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Protein

Transcription factor SOX-21

Gene

SOX21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role as an activator of transcription of OPRM1.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi8 – 7669HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. hair follicle development Source: Ensembl
  2. regulation of transcription, DNA-templated Source: UniProtKB
  3. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  4. stem cell differentiation Source: UniProtKB
  5. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-21
Alternative name(s):
SOX-A
Gene namesi
Name:SOX21
Synonyms:SOX25, SOXA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:11197. SOX21.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36034.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Transcription factor SOX-21PRO_0000048770Add
BLAST

Proteomic databases

PaxDbiQ9Y651.
PRIDEiQ9Y651.

PTM databases

PhosphoSiteiQ9Y651.

Expressioni

Gene expression databases

BgeeiQ9Y651.
CleanExiHS_SOX21.
GenevestigatoriQ9Y651.

Interactioni

Protein-protein interaction databases

BioGridi116337. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9Y651.
SMRiQ9Y651. Positions 6-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG302715.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105618.
InParanoidiQ9Y651.
KOiK09267.
OMAiKPKTLMK.
OrthoDBiEOG7TMZVP.
PhylomeDBiQ9Y651.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022097. TF_SOX.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT
60 70 80 90 100
ESEKRPFIDE AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL
110 120 130 140 150
GGVADAEHPA LKAGAGLHAG AGGGLVPESL LANPEKAAAA AAAAAARVFF
160 170 180 190 200
PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA EISSSSSGLP YASSLGYPTA
210 220 230 240 250
GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC SAWPSPGLQP
260 270
PLAYILLPGM GKPQLDPYPA AYAAAL
Length:276
Mass (Da):28,580
Last modified:October 31, 1999 - v1
Checksum:i99DC899B7EC9A96B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411R → P in CAA50466 (Ref. 4) Curated
Sequence conflicti83 – 831P → T in CAA50466 (Ref. 4) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti230 – 2301G → R.
Corresponds to variant rs6492735 [ dbSNP | Ensembl ].
VAR_049562

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107044 Genomic DNA. Translation: AAC95381.1.
AL137061 Genomic DNA. Translation: CAI14398.1.
CH471085 Genomic DNA. Translation: EAX08946.1.
X71136 mRNA. Translation: CAA50466.1.
X65666 mRNA. Translation: CAA46617.1.
CCDSiCCDS9473.1.
PIRiI38238.
S22937.
RefSeqiNP_009015.1. NM_007084.3.
UniGeneiHs.187577.

Genome annotation databases

EnsembliENST00000376945; ENSP00000366144; ENSG00000125285.
GeneIDi11166.
KEGGihsa:11166.
UCSCiuc001vma.3. human.

Polymorphism databases

DMDMi6831690.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107044 Genomic DNA. Translation: AAC95381.1.
AL137061 Genomic DNA. Translation: CAI14398.1.
CH471085 Genomic DNA. Translation: EAX08946.1.
X71136 mRNA. Translation: CAA50466.1.
X65666 mRNA. Translation: CAA46617.1.
CCDSiCCDS9473.1.
PIRiI38238.
S22937.
RefSeqiNP_009015.1. NM_007084.3.
UniGeneiHs.187577.

3D structure databases

ProteinModelPortaliQ9Y651.
SMRiQ9Y651. Positions 6-82.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116337. 1 interaction.

PTM databases

PhosphoSiteiQ9Y651.

Polymorphism databases

DMDMi6831690.

Proteomic databases

PaxDbiQ9Y651.
PRIDEiQ9Y651.

Protocols and materials databases

DNASUi11166.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376945; ENSP00000366144; ENSG00000125285.
GeneIDi11166.
KEGGihsa:11166.
UCSCiuc001vma.3. human.

Organism-specific databases

CTDi11166.
GeneCardsiGC13M095361.
H-InvDBHIX0037360.
HGNCiHGNC:11197. SOX21.
MIMi604974. gene.
neXtProtiNX_Q9Y651.
PharmGKBiPA36034.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG302715.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105618.
InParanoidiQ9Y651.
KOiK09267.
OMAiKPKTLMK.
OrthoDBiEOG7TMZVP.
PhylomeDBiQ9Y651.
TreeFamiTF351735.

Miscellaneous databases

GeneWikiiSOX21.
GenomeRNAii11166.
NextBioi42483.
PROiQ9Y651.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y651.
CleanExiHS_SOX21.
GenevestigatoriQ9Y651.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022097. TF_SOX.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3."
    Malas S., Duthie S., Deloukas P., Episkopou V.
    Mamm. Genome 10:934-937(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Stevanovic M.
    Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-87.
    Tissue: Spinal cord.
  5. "A conserved family of genes related to the testis determining gene, SRY."
    Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
    Nucleic Acids Res. 20:2887-2887(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-72.

Entry informationi

Entry nameiSOX21_HUMAN
AccessioniPrimary (citable) accession number: Q9Y651
Secondary accession number(s): P35715, Q15504, Q5TBS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2000
Last sequence update: October 31, 1999
Last modified: March 31, 2015
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.