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Q9Y616 (IRAK3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 120. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-1 receptor-associated kinase 3

Short name=IRAK-3
EC=2.7.11.1
Alternative name(s):
IL-1 receptor-associated kinase M
Short name=IRAK-M
Gene names
Name:IRAK3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length596 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex By similarity. Ref.1 UniProtKB Q8K4B2

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. Ref.1

Cofactor

Magnesium. Ref.1

Tissue specificity

Expressed predominantly in peripheral blood lymphocytes. Ref.1

Involvement in disease

Asthma-related traits 5 (ASRT5) [MIM:611064]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.5

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.

Contains 1 death domain.

Contains 1 protein kinase domain.

Caution

Ser-293 is present instead of the conserved Asp which is expected to be an active site residue. Low level autophosphorylation activity has been reported in Ref.1, while other authors describe this as an inactive kinase.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   DiseaseAsthma
   LigandATP-binding
Magnesium
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMyD88-dependent toll-like receptor signaling pathway

Traceable author statement Ref.1. Source: BHF-UCL

cytokine-mediated signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

interleukin-1-mediated signaling pathway

Inferred from mutant phenotype Ref.1. Source: BHF-UCL

negative regulation of MAP kinase activity

Inferred from mutant phenotype PubMed 17379480. Source: BHF-UCL

negative regulation of NF-kappaB transcription factor activity

Inferred from mutant phenotype Ref.1PubMed 18156187. Source: BHF-UCL

negative regulation of cytokine-mediated signaling pathway

Inferred by curator PubMed 12150927. Source: BHF-UCL

negative regulation of innate immune response

Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL

negative regulation of interleukin-12 production

Inferred from mutant phenotype PubMed 18156187. Source: BHF-UCL

negative regulation of interleukin-6 production

Inferred from mutant phenotype PubMed 18156187. Source: BHF-UCL

negative regulation of macrophage cytokine production

Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL

negative regulation of protein catabolic process

Inferred from mutant phenotype PubMed 17379480PubMed 18156187. Source: BHF-UCL

negative regulation of protein complex disassembly

Inferred from mutant phenotype PubMed 12150927. Source: BHF-UCL

negative regulation of toll-like receptor signaling pathway

Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL

negative regulation of tumor necrosis factor production

Inferred from mutant phenotype PubMed 15728517. Source: BHF-UCL

positive regulation of NF-kappaB transcription factor activity

Inferred from mutant phenotype Ref.1. Source: BHF-UCL

positive regulation of macrophage tolerance induction

Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL

protein autophosphorylation

Inferred from electronic annotation. Source: Ensembl

protein phosphorylation

Inferred from direct assay Ref.1. Source: UniProtKB

regulation of protein complex disassembly

Inferred from sequence or structural similarity. Source: UniProtKB

response to exogenous dsRNA

Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL

response to interleukin-1

Inferred from mutant phenotype Ref.1. Source: BHF-UCL

response to lipopolysaccharide

Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL

response to peptidoglycan

Inferred from sequence or structural similarity PubMed 12150927. Source: BHF-UCL

response to virus

Inferred by curator PubMed 12150927. Source: BHF-UCL

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 17379480. Source: BHF-UCL

nucleus

Inferred from direct assay PubMed 17379480. Source: BHF-UCL

   Molecular_functionATP binding

Inferred from direct assay Ref.1. Source: UniProtKB

magnesium ion binding

Inferred from direct assay Ref.1. Source: UniProtKB

protein heterodimerization activity

Inferred from physical interaction Ref.1. Source: BHF-UCL

protein homodimerization activity

Inferred from physical interaction Ref.1. Source: BHF-UCL

protein serine/threonine kinase activity

Inferred from direct assay Ref.1. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y616-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y616-2)

The sequence of this isoform differs from the canonical sequence as follows:
     45-105: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 596596Interleukin-1 receptor-associated kinase 3
PRO_0000086033

Regions

Domain41 – 10666Death
Domain165 – 452288Protein kinase
Nucleotide binding171 – 1799ATP By similarity UniProtKB P51617
Nucleotide binding295 – 2984ATP By similarity

