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Q9Y605

- MOFA1_HUMAN

UniProt

Q9Y605 - MOFA1_HUMAN

Protein

MORF4 family-associated protein 1

Gene

MRFAP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MORF4 family-associated protein 1
    Alternative name(s):
    Protein PGR1
    Protein associated with MRG of 14 kDa
    Gene namesi
    Name:MRFAP1Imported
    Synonyms:PAM141 Publication, PGR1Imported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:24549. MRFAP1.

    Subcellular locationi

    Nucleus 2 Publications. Cytoplasmperinuclear region 2 Publications
    Note: Colocalizes with MORF4L1 to cell nuclei.2 Publications

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. perinuclear region of cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671332.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 127127MORF4 family-associated protein 1PRO_0000306176Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y605.
    PaxDbiQ9Y605.
    PRIDEiQ9Y605.

    PTM databases

    PhosphoSiteiQ9Y605.

    Expressioni

    Gene expression databases

    BgeeiQ9Y605.
    CleanExiHS_MRFAP1.
    GenevestigatoriQ9Y605.

    Organism-specific databases

    HPAiCAB042447.

    Interactioni

    Subunit structurei

    Found in a complex composed of MORF4L1, MRFAP1 and RB1. Interacts via its N-terminus with MORF4L1. Interacts with CSTB and MORF4L2.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SUV39H2Q9H5I12EBI-995714,EBI-723127

    Protein-protein interaction databases

    BioGridi125039. 12 interactions.
    IntActiQ9Y605. 13 interactions.
    MINTiMINT-8247393.
    STRINGi9606.ENSP00000318352.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y605.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili92 – 12635Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG39174.
    HOGENOMiHOG000070216.
    HOVERGENiHBG104090.
    InParanoidiQ9Y605.
    OMAiRATKRCE.
    OrthoDBiEOG7K6PXM.
    PhylomeDBiQ9Y605.
    TreeFamiTF338232.

    Family and domain databases

    InterProiIPR029254. MRFAP1.
    [Graphical view]
    PfamiPF15155. MRFAP1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y605-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPLDIVELA EPEEVEVLEP EEDFEQFLLP VINEMREDIA SLTREHGRAY    50
    LRNRSKLWEM DNMLIQIKTQ VEASEESALN HLQNPGDAAE GRAAKRCEKA 100
    EEKAKEIAKM AEMLVELVRR IEKSESS 127
    Length:127
    Mass (Da):14,650
    Last modified:November 1, 1999 - v1
    Checksum:i11B115C2CCD661C8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF116272 Genomic DNA. Translation: AAD38498.1.
    CR457144 mRNA. Translation: CAG33425.1.
    AK123360 mRNA. Translation: BAG53894.1.
    CH471131 Genomic DNA. Translation: EAW82386.1.
    CH471131 Genomic DNA. Translation: EAW82387.1.
    BC022797 mRNA. Translation: AAH22797.1.
    CCDSiCCDS3389.1.
    RefSeqiNP_001258982.1. NM_001272053.1.
    NP_150638.1. NM_033296.2.
    UniGeneiHs.406590.

    Genome annotation databases

    EnsembliENST00000320912; ENSP00000318352; ENSG00000179010.
    ENST00000382581; ENSP00000372024; ENSG00000179010.
    ENST00000507420; ENSP00000422065; ENSG00000179010.
    GeneIDi93621.
    KEGGihsa:93621.
    UCSCiuc003gjg.2. human.

    Polymorphism databases

    DMDMi74735297.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF116272 Genomic DNA. Translation: AAD38498.1 .
    CR457144 mRNA. Translation: CAG33425.1 .
    AK123360 mRNA. Translation: BAG53894.1 .
    CH471131 Genomic DNA. Translation: EAW82386.1 .
    CH471131 Genomic DNA. Translation: EAW82387.1 .
    BC022797 mRNA. Translation: AAH22797.1 .
    CCDSi CCDS3389.1.
    RefSeqi NP_001258982.1. NM_001272053.1.
    NP_150638.1. NM_033296.2.
    UniGenei Hs.406590.

    3D structure databases

    ProteinModelPortali Q9Y605.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125039. 12 interactions.
    IntActi Q9Y605. 13 interactions.
    MINTi MINT-8247393.
    STRINGi 9606.ENSP00000318352.

    PTM databases

    PhosphoSitei Q9Y605.

    Polymorphism databases

    DMDMi 74735297.

    Proteomic databases

    MaxQBi Q9Y605.
    PaxDbi Q9Y605.
    PRIDEi Q9Y605.

    Protocols and materials databases

    DNASUi 93621.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320912 ; ENSP00000318352 ; ENSG00000179010 .
    ENST00000382581 ; ENSP00000372024 ; ENSG00000179010 .
    ENST00000507420 ; ENSP00000422065 ; ENSG00000179010 .
    GeneIDi 93621.
    KEGGi hsa:93621.
    UCSCi uc003gjg.2. human.

    Organism-specific databases

    CTDi 93621.
    GeneCardsi GC04P006573.
    HGNCi HGNC:24549. MRFAP1.
    HPAi CAB042447.
    neXtProti NX_Q9Y605.
    PharmGKBi PA142671332.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39174.
    HOGENOMi HOG000070216.
    HOVERGENi HBG104090.
    InParanoidi Q9Y605.
    OMAi RATKRCE.
    OrthoDBi EOG7K6PXM.
    PhylomeDBi Q9Y605.
    TreeFami TF338232.

    Miscellaneous databases

    ChiTaRSi MRFAP1. human.
    GeneWikii MRFAP1.
    GenomeRNAii 93621.
    NextBioi 78157.
    PROi Q9Y605.

    Gene expression databases

    Bgeei Q9Y605.
    CleanExi HS_MRFAP1.
    Genevestigatori Q9Y605.

    Family and domain databases

    InterProi IPR029254. MRFAP1.
    [Graphical view ]
    Pfami PF15155. MRFAP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PGR1 is a novel T-cell activation protein."
      Juwana J.P., Gerlach K., Wadle A., Pfreundschuh M., Renner C.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: T-cellImported.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Caudate nucleus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: SkinImported.
    6. "MRG15 activates the B-myb promoter through formation of a nuclear complex with the retinoblastoma protein and the novel protein PAM14."
      Leung J.K., Berube N., Venable S., Ahmed S., Timchenko N., Pereira-Smith O.M.
      J. Biol. Chem. 276:39171-39178(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MORF4L1, SUBCELLULAR LOCATION.
    7. "MRG15, a novel chromodomain protein, is present in two distinct multiprotein complexes involved in transcriptional activation."
      Pardo P.S., Leung J.K., Lucchesi J.C., Pereira-Smith O.M.
      J. Biol. Chem. 277:50860-50866(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH MORF4L1 AND RB1, SUBCELLULAR LOCATION.
    8. "MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner."
      Tominaga K., Leung J.K., Rookard P., Echigo J., Smith J.R., Pereira-Smith O.M.
      J. Biol. Chem. 278:49618-49624(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MORF4L2.
    9. "The MRG domain of human MRG15 uses a shallow hydrophobic pocket to interact with the N-terminal region of PAM14."
      Zhang P., Zhao J., Wang B., Du J., Lu Y., Chen J., Ding J.
      Protein Sci. 15:2423-2434(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MORF4L1.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMOFA1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y605
    Secondary accession number(s): B3KVT2, D3DVT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3