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Protein

SNRPN upstream reading frame protein

Gene

SNURF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Encoded on a bicistronic transcript that code for two proteins, SNRPN and SNURF. In addition to the primary 1.6-kb bicistronic SNURF-SNRPN transcript, SNURF-only transcript is also detected.

Names & Taxonomyi

Protein namesi
Recommended name:
SNRPN upstream reading frame protein
Gene namesi
Name:SNURF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:11171. SNURF.

Subcellular locationi

GO - Cellular componenti

  • nuclear speck Source: HPA
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8926.
OpenTargetsiENSG00000273173.
PharmGKBiPA36010.

Polymorphism and mutation databases

BioMutaiSNURF.
DMDMi74721518.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129931 – 71SNRPN upstream reading frame proteinAdd BLAST71

Proteomic databases

EPDiQ9Y675.
PaxDbiQ9Y675.
PeptideAtlasiQ9Y675.
PRIDEiQ9Y675.

PTM databases

iPTMnetiQ9Y675.
PhosphoSitePlusiQ9Y675.

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle and lymphoblasts (at protein level). Expressed in brain, pancreas, heart, liver, lung, kidney and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000273173.
ExpressionAtlasiQ9Y675. baseline and differential.
GenevisibleiQ9Y675. HS.

Organism-specific databases

HPAiHPA065733.

Interactioni

Protein-protein interaction databases

BioGridi114440. 2 interactors.
IntActiQ9Y675. 8 interactors.
MINTiMINT-1375900.
STRINGi9606.ENSP00000336543.

Structurei

3D structure databases

ProteinModelPortaliQ9Y675.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNURF family.Curated

Phylogenomic databases

eggNOGiENOG410J0MJ. Eukaryota.
ENOG41115Q9. LUCA.
GeneTreeiENSGT00390000009320.
HOGENOMiHOG000154361.
HOVERGENiHBG098497.
InParanoidiQ9Y675.
OMAiCHLYPRR.
OrthoDBiEOG091G150Y.
PhylomeDBiQ9Y675.
TreeFamiTF338383.

Family and domain databases

InterProiView protein in InterPro
IPR009847. SNURF.
PANTHERiPTHR14508. PTHR14508. 1 hit.
PfamiView protein in Pfam
PF07192. SNURF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERARDRLHL RRTTEQHVPE VEVQVKRRRT ASLSNQECQL YPRRSQQQQV
60 70
PVVDFQAELR QAFLAETPRG G
Length:71
Mass (Da):8,412
Last modified:November 1, 1999 - v1
Checksum:i71FC8B9F247302C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF101044 mRNA. Translation: AAD31391.1.
AC124312 Genomic DNA. No translation available.
CH471151 Genomic DNA. Translation: EAW57625.1.
CCDSiCCDS10016.1.
RefSeqiNP_005669.2. NM_005678.4.
NP_073715.1. NM_022804.2.
UniGeneiHs.564847.

Genome annotation databases

EnsembliENST00000338327; ENSP00000342152; ENSG00000273173.
ENST00000577949; ENSP00000463201; ENSG00000273173.
ENST00000580062; ENSP00000463396; ENSG00000273173.
GeneIDi8926.
KEGGihsa:8926.
UCSCiuc001ywu.4. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSNURF_HUMAN
AccessioniPrimary (citable) accession number: Q9Y675
Secondary accession number(s): A6NCW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 1, 1999
Last modified: March 15, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families