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Protein

Lymphatic vessel endothelial hyaluronic acid receptor 1

Gene

LYVE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.1 Publication

GO - Molecular functioni

  • hyaluronic acid binding Source: Ensembl
  • receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: Ensembl

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • cell-matrix adhesion Source: ProtInc
  • hyaluronan catabolic process Source: Reactome
  • movement of cell or subcellular component Source: ProtInc
  • response to wounding Source: ProtInc
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-HSA-2160916. Hyaluronan uptake and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphatic vessel endothelial hyaluronic acid receptor 1
Short name:
LYVE-1
Alternative name(s):
Cell surface retention sequence-binding protein 1
Short name:
CRSBP-1
Extracellular link domain-containing protein 1
Hyaluronic acid receptor
Gene namesi
Name:LYVE1
Synonyms:CRSBP1, HAR, XLKD1
ORF Names:UNQ230/PRO263
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14687. LYVE1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 238219ExtracellularSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST
Topological domaini260 – 32263CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162394799.

Polymorphism and mutation databases

BioMutaiLYVE1.
DMDMi115502898.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 322303Lymphatic vessel endothelial hyaluronic acid receptor 1PRO_0000252133Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)2 Publications
Disulfide bondi61 ↔ 128PROSITE-ProRule annotation
Disulfide bondi85 ↔ 106PROSITE-ProRule annotation
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y5Y7.
PeptideAtlasiQ9Y5Y7.
PRIDEiQ9Y5Y7.

PTM databases

iPTMnetiQ9Y5Y7.
PhosphoSiteiQ9Y5Y7.
SwissPalmiQ9Y5Y7.
UniCarbKBiQ9Y5Y7.

Expressioni

Tissue specificityi

Mainly expressed in endothelial cells lining lymphatic vessels.1 Publication

Gene expression databases

BgeeiQ9Y5Y7.
CleanExiHS_LYVE1.
ExpressionAtlasiQ9Y5Y7. baseline and differential.
GenevisibleiQ9Y5Y7. HS.

Organism-specific databases

HPAiCAB025860.
HPA042953.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-8P604103EBI-10329546,EBI-10171774

Protein-protein interaction databases

BioGridi116100. 4 interactions.
IntActiQ9Y5Y7. 1 interaction.
STRINGi9606.ENSP00000256178.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5Y7.
SMRiQ9Y5Y7. Positions 29-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 13091LinkPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Link domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHIF. Eukaryota.
ENOG41127CQ. LUCA.
GeneTreeiENSGT00530000063822.
HOGENOMiHOG000059545.
HOVERGENiHBG103455.
InParanoidiQ9Y5Y7.
KOiK19012.
OMAiSGFETCS.
OrthoDBiEOG77HDFT.
PhylomeDBiQ9Y5Y7.
TreeFamiTF334173.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50963. LINK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARCFSLVLL LTSIWTTRLL VQGSLRAEEL SIQVSCRIMG ITLVSKKANQ
60 70 80 90 100
QLNFTEAKEA CRLLGLSLAG KDQVETALKA SFETCSYGWV GDGFVVISRI
110 120 130 140 150
SPNPKCGKNG VGVLIWKVPV SRQFAAYCYN SSDTWTNSCI PEIITTKDPI
160 170 180 190 200
FNTQTATQTT EFIVSDSTYS VASPYSTIPA PTTTPPAPAS TSIPRRKKLI
210 220 230 240 250
CVTEVFMETS TMSTETEPFV ENKAAFKNEA AGFGGVPTAL LVLALLFFGA
260 270 280 290 300
AAGLGFCYVK RYVKAFPFTN KNQQKEMIET KVVKEEKAND SNPNEESKKT
310 320
DKNPEESKSP SKTTVRCLEA EV
Length:322
Mass (Da):35,213
Last modified:October 3, 2006 - v2
Checksum:i8B4D6D623F52D559
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751E → D in AAD42764 (PubMed:10037799).Curated
Sequence conflicti125 – 1251A → G in AAD42764 (PubMed:10037799).Curated
Sequence conflicti139 – 1391C → R in AAD42764 (PubMed:10037799).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti116 – 1161W → R.1 Publication
Corresponds to variant rs17852369 [ dbSNP | Ensembl ].
VAR_027763
Natural varianti214 – 2141T → I.
Corresponds to variant rs16907980 [ dbSNP | Ensembl ].
VAR_027764
Natural varianti315 – 3151V → M.
Corresponds to variant rs7948666 [ dbSNP | Ensembl ].
VAR_027765

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118108 mRNA. Translation: AAD42764.1.
AF127670 mRNA. Translation: AAD49220.2.
AY358925 mRNA. Translation: AAQ89284.1.
BC026231 mRNA. Translation: AAH26231.1.
CCDSiCCDS7804.1.
RefSeqiNP_006682.2. NM_006691.3.
UniGeneiHs.655332.

Genome annotation databases

EnsembliENST00000256178; ENSP00000256178; ENSG00000133800.
GeneIDi10894.
KEGGihsa:10894.
UCSCiuc001miv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118108 mRNA. Translation: AAD42764.1.
AF127670 mRNA. Translation: AAD49220.2.
AY358925 mRNA. Translation: AAQ89284.1.
BC026231 mRNA. Translation: AAH26231.1.
CCDSiCCDS7804.1.
RefSeqiNP_006682.2. NM_006691.3.
UniGeneiHs.655332.

3D structure databases

ProteinModelPortaliQ9Y5Y7.
SMRiQ9Y5Y7. Positions 29-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116100. 4 interactions.
IntActiQ9Y5Y7. 1 interaction.
STRINGi9606.ENSP00000256178.

PTM databases

iPTMnetiQ9Y5Y7.
PhosphoSiteiQ9Y5Y7.
SwissPalmiQ9Y5Y7.
UniCarbKBiQ9Y5Y7.

Polymorphism and mutation databases

BioMutaiLYVE1.
DMDMi115502898.

Proteomic databases

PaxDbiQ9Y5Y7.
PeptideAtlasiQ9Y5Y7.
PRIDEiQ9Y5Y7.

Protocols and materials databases

DNASUi10894.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256178; ENSP00000256178; ENSG00000133800.
GeneIDi10894.
KEGGihsa:10894.
UCSCiuc001miv.3. human.

Organism-specific databases

CTDi10894.
GeneCardsiLYVE1.
HGNCiHGNC:14687. LYVE1.
HPAiCAB025860.
HPA042953.
MIMi605702. gene.
neXtProtiNX_Q9Y5Y7.
PharmGKBiPA162394799.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHIF. Eukaryota.
ENOG41127CQ. LUCA.
GeneTreeiENSGT00530000063822.
HOGENOMiHOG000059545.
HOVERGENiHBG103455.
InParanoidiQ9Y5Y7.
KOiK19012.
OMAiSGFETCS.
OrthoDBiEOG77HDFT.
PhylomeDBiQ9Y5Y7.
TreeFamiTF334173.

Enzyme and pathway databases

ReactomeiR-HSA-2160916. Hyaluronan uptake and degradation.

Miscellaneous databases

GeneWikiiLYVE1.
GenomeRNAii10894.
PROiQ9Y5Y7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5Y7.
CleanExiHS_LYVE1.
ExpressionAtlasiQ9Y5Y7. baseline and differential.
GenevisibleiQ9Y5Y7. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like.
IPR016187. C-type_lectin_fold.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50963. LINK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "LYVE-1, a new homologue of the CD44 glycoprotein is a lymph-specific receptor for hyaluronan."
    Banerji S., Ni J., Wang S.-X., Clasper S., Su J., Tammi R., Jones M., Jackson D.G.
    J. Cell Biol. 144:789-801(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "HAR: a novel homolog of CD44 and putative hyaluronic acid receptor encoded by a gene on human chromosome 11p15."
    Winkelmann J.C., Basu S., Ozdemir E., Blough R.I.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-116.
    Tissue: Liver.
  5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53.
    Tissue: Plasma.
  6. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53.
    Tissue: Liver.

Entry informationi

Entry nameiLYVE1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Y7
Secondary accession number(s): Q8TC18, Q9UNF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: June 8, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.