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Q9Y676 (RT18B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
28S ribosomal protein S18b, mitochondrial

Short name=MRP-S18-b
Short name=Mrps18-b
Short name=S18mt-b
Alternative name(s):
28S ribosomal protein S18-2, mitochondrial
Short name=MRP-S18-2
Gene names
Name:MRPS18B
Synonyms:C6orf14
ORF Names:HSPC183, PTD017
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Subcellular location

Mitochondrion Ref.8.

Sequence similarities

Belongs to the ribosomal protein S18P family. Ref.8

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityPolymorphism
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Non-traceable author statement Ref.8. Source: UniProtKB

   Cellular_componentcell junction

Inferred from direct assay. Source: HPA

mitochondrial small ribosomal subunit

Non-traceable author statement Ref.8. Source: UniProtKB

mitochondrion

Inferred from direct assay. Source: HPA

nucleus

Inferred from direct assay. Source: HPA

   Molecular_functionstructural constituent of ribosome

Non-traceable author statement Ref.8. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NFKBIL1Q9UBC11EBI-750085,EBI-1043728

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 25828S ribosomal protein S18b, mitochondrialPRO_0000030627

Natural variations

Natural variant2301P → A.
Corresponds to variant rs34315095 [ dbSNP | Ensembl ].
VAR_052056

Experimental info

Sequence conflict1961G → S in AAH05373. Ref.7

Sequences

Sequence LengthMass (Da)Tools
Q9Y676 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: B4C83E5593796C5D

FASTA25829,396
        10         20         30         40         50         60 
MAASVLNTVL RRLPMLSLFR GSHRVQVPLQ TLCTKAPSEE DSLSSVPISP YKDEPWKYLE 

        70         80         90        100        110        120 
SEEYQERYGS RPVWADYRRN HKGGVPPQRT RKTCIRRNKV VGNPCPICRD HKLHVDFRNV 

       130        140        150        160        170        180 
KLLEQFVCAH TGIIFYAPYT GVCVKQHKRL TQAIQKARDH GLLIYHIPQV EPRDLDFSTS 

       190        200        210        220        230        240 
HGAVSATPPA PTLVSGDPWY PWYNWKQPPE RELSRLRRLY QGHLQEESGP PPESMPKMPP 

       250 
RTPAEASSTG QTGPQSAL 

« Hide

References

« Hide 'large scale' references
[1]Zhang Q.H., Guan Z.Q., Dai M., Song H., Mao Y.F., Wu X.Y., Mao M., Fu G., Luo M., Chen J.H., Hu R.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary tumor.
[2]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A. expand/collapse author list , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Tissue: Peripheral blood leukocyte.
[5]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
[8]"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[9]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF100761 mRNA. Translation: AAD43025.1.
AF151017 mRNA. Translation: AAF36103.1.
AL050361 mRNA. Translation: CAH56415.1.
AB110933 Genomic DNA. Translation: BAD13699.1.
AB110934 Genomic DNA. Translation: BAD13700.1.
AB202094 Genomic DNA. Translation: BAE78614.1.
AL662800 Genomic DNA. Translation: CAI18162.2.
AL662825, AL732442 Genomic DNA. Translation: CAI17840.1.
AL732442, AL662825 Genomic DNA. Translation: CAI17765.1.
BX119957 Genomic DNA. Translation: CAM25911.1.
AL845353, BX248507 Genomic DNA. Translation: CAI41878.1.
BX248507, AL845353 Genomic DNA. Translation: CAI18569.1.
CR753328 Genomic DNA. Translation: CAP58452.1.
CH471081 Genomic DNA. Translation: EAX03304.1.
BC005373 mRNA. Translation: AAH05373.1.
RefSeqNP_054765.1. NM_014046.3.
UniGeneHs.655329.

3D structure databases

ProteinModelPortalQ9Y676.
SMRQ9Y676. Positions 118-166.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118797. 26 interactions.
DIPDIP-29894N.
IntActQ9Y676. 3 interactions.
MINTMINT-1448435.
STRING9606.ENSP00000397790.

PTM databases

PhosphoSiteQ9Y676.

Polymorphism databases

DMDM24212203.

Proteomic databases

PaxDbQ9Y676.
PeptideAtlasQ9Y676.
PRIDEQ9Y676.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000259873; ENSP00000259873; ENSG00000204568.
ENST00000327800; ENSP00000383438; ENSG00000203624.
ENST00000412451; ENSP00000402718; ENSG00000223775.
ENST00000426945; ENSP00000397790; ENSG00000229861.
ENST00000430402; ENSP00000398494; ENSG00000233813.
ENST00000451032; ENSP00000415703; ENSG00000226111.
ENST00000454427; ENSP00000414972; ENSG00000227420.
GeneID28973.
KEGGhsa:28973.
UCSCuc003nqo.2. human.

Organism-specific databases

CTD28973.
GeneCardsGC06P030585.
GC06Pj30575.
GC06Pk30575.
GC06Pl30630.
GC06Pm30663.
GC06Pn30574.
GC06Po30576.
HGNCHGNC:14516. MRPS18B.
HPAHPA043485.
HPA050334.
MIM611982. gene.
neXtProtNX_Q9Y676.
PharmGKBPA31004.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG288650.
HOGENOMHOG000039992.
HOVERGENHBG054347.
InParanoidQ9Y676.
KOK16174.
OMARPVWADY.
PhylomeDBQ9Y676.
TreeFamTF315059.

Gene expression databases

ArrayExpressQ9Y676.
BgeeQ9Y676.
CleanExHS_MRPS18B.
GenevestigatorQ9Y676.

Family and domain databases

Gene3D4.10.640.10. 1 hit.
InterProIPR001648. Ribosomal_S18.
[Graphical view]
PfamPF01084. Ribosomal_S18. 1 hit.
[Graphical view]
ProDomPD002239. Ribosomal_S18. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF46911. SSF46911. 1 hit.
ProtoNetSearch...

Other

ChiTaRSMRPS18B. human.
GeneWikiMRPS18B.
GenomeRNAi28973.
NextBio51843.
PROQ9Y676.
SOURCESearch...

Entry information

Entry nameRT18B_HUMAN
AccessionPrimary (citable) accession number: Q9Y676
Secondary accession number(s): A6NDQ0, Q659G4, Q9BS27
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM