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Protein

Suppressor of tumorigenicity 14 protein

Gene

ST14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.1 Publication

Catalytic activityi

Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei656Charge relay system1
Active sitei711Charge relay system1
Active sitei805Charge relay system1

GO - Molecular functioni

GO - Biological processi

  • cornification Source: Reactome
  • epithelial cell morphogenesis involved in placental branching Source: Ensembl
  • keratinocyte differentiation Source: UniProtKB
  • neural tube closure Source: Ensembl
  • proteolysis Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.109 2681
ReactomeiR-HSA-6809371 Formation of the cornified envelope

Protein family/group databases

MEROPSiS01.302

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of tumorigenicity 14 protein (EC:3.4.21.109)
Alternative name(s):
Matriptase
Membrane-type serine protease 1
Short name:
MT-SP1
Prostamin
Serine protease 14
Serine protease TADG-15
Tumor-associated differentially-expressed gene 15 protein
Gene namesi
Name:ST14
Synonyms:PRSS14, SNC19, TADG15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000149418.10
HGNCiHGNC:11344 ST14
MIMi606797 gene
neXtProtiNX_Q9Y5Y6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55CytoplasmicSequence analysisAdd BLAST55
Transmembranei56 – 76Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini77 – 855ExtracellularSequence analysisAdd BLAST779

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Ichthyosis, congenital, autosomal recessive 11 (ARCI11)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs.
See also OMIM:602400
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032849827G → R in ARCI11. 1 PublicationCorresponds to variant dbSNP:rs137852931EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi656H → A: Abolishes catalytic activity. 1 Publication1
Mutagenesisi711D → A: Abolishes catalytic activity. 1 Publication1
Mutagenesisi805S → A: Abolishes catalytic activity. 1 Publication1

Keywords - Diseasei

Disease mutation, Hypotrichosis, Ichthyosis

Organism-specific databases

DisGeNETi6768
MalaCardsiST14
MIMi602400 phenotype
OpenTargetsiENSG00000149418
Orphaneti91132 Ichthyosis-hypotrichosis syndrome
PharmGKBiPA36168

Chemistry databases

ChEMBLiCHEMBL3018
DrugBankiDB03127 Benzamidine
DB00013 Urokinase
GuidetoPHARMACOLOGYi2418

Polymorphism and mutation databases

BioMutaiST14
DMDMi13124575

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000887121 – 855Suppressor of tumorigenicity 14 proteinAdd BLAST855

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi214 ↔ 244By similarity
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi340 ↔ 366By similarity
Disulfide bondi397 ↔ 410By similarity
Disulfide bondi453 ↔ 464By similarity
Disulfide bondi459 ↔ 477By similarity
Disulfide bondi471 ↔ 486By similarity
Glycosylationi485N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi488 ↔ 501By similarity
Disulfide bondi496 ↔ 514By similarity
Disulfide bondi508 ↔ 523By similarity
Disulfide bondi525 ↔ 537By similarity
Disulfide bondi532 ↔ 550By similarity
Disulfide bondi544 ↔ 559By similarity
Disulfide bondi567 ↔ 579By similarity
Disulfide bondi574 ↔ 593By similarity
Disulfide bondi587 ↔ 602By similarity
Disulfide bondi641 ↔ 6571 Publication
Glycosylationi772N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi776 ↔ 7901 Publication
Disulfide bondi801 ↔ 8301 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9Y5Y6
MaxQBiQ9Y5Y6
PaxDbiQ9Y5Y6
PeptideAtlasiQ9Y5Y6
PRIDEiQ9Y5Y6

PTM databases

iPTMnetiQ9Y5Y6
PhosphoSitePlusiQ9Y5Y6

Miscellaneous databases

PMAP-CutDBiQ9Y5Y6

Expressioni

Gene expression databases

BgeeiENSG00000149418
CleanExiHS_ST14
GenevisibleiQ9Y5Y6 HS

Organism-specific databases

HPAiHPA047014

Interactioni

Subunit structurei

Interacts with CDCP1. May interact with TMEFF1.2 Publications

Protein-protein interaction databases

BioGridi112645, 13 interactors
IntActiQ9Y5Y6, 14 interactors
MINTiQ9Y5Y6
STRINGi9606.ENSP00000278742

