Q9Y651 (SOX21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor SOX-21

Alternative name(s):
SOX-A

Gene names

Name:	SOX21
Synonyms:	SOX25, SOXA

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May play a role as an activator of transcription of OPRM1 By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Contains 1 HMG box DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	hair follicle development Inferred from electronic annotation. Source: Compara skin development Inferred from electronic annotation. Source: Compara stem cell differentiation Inferred from direct assay PubMed 20876214. Source: UniProtKB
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from sequence or structural similarity. Source: UniProtKB sequence-specific DNA binding RNA polymerase II transcription factor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Transcription factor SOX-21		PRO_0000048770
Regions
	DNA binding	8 – 76	69	HMG box
Natural variations
	Natural variant	230	1	G → R. Corresponds to variant rs6492735 [ dbSNP | Ensembl ].		VAR_049562
Experimental info
	Sequence conflict	41	1	R → P in CAA50466. Ref.4
	Sequence conflict	83	1	P → T in CAA50466. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Q9Y651 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 99DC899B7EC9A96B	FASTA	276	28,580
	10 20 30 40 50 60 MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT ESEKRPFIDE 70 80 90 100 110 120 AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL GGVADAEHPA LKAGAGLHAG 130 140 150 160 170 180 AGGGLVPESL LANPEKAAAA AAAAAARVFF PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA 190 200 210 220 230 240 EISSSSSGLP YASSLGYPTA GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC 250 260 270 SAWPSPGLQP PLAYILLPGM GKPQLDPYPA AYAAAL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3." Malas S., Duthie S., Deloukas P., Episkopou V. Mamm. Genome 10:934-937(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Stevanovic M. Submitted (APR-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-87. Tissue: Spinal cord.
[5]	"A conserved family of genes related to the testis determining gene, SRY." Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A. Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-72.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF107044 Genomic DNA. Translation: AAC95381.1. AL137061 Genomic DNA. Translation: CAI14398.1. CH471085 Genomic DNA. Translation: EAX08946.1. X71136 mRNA. Translation: CAA50466.1. X65666 mRNA. Translation: CAA46617.1.
IPI	IPI00001824.
PIR	I38238. S22937.
RefSeq	NP_009015.1. NM_007084.2.
UniGene	Hs.187577.
3D structure databases
ProteinModelPortal	Q9Y651.
ModBase	Search...
PTM databases
PhosphoSite	Q9Y651.
Polymorphism databases
DMDM	6831690.
Proteomic databases
PaxDb	Q9Y651.
PRIDE	Q9Y651.
Protocols and materials databases
DNASU	11166.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376945; ENSP00000366144; ENSG00000125285.
GeneID	11166.
KEGG	hsa:11166.
UCSC	uc001vma.3. human.
Organism-specific databases
CTD	11166.
GeneCards	GC13M095361.
H-InvDB	HIX0037360.
HGNC	HGNC:11197. SOX21.
MIM	604974. gene.
neXtProt	NX_Q9Y651.
PharmGKB	PA36034.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG302715.
HOGENOM	HOG000231647.
HOVERGEN	HBG105618.
InParanoid	Q9Y651.
KO	K09267.
OMA	KPKTLMK.
OrthoDB	EOG4S1T8V.
PhylomeDB	Q9Y651.
Gene expression databases
Bgee	Q9Y651.
CleanEx	HS_SOX21.
Genevestigator	Q9Y651.
GermOnline	ENSG00000125285. Homo sapiens.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR009071. HMG_box_dom. IPR022097. TF_SOX. [Graphical view]
Pfam	PF00505. HMG_box. 1 hit. PF12336. SOXp. 1 hit. [Graphical view]
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	11166.
NextBio	42483.
SOURCE	Search...

Entry information

Entry name

SOX21_HUMAN

Accession

Primary (citable) accession number: Q9Y651
Secondary accession number(s): P35715, Q15504, Q5TBS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.