SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y5Y9

- SCNAA_HUMAN

UniProt

Q9Y5Y9 - SCNAA_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Sodium channel protein type 10 subunit alpha
Gene
SCN10A
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.1 Publication

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. AV node cell to bundle of His cell communication Source: BHF-UCL
  2. bundle of His cell to Purkinje myocyte communication Source: BHF-UCL
  3. membrane depolarization during action potential Source: RefGenome
  4. neuronal action potential Source: RefGenome
  5. regulation of atrial cardiac muscle cell membrane depolarization Source: BHF-UCL
  6. regulation of cardiac muscle contraction Source: BHF-UCL
  7. regulation of heart rate Source: BHF-UCL
  8. regulation of ion transmembrane transport Source: BHF-UCL
  9. sensory perception Source: ProtInc
  10. sensory perception of pain Source: InterPro
  11. sodium ion transmembrane transport Source: BHF-UCL
  12. sodium ion transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein type 10 subunit alpha
Alternative name(s):
Peripheral nerve sodium channel 3
Short name:
PN3
Short name:
hPN3
Sodium channel protein type X subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.8
Gene namesi
Name:SCN10A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:10582. SCN10A.

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity
Note: It can be translocated to the extracellular membrane through association with S100A10 By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei126 – 14924Helical; Name=S1 of repeat I; Reviewed prediction
Add
BLAST
Transmembranei155 – 17420Helical; Name=S2 of repeat I; Reviewed prediction
Add
BLAST
Transmembranei188 – 20619Helical; Name=S3 of repeat I; Reviewed prediction
Add
BLAST
Transmembranei213 – 23220Helical; Voltage-sensor; Name=S4 of repeat I; Reviewed prediction
Add
BLAST
Transmembranei249 – 27224Helical; Name=S5 of repeat I; Reviewed prediction
Add
BLAST
Transmembranei374 – 39926Helical; Name=S6 of repeat I; Reviewed prediction
Add
BLAST
Transmembranei660 – 68425Helical; Name=S1 of repeat II; Reviewed prediction
Add
BLAST
Transmembranei696 – 71924Helical; Name=S2 of repeat II; Reviewed prediction
Add
BLAST
Transmembranei728 – 74720Helical; Name=S3 of repeat II; Reviewed prediction
Add
BLAST
Transmembranei754 – 77320Helical; Voltage-sensor; Name=S4 of repeat II; Reviewed prediction
Add
BLAST
Transmembranei790 – 81021Helical; Name=S5 of repeat II; Reviewed prediction
Add
BLAST
Transmembranei865 – 89026Helical; Name=S6 of repeat II; Reviewed prediction
Add
BLAST
Transmembranei1148 – 117124Helical; Name=S1 of repeat III; Reviewed prediction
Add
BLAST
Transmembranei1185 – 121026Helical; Name=S2 of repeat III; Reviewed prediction
Add
BLAST
Transmembranei1217 – 123822Helical; Name=S3 of repeat III; Reviewed prediction
Add
BLAST
Transmembranei1243 – 126422Helical; Voltage-sensor; Name=S4 of repeat III; Reviewed prediction
Add
BLAST
Transmembranei1284 – 131128Helical; Name=S5 of repeat III; Reviewed prediction
Add
BLAST
Transmembranei1392 – 141827Helical; Name=S6 of repeat III; Reviewed prediction
Add
BLAST
Transmembranei1472 – 149524Helical; Name=S1 of repeat IV; Reviewed prediction
Add
BLAST
Transmembranei1507 – 153024Helical; Name=S2 of repeat IV; Reviewed prediction
Add
BLAST
Transmembranei1537 – 156024Helical; Name=S3 of repeat IV; Reviewed prediction
Add
BLAST
Transmembranei1573 – 159422Helical; Voltage-sensor; Name=S4 of repeat IV; Reviewed prediction
Add
BLAST
Transmembranei1610 – 163223Helical; Name=S5 of repeat IV; Reviewed prediction
Add
BLAST
Transmembranei1698 – 172225Helical; Name=S6 of repeat IV; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. C-fiber Source: Ensembl
  2. extracellular vesicular exosome Source: UniProt
  3. voltage-gated sodium channel complex Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Episodic pain syndrome, familial, 2 (FEPS2) [MIM:615551]: An autosomal dominant neurologic disorder characterized by adult-onset of paroxysmal pain mainly affecting the distal lower extremities.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti554 – 5541L → P in FEPS2; increases the excitability of small DRG neurons. 1 Publication
VAR_070878
Natural varianti1304 – 13041A → T in FEPS2; increases the excitability of small DRG neurons. 1 Publication
VAR_070882

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi615551. phenotype.
Orphaneti88642. Channelopathy-associated congenital insensitivity to pain.
46348. Paroxysmal extreme pain disorder.
90026. Primary erythermalgia.
306577. Sodium channelopathy-related small fiber neuropathy.
PharmGKBiPA35000.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19561956Sodium channel protein type 10 subunit alpha
PRO_0000048507Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi284 – 2841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi312 – 3121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi335 – 3351N-linked (GlcNAc...) Reviewed prediction
Glycosylationi819 – 8191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1312 – 13121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1328 – 13281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1336 – 13361N-linked (GlcNAc...) Reviewed prediction
Modified residuei1451 – 14511Phosphoserine; by PKC By similarity
Glycosylationi1686 – 16861N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Ubiquitinated by NEDD4L; which promotes its endocytosis By similarity.
Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9Y5Y9.
PRIDEiQ9Y5Y9.

PTM databases

PhosphoSiteiQ9Y5Y9.

Expressioni

Tissue specificityi

Expressed in the dorsal root ganglia and sciatic nerve.1 Publication

Gene expression databases

BgeeiQ9Y5Y9.
CleanExiHS_SCN10A.
GenevestigatoriQ9Y5Y9.

Organism-specific databases

HPAiCAB022171.

Interactioni

Subunit structurei

The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others By similarity. Interacts with NEDD4 and NEDD4L.

Protein-protein interaction databases

STRINGi9606.ENSP00000390600.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5Y9.
SMRiQ9Y5Y9. Positions 130-268, 668-891, 1148-1419, 1478-1871.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati125 – 400276I
Add
BLAST
Repeati659 – 891233II
Add
BLAST
Repeati1147 – 1419273III
Add
BLAST
Repeati1471 – 1723253IV
Add
BLAST
Domaini1851 – 188030IQ
Add
BLAST

Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 IQ domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiQ9Y5Y9.
KOiK04842.
OMAiVFFTAEM.
OrthoDBiEOG7DJSK9.
PhylomeDBiQ9Y5Y9.
TreeFamiTF323985.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028809. Na_channel_a10su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF23. PTHR10037:SF23. 1 hit.
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.

Sequencei

Sequence statusi: Complete.

Q9Y5Y9-1 [UniParc]FASTAAdd to Basket

« Hide

MEFPIGSLET NNFRRFTPES LVEIEKQIAA KQGTKKAREK HREQKDQEEK     50
PRPQLDLKAC NQLPKFYGEL PAELIGEPLE DLDPFYSTHR TFMVLNKGRT 100
ISRFSATRAL WLFSPFNLIR RTAIKVSVHS WFSLFITVTI LVNCVCMTRT 150
DLPEKIEYVF TVIYTFEALI KILARGFCLN EFTYLRDPWN WLDFSVITLA 200
YVGTAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI HSVKKLADVT 250
ILTIFCLSVF ALVGLQLFKG NLKNKCVKND MAVNETTNYS SHRKPDIYIN 300
KRGTSDPLLC GNGSDSGHCP DGYICLKTSD NPDFNYTSFD SFAWAFLSLF 350
RLMTQDSWER LYQQTLRTSG KIYMIFFVLV IFLGSFYLVN LILAVVTMAY 400
EEQNQATTDE IEAKEKKFQE ALEMLRKEQE VLAALGIDTT SLHSHNGSPL 450
TSKNASERRH RIKPRVSEGS TEDNKSPRSD PYNQRRMSFL GLASGKRRAS 500
HGSVFHFRSP GRDISLPEGV TDDGVFPGDH ESHRGSLLLG GGAGQQGPLP 550
RSPLPQPSNP DSRHGEDEHQ PPPTSELAPG AVDVSAFDAG QKKTFLSAEY 600
LDEPFRAQRA MSVVSIITSV LEELEESEQK CPPCLTSLSQ KYLIWDCCPM 650
WVKLKTILFG LVTDPFAELT ITLCIVVNTI FMAMEHHGMS PTFEAMLQIG 700
NIVFTIFFTA EMVFKIIAFD PYYYFQKKWN IFDCIIVTVS LLELGVAKKG 750
SLSVLRSFRL LRVFKLAKSW PTLNTLIKII GNSVGALGNL TIILAIIVFV 800
FALVGKQLLG ENYRNNRKNI SAPHEDWPRW HMHDFFHSFL IVFRILCGEW 850
IENMWACMEV GQKSICLILF LTVMVLGNLV VLNLFIALLL NSFSADNLTA 900
PEDDGEVNNL QVALARIQVF GHRTKQALCS FFSRSCPFPQ PKAEPELVVK 950
LPLSSSKAEN HIAANTARGS SGGLQAPRGP RDEHSDFIAN PTVWVSVPIA 1000
EGESDLDDLE DDGGEDAQSF QQEVIPKGQQ EQLQQVERCG DHLTPRSPGT 1050
GTSSEDLAPS LGETWKDESV PQVPAEGVDD TSSSEGSTVD CLDPEEILRK 1100
IPELADDLEE PDDCFTEGCI RHCPCCKLDT TKSPWDVGWQ VRKTCYRIVE 1150
HSWFESFIIF MILLSSGSLA FEDYYLDQKP TVKALLEYTD RVFTFIFVFE 1200
MLLKWVAYGF KKYFTNAWCW LDFLIVNISL ISLTAKILEY SEVAPIKALR 1250
TLRALRPLRA LSRFEGMRVV VDALVGAIPS IMNVLLVCLI FWLIFSIMGV 1300
NLFAGKFWRC INYTDGEFSL VPLSIVNNKS DCKIQNSTGS FFWVNVKVNF 1350
DNVAMGYLAL LQVATFKGWM DIMYAAVDSR EVNMQPKWED NVYMYLYFVI 1400
FIIFGGFFTL NLFVGVIIDN FNQQKKKLGG QDIFMTEEQK KYYNAMKKLG 1450
SKKPQKPIPR PLNKFQGFVF DIVTRQAFDI TIMVLICLNM ITMMVETDDQ 1500
SEEKTKILGK INQFFVAVFT GECVMKMFAL RQYYFTNGWN VFDFIVVVLS 1550
IASLIFSAIL KSLQSYFSPT LFRVIRLARI GRILRLIRAA KGIRTLLFAL 1600
MMSLPALFNI GLLLFLVMFI YSIFGMSSFP HVRWEAGIDD MFNFQTFANS 1650
MLCLFQITTS AGWDGLLSPI LNTGPPYCDP NLPNSNGTRG DCGSPAVGII 1700
FFTTYIIISF LIMVNMYIAV ILENFNVATE ESTEPLSEDD FDMFYETWEK 1750
FDPEATQFIT FSALSDFADT LSGPLRIPKP NRNILIQMDL PLVPGDKIHC 1800
LDILFAFTKN VLGESGELDS LKANMEEKFM ATNLSKSSYE PIATTLRWKQ 1850
EDISATVIQK AYRSYVLHRS MALSNTPCVP RAEEEAASLP DEGFVAFTAN 1900
ENCVLPDKSE TASATSFPPS YESVTRGLSD RVNMRTSSSI QNEDEATSME 1950
LIAPGP 1956
Length:1,956
Mass (Da):220,626
Last modified:September 2, 2008 - v2
Checksum:i4A4A2C5E135B6685
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti509 – 5091S → P.
Corresponds to variant rs7630989 [ dbSNP | Ensembl ].
VAR_020605
Natural varianti554 – 5541L → P in FEPS2; increases the excitability of small DRG neurons. 1 Publication
VAR_070878
Natural varianti590 – 5901G → R.
Corresponds to variant rs35332705 [ dbSNP | Ensembl ].
VAR_048696
Natural varianti916 – 9161R → W Found in a renal cell carcinoma sample; somatic mutation. 1 Publication
VAR_064748
Natural varianti939 – 9391P → L.1 Publication
VAR_070879
Natural varianti940 – 9401Q → L.1 Publication
VAR_070880
Natural varianti1056 – 10561D → N.1 Publication
VAR_070881
Natural varianti1073 – 10731V → A.1 Publication
Corresponds to variant rs6795970 [ dbSNP | Ensembl ].
VAR_020606
Natural varianti1092 – 10921L → P.
Corresponds to variant rs12632942 [ dbSNP | Ensembl ].
VAR_020607
Natural varianti1304 – 13041A → T in FEPS2; increases the excitability of small DRG neurons. 1 Publication
VAR_070882
Natural varianti1523 – 15231C → Y No gain in function in response to depolarization. 1 Publication
VAR_070883
Natural varianti1662 – 16621G → S.1 Publication
VAR_070884
Natural varianti1713 – 17131M → V.1 Publication
Corresponds to variant rs6599241 [ dbSNP | Ensembl ].
VAR_020608

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117907 mRNA. Translation: AAD30863.1.
AC116038 Genomic DNA. No translation available.
AC137625 Genomic DNA. No translation available.
CCDSiCCDS33736.1.
RefSeqiNP_006505.2. NM_006514.2.
UniGeneiHs.250443.

Genome annotation databases

EnsembliENST00000449082; ENSP00000390600; ENSG00000185313.
GeneIDi6336.
KEGGihsa:6336.
UCSCiuc003ciq.3. human.

Polymorphism databases

DMDMi205371821.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117907 mRNA. Translation: AAD30863.1 .
AC116038 Genomic DNA. No translation available.
AC137625 Genomic DNA. No translation available.
CCDSi CCDS33736.1.
RefSeqi NP_006505.2. NM_006514.2.
UniGenei Hs.250443.

3D structure databases

ProteinModelPortali Q9Y5Y9.
SMRi Q9Y5Y9. Positions 130-268, 668-891, 1148-1419, 1478-1871.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000390600.

Chemistry

BindingDBi Q9Y5Y9.
ChEMBLi CHEMBL2331043.
DrugBanki DB01086. Benzocaine.
DB00297. Bupivacaine.
DB01161. Chloroprocaine.
DB00907. Cocaine.
DB00527. Dibucaine.
DB00645. Dyclonine.
DB00473. Hexylcaine.
DB01002. Levobupivacaine.
DB00281. Lidocaine.
DB00961. Mepivacaine.
DB00892. Oxybuprocaine.
DB00721. Procaine.
DB00807. Proparacaine.
DB00296. Ropivacaine.
GuidetoPHARMACOLOGYi 585.

PTM databases

PhosphoSitei Q9Y5Y9.

Polymorphism databases

DMDMi 205371821.

Proteomic databases

PaxDbi Q9Y5Y9.
PRIDEi Q9Y5Y9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000449082 ; ENSP00000390600 ; ENSG00000185313 .
GeneIDi 6336.
KEGGi hsa:6336.
UCSCi uc003ciq.3. human.

Organism-specific databases

CTDi 6336.
GeneCardsi GC03M038713.
H-InvDB HIX0030722.
HGNCi HGNC:10582. SCN10A.
HPAi CAB022171.
MIMi 604427. gene.
615551. phenotype.
neXtProti NX_Q9Y5Y9.
Orphaneti 88642. Channelopathy-associated congenital insensitivity to pain.
46348. Paroxysmal extreme pain disorder.
90026. Primary erythermalgia.
306577. Sodium channelopathy-related small fiber neuropathy.
PharmGKBi PA35000.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231755.
HOVERGENi HBG053100.
InParanoidi Q9Y5Y9.
KOi K04842.
OMAi VFFTAEM.
OrthoDBi EOG7DJSK9.
PhylomeDBi Q9Y5Y9.
TreeFami TF323985.

Miscellaneous databases

GeneWikii SCN10A.
GenomeRNAii 6336.
NextBioi 24604.
PROi Q9Y5Y9.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y5Y9.
CleanExi HS_SCN10A.
Genevestigatori Q9Y5Y9.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR028809. Na_channel_a10su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
PANTHERi PTHR10037:SF23. PTHR10037:SF23. 1 hit.
Pfami PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A tetrodotoxin-resistant voltage-gated sodium channel from human dorsal root ganglia, hPN3/SCN10A."
    Rabert D.K., Koch B.D., Ilnicka M., Obernolte R.A., Naylor S.L., Herman R.C., Eglen R.M., Hunter J.C., Sangameswaran L.
    Pain 78:107-114(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION IN VOLTAGE-EVOKED DEPOLARIZATION, TISSUE SPECIFICITY, VARIANTS ALA-1073 AND VAL-1713.
    Tissue: Spinal ganglion.
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: VARIANT TRP-916.
  4. Cited for: VARIANTS FEPS2 PRO-554 AND THR-1304, CHARACTERIZATION OF VARIANTS FEPS2 PRO-554 AND THR-1304, VARIANTS LEU-939; LEU-940; ASN-1056; TYR-1523 AND SER-1662, CHARACTERIZATION OF VARIANT TYR-1523.

Entry informationi

Entry nameiSCNAA_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Y9
Secondary accession number(s): A6NDQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: September 2, 2008
Last modified: September 3, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi