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Q9Y605 (MOFA1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MORF4 family-associated protein 1
Alternative name(s):
Protein PGR1
Protein associated with MRG of 14 kDa
Gene names
Name:MRFAP1
Synonyms:PAM14, PGR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length127 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2. Ref.6 Ref.7 Ref.8 Ref.9 UniProtKB Q5M820

Subcellular location

Nucleus. Cytoplasmperinuclear region. Note: Colocalizes with MORF4L1 to cell nuclei. Ref.6 Ref.7

Sequence similarities

Belongs to the MORF4 family-associated protein family.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SUV39H2Q9H5I12EBI-995714,EBI-723127

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 127127MORF4 family-associated protein 1
PRO_0000306176

Regions

Coiled coil92 – 12635 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9Y605 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 11B115C2CCD661C8

FASTA12714,650
        10         20         30         40         50         60 
MRPLDIVELA EPEEVEVLEP EEDFEQFLLP VINEMREDIA SLTREHGRAY LRNRSKLWEM 

        70         80         90        100        110        120 
DNMLIQIKTQ VEASEESALN HLQNPGDAAE GRAAKRCEKA EEKAKEIAKM AEMLVELVRR 


IEKSESS 

« Hide

References

« Hide 'large scale' references
[1]"PGR1 is a novel T-cell activation protein."
Juwana J.P., Gerlach K., Wadle A., Pfreundschuh M., Renner C.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Tissue: T-cell.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Caudate nucleus.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[6]"MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14."
Leung J.K., Berube N., Venable S., Ahmed S., Timchenko N., Pereira-Smith O.M.
J. Biol. Chem. 276:39171-39178(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MORF4L1, SUBCELLULAR LOCATION.
[7]"MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation."
Pardo P.S., Leung J.K., Lucchesi J.C., Pereira-Smith O.M.
J. Biol. Chem. 277:50860-50866(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A COMPLEX WITH MORF4L1 AND RB1, SUBCELLULAR LOCATION.
[8]"MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner."
Tominaga K., Leung J.K., Rookard P., Echigo J., Smith J.R., Pereira-Smith O.M.
J. Biol. Chem. 278:49618-49624(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MORF4L2.
[9]"The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14."
Zhang P., Zhao J., Wang B., Du J., Lu Y., Chen J., Ding J.
Protein Sci. 15:2423-2434(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MORF4L1.
[10]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF116272 Genomic DNA. Translation: AAD38498.1.
CR457144 mRNA. Translation: CAG33425.1.
AK123360 mRNA. Translation: BAG53894.1.
CH471131 Genomic DNA. Translation: EAW82386.1.
CH471131 Genomic DNA. Translation: EAW82387.1.
BC022797 mRNA. Translation: AAH22797.1.
RefSeqNP_001258982.1. NM_001272053.1.
NP_150638.1. NM_033296.2.
UniGeneHs.406590.

3D structure databases

ProteinModelPortalQ9Y605.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid125039. 12 interactions.
IntActQ9Y605. 12 interactions.
MINTMINT-8247393.
STRING9606.ENSP00000318352.

PTM databases

PhosphoSiteQ9Y605.

Polymorphism databases

DMDM74735297.

Proteomic databases

PaxDbQ9Y605.
PRIDEQ9Y605.

Protocols and materials databases

DNASU93621.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320912; ENSP00000318352; ENSG00000179010.
ENST00000382581; ENSP00000372024; ENSG00000179010.
ENST00000507420; ENSP00000422065; ENSG00000179010.
GeneID93621.
KEGGhsa:93621.
UCSCuc003gjg.2. human.

Organism-specific databases

CTD93621.
GeneCardsGC04P006573.
HGNCHGNC:24549. MRFAP1.
HPACAB042447.
neXtProtNX_Q9Y605.
PharmGKBPA142671332.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39174.
HOGENOMHOG000070216.
HOVERGENHBG104090.
InParanoidQ9Y605.
OMAGTKRCEK.
OrthoDBEOG7K6PXM.
PhylomeDBQ9Y605.
TreeFamTF338232.

Gene expression databases

BgeeQ9Y605.
CleanExHS_MRFAP1.
GenevestigatorQ9Y605.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSMRFAP1. human.
GeneWikiMRFAP1.
GenomeRNAi93621.
NextBio78157.
PROQ9Y605.

Entry information

Entry nameMOFA1_HUMAN
AccessionPrimary (citable) accession number: Q9Y605
Secondary accession number(s): B3KVT2, D3DVT3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM