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Q9Y5Z6

- B3GT1_HUMAN

UniProt

Q9Y5Z6 - B3GT1_HUMAN

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Protein

Beta-1,3-galactosyltransferase 1

Gene
B3GALT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.1 Publication

Cofactori

Manganese By similarity.

Pathwayi

GO - Molecular functioni

  1. UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. oligosaccharide biosynthetic process Source: Ensembl
  2. protein glycosylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 1 (EC:2.4.1.-)
Short name:
Beta-1,3-GalTase 1
Short name:
Beta3Gal-T1
Short name:
Beta3GalT1
Alternative name(s):
UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1
Gene namesi
Name:B3GALT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:916. B3GALT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66Cytoplasmic Reviewed prediction
Transmembranei7 – 2620Helical; Signal-anchor for type II membrane protein; Reviewed predictionAdd
BLAST
Topological domaini27 – 326300Lumenal Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25209.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Beta-1,3-galactosyltransferase 1PRO_0000219145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...) Reviewed prediction
Glycosylationi151 – 1511N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5Z6.
PRIDEiQ9Y5Z6.

PTM databases

PhosphoSiteiQ9Y5Z6.

Expressioni

Tissue specificityi

Detected in brain and colon mucosa and to a lesser extent in colon adenocarcinoma cells.2 Publications

Gene expression databases

BgeeiQ9Y5Z6.
CleanExiHS_B3GALT1.
GenevestigatoriQ9Y5Z6.

Organism-specific databases

HPAiHPA014801.

Interactioni

Protein-protein interaction databases

BioGridi114251. 1 interaction.
STRINGi9606.ENSP00000303740.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5Z6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG271304.
HOGENOMiHOG000059604.
HOVERGENiHBG101354.
InParanoidiQ9Y5Z6.
KOiK07819.
OMAiDFLINEP.
OrthoDBiEOG7M3J0F.
PhylomeDBiQ9Y5Z6.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y5Z6-1 [UniParc]FASTAAdd to Basket

« Hide

MASKVSCLYV LTVVCWASAL WYLSITRPTS SYTGSKPFSH LTVARKNFTF    50
GNIRTRPINP HSFEFLINEP NKCEKNIPFL VILISTTHKE FDARQAIRET 100
WGDENNFKGI KIATLFLLGK NADPVLNQMV EQESQIFHDI IVEDFIDSYH 150
NLTLKTLMGM RWVATFCSKA KYVMKTDSDI FVNMDNLIYK LLKPSTKPRR 200
RYFTGYVING GPIRDVRSKW YMPRDLYPDS NYPPFCSGTG YIFSADVAEL 250
IYKTSLHTRL LHLEDVYVGL CLRKLGIHPF QNSGFNHWKM AYSLCRYRRV 300
ITVHQISPEE MHRIWNDMSS KKHLRC 326
Length:326
Mass (Da):37,993
Last modified:November 1, 1999 - v1
Checksum:i83271E99B2EE74F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117222 mRNA. Translation: AAD23451.1.
AB041407 Genomic DNA. Translation: BAA94492.1.
AC016723 Genomic DNA. Translation: AAY15002.1.
CH471058 Genomic DNA. Translation: EAX11307.1.
BC101545 mRNA. Translation: AAI01546.1.
BC104813 mRNA. Translation: AAI04814.1.
CCDSiCCDS2227.1.
RefSeqiNP_066191.1. NM_020981.3.
XP_005246988.1. XM_005246931.1.
XP_006712882.1. XM_006712819.1.
UniGeneiHs.735833.

Genome annotation databases

EnsembliENST00000305861; ENSP00000303740; ENSG00000172318.
ENST00000392690; ENSP00000376456; ENSG00000172318.
GeneIDi8708.
KEGGihsa:8708.
UCSCiuc002udz.1. human.

Polymorphism databases

DMDMi61212254.

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

Beta-1,3-galactosyltransferase 1

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117222 mRNA. Translation: AAD23451.1 .
AB041407 Genomic DNA. Translation: BAA94492.1 .
AC016723 Genomic DNA. Translation: AAY15002.1 .
CH471058 Genomic DNA. Translation: EAX11307.1 .
BC101545 mRNA. Translation: AAI01546.1 .
BC104813 mRNA. Translation: AAI04814.1 .
CCDSi CCDS2227.1.
RefSeqi NP_066191.1. NM_020981.3.
XP_005246988.1. XM_005246931.1.
XP_006712882.1. XM_006712819.1.
UniGenei Hs.735833.

3D structure databases

ProteinModelPortali Q9Y5Z6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114251. 1 interaction.
STRINGi 9606.ENSP00000303740.

Chemistry

ChEMBLi CHEMBL2321634.

Protein family/group databases

CAZyi GT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSitei Q9Y5Z6.

Polymorphism databases

DMDMi 61212254.

Proteomic databases

PaxDbi Q9Y5Z6.
PRIDEi Q9Y5Z6.

Protocols and materials databases

DNASUi 8708.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000305861 ; ENSP00000303740 ; ENSG00000172318 .
ENST00000392690 ; ENSP00000376456 ; ENSG00000172318 .
GeneIDi 8708.
KEGGi hsa:8708.
UCSCi uc002udz.1. human.

Organism-specific databases

CTDi 8708.
GeneCardsi GC02P168639.
HGNCi HGNC:916. B3GALT1.
HPAi HPA014801.
MIMi 603093. gene.
neXtProti NX_Q9Y5Z6.
PharmGKBi PA25209.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271304.
HOGENOMi HOG000059604.
HOVERGENi HBG101354.
InParanoidi Q9Y5Z6.
KOi K07819.
OMAi DFLINEP.
OrthoDBi EOG7M3J0F.
PhylomeDBi Q9Y5Z6.
TreeFami TF318639.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

GenomeRNAii 8708.
NextBioi 32661.
PROi Q9Y5Z6.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y5Z6.
CleanExi HS_B3GALT1.
Genevestigatori Q9Y5Z6.

Family and domain databases

InterProi IPR002659. Glyco_trans_31.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR11214. PTHR11214. 1 hit.
Pfami PF01762. Galactosyl_T. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression of beta1,3galactosyltransferases in human colon cells derived from adenocarcinomas or normal mucosa."
    Bardoni A., Valli M., Trinchera M.
    FEBS Lett. 451:75-80(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Colon adenocarcinoma.
  2. "Human-specific amino acid changes found in 103 protein-coding genes."
    Kitano T., Liu Y.-H., Ueda S., Saitou N.
    Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. "A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family."
    Amado M., Almeida R., Carneiro F., Levery S.B., Holmes E.H., Nomoto M., Hollingsworth M.A., Hassan H., Schwientek T., Nielsen P.A., Bennett E.P., Clausen H.
    J. Biol. Chem. 273:12770-12778(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiB3GT1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Z6
Secondary accession number(s): D3DPB8, Q53SS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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