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Protein

Beta-1,3-galactosyltransferase 1

Gene

B3GALT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-N-acetylglucosamine (beta-GlcNAc) residue. Involved in the biosynthesis of the carbohydrate moieties of glycolipids and glycoproteins. Inactive towards substrates with terminal alpha-N-acetylglucosamine (alpha-GlcNAc) or alpha-N-acetylgalactosamine (alpha-GalNAc) residues.1 Publication

Cofactori

Mn2+By similarity

Pathwayi

GO - Molecular functioni

  1. UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Source: UniProtKB

GO - Biological processi

  1. oligosaccharide biosynthetic process Source: Ensembl
  2. protein glycosylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

Manganese

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 1 (EC:2.4.1.-)
Short name:
Beta-1,3-GalTase 1
Short name:
Beta3Gal-T1
Short name:
Beta3GalT1
Alternative name(s):
UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1
Gene namesi
Name:B3GALT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:916. B3GALT1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66CytoplasmicSequence Analysis
Transmembranei7 – 2620Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini27 – 326300LumenalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25209.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 326326Beta-1,3-galactosyltransferase 1PRO_0000219145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi151 – 1511N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5Z6.
PRIDEiQ9Y5Z6.

PTM databases

PhosphoSiteiQ9Y5Z6.

Expressioni

Tissue specificityi

Detected in brain and colon mucosa and to a lesser extent in colon adenocarcinoma cells.2 Publications

Gene expression databases

BgeeiQ9Y5Z6.
CleanExiHS_B3GALT1.
GenevestigatoriQ9Y5Z6.

Organism-specific databases

HPAiHPA014801.

Interactioni

Protein-protein interaction databases

BioGridi114251. 1 interaction.
STRINGi9606.ENSP00000303740.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG271304.
GeneTreeiENSGT00760000118879.
HOGENOMiHOG000059604.
HOVERGENiHBG101354.
InParanoidiQ9Y5Z6.
KOiK07819.
OMAiDFLINEP.
OrthoDBiEOG7M3J0F.
PhylomeDBiQ9Y5Z6.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y5Z6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASKVSCLYV LTVVCWASAL WYLSITRPTS SYTGSKPFSH LTVARKNFTF
60 70 80 90 100
GNIRTRPINP HSFEFLINEP NKCEKNIPFL VILISTTHKE FDARQAIRET
110 120 130 140 150
WGDENNFKGI KIATLFLLGK NADPVLNQMV EQESQIFHDI IVEDFIDSYH
160 170 180 190 200
NLTLKTLMGM RWVATFCSKA KYVMKTDSDI FVNMDNLIYK LLKPSTKPRR
210 220 230 240 250
RYFTGYVING GPIRDVRSKW YMPRDLYPDS NYPPFCSGTG YIFSADVAEL
260 270 280 290 300
IYKTSLHTRL LHLEDVYVGL CLRKLGIHPF QNSGFNHWKM AYSLCRYRRV
310 320
ITVHQISPEE MHRIWNDMSS KKHLRC
Length:326
Mass (Da):37,993
Last modified:November 1, 1999 - v1
Checksum:i83271E99B2EE74F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117222 mRNA. Translation: AAD23451.1.
AB041407 Genomic DNA. Translation: BAA94492.1.
AC016723 Genomic DNA. Translation: AAY15002.1.
CH471058 Genomic DNA. Translation: EAX11307.1.
BC101545 mRNA. Translation: AAI01546.1.
BC104813 mRNA. Translation: AAI04814.1.
CCDSiCCDS2227.1.
RefSeqiNP_066191.1. NM_020981.3.
XP_005246988.1. XM_005246931.1.
XP_006712882.1. XM_006712819.1.
UniGeneiHs.735833.

Genome annotation databases

EnsembliENST00000392690; ENSP00000376456; ENSG00000172318.
GeneIDi8708.
KEGGihsa:8708.
UCSCiuc002udz.1. human.

Polymorphism databases

DMDMi61212254.

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Functional Glycomics Gateway - GTase

Beta-1,3-galactosyltransferase 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117222 mRNA. Translation: AAD23451.1.
AB041407 Genomic DNA. Translation: BAA94492.1.
AC016723 Genomic DNA. Translation: AAY15002.1.
CH471058 Genomic DNA. Translation: EAX11307.1.
BC101545 mRNA. Translation: AAI01546.1.
BC104813 mRNA. Translation: AAI04814.1.
CCDSiCCDS2227.1.
RefSeqiNP_066191.1. NM_020981.3.
XP_005246988.1. XM_005246931.1.
XP_006712882.1. XM_006712819.1.
UniGeneiHs.735833.

3D structure databases

ProteinModelPortaliQ9Y5Z6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114251. 1 interaction.
STRINGi9606.ENSP00000303740.

Chemistry

BindingDBiQ9Y5Z6.
ChEMBLiCHEMBL2321634.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSiteiQ9Y5Z6.

Polymorphism databases

DMDMi61212254.

Proteomic databases

PaxDbiQ9Y5Z6.
PRIDEiQ9Y5Z6.

Protocols and materials databases

DNASUi8708.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392690; ENSP00000376456; ENSG00000172318.
GeneIDi8708.
KEGGihsa:8708.
UCSCiuc002udz.1. human.

Organism-specific databases

CTDi8708.
GeneCardsiGC02P168639.
HGNCiHGNC:916. B3GALT1.
HPAiHPA014801.
MIMi603093. gene.
neXtProtiNX_Q9Y5Z6.
PharmGKBiPA25209.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG271304.
GeneTreeiENSGT00760000118879.
HOGENOMiHOG000059604.
HOVERGENiHBG101354.
InParanoidiQ9Y5Z6.
KOiK07819.
OMAiDFLINEP.
OrthoDBiEOG7M3J0F.
PhylomeDBiQ9Y5Z6.
TreeFamiTF318639.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

GenomeRNAii8708.
NextBioi32661.
PROiQ9Y5Z6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5Z6.
CleanExiHS_B3GALT1.
GenevestigatoriQ9Y5Z6.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Differential expression of beta1,3galactosyltransferases in human colon cells derived from adenocarcinomas or normal mucosa."
    Bardoni A., Valli M., Trinchera M.
    FEBS Lett. 451:75-80(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Colon adenocarcinoma.
  2. "Human-specific amino acid changes found in 103 protein-coding genes."
    Kitano T., Liu Y.-H., Ueda S., Saitou N.
    Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. "A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family."
    Amado M., Almeida R., Carneiro F., Levery S.B., Holmes E.H., Nomoto M., Hollingsworth M.A., Hassan H., Schwientek T., Nielsen P.A., Bennett E.P., Clausen H.
    J. Biol. Chem. 273:12770-12778(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiB3GT1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Z6
Secondary accession number(s): D3DPB8, Q53SS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 1, 1999
Last modified: January 7, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.