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Q9Y673

- ALG5_HUMAN

UniProt

Q9Y673 - ALG5_HUMAN

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Protein

Dolichyl-phosphate beta-glucosyltransferase

Gene

ALG5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate.

Pathwayi

GO - Molecular functioni

  1. dolichyl-phosphate beta-glucosyltransferase activity Source: UniProtKB-EC
  2. oligosaccharyl transferase activity Source: ProtInc

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. determination of left/right symmetry Source: Ensembl
  3. dolichol-linked oligosaccharide biosynthetic process Source: Reactome
  4. post-translational protein modification Source: Reactome
  5. protein glycosylation Source: ProtInc
  6. protein N-linked glycosylation via asparagine Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_22346. Synthesis of dolichyl-phosphate-glucose.
SABIO-RKQ9Y673.
UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Dolichyl-phosphate beta-glucosyltransferase (EC:2.4.1.117)
Short name:
DolP-glucosyltransferase
Alternative name(s):
Asparagine-linked glycosylation protein 5 homolog
Gene namesi
Name:ALG5
ORF Names:HSPC149
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 13

Organism-specific databases

HGNCiHGNC:20266. ALG5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence Analysis
Transmembranei8 – 2821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini29 – 324296LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134977026.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Dolichyl-phosphate beta-glucosyltransferasePRO_0000059098Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi281 – 2811N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9Y673.
PaxDbiQ9Y673.
PRIDEiQ9Y673.

PTM databases

PhosphoSiteiQ9Y673.

Expressioni

Tissue specificityi

Expressed in pancreas, placenta, liver, heart, brain, kidney, skeletal muscle, and lung.

Gene expression databases

BgeeiQ9Y673.
CleanExiHS_ALG5.
GenevestigatoriQ9Y673.

Organism-specific databases

HPAiHPA007989.

Interactioni

Protein-protein interaction databases

BioGridi118935. 7 interactions.
STRINGi9606.ENSP00000239891.

Structurei

3D structure databases

ProteinModelPortaliQ9Y673.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 2 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0463.
GeneTreeiENSGT00550000074941.
HOGENOMiHOG000283250.
HOVERGENiHBG024330.
InParanoidiQ9Y673.
KOiK00729.
OMAiVRMGVFS.
OrthoDBiEOG7XPZ6G.
PhylomeDBiQ9Y673.
TreeFamiTF314844.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y673-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAPLLLQLAV LGAALAAAAL VLISIVAFTT ATKMPALHRH EEEKFFLNAK
60 70 80 90 100
GQKETLPSIW DSPTKQLSVV VPSYNEEKRL PVMMDEALSY LEKRQKRDPA
110 120 130 140 150
FTYEVIVVDD GSKDQTSKVA FKYCQKYGSD KVRVITLVKN RGKGGAIRMG
160 170 180 190 200
IFSSRGEKIL MADADGATKF PDVEKLEKGL NDLQPWPNQM AIACGSRAHL
210 220 230 240 250
EKESIAQRSY FRTLLMYGFH FLVWFLCVKG IRDTQCGFKL FTREAASRTF
260 270 280 290 300
SSLHVERWAF DVELLYIAQF FKIPIAEIAV NWTEIEGSKL VPFWSWLQMG
310 320
KDLLFIRLRY LTGAWRLEQT RKMN
Length:324
Mass (Da):36,946
Last modified:November 1, 1999 - v1
Checksum:i44E1826BAB5B36CB
GO
Isoform 2 (identifier: Q9Y673-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.

Note: No experimental confirmation available.

