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Protein

Actin-like protein 7B

Gene

ACTL7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc

Enzyme and pathway databases

SignaLinkiQ9Y614

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-like protein 7B
Alternative name(s):
Actin-like-7-beta
Gene namesi
Name:ACTL7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148156.7
HGNCiHGNC:162 ACTL7B
MIMi604304 gene
neXtProtiNX_Q9Y614

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148156
PharmGKBiPA24484

Polymorphism and mutation databases

BioMutaiACTL7B
DMDMi27923724

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000891391 – 415Actin-like protein 7BAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Y614
PeptideAtlasiQ9Y614
PRIDEiQ9Y614

PTM databases

iPTMnetiQ9Y614
PhosphoSitePlusiQ9Y614

Expressioni

Tissue specificityi

Detected only in the testis and, to a lesser extent, in the prostate.1 Publication

Gene expression databases

BgeeiENSG00000148156
CleanExiHS_ACTL7B
ExpressionAtlasiQ9Y614 baseline and differential
GenevisibleiQ9Y614 HS

Organism-specific databases

HPAiHPA021803
HPA024664

Interactioni

Protein-protein interaction databases

BioGridi116088, 1 interactor
STRINGi9606.ENSP00000363799

Structurei

3D structure databases

ProteinModelPortaliQ9Y614
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
HOGENOMiHOG000233340
HOVERGENiHBG003771
InParanoidiQ9Y614
OMAiYVGHELL
OrthoDBiEOG091G07GC
PhylomeDBiQ9Y614
TreeFamiTF354237

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR027680 ACTL7B
PANTHERiPTHR11937 PTHR11937, 1 hit
PTHR11937:SF59 PTHR11937:SF59, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRNSPMPL GTAQGDPGEA GTRPGPDASL RDTGAATQLK MKPRKVHKIK
60 70 80 90 100
AVIIDLGSQY CKCGYAGEPR PTYFISSTVG KRCPEAADAG DTRKWTLVGH
110 120 130 140 150
ELLNTEAPLK LVNPLKHGIV VDWDCVQDIW EYIFRTAMKI LPEEHAVLVS
160 170 180 190 200
DPPLSPSSNR EKYAELMFET FGIPAMHVTS QSLLSIYSYG KTSGLVVESG
210 220 230 240 250
HGVSHVVPIS EGDVLPGLTS RADYAGGDLT NYLMQLLNEA GHAFTDDHLH
260 270 280 290 300
IIEHIKKKCC YAAFLPEEEL GLVPEELRVD YELPDGKLIT IGQERFRCSE
310 320 330 340 350
MLFQPSLAGS TQPGLPELTA ACLGRCQDTG FKEEMAANVL LCGGCTMLDG
360 370 380 390 400
FPERFQRELS LLCPGDSPAV AAAPERKTSV WTGGSILASL QAFQQLWVSK
410
EEFEERGSVA IYSKC
Length:415
Mass (Da):45,234
Last modified:November 1, 1999 - v1
Checksum:iF29F29C2101F0D8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113527 Genomic DNA Translation: AAD44110.1
AB284521 Genomic DNA Translation: BAF41972.1
AK313871 mRNA Translation: BAG36599.1
AL359692 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59025.1
BC033789 mRNA Translation: AAH33789.1
CCDSiCCDS6771.1
RefSeqiNP_006677.1, NM_006686.3
UniGeneiHs.534390

Genome annotation databases

EnsembliENST00000374667; ENSP00000363799; ENSG00000148156
GeneIDi10880
KEGGihsa:10880
UCSCiuc004bdi.4 human

Similar proteinsi

Entry informationi

Entry nameiACL7B_HUMAN
AccessioniPrimary (citable) accession number: Q9Y614
Secondary accession number(s): B2R9Q2, Q5JSV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health