Chemistry databases

BindingDBiQ9Y5Y6

Structurei

Secondary structure

1855
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi629 – 634Combined sources6
Turni635 – 637Combined sources3
Beta strandi638 – 645Combined sources8
Beta strandi647 – 653Combined sources7
Helixi655 – 658Combined sources4
Helixi669 – 671Combined sources3
Beta strandi672 – 677Combined sources6
Beta strandi683 – 688Combined sources6
Beta strandi690 – 699Combined sources10
Turni705 – 707Combined sources3
Beta strandi713 – 719Combined sources7
Beta strandi724 – 726Combined sources3
Beta strandi744 – 754Combined sources11
Beta strandi764 – 770Combined sources7
Helixi773 – 779Combined sources7
Turni781 – 783Combined sources3
Beta strandi788 – 792Combined sources5
Beta strandi797 – 799Combined sources3
Turni802 – 806Combined sources5
Beta strandi808 – 812Combined sources5
Beta strandi814 – 816Combined sources3
Beta strandi818 – 826Combined sources9
Beta strandi828 – 831Combined sources4
Beta strandi833 – 835Combined sources3
Beta strandi837 – 842Combined sources6
Helixi843 – 845Combined sources3
Helixi846 – 853Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EAWX-ray2.93A/C615-855[»]
1EAXX-ray1.30A615-855[»]
2FMVmodel-A214-447[»]
2GV6X-ray2.10A615-855[»]
2GV7X-ray2.20A615-855[»]
3BN9X-ray2.17A/B615-855[»]
3NCLX-ray1.19A615-855[»]
3NPSX-ray1.50A615-855[»]
3P8FX-ray2.00A615-855[»]
3P8GX-ray1.20A615-855[»]
3SO3X-ray2.10A615-855[»]
4IS5X-ray1.48A615-855[»]
4ISLX-ray2.29A615-855[»]
4ISNX-ray2.45A615-855[»]
4ISOX-ray2.01A615-855[»]
4JYTX-ray2.00A615-855[»]
4JZ1X-ray1.90A615-855[»]
4JZIX-ray2.00A615-855[»]
4O97X-ray2.20A615-855[»]
B604-607[»]
4O9VX-ray1.90A615-855[»]
B604-607[»]
4R0IX-ray1.90A615-855[»]
5LYOX-ray2.50A/B/C604-855[»]
ProteinModelPortaliQ9Y5Y6
SMRiQ9Y5Y6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y5Y6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 203SEAPROSITE-ProRule annotationAdd BLAST118
Domaini214 – 334CUB 1PROSITE-ProRule annotationAdd BLAST121
Domaini340 – 447CUB 2PROSITE-ProRule annotationAdd BLAST108
Domaini452 – 487LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST36
Domaini487 – 524LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST38
Domaini524 – 560LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST37
Domaini566 – 603LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST38
Domaini615 – 854Peptidase S1PROSITE-ProRule annotationAdd BLAST240

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118962
HOGENOMiHOG000136851
HOVERGENiHBG012556
InParanoidiQ9Y5Y6
KOiK08670
OMAiDCGLRSF
OrthoDBiEOG091G0DF7
PhylomeDBiQ9Y5Y6
TreeFamiTF330647

Family and domain databases

CDDicd00041 CUB, 2 hits
cd00112 LDLa, 4 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di2.60.120.290, 2 hits
3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR009003 Peptidase_S1_PA
IPR017051 Peptidase_S1A_matripase
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
IPR035914 Sperma_CUB_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF00057 Ldl_recept_a, 4 hits
PF01390 SEA, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF036370 ST14, 1 hit
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00042 CUB, 2 hits
SM00192 LDLa, 4 hits
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF49854 SSF49854, 2 hits
SSF50494 SSF50494, 1 hit
SSF57424 SSF57424, 4 hits
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 2 hits
PS01209 LDLRA_1, 3 hits
PS50068 LDLRA_2, 4 hits
PS50024 SEA, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y5Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSDRARKGG GGPKDFGAGL KYNSRHEKVN GLEEGVEFLP VNNVKKVEKH
60 70 80 90 100
GPGRWVVLAA VLIGLLLVLL GIGFLVWHLQ YRDVRVQKVF NGYMRITNEN
110 120 130 140 150
FVDAYENSNS TEFVSLASKV KDALKLLYSG VPFLGPYHKE SAVTAFSEGS
160 170 180 190 200
VIAYYWSEFS IPQHLVEEAE RVMAEERVVM LPPRARSLKS FVVTSVVAFP
210 220 230 240 250
TDSKTVQRTQ DNSCSFGLHA RGVELMRFTT PGFPDSPYPA HARCQWALRG
260 270 280 290 300
DADSVLSLTF RSFDLASCDE RGSDLVTVYN TLSPMEPHAL VQLCGTYPPS
310 320 330 340 350
YNLTFHSSQN VLLITLITNT ERRHPGFEAT FFQLPRMSSC GGRLRKAQGT
360 370 380 390 400
FNSPYYPGHY PPNIDCTWNI EVPNNQHVKV RFKFFYLLEP GVPAGTCPKD
410 420 430 440 450
YVEINGEKYC GERSQFVVTS NSNKITVRFH SDQSYTDTGF LAEYLSYDSS
460 470 480 490 500
DPCPGQFTCR TGRCIRKELR CDGWADCTDH SDELNCSCDA GHQFTCKNKF
510 520 530 540 550
CKPLFWVCDS VNDCGDNSDE QGCSCPAQTF RCSNGKCLSK SQQCNGKDDC
560 570 580 590 600
GDGSDEASCP KVNVVTCTKH TYRCLNGLCL SKGNPECDGK EDCSDGSDEK
610 620 630 640 650
DCDCGLRSFT RQARVVGGTD ADEGEWPWQV SLHALGQGHI CGASLISPNW
660 670 680 690 700
LVSAAHCYID DRGFRYSDPT QWTAFLGLHD QSQRSAPGVQ ERRLKRIISH
710 720 730 740 750
PFFNDFTFDY DIALLELEKP AEYSSMVRPI CLPDASHVFP AGKAIWVTGW
760 770 780 790 800
GHTQYGGTGA LILQKGEIRV INQTTCENLL PQQITPRMMC VGFLSGGVDS
810 820 830 840 850
CQGDSGGPLS SVEADGRIFQ AGVVSWGDGC AQRNKPGVYT RLPLFRDWIK

ENTGV
Length:855
Mass (Da):94,770
Last modified:May 1, 2000 - v2
Checksum:i26143132C01F99C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti674A → V in BAB20376 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032847285M → I. Corresponds to variant dbSNP:rs7126904Ensembl.1
Natural variantiVAR_032848381R → S1 PublicationCorresponds to variant dbSNP:rs17667603Ensembl.1
Natural variantiVAR_032849827G → R in ARCI11. 1 PublicationCorresponds to variant dbSNP:rs137852931EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118224 mRNA Translation: AAD42765.2
AF133086 mRNA Translation: AAF00109.1
AB030036 mRNA Translation: BAB20376.1
AF057145 mRNA Translation: AAG15395.1
BC005826 mRNA Translation: AAH05826.2
BC030532 mRNA Translation: AAH30532.1
AF283256 Genomic DNA Translation: AAG13949.1
CCDSiCCDS8487.1
RefSeqiNP_068813.1, NM_021978.3
UniGeneiHs.504315

Genome annotation databases

EnsembliENST00000278742; ENSP00000278742; ENSG00000149418
GeneIDi6768
KEGGihsa:6768
UCSCiuc001qfw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiST14_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Y6
Secondary accession number(s): Q9BS01
, Q9H3S0, Q9HB36, Q9HCA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 185 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

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