Q9Y616 (IRAK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-1 receptor-associated kinase 3
Short name=IRAK-3
EC=2.7.11.1

Alternative name(s):
IL-1 receptor-associated kinase M
Short name=IRAK-M

Gene names

Name:

IRAK3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	596 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex By similarity. Ref.1 UniProtKB Q8K4B2
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. Ref.1
Cofactor	Magnesium. Ref.1
Tissue specificity	Expressed predominantly in peripheral blood lymphocytes. Ref.1
Involvement in disease	Asthma-related traits 5 (ASRT5) [MIM:611064]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.5
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Contains 1 death domain. Contains 1 protein kinase domain.
Caution	Ser-293 is present instead of the conserved Asp which is expected to be an active site residue. Low level autophosphorylation activity has been reported in Ref.1, while other authors describe this as an inactive kinase.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Asthma
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	MyD88-dependent toll-like receptor signaling pathway Traceable author statement Ref.1. Source: BHF-UCL interleukin-1-mediated signaling pathway Inferred from mutant phenotype Ref.1. Source: BHF-UCL negative regulation of MAP kinase activity Inferred from mutant phenotype PubMed 17379480. Source: BHF-UCL negative regulation of NF-kappaB transcription factor activity Inferred from mutant phenotype Ref.1PubMed 18156187. Source: BHF-UCL negative regulation of cytokine-mediated signaling pathway Inferred by curator PubMed 12150927. Source: BHF-UCL negative regulation of innate immune response Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL negative regulation of interleukin-12 production Inferred from mutant phenotype PubMed 18156187. Source: BHF-UCL negative regulation of interleukin-6 production Inferred from mutant phenotype PubMed 18156187. Source: BHF-UCL negative regulation of macrophage cytokine production Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL negative regulation of protein catabolic process Inferred from mutant phenotype PubMed 17379480PubMed 18156187. Source: BHF-UCL negative regulation of protein complex disassembly Inferred from mutant phenotype PubMed 12150927. Source: BHF-UCL negative regulation of toll-like receptor signaling pathway Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL negative regulation of tumor necrosis factor production Inferred from mutant phenotype PubMed 15728517. Source: BHF-UCL positive regulation of NF-kappaB transcription factor activity Inferred from mutant phenotype Ref.1. Source: BHF-UCL positive regulation of macrophage tolerance induction Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL protein autophosphorylation Inferred from electronic annotation. Source: Compara response to exogenous dsRNA Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL response to lipopolysaccharide Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL response to peptidoglycan Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL response to virus Inferred by curator PubMed 12150927. Source: BHF-UCL
Cellular_component	cytoplasm Inferred from direct assay PubMed 17379480. Source: BHF-UCL nucleus Inferred from direct assay PubMed 17379480. Source: BHF-UCL
Molecular_function	ATP binding Inferred from direct assay Ref.1. Source: UniProtKB magnesium ion binding Inferred from direct assay Ref.1. Source: UniProtKB protein serine/threonine kinase activity Inferred from direct assay Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IRAK1	P51617	3	EBI-447690,EBI-358664
IRAK2	O43187	3	EBI-447690,EBI-447733

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y616-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y616-2)

The sequence of this isoform differs from the canonical sequence as follows:
     45-105: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 596	596	Interleukin-1 receptor-associated kinase 3		PRO_0000086033
Regions
	Domain	41 – 106	66	Death
	Domain	165 – 452	288	Protein kinase
	Nucleotide binding	171 – 179	9	ATP By similarity UniProtKB P51617
	Nucleotide binding	295 – 298	4	ATP By similarity
Sites
	Binding site	192	1	ATP By similarity UniProtKB P51617
	Binding site	311	1	ATP By similarity
Amino acid modifications
	Modified residue	467	1	Phosphoserine Ref.6
Natural variations
	Alternative sequence	45 – 105	61	Missing in isoform 2.		VSP_041020
	Natural variant	22	1	P → L May be associated with ASRT5. Ref.5		VAR_035212
	Natural variant	57	1	H → R. Ref.7 Corresponds to variant rs35239505 [ dbSNP | Ensembl ].		VAR_040581
	Natural variant	84	1	G → S. Ref.7 Corresponds to variant rs34443407 [ dbSNP | Ensembl ].		VAR_040582
	Natural variant	111	1	P → A May be associated with ASRT5. Ref.5		VAR_035213
	Natural variant	134	1	V → M May be associated with ASRT5. Ref.5		VAR_035214
	Natural variant	147	1	I → V. Ref.1 Ref.2 Ref.4 Ref.7 Corresponds to variant rs1152888 [ dbSNP | Ensembl ].		VAR_019812
	Natural variant	171	1	I → V. Ref.7 Corresponds to variant rs34682166 [ dbSNP | Ensembl ].		VAR_040583
	Natural variant	269	1	G → S. Corresponds to variant rs35823766 [ dbSNP | Ensembl ].		VAR_033901
	Natural variant	270	1	I → V. Corresponds to variant rs11465972 [ dbSNP | Ensembl ].		VAR_031077
	Natural variant	288	1	S → L. Ref.7 Corresponds to variant rs35574245 [ dbSNP | Ensembl ].		VAR_040584
	Natural variant	384	1	R → Q. Ref.7 Corresponds to variant rs34272472 [ dbSNP | Ensembl ].		VAR_040585
	Natural variant	391	1	M → T. Ref.7 Corresponds to variant rs35737689 [ dbSNP | Ensembl ].		VAR_040586
	Natural variant	400	1	L → V May be associated with ASRT5. Ref.5		VAR_035215
	Natural variant	429	1	R → Q May be associated with ASRT5. Ref.5		VAR_035216
	Natural variant	482	1	D → N. Ref.7 Corresponds to variant rs35756811 [ dbSNP | Ensembl ].		VAR_040587
Experimental info
	Sequence conflict	560	1	N → D in BAG60819. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 8, 2011. Version 2. Checksum: D050150B7BDA5B9A	FASTA	596	67,767
	10 20 30 40 50 60 MAGNCGARGA LSAHTLLFDL PPALLGELCA VLDSCDGALG WRGLAERLSS SWLDVRHIEK 70 80 90 100 110 120 YVDQGKSGTR ELLWSWAQKN KTIGDLLQVL QEMGHRRAIH LITNYGAVLS PSEKSYQEGG 130 140 150 160 170 180 FPNILFKETA NVTVDNVLIP EHNEKGILLK SSISFQNIIE GTRNFHKDFL IGEGEIFEVY 190 200 210 220 230 240 RVEIQNLTYA VKLFKQEKKM QCKKHWKRFL SELEVLLLFH HPNILELAAY FTETEKFCLI 250 260 270 280 290 300 YPYMRNGTLF DRLQCVGDTA PLPWHIRIGI LIGISKAIHY LHNVQPCSVI CGSISSANIL 310 320 330 340 350 360 LDDQFQPKLT DFAMAHFRSH LEHQSCTINM TSSSSKHLWY MPEEYIRQGK LSIKTDVYSF 370 380 390 400 410 420 GIVIMEVLTG CRVVLDDPKH IQLRDLLREL MEKRGLDSCL SFLDKKVPPC PRNFSAKLFC 430 440 450 460 470 480 LAGRCAATRA KLRPSMDEVL NTLESTQASL YFAEDPPTSL KSFRCPSPLF LENVPSIPVE 490 500 510 520 530 540 DDESQNNNLL PSDEGLRIDR MTQKTPFECS QSEVMFLSLD KKPESKRNEE ACNMPSSSCE 550 560 570 580 590 ESWFPKYIVP SQDLRPYKVN IDPSSEAPGH SCRSRPVESS CSSKFSWDEY EQYKKE
	Isoform 2 [UniParc]. Checksum: 54DEDA8A162DD662	FASTA	535	60,608
	10 20 30 40 50 60 MAGNCGARGA LSAHTLLFDL PPALLGELCA VLDSCDGALG WRGLGAVLSP SEKSYQEGGF 70 80 90 100 110 120 PNILFKETAN VTVDNVLIPE HNEKGILLKS SISFQNIIEG TRNFHKDFLI GEGEIFEVYR 130 140 150 160 170 180 VEIQNLTYAV KLFKQEKKMQ CKKHWKRFLS ELEVLLLFHH PNILELAAYF TETEKFCLIY 190 200 210 220 230 240 PYMRNGTLFD RLQCVGDTAP LPWHIRIGIL IGISKAIHYL HNVQPCSVIC GSISSANILL 250 260 270 280 290 300 DDQFQPKLTD FAMAHFRSHL EHQSCTINMT SSSSKHLWYM PEEYIRQGKL SIKTDVYSFG 310 320 330 340 350 360 IVIMEVLTGC RVVLDDPKHI QLRDLLRELM EKRGLDSCLS FLDKKVPPCP RNFSAKLFCL 370 380 390 400 410 420 AGRCAATRAK LRPSMDEVLN TLESTQASLY FAEDPPTSLK SFRCPSPLFL ENVPSIPVED 430 440 450 460 470 480 DESQNNNLLP SDEGLRIDRM TQKTPFECSQ SEVMFLSLDK KPESKRNEEA CNMPSSSCEE 490 500 510 520 530 SWFPKYIVPS QDLRPYKVNI DPSSEAPGHS CRSRPVESSC SSKFSWDEYE QYKKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family." Wesche H., Gao X., Li X., Kirschning C.J., Stark G.R., Cao Z. J. Biol. Chem. 274:19403-19410(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, COFACTOR, TISSUE SPECIFICITY, VARIANT VAL-147. Tissue: Peripheral blood lymphocyte.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-147.
