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Q9Y676

- RT18B_HUMAN

UniProt

Q9Y676 - RT18B_HUMAN

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Protein
28S ribosomal protein S18b, mitochondrial
Gene
MRPS18B, C6orf14, HSPC183, PTD017
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S18b, mitochondrial
Short name:
MRP-S18-b
Short name:
Mrps18-b
Short name:
S18mt-b
Alternative name(s):
28S ribosomal protein S18-2, mitochondrial
Short name:
MRP-S18-2
Gene namesi
Name:MRPS18B
Synonyms:C6orf14
ORF Names:HSPC183, PTD017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:14516. MRPS18B.

Subcellular locationi

Mitochondrion 1 Publication

GO - Cellular componenti

  1. cell junction Source: HPA
  2. mitochondrial small ribosomal subunit Source: UniProtKB
  3. mitochondrion Source: HPA
  4. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31004.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 25828S ribosomal protein S18b, mitochondrialPRO_0000030627
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

MaxQBiQ9Y676.
PaxDbiQ9Y676.
PeptideAtlasiQ9Y676.
PRIDEiQ9Y676.

PTM databases

PhosphoSiteiQ9Y676.

Expressioni

Gene expression databases

ArrayExpressiQ9Y676.
BgeeiQ9Y676.
CleanExiHS_MRPS18B.
GenevestigatoriQ9Y676.

Organism-specific databases

HPAiHPA043485.
HPA050334.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi118797. 25 interactions.
DIPiDIP-29894N.
IntActiQ9Y676. 3 interactions.
MINTiMINT-1448435.
STRINGi9606.ENSP00000397790.

Structurei

3D structure databases

ProteinModelPortaliQ9Y676.
SMRiQ9Y676. Positions 118-166.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S18P family.1 Publication

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG288650.
HOGENOMiHOG000039992.
HOVERGENiHBG054347.
InParanoidiQ9Y676.
KOiK16174.
OMAiRPVWADY.
PhylomeDBiQ9Y676.
TreeFamiTF315059.

Family and domain databases

Gene3Di4.10.640.10. 1 hit.
InterProiIPR001648. Ribosomal_S18.
[Graphical view]
PfamiPF01084. Ribosomal_S18. 1 hit.
[Graphical view]
ProDomiPD002239. Ribosomal_S18. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF46911. SSF46911. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y676-1 [UniParc]FASTAAdd to Basket

« Hide

MAASVLNTVL RRLPMLSLFR GSHRVQVPLQ TLCTKAPSEE DSLSSVPISP    50
YKDEPWKYLE SEEYQERYGS RPVWADYRRN HKGGVPPQRT RKTCIRRNKV 100
VGNPCPICRD HKLHVDFRNV KLLEQFVCAH TGIIFYAPYT GVCVKQHKRL 150
TQAIQKARDH GLLIYHIPQV EPRDLDFSTS HGAVSATPPA PTLVSGDPWY 200
PWYNWKQPPE RELSRLRRLY QGHLQEESGP PPESMPKMPP RTPAEASSTG 250
QTGPQSAL 258
Length:258
Mass (Da):29,396
Last modified:November 1, 1999 - v1
Checksum:iB4C83E5593796C5D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti230 – 2301P → A.
Corresponds to variant rs34315095 [ dbSNP | Ensembl ].
VAR_052056

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti196 – 1961G → S in AAH05373. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF100761 mRNA. Translation: AAD43025.1.
AF151017 mRNA. Translation: AAF36103.1.
AL050361 mRNA. Translation: CAH56415.1.
AB110933 Genomic DNA. Translation: BAD13699.1.
AB110934 Genomic DNA. Translation: BAD13700.1.
AB202094 Genomic DNA. Translation: BAE78614.1.
AL662800 Genomic DNA. Translation: CAI18162.2.
AL662825, AL732442 Genomic DNA. Translation: CAI17840.1.
AL732442, AL662825 Genomic DNA. Translation: CAI17765.1.
BX119957 Genomic DNA. Translation: CAM25911.1.
AL845353, BX248507 Genomic DNA. Translation: CAI41878.1.
BX248507, AL845353 Genomic DNA. Translation: CAI18569.1.
CR753328 Genomic DNA. Translation: CAP58452.1.
CH471081 Genomic DNA. Translation: EAX03304.1.
BC005373 mRNA. Translation: AAH05373.1.
CCDSiCCDS4682.1.
RefSeqiNP_054765.1. NM_014046.3.
UniGeneiHs.655329.

