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Q9Y5Z6

- B3GT1_HUMAN

UniProt

Q9Y5Z6 - B3GT1_HUMAN

Protein

Beta-1,3-galactosyltransferase 1

Gene

B3GALT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.1 Publication

    Cofactori

    Manganese.By similarity

    Pathwayi

    GO - Molecular functioni

    1. UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Source: UniProtKB

    GO - Biological processi

    1. oligosaccharide biosynthetic process Source: Ensembl
    2. protein glycosylation Source: UniProtKB

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    Manganese

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT31. Glycosyltransferase Family 31.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-1,3-galactosyltransferase 1 (EC:2.4.1.-)
    Short name:
    Beta-1,3-GalTase 1
    Short name:
    Beta3Gal-T1
    Short name:
    Beta3GalT1
    Alternative name(s):
    UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1
    Gene namesi
    Name:B3GALT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:916. B3GALT1.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25209.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 326326Beta-1,3-galactosyltransferase 1PRO_0000219145Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y5Z6.
    PRIDEiQ9Y5Z6.

    PTM databases

    PhosphoSiteiQ9Y5Z6.

    Expressioni

    Tissue specificityi

    Detected in brain and colon mucosa and to a lesser extent in colon adenocarcinoma cells.2 Publications

    Gene expression databases

    BgeeiQ9Y5Z6.
    CleanExiHS_B3GALT1.
    GenevestigatoriQ9Y5Z6.

    Organism-specific databases

    HPAiHPA014801.

    Interactioni

    Protein-protein interaction databases

    BioGridi114251. 1 interaction.
    STRINGi9606.ENSP00000303740.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5Z6.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66CytoplasmicSequence Analysis
    Topological domaini27 – 326300LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2620Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 31 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG271304.
    HOGENOMiHOG000059604.
    HOVERGENiHBG101354.
    InParanoidiQ9Y5Z6.
    KOiK07819.
    OMAiDFLINEP.
    OrthoDBiEOG7M3J0F.
    PhylomeDBiQ9Y5Z6.
    TreeFamiTF318639.

    Family and domain databases

    InterProiIPR002659. Glyco_trans_31.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PANTHERiPTHR11214. PTHR11214. 1 hit.
    PfamiPF01762. Galactosyl_T. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Y5Z6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKVSCLYV LTVVCWASAL WYLSITRPTS SYTGSKPFSH LTVARKNFTF    50
    GNIRTRPINP HSFEFLINEP NKCEKNIPFL VILISTTHKE FDARQAIRET 100
    WGDENNFKGI KIATLFLLGK NADPVLNQMV EQESQIFHDI IVEDFIDSYH 150
    NLTLKTLMGM RWVATFCSKA KYVMKTDSDI FVNMDNLIYK LLKPSTKPRR 200
    RYFTGYVING GPIRDVRSKW YMPRDLYPDS NYPPFCSGTG YIFSADVAEL 250
    IYKTSLHTRL LHLEDVYVGL CLRKLGIHPF QNSGFNHWKM AYSLCRYRRV 300
    ITVHQISPEE MHRIWNDMSS KKHLRC 326
    Length:326
    Mass (Da):37,993
    Last modified:November 1, 1999 - v1
    Checksum:i83271E99B2EE74F5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117222 mRNA. Translation: AAD23451.1.
    AB041407 Genomic DNA. Translation: BAA94492.1.
    AC016723 Genomic DNA. Translation: AAY15002.1.
    CH471058 Genomic DNA. Translation: EAX11307.1.
    BC101545 mRNA. Translation: AAI01546.1.
    BC104813 mRNA. Translation: AAI04814.1.
    CCDSiCCDS2227.1.
    RefSeqiNP_066191.1. NM_020981.3.
    XP_005246988.1. XM_005246931.1.
    XP_006712882.1. XM_006712819.1.
    UniGeneiHs.735833.

    Genome annotation databases

    EnsembliENST00000392690; ENSP00000376456; ENSG00000172318.
    GeneIDi8708.
    KEGGihsa:8708.
    UCSCiuc002udz.1. human.

    Polymorphism databases

    DMDMi61212254.

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Functional Glycomics Gateway - GTase

    Beta-1,3-galactosyltransferase 1

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF117222 mRNA. Translation: AAD23451.1 .
    AB041407 Genomic DNA. Translation: BAA94492.1 .
    AC016723 Genomic DNA. Translation: AAY15002.1 .
    CH471058 Genomic DNA. Translation: EAX11307.1 .
    BC101545 mRNA. Translation: AAI01546.1 .
    BC104813 mRNA. Translation: AAI04814.1 .
    CCDSi CCDS2227.1.
    RefSeqi NP_066191.1. NM_020981.3.
    XP_005246988.1. XM_005246931.1.
    XP_006712882.1. XM_006712819.1.
    UniGenei Hs.735833.

    3D structure databases

    ProteinModelPortali Q9Y5Z6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114251. 1 interaction.
    STRINGi 9606.ENSP00000303740.

    Chemistry

    ChEMBLi CHEMBL2321634.

    Protein family/group databases

    CAZyi GT31. Glycosyltransferase Family 31.

    PTM databases

    PhosphoSitei Q9Y5Z6.

    Polymorphism databases

    DMDMi 61212254.

    Proteomic databases

    PaxDbi Q9Y5Z6.
    PRIDEi Q9Y5Z6.

    Protocols and materials databases

    DNASUi 8708.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000392690 ; ENSP00000376456 ; ENSG00000172318 .
    GeneIDi 8708.
    KEGGi hsa:8708.
    UCSCi uc002udz.1. human.

    Organism-specific databases

    CTDi 8708.
    GeneCardsi GC02P168639.
    HGNCi HGNC:916. B3GALT1.
    HPAi HPA014801.
    MIMi 603093. gene.
    neXtProti NX_Q9Y5Z6.
    PharmGKBi PA25209.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271304.
    HOGENOMi HOG000059604.
    HOVERGENi HBG101354.
    InParanoidi Q9Y5Z6.
    KOi K07819.
    OMAi DFLINEP.
    OrthoDBi EOG7M3J0F.
    PhylomeDBi Q9Y5Z6.
    TreeFami TF318639.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    GenomeRNAii 8708.
    NextBioi 32661.
    PROi Q9Y5Z6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y5Z6.
    CleanExi HS_B3GALT1.
    Genevestigatori Q9Y5Z6.

    Family and domain databases

    InterProi IPR002659. Glyco_trans_31.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    PANTHERi PTHR11214. PTHR11214. 1 hit.
    Pfami PF01762. Galactosyl_T. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Differential expression of beta1,3galactosyltransferases in human colon cells derived from adenocarcinomas or normal mucosa."
      Bardoni A., Valli M., Trinchera M.
      FEBS Lett. 451:75-80(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Colon adenocarcinoma.
    2. "Human-specific amino acid changes found in 103 protein-coding genes."
      Kitano T., Liu Y.-H., Ueda S., Saitou N.
      Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    6. "A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family."
      Amado M., Almeida R., Carneiro F., Levery S.B., Holmes E.H., Nomoto M., Hollingsworth M.A., Hassan H., Schwientek T., Nielsen P.A., Bennett E.P., Clausen H.
      J. Biol. Chem. 273:12770-12778(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiB3GT1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5Z6
    Secondary accession number(s): D3DPB8, Q53SS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3