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Protein

Cysteine sulfinic acid decarboxylase

Gene

CSAD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

3-sulfino-L-alanine = hypotaurine + CO2.

Cofactori

pyridoxal 5'-phosphate1 Publication

Pathwayi: taurine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes hypotaurine from L-cysteine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Cysteine dioxygenase type 1 (CDO1)
  2. Cysteine sulfinic acid decarboxylase (CSAD)
This subpathway is part of the pathway taurine biosynthesis, which is itself part of Organosulfur biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes hypotaurine from L-cysteine, the pathway taurine biosynthesis and in Organosulfur biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS06642-MONOMER.
ZFISH:HS06642-MONOMER.
BRENDAi4.1.1.29. 2681.
ReactomeiR-HSA-1614558. Degradation of cysteine and homocysteine.
UniPathwayiUPA00012; UER00538.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine sulfinic acid decarboxylase (EC:4.1.1.29)
Alternative name(s):
Cysteine-sulfinate decarboxylase
Sulfinoalanine decarboxylase
Gene namesi
Name:CSAD
Synonyms:CSD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:18966. CSAD.

Pathology & Biotechi

Organism-specific databases

DisGeNETi51380.
OpenTargetsiENSG00000139631.
PharmGKBiPA38771.

Chemistry databases

DrugBankiDB00151. L-Cysteine.

Polymorphism and mutation databases

BioMutaiCSAD.
DMDMi116241317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001470061 – 493Cysteine sulfinic acid decarboxylaseAdd BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei305N6-(pyridoxal phosphate)lysine1

Proteomic databases

PaxDbiQ9Y600.
PeptideAtlasiQ9Y600.
PRIDEiQ9Y600.

PTM databases

iPTMnetiQ9Y600.
PhosphoSitePlusiQ9Y600.

Expressioni

Gene expression databases

BgeeiENSG00000139631.
CleanExiHS_CSAD.
ExpressionAtlasiQ9Y600. baseline and differential.
GenevisibleiQ9Y600. HS.

Organism-specific databases

HPAiHPA039487.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi119512. 13 interactors.
IntActiQ9Y600. 11 interactors.
MINTiMINT-4832217.
STRINGi9606.ENSP00000267085.

Structurei

Secondary structure

1493
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 31Combined sources18
Turni32 – 34Combined sources3
Helixi35 – 37Combined sources3
Helixi49 – 56Combined sources8
Helixi67 – 80Combined sources14
Beta strandi89 – 93Combined sources5
Helixi99 – 111Combined sources13
Turni118 – 120Combined sources3
Helixi122 – 139Combined sources18
Beta strandi145 – 151Combined sources7
Helixi152 – 167Combined sources16
Helixi171 – 174Combined sources4
Helixi176 – 178Combined sources3
Beta strandi182 – 187Combined sources6
Helixi193 – 200Combined sources8
Helixi205 – 207Combined sources3
Beta strandi208 – 211Combined sources4
Helixi221 – 233Combined sources13
Beta strandi237 – 246Combined sources10
Turni248 – 250Combined sources3
Helixi256 – 266Combined sources11
Beta strandi269 – 274Combined sources6
Helixi277 – 282Combined sources6
Turni284 – 286Combined sources3
Helixi287 – 290Combined sources4
Helixi293 – 295Combined sources3
Beta strandi297 – 301Combined sources5
Beta strandi314 – 319Combined sources6
Helixi324 – 329Combined sources6
Helixi345 – 347Combined sources3
Helixi350 – 352Combined sources3
Helixi362 – 396Combined sources35
Beta strandi401 – 405Combined sources5
Beta strandi408 – 416Combined sources9
Helixi419 – 421Combined sources3
Helixi430 – 435Combined sources6
Helixi437 – 448Combined sources12
Beta strandi452 – 458Combined sources7
Beta strandi461 – 468Combined sources8
Helixi476 – 490Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JISX-ray1.60A/B1-493[»]
ProteinModelPortaliQ9Y600.
SMRiQ9Y600.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y600.

