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Protein

Heme-binding protein 2

Gene

HEBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Can promote mitochondrial permeability transition and facilitate necrotic cell death under different types of stress conditions.1 Publication

GO - Biological processi

  • negative regulation of mitochondrial membrane potential Source: UniProtKB
  • neutrophil degranulation Source: Reactome
  • positive regulation of mitochondrial membrane permeability Source: UniProtKB
  • positive regulation of necrotic cell death Source: UniProtKB

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Heme-binding protein 2
Alternative name(s):
Placental protein 23
Short name:
PP23
Protein SOUL
Gene namesi
Name:HEBP2
Synonyms:C6orf34, SOUL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:15716. HEBP2.

Subcellular locationi

GO - Cellular componenti

  • azurophil granule lumen Source: Reactome
  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • mitochondrion Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi23593.
OpenTargetsiENSG00000051620.
PharmGKBiPA25935.

Polymorphism and mutation databases

BioMutaiHEBP2.
DMDMi74753513.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001169002 – 205Heme-binding protein 2Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei181PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y5Z4.
PaxDbiQ9Y5Z4.
PeptideAtlasiQ9Y5Z4.
PRIDEiQ9Y5Z4.

PTM databases

iPTMnetiQ9Y5Z4.
PhosphoSitePlusiQ9Y5Z4.

Expressioni

Tissue specificityi

Detected in placenta.1 Publication

Gene expression databases

BgeeiENSG00000051620.
CleanExiHS_HEBP2.
ExpressionAtlasiQ9Y5Z4. baseline and differential.
GenevisibleiQ9Y5Z4. HS.

Organism-specific databases

HPAiHPA016928.

Interactioni

Subunit structurei

Monomer. Interacts with LRPPRC (PubMed:11827465). May interact with BCL2L1; an interaction with BCL2L1 was observed using a peptide, but not with the full-length protein (PubMed:21639858). The full-length protein would have to undergo a major conformation change for the interaction to occur (PubMed:21639858). Interacts with PDCD6 (PubMed:27784779).4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PDCD6O753406EBI-741593,EBI-352915

Protein-protein interaction databases

BioGridi117128. 4 interactors.
IntActiQ9Y5Z4. 3 interactors.
STRINGi9606.ENSP00000058691.

Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 31Combined sources3
Beta strandi35 – 37Combined sources3
Beta strandi39 – 43Combined sources5
Beta strandi46 – 56Combined sources11
Helixi58 – 73Combined sources16
Beta strandi89 – 94Combined sources6
Beta strandi97 – 101Combined sources5
Beta strandi103 – 110Combined sources8
Helixi113 – 116Combined sources4
Beta strandi122 – 124Combined sources3
Beta strandi127 – 132Combined sources6
Beta strandi135 – 144Combined sources10
Helixi148 – 164Combined sources17
Beta strandi174 – 183Combined sources10
Beta strandi186 – 188Combined sources3
Beta strandi190 – 196Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3R85X-ray1.95E/F/G/H147-172[»]
3R8JX-ray1.60A/B2-205[»]
3R8KX-ray2.85A/B/C/D2-205[»]
4AYZX-ray3.50A/B1-205[»]
4B0YX-ray3.50A1-205[»]
5GQQX-ray2.20A/B20-197[»]
ProteinModelPortaliQ9Y5Z4.
SMRiQ9Y5Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Forms a distorted beta-barrel structure, with two helices that are packed against the outer surface of the barrel.1 Publication

Sequence similaritiesi

Belongs to the HEBP family.Curated

Phylogenomic databases

eggNOGiENOG410IZTQ. Eukaryota.
ENOG410ZWW6. LUCA.
GeneTreeiENSGT00530000063312.
HOVERGENiHBG097982.
InParanoidiQ9Y5Z4.
OMAiNEVWLIK.
OrthoDBiEOG091G0ZIG.
PhylomeDBiQ9Y5Z4.
TreeFamiTF328887.

Family and domain databases

InterProiView protein in InterPro
IPR006917. SOUL_haem-bd.
PANTHERiPTHR11220. PTHR11220. 1 hit.
PfamiView protein in Pfam
PF04832. SOUL. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5Z4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEPLQPDPG AAEDAAAQAV ETPGWKAPED AGPQPGSYEI RHYGPAKWVS
60 70 80 90 100
TSVESMDWDS AIQTGFTKLN SYIQGKNEKE MKIKMTAPVT SYVEPGSGPF
110 120 130 140 150
SESTITISLY IPSEQQFDPP RPLESDVFIE DRAEMTVFVR SFDGFSSAQK
160 170 180 190 200
NQEQLLTLAS ILREDGKVFD EKVYYTAGYN SPVKLLNRNN EVWLIQKNEP

TKENE
Length:205
Mass (Da):22,875
Last modified:November 1, 1999 - v1
Checksum:iA0B5131F94783E07
GO
Isoform 2 (identifier: Q9Y5Z4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-33: AEDAAAQAVETPGWKAPEDAGP → F

Show »
Length:184
Mass (Da):20,859
Checksum:iE9AD02AF9E32C67B
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053364140R → Q. Corresponds to variant dbSNP:rs3734303Ensembl.1
Natural variantiVAR_053365191E → A. Corresponds to variant dbSNP:rs14812Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01705712 – 33AEDAA…EDAGP → F in isoform 2. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF117616 mRNA. Translation: AAD32099.1.
AF411610 mRNA. Translation: AAL07394.1.
AY427823 mRNA. Translation: AAR88624.1.
AL031003 Genomic DNA. Translation: CAI20539.1.
BC008205 mRNA. Translation: AAH08205.1.
BC010290 mRNA. Translation: AAH10290.1.
BC093037 mRNA. Translation: AAH93037.1.
CCDSiCCDS5191.1. [Q9Y5Z4-1]
RefSeqiNP_055135.1. NM_014320.2. [Q9Y5Z4-1]
UniGeneiHs.486589.

Genome annotation databases

EnsembliENST00000607197; ENSP00000475750; ENSG00000051620. [Q9Y5Z4-1]
GeneIDi23593.
KEGGihsa:23593.
UCSCiuc003qhw.2. human. [Q9Y5Z4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHEBP2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Z4
Secondary accession number(s): Q96P57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 1, 1999
Last modified: June 7, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has been described as heme-binding protein in mouse, but His-42, a residue essential for heme binding in mouse, is not conserved in all orthologs, or in the heme-binding family member HEBP1.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families