Q9Y5Z7 (HCFC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Host cell factor 2
Short name=HCF-2

Alternative name(s):
C2 factor

Gene names

Name:

HCFC2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	792 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Binds MLL. Component of the MLL1/MLL complex, at least composed of MLL, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2. Ref.5
Subcellular location	Cytoplasm. Nucleus Ref.1.
Tissue specificity	Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small intestine and colon. Ref.1
Sequence similarities	Contains 3 fibronectin type-III domains. Contains 4 Kelch repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Polymorphism
Domain	Kelch repeat Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB viral reproduction Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cytoplasm Inferred from direct assay Ref.1. Source: UniProtKB nucleus Inferred from direct assay Ref.1. Source: ProtInc
Molecular_function	transcription coactivator activity Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 792	792	Host cell factor 2		PRO_0000119072
Regions
	Repeat	34 – 79	46	Kelch 1
	Repeat	83 – 130	48	Kelch 2
	Repeat	207 – 255	49	Kelch 3
	Repeat	257 – 303	47	Kelch 4
	Domain	357 – 442	86	Fibronectin type-III 1
	Domain	580 – 672	93	Fibronectin type-III 2
	Domain	678 – 782	105	Fibronectin type-III 3
Natural variations
	Natural variant	46	1	A → S. Corresponds to variant rs2700500 [ dbSNP | Ensembl ].		VAR_050044
	Natural variant	268	1	G → A. Corresponds to variant rs17035206 [ dbSNP | Ensembl ].		VAR_033984

Sequences

	Sequence		Length	Mass (Da)
	Q9Y5Z7 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: EADF5FF25F70856C	FASTA	792	86,779
	10 20 30 40 50 60 MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH VYNTATNQWF 70 80 90 100 110 120 LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL YELQASRWLW KKVKPHPPPS 130 140 150 160 170 180 GLPPCPRLGH SFSLYGNKCY LFGGLANESE DSNNNVPRYL NDFYELELQH GSGVVGWSIP 190 200 210 220 230 240 VTKGVVPSPR ESHTAVIYCK KDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT 250 260 270 280 290 300 VPLPRSLHTA SVIGNKMYIF GGWVPHKGEN TETSPHDCEW RCTSSFSYLN LDTTEWTTLV 310 320 330 340 350 360 SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW YLDTEKPPAP 370 380 390 400 410 420 SQVQLIKATT NSFHVKWDEV STVEGYLLQL STDLPYQAAS SDSSAAPNMQ GVRMDPHRQG 430 440 450 460 470 480 SNNIVPNSIN DTINSTKTEQ PATKETSMKN KPDFKALTDS NAILYPSLAS NASNHNSHVV 490 500 510 520 530 540 DMLRKNEGPH TSANVGVLSS CLDVRTVIPE TSVSSTVSST QTMVTQQTIK TESSSTNGAV 550 560 570 580 590 600 VKDETSLTTF STKSEVDETY ALPATKISRV ETHATATPFS KETPSNPVAT VKAGERQWCD 610 620 630 640 650 660 VGIFKNNTAL VSQFYLLPKG KQSISKVGNA DVPDYSLLKK QDLVPGTGYR FRVAAINGCG 670 680 690 700 710 720 IGPFSKISEF KTCIPGFPGA PSAVRISKNV EGIHLSWEPP TSPSGNILEY SAYLAIRTAQ 730 740 750 760 770 780 IQDNPSQLVF MRIYCGLKTS CIVTAGQLAN AHIDYTSRPA IVFRISAKNE KGYGPATQVR 790 WLQGNNKKAP LN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2." Johnson K.M., Mahajan S.S., Wilson A.C. J. Virol. 73:3930-3940(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hippocampus.
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression." Yokoyama A., Wang Z., Wysocka J., Sanyal M., Aufiero D.J., Kitabayashi I., Herr W., Cleary M.L. Mol. Cell. Biol. 24:5639-5649(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN A COMPLEX WITH MLL.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF117210 mRNA. Translation: AAD27814.1. AK313466 mRNA. Translation: BAG36252.1. CH471054 Genomic DNA. Translation: EAW97737.1. BC033799 mRNA. Translation: AAH33799.1.
IPI	IPI00002469.
RefSeq	NP_037452.1. NM_013320.2.
UniGene	Hs.506558.
3D structure databases
ProteinModelPortal	Q9Y5Z7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y5Z7. 12 interactions.
STRING	9606.ENSP00000229330.
PTM databases
PhosphoSite	Q9Y5Z7.
Polymorphism databases
DMDM	62900381.
Proteomic databases
PaxDb	Q9Y5Z7.
PRIDE	Q9Y5Z7.
Protocols and materials databases
DNASU	29915.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000229330; ENSP00000229330; ENSG00000111727.
GeneID	29915.
KEGG	hsa:29915.
UCSC	uc001tkj.4. human.
Organism-specific databases
CTD	29915.
GeneCards	GC12P104458.
HGNC	HGNC:24972. HCFC2.
HPA	HPA006227.
MIM	607926. gene.
neXtProt	NX_Q9Y5Z7.
PharmGKB	PA134868925.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG12793.
HOGENOM	HOG000021205.
HOVERGEN	HBG051889.
InParanoid	Q9Y5Z7.
KO	K14966.
OMA	PHDCEWR.
OrthoDB	EOG49GKGP.
PhylomeDB	Q9Y5Z7.
Gene expression databases
ArrayExpress	Q9Y5Z7.
Bgee	Q9Y5Z7.
CleanEx	HS_HCFC2.
Genevestigator	Q9Y5Z7.
GermOnline	ENSG00000111727. Homo sapiens.
Family and domain databases
Gene3D	2.120.10.80. 1 hit. 2.130.10.80. 1 hit. 2.60.40.10. 3 hits.
InterPro	IPR003961. Fibronectin_type3. IPR015916. Gal_Oxidase_b-propeller. IPR013783. Ig-like_fold. IPR015915. Kelch-typ_b-propeller. [Graphical view]
SMART	SM00060. FN3. 2 hits. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 2 hits.
PROSITE	PS50853. FN3. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HCFC2. human.
GenomeRNAi	29915.
NextBio	52506.
SOURCE	Search...

Entry information

Entry name

HCFC2_HUMAN

Accession

Primary (citable) accession number: Q9Y5Z7
Secondary accession number(s): B2R8Q5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.