##gff-version 3 Q9Y657 UniProtKB Chain 1 262 . . . ID=PRO_0000181367;Note=Spindlin-1 Q9Y657 UniProtKB Region 1 51 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q9Y657 UniProtKB Region 53 116 . . . Note=Tudor-like domain 1 Q9Y657 UniProtKB Region 93 98 . . . Note=Histone H3K4me3 and H3R8me2a binding Q9Y657 UniProtKB Region 132 193 . . . Note=Tudor-like domain 2 Q9Y657 UniProtKB Region 142 142 . . . Note=Histone H3K4me3 and H3R8me2a binding Q9Y657 UniProtKB Region 213 262 . . . Note=Tudor-like domain 3 Q9Y657 UniProtKB Region 250 252 . . . Note=Histone H3K4me3 and H3R8me2a binding Q9Y657 UniProtKB Site 173 173 . . . Note=Histone H3K4me3 and H3R8me2a binding Q9Y657 UniProtKB Site 180 180 . . . Note=Histone H3K4me3 and H3R8me2a binding Q9Y657 UniProtKB Site 184 184 . . . Note=Histone H3K4me3 and H3R8me2a binding Q9Y657 UniProtKB Modified residue 44 44 . . . Note=N6-acetyllysine%3B alternate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q61142 Q9Y657 UniProtKB Modified residue 109 109 . . . Note=Phosphoserine%3B by AURKA;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22258766;Dbxref=PMID:22258766 Q9Y657 UniProtKB Modified residue 124 124 . . . Note=Phosphoserine%3B by AURKA;Ontology_term=ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:22258766,ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:20068231,PMID:22258766,PMID:23186163 Q9Y657 UniProtKB Modified residue 199 199 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q9Y657 UniProtKB Cross-link 7 7 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9Y657 UniProtKB Cross-link 28 28 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2);Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9Y657 UniProtKB Cross-link 44 44 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)%3B alternate;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:28112733;Dbxref=PMID:28112733 Q9Y657 UniProtKB Natural variant 221 221 . . . ID=VAR_053690;Note=A->P;Dbxref=dbSNP:rs34794905 Q9Y657 UniProtKB Mutagenesis 72 72 . . . Note=Impaired binding to histone H3K4me3 and H3R8me2a and impaired ability to activate the Wnt signaling pathway. W->A%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24589551;Dbxref=PMID:24589551 Q9Y657 UniProtKB Mutagenesis 98 98 . . . Note=Impaired binding to histone H3K4me3 and H3R8me2a and impaired ability to activate the Wnt signaling pathway. Y->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24589551;Dbxref=PMID:24589551 Q9Y657 UniProtKB Mutagenesis 109 109 . . . Note=Impaired phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22258766;Dbxref=PMID:22258766 Q9Y657 UniProtKB Mutagenesis 124 124 . . . Note=Impaired phosphorylation. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:22258766;Dbxref=PMID:22258766 Q9Y657 UniProtKB Mutagenesis 141 141 . . . Note=Impaired binding to histone H3K4me3 and H3R8me2a and impaired ability to activate the Wnt signaling pathway. Impaired ability to activate expression of pre-rRNA. F->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21960006,ECO:0000269|PubMed:24589551;Dbxref=PMID:21960006,PMID:24589551 Q9Y657 UniProtKB Mutagenesis 142 142 . . . Note=Impaired binding to histone H3K4me3 and H3R8me2a. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24589551;Dbxref=PMID:24589551 Q9Y657 UniProtKB Mutagenesis 170 170 . . . Note=Impaired binding to histone H3K4me3 and H3R8me2a and impaired ability to activate the Wnt signaling pathway. Impaired ability to activate expression of pre-rRNA. Y->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:21960006,ECO:0000269|PubMed:24589551;Dbxref=PMID:21960006,PMID:24589551 Q9Y657 UniProtKB Mutagenesis 177 177 . . . Note=Impaired binding to histone H3K4me3 and H3R8me2a. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24589551;Dbxref=PMID:24589551 Q9Y657 UniProtKB Mutagenesis 184 184 . . . Note=Impaired binding to histone H3K4me3 and H3R8me2a. D->A%2CR;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:23077255,ECO:0000269|PubMed:24589551;Dbxref=PMID:23077255,PMID:24589551 Q9Y657 UniProtKB Mutagenesis 189 189 . . . Note=Impaired binding to histone H3K4me3. D->A%2CR;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:23077255;Dbxref=PMID:23077255 Q9Y657 UniProtKB Mutagenesis 251 251 . . . Note=Impaired binding to histone H3K4me3 and H3R8me2a and impaired ability to activate the Wnt signaling pathway. F->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24589551;Dbxref=PMID:24589551 Q9Y657 UniProtKB Sequence conflict 49 49 . . . Note=P->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q9Y657 UniProtKB Beta strand 57 62 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Beta strand 65 67 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4MZH Q9Y657 UniProtKB Beta strand 70 79 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Beta strand 86 91 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Beta strand 98 101 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Turn 102 104 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Beta strand 108 113 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Beta strand 117 119 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6I8B Q9Y657 UniProtKB Helix 126 132 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Beta strand 136 142 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Beta strand 144 146 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:2NS2 Q9Y657 UniProtKB Beta strand 148 158 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Beta strand 160 162 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Beta strand 166 170 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Beta strand 173 179 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Helix 181 186 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Beta strand 190 192 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Helix 206 209 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7CNA Q9Y657 UniProtKB Beta strand 217 220 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Turn 223 225 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H75 Q9Y657 UniProtKB Beta strand 228 235 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Beta strand 237 239 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:4H75 Q9Y657 UniProtKB Beta strand 242 247 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB Q9Y657 UniProtKB Beta strand 254 257 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:7OCB