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Protein

28S ribosomal protein S18b, mitochondrial

Gene

MRPS18B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

There are 3 mitochondrial isoforms of bS18 in mammalia, localizing to 3 distinct sites in the mitoribosome. bS18m (bs18c) binds to the same site as bacterial bS18, mS40 (bS18b, this protein) binds to a novel location of the 28S small subunit, and mL66 (bS18a) binds to the 39S large subunit.1 Publication

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • mitochondrial translational elongation Source: Reactome
  • mitochondrial translational termination Source: Reactome
  • translation Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S18b, mitochondrial
Short name:
MRP-S18-b
Short name:
Mrps18-b
Short name:
S18mt-b
Alternative name(s):
28S ribosomal protein S18-2, mitochondrial
Short name:
MRP-S18-2
Mitochondrial small ribosomal subunit protein bS18b1 Publication
Mitochondrial small ribosomal subunit protein mS401 Publication
Gene namesi
Name:MRPS18B
Synonyms:C6orf14
ORF Names:HSPC183, PTD017
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204568.11.
HGNCiHGNC:14516. MRPS18B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi28973.
OpenTargetsiENSG00000204568.
PharmGKBiPA31004.

Polymorphism and mutation databases

BioMutaiMRPS18B.
DMDMi24212203.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 35MitochondrionBy similarityAdd BLAST35
ChainiPRO_000003062736 – 25828S ribosomal protein S18b, mitochondrialAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38PhosphoserineCombined sources1
Modified residuei49PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y676.
MaxQBiQ9Y676.
PaxDbiQ9Y676.
PeptideAtlasiQ9Y676.
PRIDEiQ9Y676.

PTM databases

iPTMnetiQ9Y676.
PhosphoSitePlusiQ9Y676.
SwissPalmiQ9Y676.

Expressioni

Gene expression databases

BgeeiENSG00000204568.
CleanExiHS_MRPS18B.
ExpressionAtlasiQ9Y676. baseline and differential.
GenevisibleiQ9Y676. HS.

Organism-specific databases

HPAiHPA043485.
HPA050334.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mS40 has a zinc binding site.1 Publication

Protein-protein interaction databases

BioGridi118797. 96 interactors.
CORUMiQ9Y676.
DIPiDIP-29894N.
IntActiQ9Y676. 14 interactors.
MINTiMINT-1448435.
STRINGi9606.ENSP00000259873.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AO1-258[»]
ProteinModelPortaliQ9Y676.
SMRiQ9Y676.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4021. Eukaryota.
ENOG4111KH6. LUCA.
GeneTreeiENSGT00390000010554.
HOGENOMiHOG000039992.
HOVERGENiHBG054347.
InParanoidiQ9Y676.
KOiK16174.
OMAiWADYRRN.
OrthoDBiEOG091G0U9G.
PhylomeDBiQ9Y676.
TreeFamiTF315059.

Family and domain databases

Gene3Di4.10.640.10. 1 hit.
InterProiView protein in InterPro
IPR001648. Ribosomal_S18.
PfamiView protein in Pfam
PF01084. Ribosomal_S18. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002239. Ribosomal_S18. 1 hit.
SUPFAMiSSF46911. SSF46911. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASVLNTVL RRLPMLSLFR GSHRVQVPLQ TLCTKAPSEE DSLSSVPISP
60 70 80 90 100
YKDEPWKYLE SEEYQERYGS RPVWADYRRN HKGGVPPQRT RKTCIRRNKV
110 120 130 140 150
VGNPCPICRD HKLHVDFRNV KLLEQFVCAH TGIIFYAPYT GVCVKQHKRL
160 170 180 190 200
TQAIQKARDH GLLIYHIPQV EPRDLDFSTS HGAVSATPPA PTLVSGDPWY
210 220 230 240 250
PWYNWKQPPE RELSRLRRLY QGHLQEESGP PPESMPKMPP RTPAEASSTG

QTGPQSAL
Length:258
Mass (Da):29,396
Last modified:November 1, 1999 - v1
Checksum:iB4C83E5593796C5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196G → S in AAH05373 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052056230P → A. Corresponds to variant dbSNP:rs34315095Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF100761 mRNA. Translation: AAD43025.1.
AF151017 mRNA. Translation: AAF36103.1.
AL050361 mRNA. Translation: CAH56415.1.
AB110933 Genomic DNA. Translation: BAD13699.1.
AB110934 Genomic DNA. Translation: BAD13700.1.
AB202094 Genomic DNA. Translation: BAE78614.1.
AL662800 Genomic DNA. Translation: CAI18162.2.
AL662825, AL732442 Genomic DNA. Translation: CAI17840.1.
AL732442, AL662825 Genomic DNA. Translation: CAI17765.1.
BX119957 Genomic DNA. Translation: CAM25911.1.
AL845353, BX248507 Genomic DNA. Translation: CAI41878.1.
BX248507, AL845353 Genomic DNA. Translation: CAI18569.1.
CR753328 Genomic DNA. Translation: CAP58452.1.
CH471081 Genomic DNA. Translation: EAX03304.1.
BC005373 mRNA. Translation: AAH05373.1.
CCDSiCCDS4682.1.
RefSeqiNP_054765.1. NM_014046.3.
UniGeneiHs.655329.

Genome annotation databases

EnsembliENST00000259873; ENSP00000259873; ENSG00000204568.
ENST00000327800; ENSP00000383438; ENSG00000203624.
ENST00000412451; ENSP00000402718; ENSG00000223775.
ENST00000426945; ENSP00000397790; ENSG00000229861.
ENST00000430402; ENSP00000398494; ENSG00000233813.
ENST00000451032; ENSP00000415703; ENSG00000226111.
ENST00000454427; ENSP00000414972; ENSG00000227420.
GeneIDi28973.
KEGGihsa:28973.
UCSCiuc003nqo.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRT18B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y676
Secondary accession number(s): A6NDQ0, Q659G4, Q9BS27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: September 27, 2017
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families