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-147. Tissue: Placenta.
[5]	"IRAK-M is involved in the pathogenesis of early-onset persistent asthma." Balaci L., Spada M.C., Olla N., Sole G., Loddo L., Anedda F., Naitza S., Zuncheddu M.A., Maschio A., Altea D., Uda M., Pilia S., Sanna S., Masala M., Crisponi L., Fattori M., Devoto M., Doratiotto S. , Rassu S., Mereu S., Giua E., Cadeddu N.G., Atzeni R., Pelosi U., Corrias A., Perra R., Torrazza P.L., Pirina P., Ginesu F., Marcias S., Schintu M.G., Del Giacco G.S., Manconi P.E., Malerba G., Bisognin A., Trabetti E., Boner A., Pescollderungg L., Pignatti P.F., Schlessinger D., Cao A., Pilia G. Am. J. Hum. Genet. 80:1103-1114(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN ASRT5, VARIANTS LEU-22; ALA-111; MET-134; VAL-400 AND GLN-429.
[6]	"Large-scale proteomics analysis of the human kinome." Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H. Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-467, MASS SPECTROMETRY.
[7]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-57; SER-84; VAL-147; VAL-171; LEU-288; GLN-384; THR-391 AND ASN-482.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF113136 mRNA. Translation: AAD40879.1. AK298645 mRNA. Translation: BAG60819.1. AC078889 Genomic DNA. No translation available. AC078927 Genomic DNA. No translation available. BC057800 mRNA. Translation: AAH57800.1. BC069388 mRNA. Translation: AAH69388.1.
IPI	IPI00026984. IPI00909153.
RefSeq	NP_001135995.1. NM_001142523.1. NP_009130.2. NM_007199.2.
UniGene	Hs.369265.
3D structure databases
ProteinModelPortal	Q9Y616.
SMR	Q9Y616. Positions 134-449.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y616. 17 interactions.
MINT	MINT-97148.
STRING	9606.ENSP00000261233.
PTM databases
PhosphoSite	Q9Y616.
Polymorphism databases
DMDM	55584013.
Proteomic databases
PaxDb	Q9Y616.
PRIDE	Q9Y616.
Protocols and materials databases
DNASU	11213.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000261233; ENSP00000261233; ENSG00000090376. ENST00000457197; ENSP00000409852; ENSG00000090376.
GeneID	11213.
KEGG	hsa:11213.
UCSC	uc001sth.3. human. uc010ssy.2. human.
Organism-specific databases
CTD	11213.
GeneCards	GC12P066582.
HGNC	HGNC:17020. IRAK3.
HPA	HPA043097.
MIM	604459. gene. 611064. phenotype.
neXtProt	NX_Q9Y616.
PharmGKB	PA38431.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000060319.
HOVERGEN	HBG052146.
InParanoid	Q9Y616.
KO	K04732.
OMA	CSVICGS.
OrthoDB	EOG4Z8XW1.
PhylomeDB	Q9Y616.
Enzyme and pathway databases
Pathway_Interaction_DB	il1pathway. IL1-mediated signaling events.
Gene expression databases
ArrayExpress	Q9Y616.
Bgee	Q9Y616.
CleanEx	HS_IRAK3.
Genevestigator	Q9Y616.
GermOnline	ENSG00000090376. Homo sapiens.
Family and domain databases
Gene3D	1.10.533.10. 1 hit.
InterPro	IPR011029. DEATH-like_dom. IPR000488. Death_domain. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. [Graphical view]
Pfam	PF00531. Death. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00005. DEATH. 1 hit. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50017. DEATH_DOMAIN. 1 hit. PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. False negative. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9Y616.
ChEMBL	CHEMBL5081.
GenomeRNAi	11213.
NextBio	42675.
SOURCE	Search...

Entry information

Entry name

IRAK3_HUMAN

Accession

Primary (citable) accession number: Q9Y616
Secondary accession number(s): B4DQ57

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 9, 2004
Last sequence update:	February 8, 2011
Last modified:	May 1, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.