Genome annotation databases

EnsembliENST00000259873; ENSP00000259873; ENSG00000204568.
ENST00000327800; ENSP00000383438; ENSG00000203624.
ENST00000412451; ENSP00000402718; ENSG00000223775.
ENST00000426945; ENSP00000397790; ENSG00000229861.
ENST00000430402; ENSP00000398494; ENSG00000233813.
ENST00000451032; ENSP00000415703; ENSG00000226111.
ENST00000454427; ENSP00000414972; ENSG00000227420.
GeneIDi28973.
KEGGihsa:28973.
UCSCiuc003nqo.2. human.

Polymorphism databases

DMDMi24212203.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF100761 mRNA. Translation: AAD43025.1 .
AF151017 mRNA. Translation: AAF36103.1 .
AL050361 mRNA. Translation: CAH56415.1 .
AB110933 Genomic DNA. Translation: BAD13699.1 .
AB110934 Genomic DNA. Translation: BAD13700.1 .
AB202094 Genomic DNA. Translation: BAE78614.1 .
AL662800 Genomic DNA. Translation: CAI18162.2 .
AL662825 , AL732442 Genomic DNA. Translation: CAI17840.1 .
AL732442 , AL662825 Genomic DNA. Translation: CAI17765.1 .
BX119957 Genomic DNA. Translation: CAM25911.1 .
AL845353 , BX248507 Genomic DNA. Translation: CAI41878.1 .
BX248507 , AL845353 Genomic DNA. Translation: CAI18569.1 .
CR753328 Genomic DNA. Translation: CAP58452.1 .
CH471081 Genomic DNA. Translation: EAX03304.1 .
BC005373 mRNA. Translation: AAH05373.1 .
CCDSi CCDS4682.1.
RefSeqi NP_054765.1. NM_014046.3.
UniGenei Hs.655329.

3D structure databases

ProteinModelPortali Q9Y676.
SMRi Q9Y676. Positions 118-166.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118797. 25 interactions.
DIPi DIP-29894N.
IntActi Q9Y676. 3 interactions.
MINTi MINT-1448435.
STRINGi 9606.ENSP00000397790.

PTM databases

PhosphoSitei Q9Y676.

Polymorphism databases

DMDMi 24212203.

Proteomic databases

MaxQBi Q9Y676.
PaxDbi Q9Y676.
PeptideAtlasi Q9Y676.
PRIDEi Q9Y676.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000259873 ; ENSP00000259873 ; ENSG00000204568 .
ENST00000327800 ; ENSP00000383438 ; ENSG00000203624 .
ENST00000412451 ; ENSP00000402718 ; ENSG00000223775 .
ENST00000426945 ; ENSP00000397790 ; ENSG00000229861 .
ENST00000430402 ; ENSP00000398494 ; ENSG00000233813 .
ENST00000451032 ; ENSP00000415703 ; ENSG00000226111 .
ENST00000454427 ; ENSP00000414972 ; ENSG00000227420 .
GeneIDi 28973.
KEGGi hsa:28973.
UCSCi uc003nqo.2. human.

Organism-specific databases

CTDi 28973.
GeneCardsi GC06P030585.
GC06Pj30575.
GC06Pk30575.
GC06Pl30630.
GC06Pm30663.
GC06Pn30574.
GC06Po30576.
HGNCi HGNC:14516. MRPS18B.
HPAi HPA043485.
HPA050334.
MIMi 611982. gene.
neXtProti NX_Q9Y676.
PharmGKBi PA31004.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG288650.
HOGENOMi HOG000039992.
HOVERGENi HBG054347.
InParanoidi Q9Y676.
KOi K16174.
OMAi RPVWADY.
PhylomeDBi Q9Y676.
TreeFami TF315059.

Miscellaneous databases

ChiTaRSi MRPS18B. human.
GeneWikii MRPS18B.
GenomeRNAii 28973.
NextBioi 51843.
PROi Q9Y676.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y676.
Bgeei Q9Y676.
CleanExi HS_MRPS18B.
Genevestigatori Q9Y676.

Family and domain databases

Gene3Di 4.10.640.10. 1 hit.
InterProi IPR001648. Ribosomal_S18.
[Graphical view ]
Pfami PF01084. Ribosomal_S18. 1 hit.
[Graphical view ]
ProDomi PD002239. Ribosomal_S18. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF46911. SSF46911. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Zhang Q.H., Guan Z.Q., Dai M., Song H., Mao Y.F., Wu X.Y., Mao M., Fu G., Luo M., Chen J.H., Hu R.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary tumor.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
    Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
    , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
    Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Tissue: Peripheral blood leukocyte.
  5. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  8. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT18B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y676
Secondary accession number(s): A6NDQ0, Q659G4, Q9BS27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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