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Q9Y616

- IRAK3_HUMAN

UniProt

Q9Y616 - IRAK3_HUMAN

Protein

Interleukin-1 receptor-associated kinase 3

Gene

IRAK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.1 Publication

    Cofactori

    Magnesium.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei192 – 1921ATPBy similarityPROSITE-ProRule annotation
    Binding sitei311 – 3111ATPPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi171 – 1799ATPBy similarityPROSITE-ProRule annotation
    Nucleotide bindingi295 – 2984ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. magnesium ion binding Source: UniProtKB
    3. protein heterodimerization activity Source: BHF-UCL
    4. protein homodimerization activity Source: BHF-UCL
    5. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. cytokine-mediated signaling pathway Source: UniProtKB
    2. interleukin-1-mediated signaling pathway Source: BHF-UCL
    3. MyD88-dependent toll-like receptor signaling pathway Source: BHF-UCL
    4. negative regulation of cytokine-mediated signaling pathway Source: BHF-UCL
    5. negative regulation of innate immune response Source: BHF-UCL
    6. negative regulation of interleukin-12 production Source: BHF-UCL
    7. negative regulation of interleukin-6 production Source: BHF-UCL
    8. negative regulation of macrophage cytokine production Source: BHF-UCL
    9. negative regulation of MAP kinase activity Source: BHF-UCL
    10. negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
    11. negative regulation of protein catabolic process Source: BHF-UCL
    12. negative regulation of protein complex disassembly Source: BHF-UCL
    13. negative regulation of toll-like receptor signaling pathway Source: BHF-UCL
    14. negative regulation of tumor necrosis factor production Source: BHF-UCL
    15. positive regulation of macrophage tolerance induction Source: BHF-UCL
    16. positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
    17. protein autophosphorylation Source: Ensembl
    18. protein phosphorylation Source: UniProtKB
    19. regulation of protein complex disassembly Source: UniProtKB
    20. response to exogenous dsRNA Source: BHF-UCL
    21. response to interleukin-1 Source: BHF-UCL
    22. response to lipopolysaccharide Source: BHF-UCL
    23. response to peptidoglycan Source: BHF-UCL
    24. response to virus Source: BHF-UCL

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_22442. Interleukin-1 signaling.
    REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
    SignaLinkiQ9Y616.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-1 receptor-associated kinase 3 (EC:2.7.11.1)
    Short name:
    IRAK-3
    Alternative name(s):
    IL-1 receptor-associated kinase M
    Short name:
    IRAK-M
    Gene namesi
    Name:IRAK3Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:17020. IRAK3.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. nucleus Source: BHF-UCL

    Pathology & Biotechi

    Involvement in diseasei

    Asthma-related traits 5 (ASRT5) [MIM:611064]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.1 Publication
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221P → L May be associated with ASRT5. 1 Publication
    VAR_035212
    Natural varianti111 – 1111P → A May be associated with ASRT5. 1 Publication
    VAR_035213
    Natural varianti134 – 1341V → M May be associated with ASRT5. 1 Publication
    VAR_035214
    Natural varianti400 – 4001L → V May be associated with ASRT5. 1 Publication
    VAR_035215
    Natural varianti429 – 4291R → Q May be associated with ASRT5. 1 Publication
    VAR_035216

    Keywords - Diseasei

    Asthma

    Organism-specific databases

    MIMi611064. phenotype.
    PharmGKBiPA38431.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 596596Interleukin-1 receptor-associated kinase 3PRO_0000086033Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei467 – 4671Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9Y616.
    PRIDEiQ9Y616.

    PTM databases

    PhosphoSiteiQ9Y616.

    Expressioni

    Tissue specificityi

    Expressed predominantly in peripheral blood lymphocytes.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y616.
    BgeeiQ9Y616.
    CleanExiHS_IRAK3.
    GenevestigatoriQ9Y616.

    Organism-specific databases

    HPAiHPA043097.

    Interactioni

    Protein-protein interaction databases

    BioGridi116382. 19 interactions.
    IntActiQ9Y616. 15 interactions.
    MINTiMINT-97148.
    STRINGi9606.ENSP00000261233.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y616.
    SMRiQ9Y616. Positions 134-449.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 10666DeathPROSITE-ProRule annotationAdd
    BLAST
    Domaini165 – 452288Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 death domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000060319.
    HOVERGENiHBG052146.
    InParanoidiQ9Y616.
    KOiK04732.
    OMAiFKQEKKM.
    OrthoDBiEOG7KQ21F.
    PhylomeDBiQ9Y616.
    TreeFamiTF328924.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00531. Death. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00005. DEATH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y616-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGNCGARGA LSAHTLLFDL PPALLGELCA VLDSCDGALG WRGLAERLSS    50
    SWLDVRHIEK YVDQGKSGTR ELLWSWAQKN KTIGDLLQVL QEMGHRRAIH 100
    LITNYGAVLS PSEKSYQEGG FPNILFKETA NVTVDNVLIP EHNEKGILLK 150
    SSISFQNIIE GTRNFHKDFL IGEGEIFEVY RVEIQNLTYA VKLFKQEKKM 200
    QCKKHWKRFL SELEVLLLFH HPNILELAAY FTETEKFCLI YPYMRNGTLF 250
    DRLQCVGDTA PLPWHIRIGI LIGISKAIHY LHNVQPCSVI CGSISSANIL 300
    LDDQFQPKLT DFAMAHFRSH LEHQSCTINM TSSSSKHLWY MPEEYIRQGK 350
    LSIKTDVYSF GIVIMEVLTG CRVVLDDPKH IQLRDLLREL MEKRGLDSCL 400
    SFLDKKVPPC PRNFSAKLFC LAGRCAATRA KLRPSMDEVL NTLESTQASL 450
    YFAEDPPTSL KSFRCPSPLF LENVPSIPVE DDESQNNNLL PSDEGLRIDR 500
    MTQKTPFECS QSEVMFLSLD KKPESKRNEE ACNMPSSSCE ESWFPKYIVP 550
    SQDLRPYKVN IDPSSEAPGH SCRSRPVESS CSSKFSWDEY EQYKKE 596
    Length:596
    Mass (Da):67,767
    Last modified:February 8, 2011 - v2
    Checksum:iD050150B7BDA5B9A
    GO
    Isoform 2 (identifier: Q9Y616-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         45-105: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:535
    Mass (Da):60,608
    Checksum:i54DEDA8A162DD662
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti560 – 5601N → D in BAG60819. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 221P → L May be associated with ASRT5. 1 Publication
    VAR_035212
    Natural varianti57 – 571H → R.1 Publication
    Corresponds to variant rs35239505 [ dbSNP | Ensembl ].
    VAR_040581
    Natural varianti84 – 841G → S.1 Publication
    Corresponds to variant rs34443407 [ dbSNP | Ensembl ].
    VAR_040582
    Natural varianti111 – 1111P → A May be associated with ASRT5. 1 Publication
    VAR_035213
    Natural varianti134 – 1341V → M May be associated with ASRT5. 1 Publication
    VAR_035214
    Natural varianti147 – 1471I → V.4 Publications
    Corresponds to variant rs1152888 [ dbSNP | Ensembl ].
    VAR_019812
    Natural varianti171 – 1711I → V.1 Publication
    Corresponds to variant rs34682166 [ dbSNP | Ensembl ].
    VAR_040583
    Natural varianti269 – 2691G → S.
    Corresponds to variant rs35823766 [ dbSNP | Ensembl ].
    VAR_033901
    Natural varianti270 – 2701I → V.
    Corresponds to variant rs11465972 [ dbSNP | Ensembl ].
    VAR_031077
    Natural varianti288 – 2881S → L.1 Publication
    Corresponds to variant rs35574245 [ dbSNP | Ensembl ].
    VAR_040584
    Natural varianti384 – 3841R → Q.1 Publication
    Corresponds to variant rs34272472 [ dbSNP | Ensembl ].
    VAR_040585
    Natural varianti391 – 3911M → T.1 Publication
    Corresponds to variant rs35737689 [ dbSNP | Ensembl ].
    VAR_040586
    Natural varianti400 – 4001L → V May be associated with ASRT5. 1 Publication
    VAR_035215
    Natural varianti429 – 4291R → Q May be associated with ASRT5. 1 Publication
    VAR_035216
    Natural varianti482 – 4821D → N.1 Publication
    Corresponds to variant rs35756811 [ dbSNP | Ensembl ].
    VAR_040587

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei45 – 10561Missing in isoform 2. 1 PublicationVSP_041020Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF113136 mRNA. Translation: AAD40879.1.
    AK298645 mRNA. Translation: BAG60819.1.
    AC078889 Genomic DNA. No translation available.
    AC078927 Genomic DNA. No translation available.
    BC057800 mRNA. Translation: AAH57800.1.
    BC069388 mRNA. Translation: AAH69388.1.
    CCDSiCCDS44937.1. [Q9Y616-2]
    CCDS8975.1. [Q9Y616-1]
    RefSeqiNP_001135995.1. NM_001142523.1. [Q9Y616-2]
    NP_009130.2. NM_007199.2. [Q9Y616-1]
    UniGeneiHs.369265.

    Genome annotation databases

    EnsembliENST00000261233; ENSP00000261233; ENSG00000090376. [Q9Y616-1]
    ENST00000457197; ENSP00000409852; ENSG00000090376. [Q9Y616-2]
    GeneIDi11213.
    KEGGihsa:11213.
    UCSCiuc001sth.3. human. [Q9Y616-1]
    uc010ssy.2. human. [Q9Y616-2]

    Polymorphism databases

    DMDMi322510038.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF113136 mRNA. Translation: AAD40879.1 .
    AK298645 mRNA. Translation: BAG60819.1 .
    AC078889 Genomic DNA. No translation available.
    AC078927 Genomic DNA. No translation available.
    BC057800 mRNA. Translation: AAH57800.1 .
    BC069388 mRNA. Translation: AAH69388.1 .
    CCDSi CCDS44937.1. [Q9Y616-2 ]
    CCDS8975.1. [Q9Y616-1 ]
    RefSeqi NP_001135995.1. NM_001142523.1. [Q9Y616-2 ]
    NP_009130.2. NM_007199.2. [Q9Y616-1 ]
    UniGenei Hs.369265.

    3D structure databases

    ProteinModelPortali Q9Y616.
    SMRi Q9Y616. Positions 134-449.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116382. 19 interactions.
    IntActi Q9Y616. 15 interactions.
    MINTi MINT-97148.
    STRINGi 9606.ENSP00000261233.

    Chemistry

    BindingDBi Q9Y616.
    ChEMBLi CHEMBL5081.
    GuidetoPHARMACOLOGYi 2044.

    PTM databases

    PhosphoSitei Q9Y616.

    Polymorphism databases

    DMDMi 322510038.

    Proteomic databases

    PaxDbi Q9Y616.
    PRIDEi Q9Y616.

    Protocols and materials databases

    DNASUi 11213.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261233 ; ENSP00000261233 ; ENSG00000090376 . [Q9Y616-1 ]
    ENST00000457197 ; ENSP00000409852 ; ENSG00000090376 . [Q9Y616-2 ]
    GeneIDi 11213.
    KEGGi hsa:11213.
    UCSCi uc001sth.3. human. [Q9Y616-1 ]
    uc010ssy.2. human. [Q9Y616-2 ]

    Organism-specific databases

    CTDi 11213.
    GeneCardsi GC12P066582.
    HGNCi HGNC:17020. IRAK3.
    HPAi HPA043097.
    MIMi 604459. gene.
    611064. phenotype.
    neXtProti NX_Q9Y616.
    PharmGKBi PA38431.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000060319.
    HOVERGENi HBG052146.
    InParanoidi Q9Y616.
    KOi K04732.
    OMAi FKQEKKM.
    OrthoDBi EOG7KQ21F.
    PhylomeDBi Q9Y616.
    TreeFami TF328924.

    Enzyme and pathway databases

    Reactomei REACT_22442. Interleukin-1 signaling.
    REACT_6788. MyD88:Mal cascade initiated on plasma membrane.
    SignaLinki Q9Y616.

    Miscellaneous databases

    GeneWikii IRAK3.
    GenomeRNAii 11213.
    NextBioi 42675.
    PROi Q9Y616.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y616.
    Bgeei Q9Y616.
    CleanExi HS_IRAK3.
    Genevestigatori Q9Y616.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00531. Death. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00005. DEATH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family."
      Wesche H., Gao X., Li X., Kirschning C.J., Stark G.R., Cao Z.
      J. Biol. Chem. 274:19403-19410(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, COFACTOR, TISSUE SPECIFICITY, VARIANT VAL-147.
      Tissue: Peripheral blood lymphocyte.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-147.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-147.
      Tissue: PlacentaImported.
    5. Cited for: INVOLVEMENT IN ASRT5, VARIANTS LEU-22; ALA-111; MET-134; VAL-400 AND GLN-429.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-57; SER-84; VAL-147; VAL-171; LEU-288; GLN-384; THR-391 AND ASN-482.

    Entry informationi

    Entry nameiIRAK3_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y616
    Secondary accession number(s): B4DQ57
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 9, 2004
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3