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Q9Y5Z7

- HCFC2_HUMAN

UniProt

Q9Y5Z7 - HCFC2_HUMAN

Protein

Host cell factor 2

Gene

HCFC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. transcription coactivator activity Source: ProtInc

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    2. regulation of transcription from RNA polymerase II promoter Source: ProtInc
    3. viral process Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Host cell factor 2
    Short name:
    HCF-2
    Alternative name(s):
    C2 factor
    Gene namesi
    Name:HCFC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24972. HCFC2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: HPA
    3. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134868925.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 792792Host cell factor 2PRO_0000119072Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y5Z7.
    PaxDbiQ9Y5Z7.
    PRIDEiQ9Y5Z7.

    PTM databases

    PhosphoSiteiQ9Y5Z7.

    Expressioni

    Tissue specificityi

    Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small intestine and colon.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y5Z7.
    BgeeiQ9Y5Z7.
    CleanExiHS_HCFC2.
    GenevestigatoriQ9Y5Z7.

    Organism-specific databases

    HPAiHPA006227.

    Interactioni

    Subunit structurei

    Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least composed of KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2.1 Publication

    Protein-protein interaction databases

    BioGridi118959. 8 interactions.
    IntActiQ9Y5Z7. 14 interactions.
    STRINGi9606.ENSP00000229330.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5Z7.
    SMRiQ9Y5Z7. Positions 354-390, 597-790.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati34 – 7946Kelch 1Add
    BLAST
    Repeati83 – 13048Kelch 2Add
    BLAST
    Repeati207 – 25549Kelch 3Add
    BLAST
    Repeati257 – 30347Kelch 4Add
    BLAST
    Domaini359 – 44991Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini583 – 67593Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini677 – 787111Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 4 Kelch repeats.Curated

    Keywords - Domaini

    Kelch repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000021205.
    HOVERGENiHBG051889.
    InParanoidiQ9Y5Z7.
    KOiK14966.
    OMAiHTSANIG.
    OrthoDBiEOG790G05.
    PhylomeDBiQ9Y5Z7.
    TreeFamiTF314757.

    Family and domain databases

    Gene3Di2.120.10.80. 1 hit.
    2.130.10.80. 1 hit.
    2.60.40.10. 3 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR011043. Gal_Oxase/kelch_b-propeller.
    IPR015916. Gal_Oxidase_b-propeller.
    IPR013783. Ig-like_fold.
    IPR015915. Kelch-typ_b-propeller.
    [Graphical view]
    SMARTiSM00060. FN3. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    SSF50965. SSF50965. 1 hit.
    PROSITEiPS50853. FN3. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y5Z7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH    50
    VYNTATNQWF LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL 100
    YELQASRWLW KKVKPHPPPS GLPPCPRLGH SFSLYGNKCY LFGGLANESE 150
    DSNNNVPRYL NDFYELELQH GSGVVGWSIP VTKGVVPSPR ESHTAVIYCK 200
    KDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT VPLPRSLHTA 250
    SVIGNKMYIF GGWVPHKGEN TETSPHDCEW RCTSSFSYLN LDTTEWTTLV 300
    SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW 350
    YLDTEKPPAP SQVQLIKATT NSFHVKWDEV STVEGYLLQL STDLPYQAAS 400
    SDSSAAPNMQ GVRMDPHRQG SNNIVPNSIN DTINSTKTEQ PATKETSMKN 450
    KPDFKALTDS NAILYPSLAS NASNHNSHVV DMLRKNEGPH TSANVGVLSS 500
    CLDVRTVIPE TSVSSTVSST QTMVTQQTIK TESSSTNGAV VKDETSLTTF 550
    STKSEVDETY ALPATKISRV ETHATATPFS KETPSNPVAT VKAGERQWCD 600
    VGIFKNNTAL VSQFYLLPKG KQSISKVGNA DVPDYSLLKK QDLVPGTGYR 650
    FRVAAINGCG IGPFSKISEF KTCIPGFPGA PSAVRISKNV EGIHLSWEPP 700
    TSPSGNILEY SAYLAIRTAQ IQDNPSQLVF MRIYCGLKTS CIVTAGQLAN 750
    AHIDYTSRPA IVFRISAKNE KGYGPATQVR WLQGNNKKAP LN 792
    Length:792
    Mass (Da):86,779
    Last modified:November 1, 1999 - v1
    Checksum:iEADF5FF25F70856C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti46 – 461A → S.
    Corresponds to variant rs2700500 [ dbSNP | Ensembl ].
    VAR_050044
    Natural varianti268 – 2681G → A.
    Corresponds to variant rs17035206 [ dbSNP | Ensembl ].
    VAR_033984

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117210 mRNA. Translation: AAD27814.1.
    AK313466 mRNA. Translation: BAG36252.1.
    CH471054 Genomic DNA. Translation: EAW97737.1.
    BC033799 mRNA. Translation: AAH33799.1.
    CCDSiCCDS9097.1.
    RefSeqiNP_037452.1. NM_013320.2.
    UniGeneiHs.506558.

    Genome annotation databases

    EnsembliENST00000229330; ENSP00000229330; ENSG00000111727.
    GeneIDi29915.
    KEGGihsa:29915.
    UCSCiuc001tkj.4. human.

    Polymorphism databases

    DMDMi62900381.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117210 mRNA. Translation: AAD27814.1 .
    AK313466 mRNA. Translation: BAG36252.1 .
    CH471054 Genomic DNA. Translation: EAW97737.1 .
    BC033799 mRNA. Translation: AAH33799.1 .
    CCDSi CCDS9097.1.
    RefSeqi NP_037452.1. NM_013320.2.
    UniGenei Hs.506558.

    3D structure databases

    ProteinModelPortali Q9Y5Z7.
    SMRi Q9Y5Z7. Positions 354-390, 597-790.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118959. 8 interactions.
    IntActi Q9Y5Z7. 14 interactions.
    STRINGi 9606.ENSP00000229330.

    PTM databases

    PhosphoSitei Q9Y5Z7.

    Polymorphism databases

    DMDMi 62900381.

    Proteomic databases

    MaxQBi Q9Y5Z7.
    PaxDbi Q9Y5Z7.
    PRIDEi Q9Y5Z7.

    Protocols and materials databases

    DNASUi 29915.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000229330 ; ENSP00000229330 ; ENSG00000111727 .
    GeneIDi 29915.
    KEGGi hsa:29915.
    UCSCi uc001tkj.4. human.

    Organism-specific databases

    CTDi 29915.
    GeneCardsi GC12P104458.
    HGNCi HGNC:24972. HCFC2.
    HPAi HPA006227.
    MIMi 607926. gene.
    neXtProti NX_Q9Y5Z7.
    PharmGKBi PA134868925.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000021205.
    HOVERGENi HBG051889.
    InParanoidi Q9Y5Z7.
    KOi K14966.
    OMAi HTSANIG.
    OrthoDBi EOG790G05.
    PhylomeDBi Q9Y5Z7.
    TreeFami TF314757.

    Miscellaneous databases

    ChiTaRSi HCFC2. human.
    GenomeRNAii 29915.
    NextBioi 52506.
    PROi Q9Y5Z7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5Z7.
    Bgeei Q9Y5Z7.
    CleanExi HS_HCFC2.
    Genevestigatori Q9Y5Z7.

    Family and domain databases

    Gene3Di 2.120.10.80. 1 hit.
    2.130.10.80. 1 hit.
    2.60.40.10. 3 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR011043. Gal_Oxase/kelch_b-propeller.
    IPR015916. Gal_Oxidase_b-propeller.
    IPR013783. Ig-like_fold.
    IPR015915. Kelch-typ_b-propeller.
    [Graphical view ]
    SMARTi SM00060. FN3. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    SSF50965. SSF50965. 1 hit.
    PROSITEi PS50853. FN3. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2."
      Johnson K.M., Mahajan S.S., Wilson A.C.
      J. Virol. 73:3930-3940(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression."
      Yokoyama A., Wang Z., Wysocka J., Sanyal M., Aufiero D.J., Kitabayashi I., Herr W., Cleary M.L.
      Mol. Cell. Biol. 24:5639-5649(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN A COMPLEX WITH KMT2A.

    Entry informationi

    Entry nameiHCFC2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5Z7
    Secondary accession number(s): B2R8Q5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3