Sites

Binding site1921ATP By similarity UniProtKB P51617
Binding site3111ATP By similarity

Amino acid modifications

Modified residue4671Phosphoserine Ref.6

Natural variations

Alternative sequence45 – 10561Missing in isoform 2.
VSP_041020
Natural variant221P → L May be associated with ASRT5. Ref.5
VAR_035212
Natural variant571H → R. Ref.7
Corresponds to variant rs35239505 [ dbSNP | Ensembl ].
VAR_040581
Natural variant841G → S. Ref.7
Corresponds to variant rs34443407 [ dbSNP | Ensembl ].
VAR_040582
Natural variant1111P → A May be associated with ASRT5. Ref.5
VAR_035213
Natural variant1341V → M May be associated with ASRT5. Ref.5
VAR_035214
Natural variant1471I → V. Ref.1 Ref.2 Ref.4 Ref.7
Corresponds to variant rs1152888 [ dbSNP | Ensembl ].
VAR_019812
Natural variant1711I → V. Ref.7
Corresponds to variant rs34682166 [ dbSNP | Ensembl ].
VAR_040583
Natural variant2691G → S.
Corresponds to variant rs35823766 [ dbSNP | Ensembl ].
VAR_033901
Natural variant2701I → V.
Corresponds to variant rs11465972 [ dbSNP | Ensembl ].
VAR_031077
Natural variant2881S → L. Ref.7
Corresponds to variant rs35574245 [ dbSNP | Ensembl ].
VAR_040584
Natural variant3841R → Q. Ref.7
Corresponds to variant rs34272472 [ dbSNP | Ensembl ].
VAR_040585
Natural variant3911M → T. Ref.7
Corresponds to variant rs35737689 [ dbSNP | Ensembl ].
VAR_040586
Natural variant4001L → V May be associated with ASRT5. Ref.5
VAR_035215
Natural variant4291R → Q May be associated with ASRT5. Ref.5
VAR_035216
Natural variant4821D → N. Ref.7
Corresponds to variant rs35756811 [ dbSNP | Ensembl ].
VAR_040587

Experimental info

Sequence conflict5601N → D in BAG60819. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified February 8, 2011. Version 2.
Checksum: D050150B7BDA5B9A

FASTA59667,767
        10         20         30         40         50         60 
MAGNCGARGA LSAHTLLFDL PPALLGELCA VLDSCDGALG WRGLAERLSS SWLDVRHIEK 

        70         80         90        100        110        120 
YVDQGKSGTR ELLWSWAQKN KTIGDLLQVL QEMGHRRAIH LITNYGAVLS PSEKSYQEGG 

       130        140        150        160        170        180 
FPNILFKETA NVTVDNVLIP EHNEKGILLK SSISFQNIIE GTRNFHKDFL IGEGEIFEVY 

       190        200        210        220        230        240 
RVEIQNLTYA VKLFKQEKKM QCKKHWKRFL SELEVLLLFH HPNILELAAY FTETEKFCLI 

       250        260        270        280        290        300 
YPYMRNGTLF DRLQCVGDTA PLPWHIRIGI LIGISKAIHY LHNVQPCSVI CGSISSANIL 

       310        320        330        340        350        360 
LDDQFQPKLT DFAMAHFRSH LEHQSCTINM TSSSSKHLWY MPEEYIRQGK LSIKTDVYSF 

       370        380        390        400        410        420 
GIVIMEVLTG CRVVLDDPKH IQLRDLLREL MEKRGLDSCL SFLDKKVPPC PRNFSAKLFC 

       430        440        450        460        470        480 
LAGRCAATRA KLRPSMDEVL NTLESTQASL YFAEDPPTSL KSFRCPSPLF LENVPSIPVE 

       490        500        510        520        530        540 
DDESQNNNLL PSDEGLRIDR MTQKTPFECS QSEVMFLSLD KKPESKRNEE ACNMPSSSCE 

       550        560        570        580        590 
ESWFPKYIVP SQDLRPYKVN IDPSSEAPGH SCRSRPVESS CSSKFSWDEY EQYKKE 

« Hide

Isoform 2 [UniParc].

