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Protein

Host cell factor 2

Gene

HCFC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • transcription coactivator activity Source: ProtInc

GO - Biological processi

  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • viral process Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111727-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Host cell factor 2
Short name:
HCF-2
Alternative name(s):
C2 factor
Gene namesi
Name:HCFC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:24972. HCFC2.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi29915.
OpenTargetsiENSG00000111727.
PharmGKBiPA134868925.

Polymorphism and mutation databases

BioMutaiHCFC2.
DMDMi62900381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001190721 – 792Host cell factor 2Add BLAST792

Proteomic databases

EPDiQ9Y5Z7.
PaxDbiQ9Y5Z7.
PeptideAtlasiQ9Y5Z7.
PRIDEiQ9Y5Z7.

PTM databases

iPTMnetiQ9Y5Z7.
PhosphoSitePlusiQ9Y5Z7.

Expressioni

Tissue specificityi

Highly expressed in testis. Detected at lower levels in spleen, thymus, prostate, ovary, small intestine and colon.1 Publication

Gene expression databases

BgeeiENSG00000111727.
CleanExiHS_HCFC2.
ExpressionAtlasiQ9Y5Z7. baseline and differential.
GenevisibleiQ9Y5Z7. HS.

Organism-specific databases

HPAiHPA006227.

Interactioni

Subunit structurei

Binds KMT2A/MLL1. Component of the MLL1/MLL complex, at least composed of KMT2A/MLL1, ASH2L, RBBP5, DPY30, WDR5, MEN1, HCFC1 and HCFC2.1 Publication

Protein-protein interaction databases

BioGridi118959. 32 interactors.
IntActiQ9Y5Z7. 17 interactors.
STRINGi9606.ENSP00000229330.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5Z7.
SMRiQ9Y5Z7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 79Kelch 1Add BLAST46
Repeati83 – 130Kelch 2Add BLAST48
Repeati207 – 255Kelch 3Add BLAST49
Repeati257 – 303Kelch 4Add BLAST47
Domaini359 – 449Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST91
Domaini583 – 675Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST93
Domaini677 – 787Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST111

Sequence similaritiesi

Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 4 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4152. Eukaryota.
ENOG410Y5AC. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000021205.
HOVERGENiHBG051889.
InParanoidiQ9Y5Z7.
KOiK14966.
OMAiAAPNMQG.
OrthoDBiEOG091G00K7.
PhylomeDBiQ9Y5Z7.
TreeFamiTF314757.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015916. Gal_Oxidase_b-propeller.
IPR013783. Ig-like_fold.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF50965. SSF50965. 1 hit.
PROSITEiPS50853. FN3. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5Z7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPSLLNWR RVSSFTGPVP RARHGHRAVA IRELMIIFGG GNEGIADELH
60 70 80 90 100
VYNTATNQWF LPAVRGDIPP GCAAHGFVCD GTRILVFGGM VEYGRYSNEL
110 120 130 140 150
YELQASRWLW KKVKPHPPPS GLPPCPRLGH SFSLYGNKCY LFGGLANESE
160 170 180 190 200
DSNNNVPRYL NDFYELELQH GSGVVGWSIP VTKGVVPSPR ESHTAVIYCK
210 220 230 240 250
KDSGSPKMYV FGGMCGARLD DLWQLDLETM SWSKPETKGT VPLPRSLHTA
260 270 280 290 300
SVIGNKMYIF GGWVPHKGEN TETSPHDCEW RCTSSFSYLN LDTTEWTTLV
310 320 330 340 350
SDSQEDKKNS RPRPRAGHCA VAIGTRLYFW SGRDGYKKAL NSQVCCKDLW
360 370 380 390 400
YLDTEKPPAP SQVQLIKATT NSFHVKWDEV STVEGYLLQL STDLPYQAAS
410 420 430 440 450
SDSSAAPNMQ GVRMDPHRQG SNNIVPNSIN DTINSTKTEQ PATKETSMKN
460 470 480 490 500
KPDFKALTDS NAILYPSLAS NASNHNSHVV DMLRKNEGPH TSANVGVLSS
510 520 530 540 550
CLDVRTVIPE TSVSSTVSST QTMVTQQTIK TESSSTNGAV VKDETSLTTF
560 570 580 590 600
STKSEVDETY ALPATKISRV ETHATATPFS KETPSNPVAT VKAGERQWCD
610 620 630 640 650
VGIFKNNTAL VSQFYLLPKG KQSISKVGNA DVPDYSLLKK QDLVPGTGYR
660 670 680 690 700
FRVAAINGCG IGPFSKISEF KTCIPGFPGA PSAVRISKNV EGIHLSWEPP
710 720 730 740 750
TSPSGNILEY SAYLAIRTAQ IQDNPSQLVF MRIYCGLKTS CIVTAGQLAN
760 770 780 790
AHIDYTSRPA IVFRISAKNE KGYGPATQVR WLQGNNKKAP LN
Length:792
Mass (Da):86,779
Last modified:November 1, 1999 - v1
Checksum:iEADF5FF25F70856C
GO
Isoform 2 (identifier: Q9Y5Z7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     411-412: GV → DQ
     413-792: Missing.

Note: No experimental confirmation available.
Show »
Length:412
Mass (Da):45,828
Checksum:i2EA7A06A247B3BCC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05004446A → S.Corresponds to variant rs2700500dbSNPEnsembl.1
Natural variantiVAR_033984268G → A.Corresponds to variant rs17035206dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057024411 – 412GV → DQ in isoform 2. 1 Publication2
Alternative sequenceiVSP_057025413 – 792Missing in isoform 2. 1 PublicationAdd BLAST380

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117210 mRNA. Translation: AAD27814.1.
AK313466 mRNA. Translation: BAG36252.1.
AC078819 Genomic DNA. No translation available.
AC084359 Genomic DNA. No translation available.
AC089983 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97736.1.
CH471054 Genomic DNA. Translation: EAW97737.1.
BC006558 mRNA. Translation: AAH06558.1.
BC033799 mRNA. Translation: AAH33799.1.
CCDSiCCDS9097.1. [Q9Y5Z7-1]
RefSeqiNP_037452.1. NM_013320.2. [Q9Y5Z7-1]
UniGeneiHs.506558.

Genome annotation databases

EnsembliENST00000229330; ENSP00000229330; ENSG00000111727. [Q9Y5Z7-1]
ENST00000544223; ENSP00000442942; ENSG00000111727. [Q9Y5Z7-2]
GeneIDi29915.
KEGGihsa:29915.
UCSCiuc001tkj.5. human. [Q9Y5Z7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117210 mRNA. Translation: AAD27814.1.
AK313466 mRNA. Translation: BAG36252.1.
AC078819 Genomic DNA. No translation available.
AC084359 Genomic DNA. No translation available.
AC089983 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97736.1.
CH471054 Genomic DNA. Translation: EAW97737.1.
BC006558 mRNA. Translation: AAH06558.1.
BC033799 mRNA. Translation: AAH33799.1.
CCDSiCCDS9097.1. [Q9Y5Z7-1]
RefSeqiNP_037452.1. NM_013320.2. [Q9Y5Z7-1]
UniGeneiHs.506558.

3D structure databases

ProteinModelPortaliQ9Y5Z7.
SMRiQ9Y5Z7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118959. 32 interactors.
IntActiQ9Y5Z7. 17 interactors.
STRINGi9606.ENSP00000229330.

PTM databases

iPTMnetiQ9Y5Z7.
PhosphoSitePlusiQ9Y5Z7.

Polymorphism and mutation databases

BioMutaiHCFC2.
DMDMi62900381.

Proteomic databases

EPDiQ9Y5Z7.
PaxDbiQ9Y5Z7.
PeptideAtlasiQ9Y5Z7.
PRIDEiQ9Y5Z7.

Protocols and materials databases

DNASUi29915.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229330; ENSP00000229330; ENSG00000111727. [Q9Y5Z7-1]
ENST00000544223; ENSP00000442942; ENSG00000111727. [Q9Y5Z7-2]
GeneIDi29915.
KEGGihsa:29915.
UCSCiuc001tkj.5. human. [Q9Y5Z7-1]

Organism-specific databases

CTDi29915.
DisGeNETi29915.
GeneCardsiHCFC2.
HGNCiHGNC:24972. HCFC2.
HPAiHPA006227.
MIMi607926. gene.
neXtProtiNX_Q9Y5Z7.
OpenTargetsiENSG00000111727.
PharmGKBiPA134868925.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4152. Eukaryota.
ENOG410Y5AC. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000021205.
HOVERGENiHBG051889.
InParanoidiQ9Y5Z7.
KOiK14966.
OMAiAAPNMQG.
OrthoDBiEOG091G00K7.
PhylomeDBiQ9Y5Z7.
TreeFamiTF314757.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111727-MONOMER.

Miscellaneous databases

ChiTaRSiHCFC2. human.
GenomeRNAii29915.
PROiQ9Y5Z7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111727.
CleanExiHS_HCFC2.
ExpressionAtlasiQ9Y5Z7. baseline and differential.
GenevisibleiQ9Y5Z7. HS.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.120.10.80. 1 hit.
2.130.10.80. 1 hit.
2.60.40.10. 3 hits.
InterProiIPR003961. FN3_dom.
IPR011043. Gal_Oxase/kelch_b-propeller.
IPR015916. Gal_Oxidase_b-propeller.
IPR013783. Ig-like_fold.
IPR015915. Kelch-typ_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF50965. SSF50965. 1 hit.
PROSITEiPS50853. FN3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHCFC2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Z7
Secondary accession number(s): B2R8Q5, C0H5X3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.