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Protein

Lymphatic vessel endothelial hyaluronic acid receptor 1

Gene

LYVE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.1 Publication

GO - Molecular functioni

  • hyaluronic acid binding Source: Ensembl
  • receptor activity Source: ProtInc
  • transmembrane signaling receptor activity Source: Ensembl

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
  • cell-matrix adhesion Source: ProtInc
  • hyaluronan catabolic process Source: Reactome
  • movement of cell or subcellular component Source: ProtInc
  • response to wounding Source: ProtInc
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133800-MONOMER.
ReactomeiR-HSA-2160916. Hyaluronan uptake and degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphatic vessel endothelial hyaluronic acid receptor 1
Short name:
LYVE-1
Alternative name(s):
Cell surface retention sequence-binding protein 1
Short name:
CRSBP-1
Extracellular link domain-containing protein 1
Hyaluronic acid receptor
Gene namesi
Name:LYVE1
Synonyms:CRSBP1, HAR, XLKD1
ORF Names:UNQ230/PRO263
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14687. LYVE1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 238ExtracellularSequence analysisAdd BLAST219
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 322CytoplasmicSequence analysisAdd BLAST63

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10894.
OpenTargetsiENSG00000133800.
PharmGKBiPA162394799.

Polymorphism and mutation databases

BioMutaiLYVE1.
DMDMi115502898.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000025213320 – 322Lymphatic vessel endothelial hyaluronic acid receptor 1Add BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...)2 Publications1
Disulfide bondi61 ↔ 128PROSITE-ProRule annotation
Disulfide bondi85 ↔ 106PROSITE-ProRule annotation
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y5Y7.
PeptideAtlasiQ9Y5Y7.
PRIDEiQ9Y5Y7.

PTM databases

iPTMnetiQ9Y5Y7.
PhosphoSitePlusiQ9Y5Y7.
SwissPalmiQ9Y5Y7.
UniCarbKBiQ9Y5Y7.

Expressioni

Tissue specificityi

Mainly expressed in endothelial cells lining lymphatic vessels.1 Publication

Gene expression databases

BgeeiENSG00000133800.
CleanExiHS_LYVE1.
ExpressionAtlasiQ9Y5Y7. baseline and differential.
GenevisibleiQ9Y5Y7. HS.

Organism-specific databases

HPAiCAB025860.
HPA042953.

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Interacts with PDGFB and IGFBP3. Forms a transient ternary complex with PDGFB and PDGFRB in TGN (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-8P604103EBI-10329546,EBI-10171774

Protein-protein interaction databases

BioGridi116100. 4 interactors.
IntActiQ9Y5Y7. 4 interactors.
STRINGi9606.ENSP00000256178.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5Y7.
SMRiQ9Y5Y7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 130LinkPROSITE-ProRule annotationAdd BLAST91

Sequence similaritiesi

Contains 1 Link domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHIF. Eukaryota.
ENOG41127CQ. LUCA.
GeneTreeiENSGT00530000063822.
HOGENOMiHOG000059545.
HOVERGENiHBG103455.
InParanoidiQ9Y5Y7.
KOiK19012.
OMAiSGFETCS.
OrthoDBiEOG091G09EL.
PhylomeDBiQ9Y5Y7.
TreeFamiTF334173.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50963. LINK_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5Y7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARCFSLVLL LTSIWTTRLL VQGSLRAEEL SIQVSCRIMG ITLVSKKANQ
60 70 80 90 100
QLNFTEAKEA CRLLGLSLAG KDQVETALKA SFETCSYGWV GDGFVVISRI
110 120 130 140 150
SPNPKCGKNG VGVLIWKVPV SRQFAAYCYN SSDTWTNSCI PEIITTKDPI
160 170 180 190 200
FNTQTATQTT EFIVSDSTYS VASPYSTIPA PTTTPPAPAS TSIPRRKKLI
210 220 230 240 250
CVTEVFMETS TMSTETEPFV ENKAAFKNEA AGFGGVPTAL LVLALLFFGA
260 270 280 290 300
AAGLGFCYVK RYVKAFPFTN KNQQKEMIET KVVKEEKAND SNPNEESKKT
310 320
DKNPEESKSP SKTTVRCLEA EV
Length:322
Mass (Da):35,213
Last modified:October 3, 2006 - v2
Checksum:i8B4D6D623F52D559
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75E → D in AAD42764 (PubMed:10037799).Curated1
Sequence conflicti125A → G in AAD42764 (PubMed:10037799).Curated1
Sequence conflicti139C → R in AAD42764 (PubMed:10037799).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027763116W → R.1 PublicationCorresponds to variant rs17852369dbSNPEnsembl.1
Natural variantiVAR_027764214T → I.Corresponds to variant rs16907980dbSNPEnsembl.1
Natural variantiVAR_027765315V → M.Corresponds to variant rs7948666dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118108 mRNA. Translation: AAD42764.1.
AF127670 mRNA. Translation: AAD49220.2.
AY358925 mRNA. Translation: AAQ89284.1.
BC026231 mRNA. Translation: AAH26231.1.
CCDSiCCDS7804.1.
RefSeqiNP_006682.2. NM_006691.3.
UniGeneiHs.655332.

Genome annotation databases

EnsembliENST00000256178; ENSP00000256178; ENSG00000133800.
GeneIDi10894.
KEGGihsa:10894.
UCSCiuc001miv.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118108 mRNA. Translation: AAD42764.1.
AF127670 mRNA. Translation: AAD49220.2.
AY358925 mRNA. Translation: AAQ89284.1.
BC026231 mRNA. Translation: AAH26231.1.
CCDSiCCDS7804.1.
RefSeqiNP_006682.2. NM_006691.3.
UniGeneiHs.655332.

3D structure databases

ProteinModelPortaliQ9Y5Y7.
SMRiQ9Y5Y7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116100. 4 interactors.
IntActiQ9Y5Y7. 4 interactors.
STRINGi9606.ENSP00000256178.

PTM databases

iPTMnetiQ9Y5Y7.
PhosphoSitePlusiQ9Y5Y7.
SwissPalmiQ9Y5Y7.
UniCarbKBiQ9Y5Y7.

Polymorphism and mutation databases

BioMutaiLYVE1.
DMDMi115502898.

Proteomic databases

PaxDbiQ9Y5Y7.
PeptideAtlasiQ9Y5Y7.
PRIDEiQ9Y5Y7.

Protocols and materials databases

DNASUi10894.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256178; ENSP00000256178; ENSG00000133800.
GeneIDi10894.
KEGGihsa:10894.
UCSCiuc001miv.3. human.

Organism-specific databases

CTDi10894.
DisGeNETi10894.
GeneCardsiLYVE1.
HGNCiHGNC:14687. LYVE1.
HPAiCAB025860.
HPA042953.
MIMi605702. gene.
neXtProtiNX_Q9Y5Y7.
OpenTargetsiENSG00000133800.
PharmGKBiPA162394799.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHIF. Eukaryota.
ENOG41127CQ. LUCA.
GeneTreeiENSGT00530000063822.
HOGENOMiHOG000059545.
HOVERGENiHBG103455.
InParanoidiQ9Y5Y7.
KOiK19012.
OMAiSGFETCS.
OrthoDBiEOG091G09EL.
PhylomeDBiQ9Y5Y7.
TreeFamiTF334173.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000133800-MONOMER.
ReactomeiR-HSA-2160916. Hyaluronan uptake and degradation.

Miscellaneous databases

GeneWikiiLYVE1.
GenomeRNAii10894.
PROiQ9Y5Y7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133800.
CleanExiHS_LYVE1.
ExpressionAtlasiQ9Y5Y7. baseline and differential.
GenevisibleiQ9Y5Y7. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000538. Link_dom.
[Graphical view]
PfamiPF00193. Xlink. 1 hit.
[Graphical view]
PRINTSiPR01265. LINKMODULE.
SMARTiSM00445. LINK. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50963. LINK_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLYVE1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Y7
Secondary accession number(s): Q8TC18, Q9UNF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.