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000005382.
HOVERGENiHBG004980.
InParanoidiQ9Y600.
KOiK01594.
OMAiISNMYAV.
OrthoDBiEOG091G07ZU.
PhylomeDBiQ9Y600.
TreeFamiTF314688.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y600-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADSEALPSL AGDPVAVEAL LRAVFGVVVD EAIQKGTSVS QKVCEWKEPE
60 70 80 90 100
ELKQLLDLEL RSQGESQKQI LERCRAVIRY SVKTGHPRFF NQLFSGLDPH
110 120 130 140 150
ALAGRIITES LNTSQYTYEI APVFVLMEEE VLRKLRALVG WSSGDGIFCP
160 170 180 190 200
GGSISNMYAV NLARYQRYPD CKQRGLRTLP PLALFTSKEC HYSIQKGAAF
210 220 230 240 250
LGLGTDSVRV VKADERGKMV PEDLERQIGM AEAEGAVPFL VSATSGTTVL
260 270 280 290 300
GAFDPLEAIA DVCQRHGLWL HVDAAWGGSV LLSQTHRHLL DGIQRADSVA
310 320 330 340 350
WNPHKLLAAG LQCSALLLQD TSNLLKRCHG SQASYLFQQD KFYDVALDTG
360 370 380 390 400
DKVVQCGRRV DCLKLWLMWK AQGDQGLERR IDQAFVLARY LVEEMKKREG
410 420 430 440 450
FELVMEPEFV NVCFWFVPPS LRGKQESPDY HERLSKVAPV LKERMVKEGS
460 470 480 490
MMIGYQPHGT RGNFFRVVVA NSALTCADMD FLLNELERLG QDL
Length:493
Mass (Da):55,023
Last modified:October 17, 2006 - v2
Checksum:i09BA2028D942016E
GO
Isoform 2 (identifier: Q9Y600-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     43-189: Missing.

Show »
Length:346
Mass (Da):38,232
Checksum:iE214BE34AFA35101
GO
Isoform 3 (identifier: Q9Y600-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSIPLKSSFLLSYLCTLPPALLSREILM

Note: No experimental confirmation available.Curated
Show »
Length:520
Mass (Da):58,012
Checksum:i5EE3EF5294A87E27
GO

Sequence cautioni

The sequence AAD32546 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH98278 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH98342 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAH99717 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI05919 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257E → G in AAD32545 (Ref. 1) Curated1
Sequence conflicti377L → P in AAD32546 (Ref. 1) Curated1
Sequence conflicti433R → G in AAD32544 (Ref. 1) Curated1
Isoform 3 (identifier: Q9Y600-3)
Sequence conflicti9F → S in AAH98342 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0390021M → MSIPLKSSFLLSYLCTLPPA LLSREILM in isoform 3. 2 Publications1
Alternative sequenceiVSP_00130743 – 189Missing in isoform 2. 2 PublicationsAdd BLAST147

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116546 mRNA. Translation: AAD32544.1.
AF116547 mRNA. Translation: AAD32545.1.
AF116548 mRNA. Translation: AAD32546.1. Different initiation.
AK289659 mRNA. Translation: BAF82348.1.
CH471054 Genomic DNA. Translation: EAW96670.1.
BC098278 mRNA. Translation: AAH98278.1. Different initiation.
BC098342 mRNA. Translation: AAH98342.1. Different initiation.
BC099717 mRNA. Translation: AAH99717.1. Different initiation.
BC105918 mRNA. Translation: AAI05919.1. Different initiation.
CCDSiCCDS58235.1. [Q9Y600-1]
CCDS8848.2. [Q9Y600-3]
RefSeqiNP_001231634.1. NM_001244705.1. [Q9Y600-1]
NP_057073.4. NM_015989.4. [Q9Y600-3]
XP_011536748.1. XM_011538446.2. [Q9Y600-3]
UniGeneiHs.279815.

Genome annotation databases

EnsembliENST00000267085; ENSP00000267085; ENSG00000139631. [Q9Y600-3]
ENST00000379846; ENSP00000369175; ENSG00000139631. [Q9Y600-2]
ENST00000444623; ENSP00000415485; ENSG00000139631. [Q9Y600-1]
ENST00000453446; ENSP00000410648; ENSG00000139631. [Q9Y600-1]
GeneIDi51380.
KEGGihsa:51380.
UCSCiuc001sbz.4. human. [Q9Y600-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116546 mRNA. Translation: AAD32544.1.
AF116547 mRNA. Translation: AAD32545.1.
AF116548 mRNA. Translation: AAD32546.1. Different initiation.
AK289659 mRNA. Translation: BAF82348.1.
CH471054 Genomic DNA. Translation: EAW96670.1.
BC098278 mRNA. Translation: AAH98278.1. Different initiation.
BC098342 mRNA. Translation: AAH98342.1. Different initiation.
BC099717 mRNA. Translation: AAH99717.1. Different initiation.
BC105918 mRNA. Translation: AAI05919.1. Different initiation.
CCDSiCCDS58235.1. [Q9Y600-1]
CCDS8848.2. [Q9Y600-3]
RefSeqiNP_001231634.1. NM_001244705.1. [Q9Y600-1]
NP_057073.4. NM_015989.4. [Q9Y600-3]
XP_011536748.1. XM_011538446.2. [Q9Y600-3]
UniGeneiHs.279815.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JISX-ray1.60A/B1-493[»]
ProteinModelPortaliQ9Y600.
SMRiQ9Y600.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119512. 13 interactors.
IntActiQ9Y600. 11 interactors.
MINTiMINT-4832217.
STRINGi9606.ENSP00000267085.

Chemistry databases

DrugBankiDB00151. L-Cysteine.

PTM databases

iPTMnetiQ9Y600.
PhosphoSitePlusiQ9Y600.

Polymorphism and mutation databases

BioMutaiCSAD.
DMDMi116241317.

Proteomic databases

PaxDbiQ9Y600.
PeptideAtlasiQ9Y600.
PRIDEiQ9Y600.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267085; ENSP00000267085; ENSG00000139631. [Q9Y600-3]
ENST00000379846; ENSP00000369175; ENSG00000139631. [Q9Y600-2]
ENST00000444623; ENSP00000415485; ENSG00000139631. [Q9Y600-1]
ENST00000453446; ENSP00000410648; ENSG00000139631. [Q9Y600-1]
GeneIDi51380.
KEGGihsa:51380.
UCSCiuc001sbz.4. human. [Q9Y600-1]

Organism-specific databases

CTDi51380.
DisGeNETi51380.
GeneCardsiCSAD.
HGNCiHGNC:18966. CSAD.
HPAiHPA039487.
MIMi616569. gene.
neXtProtiNX_Q9Y600.
OpenTargetsiENSG00000139631.
PharmGKBiPA38771.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0629. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.
HOGENOMiHOG000005382.
HOVERGENiHBG004980.
InParanoidiQ9Y600.
KOiK01594.
OMAiISNMYAV.
OrthoDBiEOG091G07ZU.
PhylomeDBiQ9Y600.
TreeFamiTF314688.

Enzyme and pathway databases

UniPathwayiUPA00012; UER00538.
BioCyciMetaCyc:HS06642-MONOMER.
ZFISH:HS06642-MONOMER.
BRENDAi4.1.1.29. 2681.
ReactomeiR-HSA-1614558. Degradation of cysteine and homocysteine.

Miscellaneous databases

ChiTaRSiCSAD. human.
EvolutionaryTraceiQ9Y600.
GenomeRNAii51380.
PROiQ9Y600.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139631.
CleanExiHS_CSAD.
ExpressionAtlasiQ9Y600. baseline and differential.
GenevisibleiQ9Y600. HS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCSAD_HUMAN
AccessioniPrimary (citable) accession number: Q9Y600
Secondary accession number(s): A8K0U4
, Q4QQH9, Q9UNJ5, Q9Y601
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: November 2, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.