Q9Y600 (CSAD_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cysteine sulfinic acid decarboxylase
EC=4.1.1.29

Alternative name(s):
Cysteine-sulfinate decarboxylase
Sulfinoalanine decarboxylase

Gene names

Name:	CSAD
Synonyms:	CSD

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	3-sulfino-L-alanine = hypotaurine + CO2.
Cofactor	Pyridoxal phosphate. Ref.5
Pathway	Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 2/2.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the group II decarboxylase family.
Sequence caution	The sequence AAD32546.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH98278.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH98342.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAH99717.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI05919.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular nitrogen compound metabolic process Traceable author statement. Source: Reactome sulfur amino acid catabolic process Traceable author statement. Source: Reactome taurine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro sulfinoalanine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y600-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y600-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     43-189: Missing.

Isoform 3 (identifier: Q9Y600-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSIPLKSSFLLSYLCTLPPALLSREILM

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 493

493

Cysteine sulfinic acid decarboxylase

PRO_0000147006

Amino acid modifications

Modified residue

305

1

N6-(pyridoxal phosphate)lysine

Natural variations

Alternative sequence

1

1

M → MSIPLKSSFLLSYLCTLPPA LLSREILM in isoform 3.

VSP_039002

Alternative sequence

43 – 189

147

Missing in isoform 2.

VSP_001307

Experimental info

Sequence conflict

257

1

E → G in AAD32545. Ref.1

Sequence conflict

377

1

L → P in AAD32546. Ref.1

Sequence conflict

433

1

R → G in AAD32544. Ref.1

Isoform 3:

Sequence conflict

9

1

F → S in AAH98342. Ref.4

Secondary structure

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493

Helix Strand Turn

Details...

Helix

14 – 31

18

Turn

32 – 34

3

Helix

35 – 37

3

Helix

49 – 56

8

Helix

67 – 80

14

Beta strand

89 – 93

5

Helix

99 – 111

13

Turn

118 – 120

3

Helix

122 – 139

18

Beta strand

145 – 151

7

Helix

152 – 167

16

Helix

171 – 174

4

Helix

176 – 178

3

Beta strand

182 – 187

6

Helix

193 – 200

8

Helix

205 – 207

3

Beta strand

208 – 211

4

Helix

221 – 233

13

Beta strand

237 – 246

10

Turn

248 – 250

3

Helix

256 – 266

11

Beta strand

269 – 274

6

Helix

277 – 282

6

Turn

284 – 286

3

Helix

287 – 290

4

Helix

293 – 295

3

Beta strand

297 – 301

5

Beta strand

314 – 319

6

Helix

324 – 329

6

Helix

345 – 347

3

Helix

350 – 352

3

Helix

362 – 396

35

Beta strand

401 – 405

5

Beta strand

408 – 416

9

Helix

419 – 421

3

Helix

430 – 435

6

Helix

437 – 448

12

Beta strand

452 – 458

7

Beta strand

461 – 468

8

Helix

476 – 490

15

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified October 17, 2006. Version 2. Checksum: 09BA2028D942016E	FASTA	493	55,023
	10 20 30 40 50 60 MADSEALPSL AGDPVAVEAL LRAVFGVVVD EAIQKGTSVS QKVCEWKEPE ELKQLLDLEL 70 80 90 100 110 120 RSQGESQKQI LERCRAVIRY SVKTGHPRFF NQLFSGLDPH ALAGRIITES LNTSQYTYEI 130 140 150 160 170 180 APVFVLMEEE VLRKLRALVG WSSGDGIFCP GGSISNMYAV NLARYQRYPD CKQRGLRTLP 190 200 210 220 230 240 PLALFTSKEC HYSIQKGAAF LGLGTDSVRV VKADERGKMV PEDLERQIGM AEAEGAVPFL 250 260 270 280 290 300 VSATSGTTVL GAFDPLEAIA DVCQRHGLWL HVDAAWGGSV LLSQTHRHLL DGIQRADSVA 310 320 330 340 350 360 WNPHKLLAAG LQCSALLLQD TSNLLKRCHG SQASYLFQQD KFYDVALDTG DKVVQCGRRV 370 380 390 400 410 420 DCLKLWLMWK AQGDQGLERR IDQAFVLARY LVEEMKKREG FELVMEPEFV NVCFWFVPPS 430 440 450 460 470 480 LRGKQESPDY HERLSKVAPV LKERMVKEGS MMIGYQPHGT RGNFFRVVVA NSALTCADMD 490 FLLNELERLG QDL
	Isoform 2 (Short) [UniParc]. Checksum: E214BE34AFA35101	FASTA	346	38,232
	10 20 30 40 50 60 MADSEALPSL AGDPVAVEAL LRAVFGVVVD EAIQKGTSVS QKCHYSIQKG AAFLGLGTDS 70 80 90 100 110 120 VRVVKADERG KMVPEDLERQ IGMAEAEGAV PFLVSATSGT TVLGAFDPLE AIADVCQRHG 130 140 150 160 170 180 LWLHVDAAWG GSVLLSQTHR HLLDGIQRAD SVAWNPHKLL AAGLQCSALL LQDTSNLLKR 190 200 210 220 230 240 CHGSQASYLF QQDKFYDVAL DTGDKVVQCG RRVDCLKLWL MWKAQGDQGL ERRIDQAFVL 250 260 270 280 290 300 ARYLVEEMKK REGFELVMEP EFVNVCFWFV PPSLRGKQES PDYHERLSKV APVLKERMVK 310 320 330 340 EGSMMIGYQP HGTRGNFFRV VVANSALTCA DMDFLLNELE RLGQDL
	Isoform 3 [UniParc]. Checksum: 5EE3EF5294A87E27	FASTA	520	58,012
	10 20 30 40 50 60 MSIPLKSSFL LSYLCTLPPA LLSREILMAD SEALPSLAGD PVAVEALLRA VFGVVVDEAI 70 80 90 100 110 120 QKGTSVSQKV CEWKEPEELK QLLDLELRSQ GESQKQILER CRAVIRYSVK TGHPRFFNQL 130 140 150 160 170 180 FSGLDPHALA GRIITESLNT SQYTYEIAPV FVLMEEEVLR KLRALVGWSS GDGIFCPGGS 190 200 210 220 230 240 ISNMYAVNLA RYQRYPDCKQ RGLRTLPPLA LFTSKECHYS IQKGAAFLGL GTDSVRVVKA 250 260 270 280 290 300 DERGKMVPED LERQIGMAEA EGAVPFLVSA TSGTTVLGAF DPLEAIADVC QRHGLWLHVD 310 320 330 340 350 360 AAWGGSVLLS QTHRHLLDGI QRADSVAWNP HKLLAAGLQC SALLLQDTSN LLKRCHGSQA 370 380 390 400 410 420 SYLFQQDKFY DVALDTGDKV VQCGRRVDCL KLWLMWKAQG DQGLERRIDQ AFVLARYLVE 430 440 450 460 470 480 EMKKREGFEL VMEPEFVNVC FWFVPPSLRG KQESPDYHER LSKVAPVLKE RMVKEGSMMI 490 500 510 520 GYQPHGTRGN FFRVVVANSA LTCADMDFLL NELERLGQDL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Pritchard J.E., Ramsden D.B. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Amygdala.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[5]	"The crystal structure of human cysteine sulfinic acid decarboxylase (CSAD)." Structural genomics consortium (SGC) Submitted (AUG-2007) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) IN COMPLEX WITH PYRIDOXAL PHOSPHATE, COFACTOR.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF116546 mRNA. Translation: AAD32544.1.
AF116547 mRNA. Translation: AAD32545.1.
AF116548 mRNA. Translation: AAD32546.1. Different initiation.
AK289659 mRNA. Translation: BAF82348.1.
CH471054 Genomic DNA. Translation: EAW96670.1.
BC098278 mRNA. Translation: AAH98278.1. Different initiation.
BC098342 mRNA. Translation: AAH98342.1. Different initiation.
BC099717 mRNA. Translation: AAH99717.1. Different initiation.
BC105918 mRNA. Translation: AAI05919.1. Different initiation.

IPI

IPI00220948.
IPI00465165.
IPI00925494.

RefSeq

NP_001231634.1. NM_001244705.1.
NP_057073.4. NM_015989.4.

UniGene

Hs.279815.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2JIS	X-ray	1.60	A/B	1-493	[»]

ProteinModelPortal

Q9Y600.

ModBase

Search...

Protein-protein interaction databases

MINT

MINT-4832217.

STRING

9606.ENSP00000267085.

PTM databases

PhosphoSite

Q9Y600.

Polymorphism databases

DMDM

116241317.

Proteomic databases

PaxDb

Q9Y600.

PRIDE

Q9Y600.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000267085; ENSP00000267085; ENSG00000139631.
ENST00000379843; ENSP00000369172; ENSG00000139631.
ENST00000379846; ENSP00000369175; ENSG00000139631.
ENST00000444623; ENSP00000415485; ENSG00000139631.
ENST00000453446; ENSP00000410648; ENSG00000139631.

GeneID

51380.

KEGG

hsa:51380.

UCSC

uc001sbw.3. human.
uc001sby.3. human.
uc010snx.2. human.

Organism-specific databases

CTD

51380.

GeneCards

GC12M053551.

HGNC

HGNC:18966. CSAD.

HPA

HPA039487.

neXtProt

NX_Q9Y600.

PharmGKB

PA38771.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG0076.

HOGENOM

HOG000005382.

HOVERGEN

HBG004980.

InParanoid

Q9Y600.

KO

K01594.

OrthoDB

EOG4MKNG7.

PhylomeDB

Q9Y600.

Enzyme and pathway databases

Reactome

REACT_111217. Metabolism.

UniPathway

UPA00012; UER00538.

Gene expression databases

ArrayExpress

Q9Y600.

Bgee

Q9Y600.

CleanEx

HS_CSAD.

Genevestigator

Q9Y600.

GermOnline

ENSG00000139631. Homo sapiens.

Family and domain databases

Gene3D

3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.

InterPro

IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]

Pfam

PF00282. Pyridoxal_deC. 1 hit.
[Graphical view]

SUPFAM

SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.

PROSITE

PS00392. DDC_GAD_HDC_YDC. False negative.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

CSAD. human.

DrugBank

DB00151. L-Cysteine.
DB00114. Pyridoxal Phosphate.

EvolutionaryTrace

Q9Y600.

GenomeRNAi

51380.

NextBio

54887.

Entry information

Entry name

CSAD_HUMAN

Accession

Primary (citable) accession number: Q9Y600
Secondary accession number(s): A8K0U4 , Q4QQH9, Q9UNJ5, Q9Y601

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	October 17, 2006
Last modified:	May 29, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.