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Q9Y605

- MOFA1_HUMAN

UniProt

Q9Y605 - MOFA1_HUMAN

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Protein
MORF4 family-associated protein 1
Gene
MRFAP1, PAM14, PGR1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
MORF4 family-associated protein 1
Alternative name(s):
Protein PGR1
Protein associated with MRG of 14 kDa
Gene namesi
Name:MRFAP1
Synonyms:PAM14, PGR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:24549. MRFAP1.

Subcellular locationi

Nucleus. Cytoplasmperinuclear region
Note: Colocalizes with MORF4L1 to cell nuclei.2 Publications

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. perinuclear region of cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671332.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127MORF4 family-associated protein 1
PRO_0000306176Add
BLAST

Proteomic databases

MaxQBiQ9Y605.
PaxDbiQ9Y605.
PRIDEiQ9Y605.

PTM databases

PhosphoSiteiQ9Y605.

Expressioni

Gene expression databases

BgeeiQ9Y605.
CleanExiHS_MRFAP1.
GenevestigatoriQ9Y605.

Organism-specific databases

HPAiCAB042447.

Interactioni

Subunit structurei

Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H2Q9H5I12EBI-995714,EBI-723127

Protein-protein interaction databases

BioGridi125039. 12 interactions.
IntActiQ9Y605. 13 interactions.
MINTiMINT-8247393.
STRINGi9606.ENSP00000318352.

Structurei

3D structure databases

ProteinModelPortaliQ9Y605.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili92 – 12635 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG39174.
HOGENOMiHOG000070216.
HOVERGENiHBG104090.
InParanoidiQ9Y605.
OMAiRATKRCE.
OrthoDBiEOG7K6PXM.
PhylomeDBiQ9Y605.
TreeFamiTF338232.

Family and domain databases

InterProiIPR029254. MRFAP1.
[Graphical view]
PfamiPF15155. MRFAP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y605-1 [UniParc]FASTAAdd to Basket

« Hide

MRPLDIVELA EPEEVEVLEP EEDFEQFLLP VINEMREDIA SLTREHGRAY    50
LRNRSKLWEM DNMLIQIKTQ VEASEESALN HLQNPGDAAE GRAAKRCEKA 100
EEKAKEIAKM AEMLVELVRR IEKSESS 127
Length:127
Mass (Da):14,650
Last modified:November 1, 1999 - v1
Checksum:i11B115C2CCD661C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF116272 Genomic DNA. Translation: AAD38498.1.
CR457144 mRNA. Translation: CAG33425.1.
AK123360 mRNA. Translation: BAG53894.1.
CH471131 Genomic DNA. Translation: EAW82386.1.
CH471131 Genomic DNA. Translation: EAW82387.1.
BC022797 mRNA. Translation: AAH22797.1.
CCDSiCCDS3389.1.
RefSeqiNP_001258982.1. NM_001272053.1.
NP_150638.1. NM_033296.2.
UniGeneiHs.406590.

Genome annotation databases

EnsembliENST00000320912; ENSP00000318352; ENSG00000179010.
ENST00000382581; ENSP00000372024; ENSG00000179010.
ENST00000507420; ENSP00000422065; ENSG00000179010.
GeneIDi93621.
KEGGihsa:93621.
UCSCiuc003gjg.2. human.

Polymorphism databases

DMDMi74735297.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF116272 Genomic DNA. Translation: AAD38498.1 .
CR457144 mRNA. Translation: CAG33425.1 .
AK123360 mRNA. Translation: BAG53894.1 .
CH471131 Genomic DNA. Translation: EAW82386.1 .
CH471131 Genomic DNA. Translation: EAW82387.1 .
BC022797 mRNA. Translation: AAH22797.1 .
CCDSi CCDS3389.1.
RefSeqi NP_001258982.1. NM_001272053.1.
NP_150638.1. NM_033296.2.
UniGenei Hs.406590.

3D structure databases

ProteinModelPortali Q9Y605.
ModBasei Search...

Protein-protein interaction databases

BioGridi 125039. 12 interactions.
IntActi Q9Y605. 13 interactions.
MINTi MINT-8247393.
STRINGi 9606.ENSP00000318352.

PTM databases

PhosphoSitei Q9Y605.

Polymorphism databases

DMDMi 74735297.

Proteomic databases

MaxQBi Q9Y605.
PaxDbi Q9Y605.
PRIDEi Q9Y605.

Protocols and materials databases

DNASUi 93621.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320912 ; ENSP00000318352 ; ENSG00000179010 .
ENST00000382581 ; ENSP00000372024 ; ENSG00000179010 .
ENST00000507420 ; ENSP00000422065 ; ENSG00000179010 .
GeneIDi 93621.
KEGGi hsa:93621.
UCSCi uc003gjg.2. human.

Organism-specific databases

CTDi 93621.
GeneCardsi GC04P006573.
HGNCi HGNC:24549. MRFAP1.
HPAi CAB042447.
neXtProti NX_Q9Y605.
PharmGKBi PA142671332.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39174.
HOGENOMi HOG000070216.
HOVERGENi HBG104090.
InParanoidi Q9Y605.
OMAi RATKRCE.
OrthoDBi EOG7K6PXM.
PhylomeDBi Q9Y605.
TreeFami TF338232.

Miscellaneous databases

ChiTaRSi MRFAP1. human.
GeneWikii MRFAP1.
GenomeRNAii 93621.
NextBioi 78157.
PROi Q9Y605.

Gene expression databases

Bgeei Q9Y605.
CleanExi HS_MRFAP1.
Genevestigatori Q9Y605.

Family and domain databases

InterProi IPR029254. MRFAP1.
[Graphical view ]
Pfami PF15155. MRFAP1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PGR1 is a novel T-cell activation protein."
    Juwana J.P., Gerlach K., Wadle A., Pfreundschuh M., Renner C.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: T-cell.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Caudate nucleus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  6. "MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14."
    Leung J.K., Berube N., Venable S., Ahmed S., Timchenko N., Pereira-Smith O.M.
    J. Biol. Chem. 276:39171-39178(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MORF4L1, SUBCELLULAR LOCATION.
  7. "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation."
    Pardo P.S., Leung J.K., Lucchesi J.C., Pereira-Smith O.M.
    J. Biol. Chem. 277:50860-50866(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN A COMPLEX WITH MORF4L1 AND RB1, SUBCELLULAR LOCATION.
  8. "MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner."
    Tominaga K., Leung J.K., Rookard P., Echigo J., Smith J.R., Pereira-Smith O.M.
    J. Biol. Chem. 278:49618-49624(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MORF4L2.
  9. "The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14."
    Zhang P., Zhao J., Wang B., Du J., Lu Y., Chen J., Ding J.
    Protein Sci. 15:2423-2434(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MORF4L1.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMOFA1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y605
Secondary accession number(s): B3KVT2, D3DVT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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