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Protein

Actin-like protein 7B

Gene

ACTL7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ9Y614.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein 7B
Alternative name(s):
Actin-like-7-beta
Gene namesi
Name:ACTL7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:162. ACTL7B.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: ProtInc
  • cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24484.

Polymorphism and mutation databases

BioMutaiACTL7B.
DMDMi27923724.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Actin-like protein 7BPRO_0000089139Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Y614.
PeptideAtlasiQ9Y614.
PRIDEiQ9Y614.

PTM databases

iPTMnetiQ9Y614.
PhosphoSiteiQ9Y614.

Expressioni

Tissue specificityi

Detected only in the testis and, to a lesser extent, in the prostate.1 Publication

Gene expression databases

BgeeiQ9Y614.
CleanExiHS_ACTL7B.
GenevisibleiQ9Y614. HS.

Organism-specific databases

HPAiHPA021803.
HPA024664.

Interactioni

Protein-protein interaction databases

BioGridi116088. 1 interaction.
STRINGi9606.ENSP00000363799.

Structurei

3D structure databases

ProteinModelPortaliQ9Y614.
SMRiQ9Y614. Positions 49-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ9Y614.
OMAiYVGHELL.
OrthoDBiEOG7VHSX3.
PhylomeDBiQ9Y614.
TreeFamiTF354237.

Family and domain databases

InterProiIPR004000. Actin.
IPR027680. ACTL7B.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF59. PTHR11937:SF59. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRNSPMPL GTAQGDPGEA GTRPGPDASL RDTGAATQLK MKPRKVHKIK
60 70 80 90 100
AVIIDLGSQY CKCGYAGEPR PTYFISSTVG KRCPEAADAG DTRKWTLVGH
110 120 130 140 150
ELLNTEAPLK LVNPLKHGIV VDWDCVQDIW EYIFRTAMKI LPEEHAVLVS
160 170 180 190 200
DPPLSPSSNR EKYAELMFET FGIPAMHVTS QSLLSIYSYG KTSGLVVESG
210 220 230 240 250
HGVSHVVPIS EGDVLPGLTS RADYAGGDLT NYLMQLLNEA GHAFTDDHLH
260 270 280 290 300
IIEHIKKKCC YAAFLPEEEL GLVPEELRVD YELPDGKLIT IGQERFRCSE
310 320 330 340 350
MLFQPSLAGS TQPGLPELTA ACLGRCQDTG FKEEMAANVL LCGGCTMLDG
360 370 380 390 400
FPERFQRELS LLCPGDSPAV AAAPERKTSV WTGGSILASL QAFQQLWVSK
410
EEFEERGSVA IYSKC
Length:415
Mass (Da):45,234
Last modified:November 1, 1999 - v1
Checksum:iF29F29C2101F0D8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113527 Genomic DNA. Translation: AAD44110.1.
AB284521 Genomic DNA. Translation: BAF41972.1.
AK313871 mRNA. Translation: BAG36599.1.
AL359692 Genomic DNA. Translation: CAI40570.1.
CH471105 Genomic DNA. Translation: EAW59025.1.
BC033789 mRNA. Translation: AAH33789.1.
CCDSiCCDS6771.1.
RefSeqiNP_006677.1. NM_006686.3.
UniGeneiHs.534390.

Genome annotation databases

EnsembliENST00000374667; ENSP00000363799; ENSG00000148156.
GeneIDi10880.
KEGGihsa:10880.
UCSCiuc004bdi.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113527 Genomic DNA. Translation: AAD44110.1.
AB284521 Genomic DNA. Translation: BAF41972.1.
AK313871 mRNA. Translation: BAG36599.1.
AL359692 Genomic DNA. Translation: CAI40570.1.
CH471105 Genomic DNA. Translation: EAW59025.1.
BC033789 mRNA. Translation: AAH33789.1.
CCDSiCCDS6771.1.
RefSeqiNP_006677.1. NM_006686.3.
UniGeneiHs.534390.

3D structure databases

ProteinModelPortaliQ9Y614.
SMRiQ9Y614. Positions 49-415.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116088. 1 interaction.
STRINGi9606.ENSP00000363799.

PTM databases

iPTMnetiQ9Y614.
PhosphoSiteiQ9Y614.

Polymorphism and mutation databases

BioMutaiACTL7B.
DMDMi27923724.

Proteomic databases

PaxDbiQ9Y614.
PeptideAtlasiQ9Y614.
PRIDEiQ9Y614.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374667; ENSP00000363799; ENSG00000148156.
GeneIDi10880.
KEGGihsa:10880.
UCSCiuc004bdi.4. human.

Organism-specific databases

CTDi10880.
GeneCardsiACTL7B.
HGNCiHGNC:162. ACTL7B.
HPAiHPA021803.
HPA024664.
MIMi604304. gene.
neXtProtiNX_Q9Y614.
PharmGKBiPA24484.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
HOGENOMiHOG000233340.
HOVERGENiHBG003771.
InParanoidiQ9Y614.
OMAiYVGHELL.
OrthoDBiEOG7VHSX3.
PhylomeDBiQ9Y614.
TreeFamiTF354237.

Enzyme and pathway databases

SignaLinkiQ9Y614.

Miscellaneous databases

GenomeRNAii10880.
PROiQ9Y614.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y614.
CleanExiHS_ACTL7B.
GenevisibleiQ9Y614. HS.

Family and domain databases

InterProiIPR004000. Actin.
IPR027680. ACTL7B.
[Graphical view]
PANTHERiPTHR11937. PTHR11937. 1 hit.
PTHR11937:SF59. PTHR11937:SF59. 1 hit.
PfamiPF00022. Actin. 1 hit.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31."
    Chadwick B.P., Mull J., Helbling L.A., Gill S., Leyne M., Robbins C.M., Pinkett H.W., Makalowska I., Maayan C., Blumenfeld A., Axelrod F.B., Brownstein M., Gusella J.F., Slaugenhaupt S.A.
    Genomics 58:302-309(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  2. "Single nucleotide polymorphisms: discovery of the genetic causes of male infertility."
    Tanaka H., Hirose M., Tokuhiro K., Matsuoka Y., Miyagawa Y., Tsujimura A., Okuyama A., Nishimune Y.
    Soc. Reprod. Fertil. Suppl. 65:531-534(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiACL7B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y614
Secondary accession number(s): B2R9Q2, Q5JSV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: November 1, 1999
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.