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Protein

Probable G-protein coupled receptor 45

Gene

GPR45

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May play a role in brain function.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135973-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
SignaLinkiQ9Y5Y3.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 45
Alternative name(s):
PSP24-1
PSP24-alpha
Gene namesi
Name:GPR45
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4503. GPR45.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 59Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini60 – 75CytoplasmicSequence analysisAdd BLAST16
Transmembranei76 – 96Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini97 – 109ExtracellularSequence analysisAdd BLAST13
Transmembranei110 – 130Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini131 – 149CytoplasmicSequence analysisAdd BLAST19
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 198ExtracellularSequence analysisAdd BLAST28
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 268CytoplasmicSequence analysisAdd BLAST49
Transmembranei269 – 289Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini290 – 305ExtracellularSequence analysisAdd BLAST16
Transmembranei306 – 326Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini327 – 372CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135973.
PharmGKBiPA28892.

Polymorphism and mutation databases

BioMutaiGPR45.
DMDMi82654940.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695741 – 372Probable G-protein coupled receptor 45Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi17N-linked (GlcNAc...)Sequence analysis1
Glycosylationi20N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y5Y3.
PRIDEiQ9Y5Y3.

PTM databases

iPTMnetiQ9Y5Y3.
PhosphoSitePlusiQ9Y5Y3.

Expressioni

Tissue specificityi

Expressed in brain; detected in the basal forebrain, frontal cortex, and caudate, but not in thalamus, hippocampus, or putamen.

Gene expression databases

BgeeiENSG00000135973.
CleanExiHS_GPR45.
ExpressionAtlasiQ9Y5Y3. baseline and differential.

Organism-specific databases

HPAiHPA055940.

Interactioni

Protein-protein interaction databases

IntActiQ9Y5Y3. 4 interactors.
MINTiMINT-7240785.
STRINGi9606.ENSP00000258456.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5Y3.
SMRiQ9Y5Y3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOVERGENiHBG051812.
InParanoidiQ9Y5Y3.
KOiK08409.
OMAiVCIIVYQ.
OrthoDBiEOG091G07RP.
PhylomeDBiQ9Y5Y3.
TreeFamiTF338633.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y5Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACNSTSLEA YTYLLLNTSN ASDSGSTQLP APLRISLAIV MLLMTVVGFL
60 70 80 90 100
GNTVVCIIVY QRPAMRSAIN LLLATLAFSD IMLSLCCMPF TAVTLITVRW
110 120 130 140 150
HFGDHFCRLS ATLYWFFVLE GVAILLIISV DRFLIIVQRQ DKLNPRRAKV
160 170 180 190 200
IIAVSWVLSF CIAGPSLTGW TLVEVPARAP QCVLGYTELP ADRAYVVTLV
210 220 230 240 250
VAVFFAPFGV MLCAYMCILN TVRKNAVRVH NQSDSLDLRQ LTRAGLRRLQ
260 270 280 290 300
RQQQVSVDLS FKTKAFTTIL ILFVGFSLCW LPHSVYSLLS VFSQRFYCGS
310 320 330 340 350
SFYATSTCVL WLSYLKSVFN PIVYCWRIKK FREACIELLP QTFQILPKVP
360 370
ERIRRRIQPS TVYVCNENQS AV
Length:372
Mass (Da):41,967
Last modified:November 22, 2005 - v2
Checksum:iBA54EC7AE7E80193
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270L → P in AAH67455 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0357597S → C in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_049394312L → F.1 PublicationCorresponds to variant rs35946826dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118266 Genomic DNA. Translation: AAD21056.1.
AC012360 Genomic DNA. Translation: AAY15009.1.
BC066879 mRNA. Translation: AAH66879.1.
BC066880 mRNA. Translation: AAH66880.1.
BC067455 mRNA. Translation: AAH67455.1.
CCDSiCCDS2066.1.
RefSeqiNP_009158.3. NM_007227.3.
UniGeneiHs.590903.

Genome annotation databases

EnsembliENST00000258456; ENSP00000258456; ENSG00000135973.
GeneIDi11250.
KEGGihsa:11250.
UCSCiuc002tco.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118266 Genomic DNA. Translation: AAD21056.1.
AC012360 Genomic DNA. Translation: AAY15009.1.
BC066879 mRNA. Translation: AAH66879.1.
BC066880 mRNA. Translation: AAH66880.1.
BC067455 mRNA. Translation: AAH67455.1.
CCDSiCCDS2066.1.
RefSeqiNP_009158.3. NM_007227.3.
UniGeneiHs.590903.

3D structure databases

ProteinModelPortaliQ9Y5Y3.
SMRiQ9Y5Y3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Y5Y3. 4 interactors.
MINTiMINT-7240785.
STRINGi9606.ENSP00000258456.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9Y5Y3.
PhosphoSitePlusiQ9Y5Y3.

Polymorphism and mutation databases

BioMutaiGPR45.
DMDMi82654940.

Proteomic databases

PaxDbiQ9Y5Y3.
PRIDEiQ9Y5Y3.

Protocols and materials databases

DNASUi11250.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258456; ENSP00000258456; ENSG00000135973.
GeneIDi11250.
KEGGihsa:11250.
UCSCiuc002tco.2. human.

Organism-specific databases

CTDi11250.
GeneCardsiGPR45.
HGNCiHGNC:4503. GPR45.
HPAiHPA055940.
MIMi604838. gene.
neXtProtiNX_Q9Y5Y3.
OpenTargetsiENSG00000135973.
PharmGKBiPA28892.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOVERGENiHBG051812.
InParanoidiQ9Y5Y3.
KOiK08409.
OMAiVCIIVYQ.
OrthoDBiEOG091G07RP.
PhylomeDBiQ9Y5Y3.
TreeFamiTF338633.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135973-MONOMER.
ReactomeiR-HSA-418555. G alpha (s) signalling events.
SignaLinkiQ9Y5Y3.

Miscellaneous databases

GeneWikiiGPR45.
GenomeRNAii11250.
PROiQ9Y5Y3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135973.
CleanExiHS_GPR45.
ExpressionAtlasiQ9Y5Y3. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPR45_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Y3
Secondary accession number(s): Q6NWS4, Q6NXU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 22, 2005
Last modified: November 2, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.