Show »
Length:294
Mass (Da):33,525
Checksum:i3A5E796B95FDC6C6
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei95 – 12430Missing in isoform 2. 1 PublicationVSP_041019Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102850 mRNA. Translation: AAD41465.1.
AF161498 mRNA. Translation: AAF29113.1.
AK299085 mRNA. Translation: BAG61149.1.
AL138706 Genomic DNA. Translation: CAI14011.1.
CH471075 Genomic DNA. Translation: EAX08578.1.
BC012531 mRNA. Translation: AAH12531.1.
CCDSiCCDS45033.1. [Q9Y673-2]
CCDS9361.1. [Q9Y673-1]
PIRiT51776.
RefSeqiNP_001135836.1. NM_001142364.1. [Q9Y673-2]
NP_037470.1. NM_013338.4. [Q9Y673-1]
UniGeneiHs.507769.

Genome annotation databases

EnsembliENST00000239891; ENSP00000239891; ENSG00000120697. [Q9Y673-1]
ENST00000443765; ENSP00000390533; ENSG00000120697. [Q9Y673-2]
GeneIDi29880.
KEGGihsa:29880.
UCSCiuc001uvy.3. human. [Q9Y673-1]
uc010teq.2. human. [Q9Y673-2]

Polymorphism databases

DMDMi27734217.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF102850 mRNA. Translation: AAD41465.1 .
AF161498 mRNA. Translation: AAF29113.1 .
AK299085 mRNA. Translation: BAG61149.1 .
AL138706 Genomic DNA. Translation: CAI14011.1 .
CH471075 Genomic DNA. Translation: EAX08578.1 .
BC012531 mRNA. Translation: AAH12531.1 .
CCDSi CCDS45033.1. [Q9Y673-2 ]
CCDS9361.1. [Q9Y673-1 ]
PIRi T51776.
RefSeqi NP_001135836.1. NM_001142364.1. [Q9Y673-2 ]
NP_037470.1. NM_013338.4. [Q9Y673-1 ]
UniGenei Hs.507769.

3D structure databases

ProteinModelPortali Q9Y673.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118935. 7 interactions.
STRINGi 9606.ENSP00000239891.

Protein family/group databases

CAZyi GT2. Glycosyltransferase Family 2.

PTM databases

PhosphoSitei Q9Y673.

Polymorphism databases

DMDMi 27734217.

Proteomic databases

MaxQBi Q9Y673.
PaxDbi Q9Y673.
PRIDEi Q9Y673.

Protocols and materials databases

DNASUi 29880.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000239891 ; ENSP00000239891 ; ENSG00000120697 . [Q9Y673-1 ]
ENST00000443765 ; ENSP00000390533 ; ENSG00000120697 . [Q9Y673-2 ]
GeneIDi 29880.
KEGGi hsa:29880.
UCSCi uc001uvy.3. human. [Q9Y673-1 ]
uc010teq.2. human. [Q9Y673-2 ]

Organism-specific databases

CTDi 29880.
GeneCardsi GC13M037523.
HGNCi HGNC:20266. ALG5.
HPAi HPA007989.
MIMi 604565. gene.
neXtProti NX_Q9Y673.
PharmGKBi PA134977026.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0463.
GeneTreei ENSGT00550000074941.
HOGENOMi HOG000283250.
HOVERGENi HBG024330.
InParanoidi Q9Y673.
KOi K00729.
OMAi VRMGVFS.
OrthoDBi EOG7XPZ6G.
PhylomeDBi Q9Y673.
TreeFami TF314844.

Enzyme and pathway databases

UniPathwayi UPA00378 .
Reactomei REACT_22346. Synthesis of dolichyl-phosphate-glucose.
SABIO-RK Q9Y673.

Miscellaneous databases

ChiTaRSi ALG5. human.
GenomeRNAii 29880.
NextBioi 52401.
PROi Q9Y673.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y673.
CleanExi HS_ALG5.
Genevestigatori Q9Y673.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF00535. Glycos_transf_2. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic."
    Imbach T., Burda P., Kuhnert P., Wevers R.A., Aebi M., Berger E.G., Hennet T.
    Proc. Natl. Acad. Sci. U.S.A. 96:6982-6987(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Umbilical cord blood.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Prostate.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiALG5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y673
Secondary accession number(s): B4DR37, Q5TBA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3