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Q9Y614 (ACL7B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Actin-like protein 7B
Alternative name(s):
Actin-like-7-beta
Gene names
Name:ACTL7B
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasmcytoskeleton By similarity.

Tissue specificity

Detected only in the testis and, to a lesser extent, in the prostate. Ref.1

Sequence similarities

Belongs to the actin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentactin cytoskeleton

Traceable author statement. Source: ProtInc

cytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionstructural constituent of cytoskeleton

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Actin-like protein 7B
PRO_0000089139

Sequences

Sequence LengthMass (Da)Tools
Q9Y614 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: F29F29C2101F0D8E

FASTA41545,234
        10         20         30         40         50         60 
MATRNSPMPL GTAQGDPGEA GTRPGPDASL RDTGAATQLK MKPRKVHKIK AVIIDLGSQY 

        70         80         90        100        110        120 
CKCGYAGEPR PTYFISSTVG KRCPEAADAG DTRKWTLVGH ELLNTEAPLK LVNPLKHGIV 

       130        140        150        160        170        180 
VDWDCVQDIW EYIFRTAMKI LPEEHAVLVS DPPLSPSSNR EKYAELMFET FGIPAMHVTS 

       190        200        210        220        230        240 
QSLLSIYSYG KTSGLVVESG HGVSHVVPIS EGDVLPGLTS RADYAGGDLT NYLMQLLNEA 

       250        260        270        280        290        300 
GHAFTDDHLH IIEHIKKKCC YAAFLPEEEL GLVPEELRVD YELPDGKLIT IGQERFRCSE 

       310        320        330        340        350        360 
MLFQPSLAGS TQPGLPELTA ACLGRCQDTG FKEEMAANVL LCGGCTMLDG FPERFQRELS 

       370        380        390        400        410 
LLCPGDSPAV AAAPERKTSV WTGGSILASL QAFQQLWVSK EEFEERGSVA IYSKC 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, mapping, and expression of two novel actin genes, actin-like-7A (ACTL7A) and actin-like-7B (ACTL7B), from the familial dysautonomia candidate region on 9q31."
Chadwick B.P., Mull J., Helbling L.A., Gill S., Leyne M., Robbins C.M., Pinkett H.W., Makalowska I., Maayan C., Blumenfeld A., Axelrod F.B., Brownstein M., Gusella J.F., Slaugenhaupt S.A.
Genomics 58:302-309(1999) [PubMed: 10373328] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[2]"Single nucleotide polymorphisms: discovery of the genetic causes of male infertility."
Tanaka H., Hirose M., Tokuhiro K., Matsuoka Y., Miyagawa Y., Tsujimura A., Okuyama A., Nishimune Y.
Soc. Reprod. Fertil. Suppl. 65:531-534(2007) [PubMed: 17644991] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed: 15164053] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF113527 Genomic DNA. Translation: AAD44110.1.
AB284521 Genomic DNA. Translation: BAF41972.1.
AK313871 mRNA. Translation: BAG36599.1.
AL359692 Genomic DNA. Translation: CAI40570.1.
CH471105 Genomic DNA. Translation: EAW59025.1.
BC033789 mRNA. Translation: AAH33789.1.
IPIIPI00009126.
RefSeqNP_006677.1. NM_006686.3.
UniGeneHs.534390.

3D structure databases

ProteinModelPortalQ9Y614.
SMRQ9Y614. Positions 48-415.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9Y614.

PTM databases

PhosphoSiteQ9Y614.

Polymorphism databases

DMDM27923724.

Proteomic databases

PRIDEQ9Y614.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000374667; ENSP00000363799; ENSG00000148156.
GeneID10880.
KEGGhsa:10880.
UCSCuc004bdi.1. human.

Organism-specific databases

CTD10880.
GeneCardsGC09M111616.
H-InvDBHIX0008263.
HGNCHGNC:162. ACTL7B.
HPAHPA021803.
HPA024664.
MIM604304. gene.
neXtProtNX_Q9Y614.
PharmGKBPA24484.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG11986.
GeneTreeENSGT00560000076554.
HOGENOMHBG559892.
HOVERGENHBG003771.
InParanoidQ9Y614.
OMAVVDWDCV.
OrthoDBEOG45QHD9.
PhylomeDBQ9Y614.

Gene expression databases

ArrayExpressQ9Y614.
BgeeQ9Y614.
CleanExHS_ACTL7B.
GenevestigatorQ9Y614.
GermOnlineENSG00000148156. Homo sapiens.

Family and domain databases

InterProIPR004000. Actin-like.
[Graphical view]
PANTHERPTHR11937. Actin_like. 1 hit.
PfamPF00022. Actin. 1 hit.
[Graphical view]
PRINTSPR00190. ACTIN.
SMARTSM00268. ACTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio41315.
SOURCESearch...

Entry information

Entry nameACL7B_HUMAN
AccessionPrimary (citable) accession number: Q9Y614
Secondary accession number(s): B2R9Q2, Q5JSV1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: November 1, 1999
Last modified: January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families