Reviewed,
UniProtKB/Swiss-Prot Q9Y614 (ACL7B_HUMAN)
Last modified
November 24, 2009.
Version 72.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Actin-like protein 7B Alternative name(s): Actin-like-7-beta | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 415 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Subcellular location | Cytoplasm › cytoskeleton By similarity. |
| Tissue specificity | Detected only in the testis and, to a lesser extent, in the prostate. Ref.1 |
| Sequence similarities | Belongs to the actin family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Cytoskeleton |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | actin cytoskeleton Ref.1 Traceable author statement. Source: ProtInc cytoplasmInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | protein binding Inferred from electronic annotation. Source: InterPro structural constituent of cytoskeleton Ref.1Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 415 | 415 | Actin-like protein 7B | PRO_0000089139 | |||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31." Chadwick B.P., Mull J., Helbling L.A., Gill S., Leyne M., Robbins C.M., Pinkett H.W., Makalowska I., Maayan C., Blumenfeld A., Axelrod F.B., Brownstein M., Gusella J.F., Slaugenhaupt S.A. Genomics 58:302-309(1999) [PubMed: 10373328] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY. |
| [2] | "Single nucleotide polymorphisms: discovery of the genetic causes of male infertility." Tanaka H., Hirose M., Tokuhiro K., Matsuoka Y., Miyagawa Y., Tsujimura A., Okuyama A., Nishimune Y. Soc. Reprod. Fertil. Suppl. 65:531-534(2007) [PubMed: 17644991] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis. |
| [4] | "DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. Dunham I.Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
Cross-references
Sequence databases | |
|---|---|
| AF113527 Genomic DNA. Translation: AAD44110.1. AB284521 Genomic DNA. Translation: BAF41972.1. AK313871 mRNA. Translation: BAG36599.1. AL359692 Genomic DNA. Translation: CAI40570.1. CH471105 Genomic DNA. Translation: EAW59025.1. BC033789 mRNA. Translation: AAH33789.1. | |
| IPI | IPI00009126. |
| RefSeq | NP_006677.1. |
| UniGene | Hs.534390 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9Y614. |
PTM databases | |
| PhosphoSite | Q9Y614. |
Proteomic databases | |
| PRIDE | Q9Y614. |
Genome annotation databases | |
| Ensembl | ENST00000374667; ENSP00000363799; ENSG00000148156; Homo sapiens. [Genome view] |
| GeneID | 10880. |
| KEGG | hsa:10880. |
| UCSC | uc004bdi.1. human. |
Organism-specific databases | |
| CTD | 10880. |
| GeneCards | GC09M110657. |
| H-InvDB | HIX0008263. |
| HGNC | HGNC:162. ACTL7B. |
| HPA | HPA021803. HPA024664. |
| MIM | 604304. gene. |
| PharmGKB | PA24484. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q9Y614. |
| HOVERGEN | Q9Y614. |
| OMA | VDWDCVQ |
| OrthoDB | EOG9RFPD3 |
Gene expression databases | |
| ArrayExpress | Q9Y614. |
| Bgee | Q9Y614. |
| CleanEx | HS_ACTL7B. |
| Genevestigator | Q9Y614. |
| GermOnline | ENSG00000148156. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR004000. Actin-like. [Graphical view] |
| PANTHER | PTHR11937. Actin_like. 1 hit. |
| Pfam | PF00022. Actin. 1 hit. [Graphical view] |
| PRINTS | PR00190. ACTIN. |
| SMART | SM00268. ACTIN. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 41315. |
| SOURCE | Search... |
Entry information
| Entry name | ACL7B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y614 Secondary accession number(s): B2R9Q2, Q5JSV1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


