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Protein

Prostaglandin D2 receptor 2

Gene

PTGDR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca2+ mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:G66-31442-MONOMER.
ReactomeiR-HSA-391908. Prostanoid ligand receptors.
R-HSA-418594. G alpha (i) signalling events.

Chemistry databases

SwissLipidsiSLP:000001575.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor 2
Alternative name(s):
Chemoattractant receptor-homologous molecule expressed on Th2 cells
G-protein coupled receptor 44
CD_antigen: CD294
Gene namesi
Name:PTGDR2
Synonyms:CRTH2, DL1R, GPR44
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:4502. PTGDR2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 56Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini57 – 67CytoplasmicSequence analysisAdd BLAST11
Transmembranei68 – 89Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini90 – 106ExtracellularSequence analysisAdd BLAST17
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 146CytoplasmicSequence analysisAdd BLAST19
Transmembranei147 – 168Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini169 – 210ExtracellularSequence analysisAdd BLAST42
Transmembranei211 – 231Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini232 – 247CytoplasmicSequence analysisAdd BLAST16
Transmembranei248 – 269Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini270 – 288ExtracellularSequence analysisAdd BLAST19
Transmembranei289 – 308Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini309 – 395CytoplasmicSequence analysisAdd BLAST87

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: GOC
  • neuron projection Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi330D → A: 45% increases internalization of PTGDR2. 1 Publication1
Mutagenesisi331S → A: 45% increases internalization of PTGDR2. 1 Publication1
Mutagenesisi332E → A: 45% increases internalization of PTGDR2. 1 Publication1
Mutagenesisi333L → A: 45% increase in internalization of PTGDR2. 1 Publication1
Mutagenesisi347T → A: Decreases in PKC-induced internalization of PTGDR2. 1 Publication1

Organism-specific databases

DisGeNETi11251.
OpenTargetsiENSG00000183134.
PharmGKBiPA28891.

Chemistry databases

ChEMBLiCHEMBL5071.
DrugBankiDB00328. Indomethacin.
DB00605. Sulindac.
GuidetoPHARMACOLOGYi339.

Polymorphism and mutation databases

BioMutaiPTGDR2.
DMDMi296439334.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695721 – 395Prostaglandin D2 receptor 2Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi25N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi104 ↔ 182PROSITE-ProRule annotation
Modified residuei331PhosphoserineBy similarity1
Modified residuei345PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9Y5Y4.
PeptideAtlasiQ9Y5Y4.
PRIDEiQ9Y5Y4.

PTM databases

iPTMnetiQ9Y5Y4.
PhosphoSitePlusiQ9Y5Y4.

Expressioni

Tissue specificityi

Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils.4 Publications

Gene expression databases

BgeeiENSG00000183134.
CleanExiHS_GPR44.
GenevisibleiQ9Y5Y4. HS.

Organism-specific databases

HPAiHPA014259.

Interactioni

Protein-protein interaction databases

BioGridi116412. 3 interactors.
STRINGi9606.ENSP00000332812.

Chemistry databases

BindingDBiQ9Y5Y4.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5Y4.
SMRiQ9Y5Y4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi330 – 333Involved in the recycling of CRTH24

Domaini

The 330-DSEL-333 motif is involved in the recycling of PTGDR2 to the cell surface after agonist-induced internalization. This motif seems to be required for GRK2 and GPRK5/GRK5 to promote agonist-induced internalization. Thr-347 is a major site for PKC-induced internalization of the receptor.

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IV6V. Eukaryota.
ENOG410YAX7. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG099857.
InParanoidiQ9Y5Y4.
KOiK06715.
OMAiGCRMRQT.
OrthoDBiEOG091G0FTA.
PhylomeDBiQ9Y5Y4.
TreeFamiTF330976.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y5Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSANATLKPL CPILEQMSRL QSHSNTSIRY IDHAAVLLHG LASLLGLVEN
60 70 80 90 100
GVILFVVGCR MRQTVVTTWV LHLALSDLLA SASLPFFTYF LAVGHSWELG
110 120 130 140 150
TTFCKLHSSI FFLNMFASGF LLSAISLDRC LQVVRPVWAQ NHRTVAAAHK
160 170 180 190 200
VCLVLWALAV LNTVPYFVFR DTISRLDGRI MCYYNVLLLN PGPDRDATCN
210 220 230 240 250
SRQVALAVSK FLLAFLVPLA IIASSHAAVS LRLQHRGRRR PGRFVRLVAA
260 270 280 290 300
VVAAFALCWG PYHVFSLLEA RAHANPGLRP LVWRGLPFVT SLAFFNSVAN
310 320 330 340 350
PVLYVLTCPD MLRKLRRSLR TVLESVLVDD SELGGAGSSR RRRTSSTARS
360 370 380 390
ASPLALCSRP EEPRGPARLL GWLLGSCAAS PQTGPLNRAL SSTSS
Length:395
Mass (Da):43,268
Last modified:May 18, 2010 - v3
Checksum:i99A63CBDA418DEC9
GO

Sequence cautioni

The sequence AAD21055 differs from that shown. Reason: Frameshift at position 375.Curated
The sequence AAD21055 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_063131204V → A.5 PublicationsCorresponds to variant rs2467642dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118265 Genomic DNA. Translation: AAD21055.1. Sequence problems.
AB008535 mRNA. Translation: BAA74518.1.
AF144308 mRNA. Translation: AAD34539.1.
AY507142 mRNA. Translation: AAR92484.1.
AP000777 Genomic DNA. No translation available.
BC096841 mRNA. Translation: AAH96841.1.
CCDSiCCDS7994.1.
RefSeqiNP_004769.2. NM_004778.2.
UniGeneiHs.299567.

Genome annotation databases

EnsembliENST00000332539; ENSP00000332812; ENSG00000183134.
GeneIDi11251.
KEGGihsa:11251.
UCSCiuc001nqc.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118265 Genomic DNA. Translation: AAD21055.1. Sequence problems.
AB008535 mRNA. Translation: BAA74518.1.
AF144308 mRNA. Translation: AAD34539.1.
AY507142 mRNA. Translation: AAR92484.1.
AP000777 Genomic DNA. No translation available.
BC096841 mRNA. Translation: AAH96841.1.
CCDSiCCDS7994.1.
RefSeqiNP_004769.2. NM_004778.2.
UniGeneiHs.299567.

3D structure databases

ProteinModelPortaliQ9Y5Y4.
SMRiQ9Y5Y4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116412. 3 interactors.
STRINGi9606.ENSP00000332812.

Chemistry databases

BindingDBiQ9Y5Y4.
ChEMBLiCHEMBL5071.
DrugBankiDB00328. Indomethacin.
DB00605. Sulindac.
GuidetoPHARMACOLOGYi339.
SwissLipidsiSLP:000001575.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9Y5Y4.
PhosphoSitePlusiQ9Y5Y4.

Polymorphism and mutation databases

BioMutaiPTGDR2.
DMDMi296439334.

Proteomic databases

PaxDbiQ9Y5Y4.
PeptideAtlasiQ9Y5Y4.
PRIDEiQ9Y5Y4.

Protocols and materials databases

DNASUi11251.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332539; ENSP00000332812; ENSG00000183134.
GeneIDi11251.
KEGGihsa:11251.
UCSCiuc001nqc.3. human.

Organism-specific databases

CTDi11251.
DisGeNETi11251.
GeneCardsiPTGDR2.
HGNCiHGNC:4502. PTGDR2.
HPAiHPA014259.
MIMi604837. gene.
neXtProtiNX_Q9Y5Y4.
OpenTargetsiENSG00000183134.
PharmGKBiPA28891.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IV6V. Eukaryota.
ENOG410YAX7. LUCA.
GeneTreeiENSGT00760000118990.
HOGENOMiHOG000234122.
HOVERGENiHBG099857.
InParanoidiQ9Y5Y4.
KOiK06715.
OMAiGCRMRQT.
OrthoDBiEOG091G0FTA.
PhylomeDBiQ9Y5Y4.
TreeFamiTF330976.

Enzyme and pathway databases

BioCyciZFISH:G66-31442-MONOMER.
ReactomeiR-HSA-391908. Prostanoid ligand receptors.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GeneWikiiGPR44.
GenomeRNAii11251.
PROiQ9Y5Y4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183134.
CleanExiHS_GPR44.
GenevisibleiQ9Y5Y4. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPD2R2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Y4
Secondary accession number(s): O94765, Q4QRI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.