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Protein

28S ribosomal protein S18b, mitochondrial

Gene

MRPS18B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • mitochondrial translational elongation Source: Reactome
  • mitochondrial translational termination Source: Reactome
  • translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S18b, mitochondrial
Short name:
MRP-S18-b
Short name:
Mrps18-b
Short name:
S18mt-b
Alternative name(s):
28S ribosomal protein S18-2, mitochondrial
Short name:
MRP-S18-2
Gene namesi
Name:MRPS18B
Synonyms:C6orf14
ORF Names:HSPC183, PTD017
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14516. MRPS18B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31004.

Polymorphism and mutation databases

BioMutaiMRPS18B.
DMDMi24212203.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 25828S ribosomal protein S18b, mitochondrialPRO_0000030627
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381PhosphoserineCombined sources
Modified residuei49 – 491PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y676.
MaxQBiQ9Y676.
PaxDbiQ9Y676.
PeptideAtlasiQ9Y676.
PRIDEiQ9Y676.

PTM databases

iPTMnetiQ9Y676.
PhosphoSiteiQ9Y676.
SwissPalmiQ9Y676.

Expressioni

Gene expression databases

BgeeiENSG00000203624.
CleanExiHS_MRPS18B.
ExpressionAtlasiQ9Y676. baseline and differential.
GenevisibleiQ9Y676. HS.

Organism-specific databases

HPAiHPA043485.
HPA050334.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi118797. 49 interactions.
DIPiDIP-29894N.
IntActiQ9Y676. 9 interactions.
MINTiMINT-1448435.
STRINGi9606.ENSP00000259873.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AO1-258[»]
ProteinModelPortaliQ9Y676.
SMRiQ9Y676. Positions 51-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S18P family.1 Publication

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4021. Eukaryota.
ENOG4111KH6. LUCA.
GeneTreeiENSGT00390000010554.
HOGENOMiHOG000039992.
HOVERGENiHBG054347.
InParanoidiQ9Y676.
KOiK16174.
OMAiHGLLSYH.
OrthoDBiEOG091G0U9G.
PhylomeDBiQ9Y676.
TreeFamiTF315059.

Family and domain databases

Gene3Di4.10.640.10. 1 hit.
InterProiIPR001648. Ribosomal_S18.
[Graphical view]
PfamiPF01084. Ribosomal_S18. 1 hit.
[Graphical view]
ProDomiPD002239. Ribosomal_S18. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46911. SSF46911. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASVLNTVL RRLPMLSLFR GSHRVQVPLQ TLCTKAPSEE DSLSSVPISP
60 70 80 90 100
YKDEPWKYLE SEEYQERYGS RPVWADYRRN HKGGVPPQRT RKTCIRRNKV
110 120 130 140 150
VGNPCPICRD HKLHVDFRNV KLLEQFVCAH TGIIFYAPYT GVCVKQHKRL
160 170 180 190 200
TQAIQKARDH GLLIYHIPQV EPRDLDFSTS HGAVSATPPA PTLVSGDPWY
210 220 230 240 250
PWYNWKQPPE RELSRLRRLY QGHLQEESGP PPESMPKMPP RTPAEASSTG

QTGPQSAL
Length:258
Mass (Da):29,396
Last modified:November 1, 1999 - v1
Checksum:iB4C83E5593796C5D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961G → S in AAH05373 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti230 – 2301P → A.
Corresponds to variant rs34315095 [ dbSNP | Ensembl ].
VAR_052056

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100761 mRNA. Translation: AAD43025.1.
AF151017 mRNA. Translation: AAF36103.1.
AL050361 mRNA. Translation: CAH56415.1.
AB110933 Genomic DNA. Translation: BAD13699.1.
AB110934 Genomic DNA. Translation: BAD13700.1.
AB202094 Genomic DNA. Translation: BAE78614.1.
AL662800 Genomic DNA. Translation: CAI18162.2.
AL662825, AL732442 Genomic DNA. Translation: CAI17840.1.
AL732442, AL662825 Genomic DNA. Translation: CAI17765.1.
BX119957 Genomic DNA. Translation: CAM25911.1.
AL845353, BX248507 Genomic DNA. Translation: CAI41878.1.
BX248507, AL845353 Genomic DNA. Translation: CAI18569.1.
CR753328 Genomic DNA. Translation: CAP58452.1.
CH471081 Genomic DNA. Translation: EAX03304.1.
BC005373 mRNA. Translation: AAH05373.1.
CCDSiCCDS4682.1.
RefSeqiNP_054765.1. NM_014046.3.
UniGeneiHs.655329.

Genome annotation databases

EnsembliENST00000259873; ENSP00000259873; ENSG00000204568.
ENST00000327800; ENSP00000383438; ENSG00000203624.
ENST00000412451; ENSP00000402718; ENSG00000223775.
ENST00000426945; ENSP00000397790; ENSG00000229861.
ENST00000430402; ENSP00000398494; ENSG00000233813.
ENST00000451032; ENSP00000415703; ENSG00000226111.
ENST00000454427; ENSP00000414972; ENSG00000227420.
GeneIDi28973.
KEGGihsa:28973.
UCSCiuc003nqo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100761 mRNA. Translation: AAD43025.1.
AF151017 mRNA. Translation: AAF36103.1.
AL050361 mRNA. Translation: CAH56415.1.
AB110933 Genomic DNA. Translation: BAD13699.1.
AB110934 Genomic DNA. Translation: BAD13700.1.
AB202094 Genomic DNA. Translation: BAE78614.1.
AL662800 Genomic DNA. Translation: CAI18162.2.
AL662825, AL732442 Genomic DNA. Translation: CAI17840.1.
AL732442, AL662825 Genomic DNA. Translation: CAI17765.1.
BX119957 Genomic DNA. Translation: CAM25911.1.
AL845353, BX248507 Genomic DNA. Translation: CAI41878.1.
BX248507, AL845353 Genomic DNA. Translation: CAI18569.1.
CR753328 Genomic DNA. Translation: CAP58452.1.
CH471081 Genomic DNA. Translation: EAX03304.1.
BC005373 mRNA. Translation: AAH05373.1.
CCDSiCCDS4682.1.
RefSeqiNP_054765.1. NM_014046.3.
UniGeneiHs.655329.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AO1-258[»]
ProteinModelPortaliQ9Y676.
SMRiQ9Y676. Positions 51-238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118797. 49 interactions.
DIPiDIP-29894N.
IntActiQ9Y676. 9 interactions.
MINTiMINT-1448435.
STRINGi9606.ENSP00000259873.

PTM databases

iPTMnetiQ9Y676.
PhosphoSiteiQ9Y676.
SwissPalmiQ9Y676.

Polymorphism and mutation databases

BioMutaiMRPS18B.
DMDMi24212203.

Proteomic databases

EPDiQ9Y676.
MaxQBiQ9Y676.
PaxDbiQ9Y676.
PeptideAtlasiQ9Y676.
PRIDEiQ9Y676.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259873; ENSP00000259873; ENSG00000204568.
ENST00000327800; ENSP00000383438; ENSG00000203624.
ENST00000412451; ENSP00000402718; ENSG00000223775.
ENST00000426945; ENSP00000397790; ENSG00000229861.
ENST00000430402; ENSP00000398494; ENSG00000233813.
ENST00000451032; ENSP00000415703; ENSG00000226111.
ENST00000454427; ENSP00000414972; ENSG00000227420.
GeneIDi28973.
KEGGihsa:28973.
UCSCiuc003nqo.3. human.

Organism-specific databases

CTDi28973.
GeneCardsiMRPS18B.
HGNCiHGNC:14516. MRPS18B.
HPAiHPA043485.
HPA050334.
MIMi611982. gene.
neXtProtiNX_Q9Y676.
PharmGKBiPA31004.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4021. Eukaryota.
ENOG4111KH6. LUCA.
GeneTreeiENSGT00390000010554.
HOGENOMiHOG000039992.
HOVERGENiHBG054347.
InParanoidiQ9Y676.
KOiK16174.
OMAiHGLLSYH.
OrthoDBiEOG091G0U9G.
PhylomeDBiQ9Y676.
TreeFamiTF315059.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS18B. human.
GeneWikiiMRPS18B.
GenomeRNAii28973.
PROiQ9Y676.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000203624.
CleanExiHS_MRPS18B.
ExpressionAtlasiQ9Y676. baseline and differential.
GenevisibleiQ9Y676. HS.

Family and domain databases

Gene3Di4.10.640.10. 1 hit.
InterProiIPR001648. Ribosomal_S18.
[Graphical view]
PfamiPF01084. Ribosomal_S18. 1 hit.
[Graphical view]
ProDomiPD002239. Ribosomal_S18. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46911. SSF46911. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRT18B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y676
Secondary accession number(s): A6NDQ0, Q659G4, Q9BS27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.