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Protein

28S ribosomal protein S18b, mitochondrial

Gene

MRPS18B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There are 3 mitochondrial isoforms of bS18 in mammalia, localizing to 3 distinct sites in the mitoribosome. bS18m (bs18c) binds to the same site as bacterial bS18, mS40 (bS18b, this protein) binds to a novel location of the 28S small subunit, and mL66 (bS18a) binds to the 39S large subunit.1 Publication

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • mitochondrial translational elongation Source: Reactome
  • mitochondrial translational termination Source: Reactome
  • translation Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S18b, mitochondrial
Short name:
MRP-S18-b
Short name:
Mrps18-b
Short name:
S18mt-b
Alternative name(s):
28S ribosomal protein S18-2, mitochondrial
Short name:
MRP-S18-2
Mitochondrial small ribosomal subunit protein bS18b1 Publication
Mitochondrial small ribosomal subunit protein mS401 Publication
Gene namesi
Name:MRPS18B
Synonyms:C6orf14
ORF Names:HSPC183, PTD017
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204568.11
HGNCiHGNC:14516 MRPS18B
MIMi611982 gene
neXtProtiNX_Q9Y676

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi28973
OpenTargetsiENSG00000204568
PharmGKBiPA31004

Polymorphism and mutation databases

BioMutaiMRPS18B
DMDMi24212203

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionBy similarityAdd BLAST35
ChainiPRO_000003062736 – 25828S ribosomal protein S18b, mitochondrialAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1
Modified residuei49PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y676
MaxQBiQ9Y676
PaxDbiQ9Y676
PeptideAtlasiQ9Y676
PRIDEiQ9Y676

PTM databases

iPTMnetiQ9Y676
PhosphoSitePlusiQ9Y676
SwissPalmiQ9Y676

Expressioni

Gene expression databases

BgeeiENSG00000204568
CleanExiHS_MRPS18B
ExpressionAtlasiQ9Y676 baseline and differential
GenevisibleiQ9Y676 HS

Organism-specific databases

HPAiHPA043485
HPA050334

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mS40 has a zinc binding site.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118797, 99 interactors
CORUMiQ9Y676
DIPiDIP-29894N
IntActiQ9Y676, 22 interactors
MINTiQ9Y676
STRINGi9606.ENSP00000259873

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AO1-258[»]
ProteinModelPortaliQ9Y676
SMRiQ9Y676
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4021 Eukaryota
ENOG4111KH6 LUCA
GeneTreeiENSGT00390000010554
HOGENOMiHOG000039992
HOVERGENiHBG054347
InParanoidiQ9Y676
KOiK16174
OMAiWADYRRN
OrthoDBiEOG091G0U9G
PhylomeDBiQ9Y676
TreeFamiTF315059

Family and domain databases

Gene3Di4.10.640.10, 1 hit
InterProiView protein in InterPro
IPR001648 Ribosomal_S18
IPR036870 Ribosomal_S18_sf
PfamiView protein in Pfam
PF01084 Ribosomal_S18, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002239 Ribosomal_S18, 1 hit
SUPFAMiSSF46911 SSF46911, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASVLNTVL RRLPMLSLFR GSHRVQVPLQ TLCTKAPSEE DSLSSVPISP
60 70 80 90 100
YKDEPWKYLE SEEYQERYGS RPVWADYRRN HKGGVPPQRT RKTCIRRNKV
110 120 130 140 150
VGNPCPICRD HKLHVDFRNV KLLEQFVCAH TGIIFYAPYT GVCVKQHKRL
160 170 180 190 200
TQAIQKARDH GLLIYHIPQV EPRDLDFSTS HGAVSATPPA PTLVSGDPWY
210 220 230 240 250
PWYNWKQPPE RELSRLRRLY QGHLQEESGP PPESMPKMPP RTPAEASSTG

QTGPQSAL
Length:258
Mass (Da):29,396
Last modified:November 1, 1999 - v1
Checksum:iB4C83E5593796C5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196G → S in AAH05373 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052056230P → A. Corresponds to variant dbSNP:rs34315095Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100761 mRNA Translation: AAD43025.1
AF151017 mRNA Translation: AAF36103.1
AL050361 mRNA Translation: CAH56415.1
AB110933 Genomic DNA Translation: BAD13699.1
AB110934 Genomic DNA Translation: BAD13700.1
AB202094 Genomic DNA Translation: BAE78614.1
AL662800 Genomic DNA No translation available.
AL662825 Genomic DNA No translation available.
AL732442 Genomic DNA No translation available.
BX119957 Genomic DNA No translation available.
AL845353 Genomic DNA No translation available.
BX248507 Genomic DNA No translation available.
CR753328 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03304.1
BC005373 mRNA Translation: AAH05373.1
CCDSiCCDS4682.1
RefSeqiNP_054765.1, NM_014046.3
UniGeneiHs.655329

Genome annotation databases

EnsembliENST00000259873; ENSP00000259873; ENSG00000204568
ENST00000327800; ENSP00000383438; ENSG00000203624
ENST00000412451; ENSP00000402718; ENSG00000223775
ENST00000426945; ENSP00000397790; ENSG00000229861
ENST00000430402; ENSP00000398494; ENSG00000233813
ENST00000451032; ENSP00000415703; ENSG00000226111
ENST00000454427; ENSP00000414972; ENSG00000227420
GeneIDi28973
KEGGihsa:28973
UCSCiuc003nqo.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRT18B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y676
Secondary accession number(s): A6NDQ0, Q659G4, Q9BS27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health