Checksum: 54DEDA8A162DD662
Show »

FASTA53560,608

References

« Hide 'large scale' references
[1]"IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family."
Wesche H., Gao X., Li X., Kirschning C.J., Stark G.R., Cao Z.
J. Biol. Chem. 274:19403-19410(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, COFACTOR, TISSUE SPECIFICITY, VARIANT VAL-147.
Tissue: Peripheral blood lymphocyte.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT VAL-147.
[3]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-147.
Tissue: Placenta.
[5]"IRAK-M is involved in the pathogenesis of early-onset persistent asthma."
Balaci L., Spada M.C., Olla N., Sole G., Loddo L., Anedda F., Naitza S., Zuncheddu M.A., Maschio A., Altea D., Uda M., Pilia S., Sanna S., Masala M., Crisponi L., Fattori M., Devoto M., Doratiotto S. expand/collapse author list , Rassu S., Mereu S., Giua E., Cadeddu N.G., Atzeni R., Pelosi U., Corrias A., Perra R., Torrazza P.L., Pirina P., Ginesu F., Marcias S., Schintu M.G., Del Giacco G.S., Manconi P.E., Malerba G., Bisognin A., Trabetti E., Boner A., Pescollderungg L., Pignatti P.F., Schlessinger D., Cao A., Pilia G.
Am. J. Hum. Genet. 80:1103-1114(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN ASRT5, VARIANTS LEU-22; ALA-111; MET-134; VAL-400 AND GLN-429.
[6]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-467, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ARG-57; SER-84; VAL-147; VAL-171; LEU-288; GLN-384; THR-391 AND ASN-482.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF113136 mRNA. Translation: AAD40879.1.
AK298645 mRNA. Translation: BAG60819.1.
AC078889 Genomic DNA. No translation available.
AC078927 Genomic DNA. No translation available.
BC057800 mRNA. Translation: AAH57800.1.
BC069388 mRNA. Translation: AAH69388.1.
RefSeqNP_001135995.1. NM_001142523.1.
NP_009130.2. NM_007199.2.
UniGeneHs.369265.

3D structure databases

ProteinModelPortalQ9Y616.
SMRQ9Y616. Positions 134-449.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116382. 19 interactions.
IntActQ9Y616. 15 interactions.
MINTMINT-97148.
STRING9606.ENSP00000261233.

Chemistry

BindingDBQ9Y616.
ChEMBLCHEMBL5081.
GuidetoPHARMACOLOGY2044.

PTM databases

PhosphoSiteQ9Y616.

Polymorphism databases

DMDM322510038.

Proteomic databases

PaxDbQ9Y616.
PRIDEQ9Y616.

Protocols and materials databases

DNASU11213.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261233; ENSP00000261233; ENSG00000090376. [Q9Y616-1]
ENST00000457197; ENSP00000409852; ENSG00000090376. [Q9Y616-2]
GeneID11213.
KEGGhsa:11213.
UCSCuc001sth.3. human. [Q9Y616-1]
uc010ssy.2. human. [Q9Y616-2]

Organism-specific databases

CTD11213.
GeneCardsGC12P066582.
HGNCHGNC:17020. IRAK3.
HPAHPA043097.
MIM604459. gene.
611064. phenotype.
neXtProtNX_Q9Y616.
PharmGKBPA38431.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000060319.
HOVERGENHBG052146.
InParanoidQ9Y616.
KOK04732.
OMAFKQEKKM.
OrthoDBEOG7KQ21F.
PhylomeDBQ9Y616.
TreeFamTF328924.

Enzyme and pathway databases

SignaLinkQ9Y616.

Gene expression databases

ArrayExpressQ9Y616.
BgeeQ9Y616.
CleanExHS_IRAK3.
GenevestigatorQ9Y616.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
InterProIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamPF00531. Death. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00005. DEATH. 1 hit.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS50017. DEATH_DOMAIN. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiIRAK3.
GenomeRNAi11213.
NextBio42675.
PROQ9Y616.
SOURCESearch...

Entry information

Entry nameIRAK3_HUMAN
AccessionPrimary (citable) accession number: Q9Y616
Secondary accession number(s): B4DQ57
Entry history
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: February 8, 2011
Last modified: April 16, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM