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Q9Y676

- RT18B_HUMAN

UniProt

Q9Y676 - RT18B_HUMAN

Protein

28S ribosomal protein S18b, mitochondrial

Gene

MRPS18B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S18b, mitochondrial
    Short name:
    MRP-S18-b
    Short name:
    Mrps18-b
    Short name:
    S18mt-b
    Alternative name(s):
    28S ribosomal protein S18-2, mitochondrial
    Short name:
    MRP-S18-2
    Gene namesi
    Name:MRPS18B
    Synonyms:C6orf14
    ORF Names:HSPC183, PTD017
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:14516. MRPS18B.

    Subcellular locationi

    Mitochondrion 1 Publication

    GO - Cellular componenti

    1. cell junction Source: HPA
    2. mitochondrial small ribosomal subunit Source: UniProtKB
    3. mitochondrion Source: HPA
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31004.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 25828S ribosomal protein S18b, mitochondrialPRO_0000030627
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiQ9Y676.
    PaxDbiQ9Y676.
    PeptideAtlasiQ9Y676.
    PRIDEiQ9Y676.

    PTM databases

    PhosphoSiteiQ9Y676.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y676.
    BgeeiQ9Y676.
    CleanExiHS_MRPS18B.
    GenevestigatoriQ9Y676.

    Organism-specific databases

    HPAiHPA043485.
    HPA050334.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Protein-protein interaction databases

    BioGridi118797. 25 interactions.
    DIPiDIP-29894N.
    IntActiQ9Y676. 3 interactions.
    MINTiMINT-1448435.
    STRINGi9606.ENSP00000397790.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y676.
    SMRiQ9Y676. Positions 118-166.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S18P family.1 Publication

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG288650.
    HOGENOMiHOG000039992.
    HOVERGENiHBG054347.
    InParanoidiQ9Y676.
    KOiK16174.
    OMAiRPVWADY.
    PhylomeDBiQ9Y676.
    TreeFamiTF315059.

    Family and domain databases

    Gene3Di4.10.640.10. 1 hit.
    InterProiIPR001648. Ribosomal_S18.
    [Graphical view]
    PfamiPF01084. Ribosomal_S18. 1 hit.
    [Graphical view]
    ProDomiPD002239. Ribosomal_S18. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF46911. SSF46911. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y676-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASVLNTVL RRLPMLSLFR GSHRVQVPLQ TLCTKAPSEE DSLSSVPISP    50
    YKDEPWKYLE SEEYQERYGS RPVWADYRRN HKGGVPPQRT RKTCIRRNKV 100
    VGNPCPICRD HKLHVDFRNV KLLEQFVCAH TGIIFYAPYT GVCVKQHKRL 150
    TQAIQKARDH GLLIYHIPQV EPRDLDFSTS HGAVSATPPA PTLVSGDPWY 200
    PWYNWKQPPE RELSRLRRLY QGHLQEESGP PPESMPKMPP RTPAEASSTG 250
    QTGPQSAL 258
    Length:258
    Mass (Da):29,396
    Last modified:November 1, 1999 - v1
    Checksum:iB4C83E5593796C5D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti196 – 1961G → S in AAH05373. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti230 – 2301P → A.
    Corresponds to variant rs34315095 [ dbSNP | Ensembl ].
    VAR_052056

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF100761 mRNA. Translation: AAD43025.1.
    AF151017 mRNA. Translation: AAF36103.1.
    AL050361 mRNA. Translation: CAH56415.1.
    AB110933 Genomic DNA. Translation: BAD13699.1.
    AB110934 Genomic DNA. Translation: BAD13700.1.
    AB202094 Genomic DNA. Translation: BAE78614.1.
    AL662800 Genomic DNA. Translation: CAI18162.2.
    AL662825, AL732442 Genomic DNA. Translation: CAI17840.1.
    AL732442, AL662825 Genomic DNA. Translation: CAI17765.1.
    BX119957 Genomic DNA. Translation: CAM25911.1.
    AL845353, BX248507 Genomic DNA. Translation: CAI41878.1.
    BX248507, AL845353 Genomic DNA. Translation: CAI18569.1.
    CR753328 Genomic DNA. Translation: CAP58452.1.
    CH471081 Genomic DNA. Translation: EAX03304.1.
    BC005373 mRNA. Translation: AAH05373.1.
    CCDSiCCDS4682.1.
    RefSeqiNP_054765.1. NM_014046.3.
    UniGeneiHs.655329.

    Genome annotation databases

    EnsembliENST00000259873; ENSP00000259873; ENSG00000204568.
    ENST00000327800; ENSP00000383438; ENSG00000203624.
    ENST00000412451; ENSP00000402718; ENSG00000223775.
    ENST00000426945; ENSP00000397790; ENSG00000229861.
    ENST00000430402; ENSP00000398494; ENSG00000233813.
    ENST00000451032; ENSP00000415703; ENSG00000226111.
    ENST00000454427; ENSP00000414972; ENSG00000227420.
    GeneIDi28973.
    KEGGihsa:28973.
    UCSCiuc003nqo.2. human.

    Polymorphism databases

    DMDMi24212203.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF100761 mRNA. Translation: AAD43025.1 .
    AF151017 mRNA. Translation: AAF36103.1 .
    AL050361 mRNA. Translation: CAH56415.1 .
    AB110933 Genomic DNA. Translation: BAD13699.1 .
    AB110934 Genomic DNA. Translation: BAD13700.1 .
    AB202094 Genomic DNA. Translation: BAE78614.1 .
    AL662800 Genomic DNA. Translation: CAI18162.2 .
    AL662825 , AL732442 Genomic DNA. Translation: CAI17840.1 .
    AL732442 , AL662825 Genomic DNA. Translation: CAI17765.1 .
    BX119957 Genomic DNA. Translation: CAM25911.1 .
    AL845353 , BX248507 Genomic DNA. Translation: CAI41878.1 .
    BX248507 , AL845353 Genomic DNA. Translation: CAI18569.1 .
    CR753328 Genomic DNA. Translation: CAP58452.1 .
    CH471081 Genomic DNA. Translation: EAX03304.1 .
    BC005373 mRNA. Translation: AAH05373.1 .
    CCDSi CCDS4682.1.
    RefSeqi NP_054765.1. NM_014046.3.
    UniGenei Hs.655329.

    3D structure databases

    ProteinModelPortali Q9Y676.
    SMRi Q9Y676. Positions 118-166.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118797. 25 interactions.
    DIPi DIP-29894N.
    IntActi Q9Y676. 3 interactions.
    MINTi MINT-1448435.
    STRINGi 9606.ENSP00000397790.

    PTM databases

    PhosphoSitei Q9Y676.

    Polymorphism databases

    DMDMi 24212203.

    Proteomic databases

    MaxQBi Q9Y676.
    PaxDbi Q9Y676.
    PeptideAtlasi Q9Y676.
    PRIDEi Q9Y676.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259873 ; ENSP00000259873 ; ENSG00000204568 .
    ENST00000327800 ; ENSP00000383438 ; ENSG00000203624 .
    ENST00000412451 ; ENSP00000402718 ; ENSG00000223775 .
    ENST00000426945 ; ENSP00000397790 ; ENSG00000229861 .
    ENST00000430402 ; ENSP00000398494 ; ENSG00000233813 .
    ENST00000451032 ; ENSP00000415703 ; ENSG00000226111 .
    ENST00000454427 ; ENSP00000414972 ; ENSG00000227420 .
    GeneIDi 28973.
    KEGGi hsa:28973.
    UCSCi uc003nqo.2. human.

    Organism-specific databases

    CTDi 28973.
    GeneCardsi GC06P030585.
    GC06Pj30575.
    GC06Pk30575.
    GC06Pl30630.
    GC06Pm30663.
    GC06Pn30574.
    GC06Po30576.
    HGNCi HGNC:14516. MRPS18B.
    HPAi HPA043485.
    HPA050334.
    MIMi 611982. gene.
    neXtProti NX_Q9Y676.
    PharmGKBi PA31004.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG288650.
    HOGENOMi HOG000039992.
    HOVERGENi HBG054347.
    InParanoidi Q9Y676.
    KOi K16174.
    OMAi RPVWADY.
    PhylomeDBi Q9Y676.
    TreeFami TF315059.

    Miscellaneous databases

    ChiTaRSi MRPS18B. human.
    GeneWikii MRPS18B.
    GenomeRNAii 28973.
    NextBioi 51843.
    PROi Q9Y676.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y676.
    Bgeei Q9Y676.
    CleanExi HS_MRPS18B.
    Genevestigatori Q9Y676.

    Family and domain databases

    Gene3Di 4.10.640.10. 1 hit.
    InterProi IPR001648. Ribosomal_S18.
    [Graphical view ]
    Pfami PF01084. Ribosomal_S18. 1 hit.
    [Graphical view ]
    ProDomi PD002239. Ribosomal_S18. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF46911. SSF46911. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Zhang Q.H., Guan Z.Q., Dai M., Song H., Mao Y.F., Wu X.Y., Mao M., Fu G., Luo M., Chen J.H., Hu R.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary tumor.
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
      Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
      , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
      Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Tissue: Peripheral blood leukocyte.
    5. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    8. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT18B_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y676
    Secondary accession number(s): A6NDQ0, Q659G4, Q9BS27
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 115 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3