Q9Y5Y4O94765Q4QRI6PD2R2_HUMANProstaglandin D2 receptor 2Chemoattractant receptor-homologous molecule expressed on Th2 cellsG-protein coupled receptor 44CD294PTGDR2CRTH2DL1RGPR44Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoDiscovery of three novel orphan G-protein-coupled receptors.NUCLEOTIDE SEQUENCE [GENOMIC DNA]VARIANT ALA-204Selective expression of a novel surface molecule by human Th2 cells in vivo.NUCLEOTIDE SEQUENCE [MRNA]TISSUE SPECIFICITYVARIANT ALA-204Tissue expression and chromosomal organization of a novel G protein-coupled receptor.NUCLEOTIDE SEQUENCE [MRNA]VARIANT ALA-204cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]VARIANT ALA-204Human chromosome 11 DNA sequence and analysis including novel gene identification.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]VARIANT ALA-204Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor.FUNCTION AS RECEPTOR FOR PGD2A novel surface molecule of Th2- and Tc2-type cells, CRTH2 expression on human peripheral and decidual CD4+ and CD8+ T cells during the early stage of pregnancy.TISSUE SPECIFICITYProstaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2.FUNCTION AS RECEPTOR FOR PGD2TISSUE SPECIFICITYMolecular pharmacology of the human prostaglandin D2 receptor, CRTH2.TISSUE SPECIFICITYCHARACTERIZATIONInhibition of PI3K and calcineurin suppresses chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)-dependent responses of Th2 lymphocytes to prostaglandin D(2).FUNCTION AS PGD2 RECEPTORFUNCTION IN PI3K SIGNALINGDifferential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2.SUBCELLULAR LOCATIONPHOSPHORYLATIONCharacterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: identification of a recycling motif.MUTAGENESIS OF ASP-330; SER-331; GLU-332; LEU-333 AND THR-347IDENTIFICATION OF A RECYCLING MOTIFReceptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.Cell membraneMulti-pass membrane proteinInternalized receptors colocalized with RAB11A.Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils.The 330-DSEL-333 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced internalization. Thr-347 is a major site for PKC-induced internalization of the receptor.Phosphorylated.Belongs to the G-protein coupled receptor 1 family.Extended N-terminus.3D-structureCell membraneDisulfide bondG-protein coupled receptorGlycoproteinMembranePhosphoproteinReceptorReference proteomeTransducerTransmembraneTransmembrane helixVADASAEALATAMSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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