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Protein

Transcription factor SOX-21

Gene

SOX21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role as an activator of transcription of OPRM1.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi8 – 76HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

  • hair follicle development Source: Ensembl
  • regulation of transcription, DNA-templated Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: UniProtKB
  • stem cell differentiation Source: UniProtKB

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-21
Alternative name(s):
SOX-A
Gene namesi
Name:SOX21
Synonyms:SOX25, SOXA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000125285.5
HGNCiHGNC:11197 SOX21
MIMi604974 gene
neXtProtiNX_Q9Y651

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11166
OpenTargetsiENSG00000125285
PharmGKBiPA36034

Polymorphism and mutation databases

BioMutaiSOX21
DMDMi6831690

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487701 – 276Transcription factor SOX-21Add BLAST276

Proteomic databases

EPDiQ9Y651
MaxQBiQ9Y651
PaxDbiQ9Y651
PeptideAtlasiQ9Y651
PRIDEiQ9Y651

PTM databases

iPTMnetiQ9Y651
PhosphoSitePlusiQ9Y651

Expressioni

Gene expression databases

BgeeiENSG00000125285
CleanExiHS_SOX21
GenevisibleiQ9Y651 HS

Organism-specific databases

HPAiHPA064084

Interactioni

Protein-protein interaction databases

BioGridi116337, 3 interactors
STRINGi9606.ENSP00000366144

Structurei

3D structure databases

ProteinModelPortaliQ9Y651
SMRiQ9Y651
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IPZA Eukaryota
ENOG4110UF6 LUCA
GeneTreeiENSGT00760000118988
HOGENOMiHOG000231647
HOVERGENiHBG105618
InParanoidiQ9Y651
KOiK09267
OMAiMIPCNCT
OrthoDBiEOG091G0F15
PhylomeDBiQ9Y651
TreeFamiTF351735

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR022097 SOX_fam
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12336 SOXp, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y651-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT
60 70 80 90 100
ESEKRPFIDE AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL
110 120 130 140 150
GGVADAEHPA LKAGAGLHAG AGGGLVPESL LANPEKAAAA AAAAAARVFF
160 170 180 190 200
PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA EISSSSSGLP YASSLGYPTA
210 220 230 240 250
GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC SAWPSPGLQP
260 270
PLAYILLPGM GKPQLDPYPA AYAAAL
Length:276
Mass (Da):28,580
Last modified:November 1, 1999 - v1
Checksum:i99DC899B7EC9A96B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41R → P in CAA50466 (Ref. 4) Curated1
Sequence conflicti83P → T in CAA50466 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049562230G → R. Corresponds to variant dbSNP:rs6492735Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF107044 Genomic DNA Translation: AAC95381.1
AL137061 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX08946.1
X71136 mRNA Translation: CAA50466.1
X65666 mRNA Translation: CAA46617.1
CCDSiCCDS9473.1
PIRiI38238
S22937
RefSeqiNP_009015.1, NM_007084.3
UniGeneiHs.187577

Genome annotation databases

EnsembliENST00000376945; ENSP00000366144; ENSG00000125285
GeneIDi11166
KEGGihsa:11166
UCSCiuc001vma.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSOX21_HUMAN
AccessioniPrimary (citable) accession number: Q9Y651
Secondary accession number(s): P35715, Q15504, Q5TBS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health