Q9Y605 (MOFA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
MORF4 family-associated protein 1

Alternative name(s):
Protein PGR1
Protein associated with MRG of 14 kDa

Gene names

Name:	MRFAP1
Synonyms:	PAM14, PGR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2. Ref.6 Ref.7 Ref.8 Ref.9 UniProtKB Q5M820
Subcellular location	Nucleus. Cytoplasm › perinuclear region. Note: Colocalizes with MORF4L1 to cell nuclei. Ref.6 Ref.7
Sequence similarities	Belongs to the MORF4 family-associated protein family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 127	127	MORF4 family-associated protein 1		PRO_0000306176
Regions
	Coiled coil	92 – 126	35	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9Y605 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 11B115C2CCD661C8	FASTA	127	14,650
	10 20 30 40 50 60 MRPLDIVELA EPEEVEVLEP EEDFEQFLLP VINEMREDIA SLTREHGRAY LRNRSKLWEM 70 80 90 100 110 120 DNMLIQIKTQ VEASEESALN HLQNPGDAAE GRAAKRCEKA EEKAKEIAKM AEMLVELVRR IEKSESS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PGR1 is a novel T-cell activation protein." Juwana J.P., Gerlach K., Wadle A., Pfreundschuh M., Renner C. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Tissue: T-cell.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Caudate nucleus.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[6]	"MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14." Leung J.K., Berube N., Venable S., Ahmed S., Timchenko N., Pereira-Smith O.M. J. Biol. Chem. 276:39171-39178(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MORF4L1, SUBCELLULAR LOCATION.
[7]	"MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation." Pardo P.S., Leung J.K., Lucchesi J.C., Pereira-Smith O.M. J. Biol. Chem. 277:50860-50866(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A COMPLEX WITH MORF4L1 AND RB1, SUBCELLULAR LOCATION.
[8]	"MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner." Tominaga K., Leung J.K., Rookard P., Echigo J., Smith J.R., Pereira-Smith O.M. J. Biol. Chem. 278:49618-49624(2003) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MORF4L2.
[9]	"The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14." Zhang P., Zhao J., Wang B., Du J., Lu Y., Chen J., Ding J. Protein Sci. 15:2423-2434(2006) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MORF4L1.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF116272 Genomic DNA. Translation: AAD38498.1. CR457144 mRNA. Translation: CAG33425.1. AK123360 mRNA. Translation: BAG53894.1. CH471131 Genomic DNA. Translation: EAW82386.1. CH471131 Genomic DNA. Translation: EAW82387.1. BC022797 mRNA. Translation: AAH22797.1.
IPI	IPI00020915.
RefSeq	NP_001258982.1. NM_001272053.1. NP_150638.1. NM_033296.2.
UniGene	Hs.727355.
3D structure databases
ProteinModelPortal	Q9Y605.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y605. 7 interactions.
STRING	9606.ENSP00000318352.
PTM databases
PhosphoSite	Q9Y605.
Polymorphism databases
DMDM	74735297.
Proteomic databases
PaxDb	Q9Y605.
PRIDE	Q9Y605.
Protocols and materials databases
DNASU	93621.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000320912; ENSP00000318352; ENSG00000179010. ENST00000382581; ENSP00000372024; ENSG00000179010. ENST00000507420; ENSP00000422065; ENSG00000179010.
GeneID	93621.
KEGG	hsa:93621.
UCSC	uc003gjg.1. human.
Organism-specific databases
CTD	93621.
GeneCards	GC04P006573.
HGNC	HGNC:24549. MRFAP1.
HPA	CAB042447.
neXtProt	NX_Q9Y605.
PharmGKB	PA142671332.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39174.
HOGENOM	HOG000070216.
HOVERGEN	HBG104090.
InParanoid	Q9Y605.
OMA	GTKRCEK.
OrthoDB	EOG4B2SZT.
PhylomeDB	Q9Y605.
Gene expression databases
Bgee	Q9Y605.
CleanEx	HS_MRFAP1.
Genevestigator	Q9Y605.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	MRFAP1. human.
GenomeRNAi	93621.
NextBio	78157.

Entry information

Entry name

MOFA1_HUMAN

Accession

Primary (citable) accession number: Q9Y605
Secondary accession number(s): B3KVT2, D3DVT3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	November 1, 1999
Last modified:	April 3, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.