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Protein

Transcription factor SOX-21

Gene

SOX21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role as an activator of transcription of OPRM1.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi8 – 76HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125285-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-21
Alternative name(s):
SOX-A
Gene namesi
Name:SOX21
Synonyms:SOX25, SOXA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:11197. SOX21.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11166.
OpenTargetsiENSG00000125285.
PharmGKBiPA36034.

Polymorphism and mutation databases

BioMutaiSOX21.
DMDMi6831690.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487701 – 276Transcription factor SOX-21Add BLAST276

Proteomic databases

EPDiQ9Y651.
MaxQBiQ9Y651.
PaxDbiQ9Y651.
PeptideAtlasiQ9Y651.
PRIDEiQ9Y651.

PTM databases

iPTMnetiQ9Y651.
PhosphoSitePlusiQ9Y651.

Expressioni

Gene expression databases

BgeeiENSG00000125285.
CleanExiHS_SOX21.
GenevisibleiQ9Y651. HS.

Interactioni

Protein-protein interaction databases

BioGridi116337. 3 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ9Y651.
SMRiQ9Y651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IPZA. Eukaryota.
ENOG4110UF6. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105618.
InParanoidiQ9Y651.
KOiK09267.
OMAiKPQLEPY.
OrthoDBiEOG091G0F15.
PhylomeDBiQ9Y651.
TreeFamiTF351735.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022097. SOX_fam.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT
60 70 80 90 100
ESEKRPFIDE AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL
110 120 130 140 150
GGVADAEHPA LKAGAGLHAG AGGGLVPESL LANPEKAAAA AAAAAARVFF
160 170 180 190 200
PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA EISSSSSGLP YASSLGYPTA
210 220 230 240 250
GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC SAWPSPGLQP
260 270
PLAYILLPGM GKPQLDPYPA AYAAAL
Length:276
Mass (Da):28,580
Last modified:November 1, 1999 - v1
Checksum:i99DC899B7EC9A96B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41R → P in CAA50466 (Ref. 4) Curated1
Sequence conflicti83P → T in CAA50466 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049562230G → R.Corresponds to variant rs6492735dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107044 Genomic DNA. Translation: AAC95381.1.
AL137061 Genomic DNA. Translation: CAI14398.1.
CH471085 Genomic DNA. Translation: EAX08946.1.
X71136 mRNA. Translation: CAA50466.1.
X65666 mRNA. Translation: CAA46617.1.
CCDSiCCDS9473.1.
PIRiI38238.
S22937.
RefSeqiNP_009015.1. NM_007084.3.
UniGeneiHs.187577.

Genome annotation databases

EnsembliENST00000376945; ENSP00000366144; ENSG00000125285.
GeneIDi11166.
KEGGihsa:11166.
UCSCiuc001vma.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107044 Genomic DNA. Translation: AAC95381.1.
AL137061 Genomic DNA. Translation: CAI14398.1.
CH471085 Genomic DNA. Translation: EAX08946.1.
X71136 mRNA. Translation: CAA50466.1.
X65666 mRNA. Translation: CAA46617.1.
CCDSiCCDS9473.1.
PIRiI38238.
S22937.
RefSeqiNP_009015.1. NM_007084.3.
UniGeneiHs.187577.

3D structure databases

ProteinModelPortaliQ9Y651.
SMRiQ9Y651.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116337. 3 interactors.

PTM databases

iPTMnetiQ9Y651.
PhosphoSitePlusiQ9Y651.

Polymorphism and mutation databases

BioMutaiSOX21.
DMDMi6831690.

Proteomic databases

EPDiQ9Y651.
MaxQBiQ9Y651.
PaxDbiQ9Y651.
PeptideAtlasiQ9Y651.
PRIDEiQ9Y651.

Protocols and materials databases

DNASUi11166.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376945; ENSP00000366144; ENSG00000125285.
GeneIDi11166.
KEGGihsa:11166.
UCSCiuc001vma.4. human.

Organism-specific databases

CTDi11166.
DisGeNETi11166.
GeneCardsiSOX21.
H-InvDBHIX0037360.
HGNCiHGNC:11197. SOX21.
MIMi604974. gene.
neXtProtiNX_Q9Y651.
OpenTargetsiENSG00000125285.
PharmGKBiPA36034.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IPZA. Eukaryota.
ENOG4110UF6. LUCA.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000231647.
HOVERGENiHBG105618.
InParanoidiQ9Y651.
KOiK09267.
OMAiKPQLEPY.
OrthoDBiEOG091G0F15.
PhylomeDBiQ9Y651.
TreeFamiTF351735.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125285-MONOMER.

Miscellaneous databases

GeneWikiiSOX21.
GenomeRNAii11166.
PROiQ9Y651.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125285.
CleanExiHS_SOX21.
GenevisibleiQ9Y651. HS.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR022097. SOX_fam.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSOX21_HUMAN
AccessioniPrimary (citable) accession number: Q9Y651
Secondary accession number(s): P35715, Q15504, Q5TBS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.