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Q9Y600 (CSAD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine sulfinic acid decarboxylase

EC=4.1.1.29
Alternative name(s):
Cysteine-sulfinate decarboxylase
Sulfinoalanine decarboxylase
Gene names
Name:CSAD
Synonyms:CSD
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

3-sulfino-L-alanine = hypotaurine + CO2.

Cofactor

Pyridoxal phosphate. Ref.5

Pathway

Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the group II decarboxylase family.

Sequence caution

The sequence AAD32546.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAH98278.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAH98342.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAH99717.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAI05919.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y600-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y600-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     43-189: Missing.
Isoform 3 (identifier: Q9Y600-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSIPLKSSFLLSYLCTLPPALLSREILM
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 493493Cysteine sulfinic acid decarboxylase
PRO_0000147006

Amino acid modifications

Modified residue3051N6-(pyridoxal phosphate)lysine

Natural variations

Alternative sequence11M → MSIPLKSSFLLSYLCTLPPA LLSREILM in isoform 3.
VSP_039002
Alternative sequence43 – 189147Missing in isoform 2.
VSP_001307

Experimental info

Sequence conflict2571E → G in AAD32545. Ref.1
Sequence conflict3771L → P in AAD32546. Ref.1
Sequence conflict4331R → G in AAD32544. Ref.1
Isoform 3:
Sequence conflict91F → S in AAH98342. Ref.4

Secondary structure

............................................................................ 493
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Long) [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: 09BA2028D942016E

FASTA49355,023
        10         20         30         40         50         60 
MADSEALPSL AGDPVAVEAL LRAVFGVVVD EAIQKGTSVS QKVCEWKEPE ELKQLLDLEL 

        70         80         90        100        110        120 
RSQGESQKQI LERCRAVIRY SVKTGHPRFF NQLFSGLDPH ALAGRIITES LNTSQYTYEI 

       130        140        150        160        170        180 
APVFVLMEEE VLRKLRALVG WSSGDGIFCP GGSISNMYAV NLARYQRYPD CKQRGLRTLP 

       190        200        210        220        230        240 
PLALFTSKEC HYSIQKGAAF LGLGTDSVRV VKADERGKMV PEDLERQIGM AEAEGAVPFL 

       250        260        270        280        290        300 
VSATSGTTVL GAFDPLEAIA DVCQRHGLWL HVDAAWGGSV LLSQTHRHLL DGIQRADSVA 

       310        320        330        340        350        360 
WNPHKLLAAG LQCSALLLQD TSNLLKRCHG SQASYLFQQD KFYDVALDTG DKVVQCGRRV 

       370        380        390        400        410        420 
DCLKLWLMWK AQGDQGLERR IDQAFVLARY LVEEMKKREG FELVMEPEFV NVCFWFVPPS 

       430        440        450        460        470        480 
LRGKQESPDY HERLSKVAPV LKERMVKEGS MMIGYQPHGT RGNFFRVVVA NSALTCADMD 

       490 
FLLNELERLG QDL 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: E214BE34AFA35101
Show »

FASTA34638,232
Isoform 3 [UniParc].

Checksum: 5EE3EF5294A87E27
Show »

FASTA52058,012

References

« Hide 'large scale' references
[1]Pritchard J.E., Ramsden D.B.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Amygdala.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[5]"The crystal structure of human cysteine sulfinic acid decarboxylase (CSAD)."
Structural genomics consortium (SGC)
Submitted (AUG-2007) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) IN COMPLEX WITH PYRIDOXAL PHOSPHATE, COFACTOR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF116546 mRNA. Translation: AAD32544.1.
AF116547 mRNA. Translation: AAD32545.1.
AF116548 mRNA. Translation: AAD32546.1. Different initiation.
AK289659 mRNA. Translation: BAF82348.1.
CH471054 Genomic DNA. Translation: EAW96670.1.
BC098278 mRNA. Translation: AAH98278.1. Different initiation.
BC098342 mRNA. Translation: AAH98342.1. Different initiation.
BC099717 mRNA. Translation: AAH99717.1. Different initiation.
BC105918 mRNA. Translation: AAI05919.1. Different initiation.
CCDSCCDS58235.1. [Q9Y600-1]
CCDS8848.2. [Q9Y600-3]
RefSeqNP_001231634.1. NM_001244705.1. [Q9Y600-1]
NP_057073.4. NM_015989.4. [Q9Y600-3]
XP_006719510.1. XM_006719447.1. [Q9Y600-3]
UniGeneHs.279815.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2JISX-ray1.60A/B1-493[»]
ProteinModelPortalQ9Y600.
SMRQ9Y600. Positions 7-493.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119512. 11 interactions.
IntActQ9Y600. 10 interactions.
MINTMINT-4832217.
STRING9606.ENSP00000267085.

Chemistry

DrugBankDB00151. L-Cysteine.
DB00114. Pyridoxal Phosphate.

PTM databases

PhosphoSiteQ9Y600.

Polymorphism databases

DMDM116241317.

Proteomic databases

MaxQBQ9Y600.
PaxDbQ9Y600.
PRIDEQ9Y600.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267085; ENSP00000267085; ENSG00000139631. [Q9Y600-3]
ENST00000379843; ENSP00000369172; ENSG00000139631. [Q9Y600-2]
ENST00000379846; ENSP00000369175; ENSG00000139631. [Q9Y600-2]
ENST00000444623; ENSP00000415485; ENSG00000139631. [Q9Y600-1]
ENST00000453446; ENSP00000410648; ENSG00000139631. [Q9Y600-1]
GeneID51380.
KEGGhsa:51380.
UCSCuc001sbw.3. human. [Q9Y600-2]
uc001sby.3. human. [Q9Y600-1]
uc010snx.2. human. [Q9Y600-3]

Organism-specific databases

CTD51380.
GeneCardsGC12M053551.
HGNCHGNC:18966. CSAD.
HPAHPA039487.
neXtProtNX_Q9Y600.
PharmGKBPA38771.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0076.
HOGENOMHOG000005382.
HOVERGENHBG004980.
InParanoidQ9Y600.
KOK01594.
OMALQDTSNL.
OrthoDBEOG7H1JM3.
PhylomeDBQ9Y600.
TreeFamTF314688.

Enzyme and pathway databases

BioCycMetaCyc:HS06642-MONOMER.
ReactomeREACT_111217. Metabolism.
UniPathwayUPA00012; UER00538.

Gene expression databases

ArrayExpressQ9Y600.
BgeeQ9Y600.
CleanExHS_CSAD.
GenevestigatorQ9Y600.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
ProtoNetSearch...

Other

ChiTaRSCSAD. human.
EvolutionaryTraceQ9Y600.
GenomeRNAi51380.
NextBio54887.
PROQ9Y600.

Entry information

Entry nameCSAD_HUMAN
AccessionPrimary (citable) accession number: Q9Y600
Secondary accession number(s): A8K0U4 expand/collapse secondary AC list , Q4QQH9, Q9UNJ5, Q9Y601
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 17, 2006
Last modified: July 9, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM