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Q9Y5Y0

- FLVC1_HUMAN

UniProt

Q9Y5Y0 - FLVC1_HUMAN

Protein

Feline leukemia virus subgroup C receptor-related protein 1

Gene

FLVCR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro. Required during erythtopoiesis to maintain intracellular free heme balance since in proerythroblasts, heme synthesis intensifies and it's accumulation is toxic for cells.
    Isoform 2: Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation.

    GO - Molecular functioni

    1. heme transporter activity Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. transporter activity Source: ProtInc

    GO - Biological processi

    1. blood vessel development Source: Ensembl
    2. cell death Source: UniProtKB-KW
    3. cellular iron ion homeostasis Source: Reactome
    4. embryonic digit morphogenesis Source: Ensembl
    5. embryonic skeletal system morphogenesis Source: Ensembl
    6. erythrocyte differentiation Source: MGI
    7. erythrocyte maturation Source: UniProtKB-KW
    8. head morphogenesis Source: Ensembl
    9. heme export Source: UniProtKB
    10. heme transport Source: MGI
    11. in utero embryonic development Source: Ensembl
    12. mitochondrial transport Source: MGI
    13. multicellular organismal development Source: ProtInc
    14. multicellular organism growth Source: Ensembl
    15. regulation of organ growth Source: Ensembl
    16. spleen development Source: Ensembl
    17. transmembrane transport Source: Reactome
    18. transport Source: ProtInc

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Erythrocyte maturation, Transport

    Enzyme and pathway databases

    ReactomeiREACT_25060. Iron uptake and transport.

    Protein family/group databases

    TCDBi2.A.1.28.1. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Feline leukemia virus subgroup C receptor-related protein 1
    Short name:
    Feline leukemia virus subgroup C receptor
    Short name:
    hFLVCR
    Gene namesi
    Name:FLVCR1
    Synonyms:FLVCR
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:24682. FLVCR1.

    Subcellular locationi

    Isoform 1 : Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. mitochondrial membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: MGI
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane, Mitochondrion

    Pathology & Biotechi

    Involvement in diseasei

    Posterior column ataxia with retinitis pigmentosa (PCARP) [MIM:609033]: A neurodegenerative syndrome beginning in infancy with areflexia and retinitis pigmentosa. Nyctalopia (night blindness) and peripheral visual field loss are usually evident during late childhood or teenage years, with subsequent progressive constriction of the visual fields and loss of central retinal function over time. A sensory ataxia caused by degeneration of the posterior columns of the spinal cord results in a loss of proprioceptive sensation that is clinically evident in the second decade of life and gradually progresses. Scoliosis, camptodactyly, achalasia, gastrointestinal dysmotility, and a sensory peripheral neuropathy are variable features of the disease. Affected individuals have no clinical or radiological evidence of cerebral or cerebellar involvement.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry. Defective neuronal heme transmembrane export due to FLVCR1 mutations may abrogate the neuroprotective effects of neuroglobin and initiate an apoptotic cascade that results in the selective degeneration of photoreceptors in the neurosensory retina and sensory neurons in the posterior spinal cord.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti121 – 1211N → D in PCARP. 1 Publication
    VAR_065158
    Natural varianti192 – 1921C → R in PCARP. 1 Publication
    VAR_065159
    Natural varianti241 – 2411A → T in PCARP. 1 Publication
    VAR_065160
    Natural varianti493 – 4931G → R in PCARP. 1 Publication
    VAR_065161

    Keywords - Diseasei

    Disease mutation, Neurodegeneration, Retinitis pigmentosa

    Organism-specific databases

    MIMi609033. phenotype.
    Orphaneti88628. Posterior column ataxia - retinitis pigmentosa.
    PharmGKBiPA162388695.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 555555Feline leukemia virus subgroup C receptor-related protein 1PRO_0000084844Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei56 – 561Phosphoserine1 Publication
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-Glycosylated.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y5Y0.
    PaxDbiQ9Y5Y0.
    PRIDEiQ9Y5Y0.

    PTM databases

    PhosphoSiteiQ9Y5Y0.

    Expressioni

    Tissue specificityi

    Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney.1 Publication

    Developmental stagei

    Down-regulated in haemopoietic progenitor cells undergoing differentiation and hemoglobinization. Abundant in fetal liver.1 Publication

    Gene expression databases

    BgeeiQ9Y5Y0.
    CleanExiHS_FLVCR1.
    GenevestigatoriQ9Y5Y0.

    Organism-specific databases

    HPAiHPA046646.

    Interactioni

    Subunit structurei

    Interacts with HPX.1 Publication

    Protein-protein interaction databases

    BioGridi118803. 1 interaction.
    STRINGi9606.ENSP00000355938.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5Y0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 107107CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini129 – 14719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini169 – 1746CytoplasmicSequence Analysis
    Topological domaini196 – 1994ExtracellularSequence Analysis
    Topological domaini221 – 24020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 27514ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini297 – 33135CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini353 – 37220ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini394 – 4018CytoplasmicSequence Analysis
    Topological domaini423 – 4242ExtracellularSequence Analysis
    Topological domaini446 – 45914CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini481 – 49010ExtracellularSequence Analysis
    Topological domaini512 – 55544CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei108 – 12821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei175 – 19521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei200 – 22021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei373 – 39321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei402 – 42221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei425 – 44521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei460 – 48021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei491 – 51121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG297699.
    HOGENOMiHOG000019717.
    HOVERGENiHBG051631.
    InParanoidiQ9Y5Y0.
    KOiK08220.
    OMAiFKEKPQY.
    OrthoDBiEOG7KQ21D.
    PhylomeDBiQ9Y5Y0.
    TreeFamiTF314292.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y5Y0-1) [UniParc]FASTAAdd to Basket

    Also known as: FLVC1a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARPDDEEGA AVAPGHPLAK GYLPLPRGAP VGKESVELQN GPKAGTFPVN    50
    GAPRDSLAAA SGVLGGPQTP LAPEEETQAR LLPAGAGAET PGAESSPLPL 100
    TALSPRRFVV LLIFSLYSLV NAFQWIQYSI ISNVFEGFYG VTLLHIDWLS 150
    MVYMLAYVPL IFPATWLLDT RGLRLTALLG SGLNCLGAWI KCGSVQQHLF 200
    WVTMLGQCLC SVAQVFILGL PSRIASVWFG PKEVSTACAT AVLGNQLGTA 250
    VGFLLPPVLV PNTQNDTNLL ACNISTMFYG TSAVATLLFI LTAIAFKEKP 300
    RYPPSQAQAA LQDSPPEEYS YKKSIRNLFK NIPFVLLLIT YGIMTGAFYS 350
    VSTLLNQMIL TYYEGEEVNA GRIGLTLVVA GMVGSILCGL WLDYTKTYKQ 400
    TTLIVYILSF IGMVIFTFTL DLRYIIIVFV TGGVLGFFMT GYLPLGFEFA 450
    VEITYPESEG TSSGLLNASA QIFGILFTLA QGKLTSDYGP KAGNIFLCVW 500
    MFIGIILTAL IKSDLRRHNI NIGITNVDVK AIPADSPTDQ EPKTVMLSKQ 550
    SESAI 555
    Length:555
    Mass (Da):59,863
    Last modified:November 1, 1999 - v1
    Checksum:iD0EBA9886CC8E747
    GO
    Isoform 2 (identifier: Q9Y5Y0-2) [UniParc]FASTAAdd to Basket

    Also known as: FLVC1b, mitochondrial

    The sequence of this isoform differs from the canonical sequence as follows:
         1-276: Missing.

    Note: Has a probable mitochondrial transit peptide at positions 1-38.

    Show »
    Length:279
    Mass (Da):30,744
    Checksum:iFA59C9CBEE5CE3CA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti52 – 521A → P.1 Publication
    Corresponds to variant rs11120047 [ dbSNP | Ensembl ].
    VAR_050297
    Natural varianti121 – 1211N → D in PCARP. 1 Publication
    VAR_065158
    Natural varianti192 – 1921C → R in PCARP. 1 Publication
    VAR_065159
    Natural varianti241 – 2411A → T in PCARP. 1 Publication
    VAR_065160
    Natural varianti493 – 4931G → R in PCARP. 1 Publication
    VAR_065161
    Natural varianti544 – 5441T → M.1 Publication
    Corresponds to variant rs3207090 [ dbSNP | Ensembl ].
    VAR_050298

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 276276Missing in isoform 2. 2 PublicationsVSP_047866Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118637 mRNA. Translation: AAD45243.1.
    AK001419 mRNA. Translation: BAA91679.1.
    DQ496107 Genomic DNA. