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Q9Y651 (SOX21_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor SOX-21
Alternative name(s):
SOX-A
Gene names
Name:SOX21
Synonyms:SOX25, SOXA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length276 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role as an activator of transcription of OPRM1 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 276276Transcription factor SOX-21
PRO_0000048770

Regions

DNA binding8 – 7669HMG box

Natural variations

Natural variant2301G → R.
Corresponds to variant rs6492735 [ dbSNP | Ensembl ].
VAR_049562

Experimental info

Sequence conflict411R → P in CAA50466. Ref.4
Sequence conflict831P → T in CAA50466. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9Y651 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 99DC899B7EC9A96B

FASTA27628,580
        10         20         30         40         50         60 
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT ESEKRPFIDE 

        70         80         90        100        110        120 
AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL GGVADAEHPA LKAGAGLHAG 

       130        140        150        160        170        180 
AGGGLVPESL LANPEKAAAA AAAAAARVFF PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA 

       190        200        210        220        230        240 
EISSSSSGLP YASSLGYPTA GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC 

       250        260        270 
SAWPSPGLQP PLAYILLPGM GKPQLDPYPA AYAAAL 

« Hide

References

« Hide 'large scale' references
[1]"The isolation and high-resolution chromosomal mapping of human SOX14 and SOX21; two members of the SOX gene family related to SOX1, SOX2, and SOX3."
Malas S., Duthie S., Deloukas P., Episkopou V.
Mamm. Genome 10:934-937(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Stevanovic M.
Submitted (APR-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-87.
Tissue: Spinal cord.
[5]"A conserved family of genes related to the testis determining gene, SRY."
Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
Nucleic Acids Res. 20:2887-2887(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 19-72.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF107044 Genomic DNA. Translation: AAC95381.1.
AL137061 Genomic DNA. Translation: CAI14398.1.
CH471085 Genomic DNA. Translation: EAX08946.1.
X71136 mRNA. Translation: CAA50466.1.
X65666 mRNA. Translation: CAA46617.1.
CCDSCCDS9473.1.
PIRI38238.
S22937.
RefSeqNP_009015.1. NM_007084.2.
UniGeneHs.187577.

3D structure databases

ProteinModelPortalQ9Y651.
SMRQ9Y651. Positions 6-82.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9Y651.

Polymorphism databases

DMDM6831690.

Proteomic databases

PaxDbQ9Y651.
PRIDEQ9Y651.

Protocols and materials databases

DNASU11166.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000376945; ENSP00000366144; ENSG00000125285.
GeneID11166.
KEGGhsa:11166.
UCSCuc001vma.3. human.

Organism-specific databases

CTD11166.
GeneCardsGC13M095361.
H-InvDBHIX0037360.
HGNCHGNC:11197. SOX21.
MIM604974. gene.
neXtProtNX_Q9Y651.
PharmGKBPA36034.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG302715.
HOGENOMHOG000231647.
HOVERGENHBG105618.
InParanoidQ9Y651.
KOK09267.
OMAKPKTLMK.
OrthoDBEOG7TMZVP.
PhylomeDBQ9Y651.
TreeFamTF351735.

Gene expression databases

BgeeQ9Y651.
CleanExHS_SOX21.
GenevestigatorQ9Y651.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
IPR022097. TF_SOX.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
PF12336. SOXp. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSOX21.
GenomeRNAi11166.
NextBio42483.
PROQ9Y651.
SOURCESearch...

Entry information

Entry nameSOX21_HUMAN
AccessionPrimary (citable) accession number: Q9Y651
Secondary accession number(s): P35715, Q15504, Q5TBS1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM