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Q9Y5Z7 (HCFC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Host cell factor 2

Short name=HCF-2
Alternative name(s):
C2 factor
Gene names
Name:HCFC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length792 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least composed of KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2. Ref.5

Subcellular location

Cytoplasm. Nucleus Ref.1.

Tissue specificity

Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small intestine and colon. Ref.1

Sequence similarities

Contains 3 fibronectin type-III domains.

Contains 4 Kelch repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 792792Host cell factor 2
PRO_0000119072

Regions

Repeat34 – 7946Kelch 1
Repeat83 – 13048Kelch 2
Repeat207 – 25549Kelch 3
Repeat257 – 30347Kelch 4
Domain359 – 44991Fibronectin type-III 1
Domain583 – 67593Fibronectin type-III 2
Domain677 – 787111Fibronectin type-III 3

Natural variations

Natural variant461A → S.
Corresponds to variant rs2700500 [ dbSNP | Ensembl ].
VAR_050044
Natural variant2681G → A.
Corresponds to variant rs17035206 [ dbSNP | Ensembl ].
VAR_033984

Sequences

Sequence LengthMass (Da)Tools
Q9Y5Z7 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: EADF5FF25F70856C

FASTA79286,779
        10         20         30         40         50         60 
MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH VYNTATNQWF 

        70         80         90        100        110        120 
LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL YELQASRWLW KKVKPHPPPS 

       130        140        150        160        170        180 
GLPPCPRLGH SFSLYGNKCY LFGGLANESE DSNNNVPRYL NDFYELELQH GSGVVGWSIP 

       190        200        210        220        230        240 
VTKGVVPSPR ESHTAVIYCK KDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT 

       250        260        270        280        290        300 
VPLPRSLHTA SVIGNKMYIF GGWVPHKGEN TETSPHDCEW RCTSSFSYLN LDTTEWTTLV 

       310        320        330        340        350        360 
SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW YLDTEKPPAP 

       370        380        390        400        410        420 
SQVQLIKATT NSFHVKWDEV STVEGYLLQL STDLPYQAAS SDSSAAPNMQ GVRMDPHRQG 

       430        440        450        460        470        480 
SNNIVPNSIN DTINSTKTEQ PATKETSMKN KPDFKALTDS NAILYPSLAS NASNHNSHVV 

       490        500        510        520        530        540 
DMLRKNEGPH TSANVGVLSS CLDVRTVIPE TSVSSTVSST QTMVTQQTIK TESSSTNGAV 

       550        560        570        580        590        600 
VKDETSLTTF STKSEVDETY ALPATKISRV ETHATATPFS KETPSNPVAT VKAGERQWCD 

       610        620        630        640        650        660 
VGIFKNNTAL VSQFYLLPKG KQSISKVGNA DVPDYSLLKK QDLVPGTGYR FRVAAINGCG 

       670        680        690        700        710        720 
IGPFSKISEF KTCIPGFPGA PSAVRISKNV EGIHLSWEPP TSPSGNILEY SAYLAIRTAQ 

       730        740        750        760        770        780 
IQDNPSQLVF MRIYCGLKTS CIVTAGQLAN AHIDYTSRPA IVFRISAKNE KGYGPATQVR 

       790 
WLQGNNKKAP LN 

« Hide

References

« Hide 'large scale' references
[1]"Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2."
Johnson K.M., Mahajan S.S., Wilson A.C.
J. Virol. 73:3930-3940(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Testis.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hippocampus.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression."
Yokoyama A., Wang Z., Wysocka J., Sanyal M., Aufiero D.J., Kitabayashi I., Herr W., Cleary M.L.
Mol. Cell. Biol. 24:5639-5649(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN A COMPLEX WITH KMT2A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF117210 mRNA. Translation: AAD27814.1.
AK313466 mRNA. Translation: BAG36252.1.
CH471054 Genomic DNA. Translation: EAW97737.1.
BC033799 mRNA. Translation: AAH33799.1.
RefSeqNP_037452.1. NM_013320.2.
UniGeneHs.506558.

3D structure databases

ProteinModelPortalQ9Y5Z7.
SMRQ9Y5Z7. Positions 354-390, 597-790.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118959. 8 interactions.
IntActQ9Y5Z7. 12 interactions.
STRING9606.ENSP00000229330.

PTM databases

PhosphoSiteQ9Y5Z7.

Polymorphism databases

DMDM62900381.

Proteomic databases

PaxDbQ9Y5Z7.
PRIDEQ9Y5Z7.

Protocols and materials databases

DNASU29915.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000229330; ENSP00000229330; ENSG00000111727.
GeneID29915.
KEGGhsa:29915.
UCSCuc001tkj.4. human.

Organism-specific databases

CTD29915.
GeneCardsGC12P104458.
HGNCHGNC:24972. HCFC2.
HPAHPA006227.
MIM607926. gene.
neXtProtNX_Q9Y5Z7.
PharmGKBPA134868925.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG12793.
HOGENOMHOG000021205.
HOVERGENHBG051889.
InParanoidQ9Y5Z7.
KOK14966.
OMAHTSANIG.
OrthoDBEOG790G05.
PhylomeDBQ9Y5Z7.
TreeFamTF314757.

Gene expression databases

ArrayExpressQ9Y5Z7.
BgeeQ9Y5Z7.
CleanExHS_HCFC2.
GenevestigatorQ9Y5Z7.

Family and domain databases

Gene3D2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
2.60.40.10. 3 hits.
InterProIPR003961. Fibronectin_type3.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015916. Gal_Oxidase_b-propeller.
IPR013783. Ig-like_fold.
IPR015915. Kelch-typ_b-propeller.
[Graphical view]
SMARTSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 2 hits.
SSF50965. SSF50965. 1 hit.
PROSITEPS50853. FN3. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHCFC2. human.
GenomeRNAi29915.
NextBio52506.
PROQ9Y5Z7.
SOURCESearch...

Entry information

Entry nameHCFC2_HUMAN
AccessionPrimary (citable) accession number: Q9Y5Z7
Secondary accession number(s): B2R8Q5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM