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Q9Y651

- SOX21_HUMAN

UniProt

Q9Y651 - SOX21_HUMAN

Protein

Transcription factor SOX-21

Gene

SOX21

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    May play a role as an activator of transcription of OPRM1.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi8 – 7669HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. hair follicle development Source: Ensembl
    2. regulation of transcription, DNA-templated Source: UniProtKB
    3. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    4. stem cell differentiation Source: UniProtKB
    5. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-21
    Alternative name(s):
    SOX-A
    Gene namesi
    Name:SOX21
    Synonyms:SOX25, SOXA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:11197. SOX21.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36034.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 276276Transcription factor SOX-21PRO_0000048770Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y651.
    PRIDEiQ9Y651.

    PTM databases

    PhosphoSiteiQ9Y651.

    Expressioni

    Gene expression databases

    BgeeiQ9Y651.
    CleanExiHS_SOX21.
    GenevestigatoriQ9Y651.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y651.
    SMRiQ9Y651. Positions 6-82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG302715.
    HOGENOMiHOG000231647.
    HOVERGENiHBG105618.
    InParanoidiQ9Y651.
    KOiK09267.
    OMAiKPKTLMK.
    OrthoDBiEOG7TMZVP.
    PhylomeDBiQ9Y651.
    TreeFamiTF351735.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR022097. TF_SOX.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    PF12336. SOXp. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y651-1 [UniParc]FASTAAdd to Basket

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    MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT    50
    ESEKRPFIDE AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL 100
    GGVADAEHPA LKAGAGLHAG AGGGLVPESL LANPEKAAAA AAAAAARVFF 150
    PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA EISSSSSGLP YASSLGYPTA 200
    GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC SAWPSPGLQP 250
    PLAYILLPGM GKPQLDPYPA AYAAAL 276
    Length:276
    Mass (Da):28,580
    Last modified:November 1, 1999 - v1
    Checksum:i99DC899B7EC9A96B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti41 – 411R → P in CAA50466. 1 PublicationCurated
    Sequence conflicti83 – 831P → T in CAA50466. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti230 – 2301G → R.
    Corresponds to variant rs6492735 [ dbSNP | Ensembl ].
    VAR_049562

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF107044 Genomic DNA. Translation: AAC95381.1.
    AL137061 Genomic DNA. Translation: CAI14398.1.
    CH471085 Genomic DNA. Translation: EAX08946.1.
    X71136 mRNA. Translation: CAA50466.1.
    X65666 mRNA. Translation: CAA46617.1.
    CCDSiCCDS9473.1.
    PIRiI38238.
    S22937.
    RefSeqiNP_009015.1. NM_007084.2.
    UniGeneiHs.187577.

    Genome annotation databases

    EnsembliENST00000376945; ENSP00000366144; ENSG00000125285.
    GeneIDi11166.
    KEGGihsa:11166.
    UCSCiuc001vma.3. human.

    Polymorphism databases

    DMDMi6831690.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF107044 Genomic DNA. Translation: AAC95381.1 .
    AL137061 Genomic DNA. Translation: CAI14398.1 .
    CH471085 Genomic DNA. Translation: EAX08946.1 .
    X71136 mRNA. Translation: CAA50466.1 .
    X65666 mRNA. Translation: CAA46617.1 .
    CCDSi CCDS9473.1.
    PIRi I38238.
    S22937.
    RefSeqi NP_009015.1. NM_007084.2.
    UniGenei Hs.187577.

    3D structure databases

    ProteinModelPortali Q9Y651.
    SMRi Q9Y651. Positions 6-82.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9Y651.

    Polymorphism databases

    DMDMi 6831690.

    Proteomic databases

    PaxDbi Q9Y651.
    PRIDEi Q9Y651.

    Protocols and materials databases

    DNASUi 11166.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376945 ; ENSP00000366144 ; ENSG00000125285 .
    GeneIDi 11166.
    KEGGi hsa:11166.
    UCSCi uc001vma.3. human.

    Organism-specific databases

    CTDi 11166.
    GeneCardsi GC13M095361.
    H-InvDB HIX0037360.
    HGNCi HGNC:11197. SOX21.
    MIMi 604974. gene.
    neXtProti NX_Q9Y651.
    PharmGKBi PA36034.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG302715.
    HOGENOMi HOG000231647.
    HOVERGENi HBG105618.
    InParanoidi Q9Y651.
    KOi K09267.
    OMAi KPKTLMK.
    OrthoDBi EOG7TMZVP.
    PhylomeDBi Q9Y651.
    TreeFami TF351735.

    Miscellaneous databases

    GeneWikii SOX21.
    GenomeRNAii 11166.
    NextBioi 42483.
    PROi Q9Y651.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y651.
    CleanExi HS_SOX21.
    Genevestigatori Q9Y651.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR022097. TF_SOX.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    PF12336. SOXp. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3."
      Malas S., Duthie S., Deloukas P., Episkopou V.
      Mamm. Genome 10:934-937(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Stevanovic M.
      Submitted (APR-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-87.
      Tissue: Spinal cord.
    5. "A conserved family of genes related to the testis determining gene, SRY."
      Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
      Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-72.

    Entry informationi

    Entry nameiSOX21_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y651
    Secondary accession number(s): P35715, Q15504, Q5TBS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3