochondrial		PRO_0000030627
Natural variations
	Natural variant	230	1	P → A. Corresponds to variant rs34315095 [ dbSNP | Ensembl ].		VAR_052056
Experimental info
	Sequence conflict	196	1	G → S in AAH05373. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Q9Y676 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: B4C83E5593796C5D	FASTA	258	29,396
	10 20 30 40 50 60 MAASVLNTVL RRLPMLSLFR GSHRVQVPLQ TLCTKAPSEE DSLSSVPISP YKDEPWKYLE 70 80 90 100 110 120 SEEYQERYGS RPVWADYRRN HKGGVPPQRT RKTCIRRNKV VGNPCPICRD HKLHVDFRNV 130 140 150 160 170 180 KLLEQFVCAH TGIIFYAPYT GVCVKQHKRL TQAIQKARDH GLLIYHIPQV EPRDLDFSTS 190 200 210 220 230 240 HGAVSATPPA PTLVSGDPWY PWYNWKQPPE RELSRLRRLY QGHLQEESGP PPESMPKMPP 250 RTPAEASSTG QTGPQSAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Zhang Q.H., Guan Z.Q., Dai M., Song H., Mao Y.F., Wu X.Y., Mao M., Fu G., Luo M., Chen J.H., Hu R. Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary tumor.
[2]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[4]	"Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity." Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A. , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S. Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Tissue: Peripheral blood leukocyte.
[5]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Heart.
[8]	"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L. J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[9]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF100761 mRNA. Translation: AAD43025.1. AF151017 mRNA. Translation: AAF36103.1. AL050361 mRNA. Translation: CAH56415.1. AB110933 Genomic DNA. Translation: BAD13699.1. AB110934 Genomic DNA. Translation: BAD13700.1. AB202094 Genomic DNA. Translation: BAE78614.1. AL662800 Genomic DNA. Translation: CAI18162.2. AL662825, AL732442 Genomic DNA. Translation: CAI17840.1. AL732442, AL662825 Genomic DNA. Translation: CAI17765.1. BX119957 Genomic DNA. Translation: CAM25911.1. AL845353, BX248507 Genomic DNA. Translation: CAI41878.1. BX248507, AL845353 Genomic DNA. Translation: CAI18569.1. CR753328 Genomic DNA. Translation: CAP58452.1. CH471081 Genomic DNA. Translation: EAX03304.1. BC005373 mRNA. Translation: AAH05373.1.
IPI	IPI00022316.
RefSeq	NP_054765.1. NM_014046.3.
UniGene	Hs.655329.
3D structure databases
ProteinModelPortal	Q9Y676.
SMR	Q9Y676. Positions 118-166.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-29894N.
IntAct	Q9Y676. 1 interaction.
MINT	MINT-1448435.
STRING	9606.ENSP00000397790.
PTM databases
PhosphoSite	Q9Y676.
Polymorphism databases
DMDM	24212203.
Proteomic databases
PaxDb	Q9Y676.
PeptideAtlas	Q9Y676.
PRIDE	Q9Y676.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000259873; ENSP00000259873; ENSG00000204568. ENST00000327800; ENSP00000383438; ENSG00000203624. ENST00000412451; ENSP00000402718; ENSG00000223775. ENST00000426945; ENSP00000397790; ENSG00000229861. ENST00000430402; ENSP00000398494; ENSG00000233813. ENST00000451032; ENSP00000415703; ENSG00000226111. ENST00000454427; ENSP00000414972; ENSG00000227420.
GeneID	28973.
KEGG	hsa:28973.
UCSC	uc003nqo.2. human.
Organism-specific databases
CTD	28973.
GeneCards	GC06P030585.
HGNC	HGNC:14516. MRPS18B.
HPA	HPA043485. HPA050334.
MIM	611982. gene.
neXtProt	NX_Q9Y676.
PharmGKB	PA31004.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG288650.
HOGENOM	HOG000039992.
HOVERGEN	HBG054347.
InParanoid	Q9Y676.
KO	K16174.
OMA	RPVWADY.
OrthoDB	EOG4WSWBX.
PhylomeDB	Q9Y676.
Gene expression databases
ArrayExpress	Q9Y676.
Bgee	Q9Y676.
CleanEx	HS_MRPS18B.
Genevestigator	Q9Y676.
GermOnline	ENSG00000204568. Homo sapiens.
Family and domain databases
Gene3D	4.10.640.10. 1 hit.
InterPro	IPR001648. Ribosomal_S18. [Graphical view]
Pfam	PF01084. Ribosomal_S18. 1 hit. [Graphical view]
ProDom	PD002239. Ribosomal_S18. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF46911. Ribosomal_S18. 1 hit.
PROSITE	PS00057. RIBOSOMAL_S18. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	MRPS18B. human.
GenomeRNAi	28973.
NextBio	51843.
SOURCE	Search...

Entry information

Entry name

RT18B_HUMAN

Accession

Primary (citable) accession number: Q9Y676
Secondary accession number(s): A6NDQ0, Q659G4, Q9BS27

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 103 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.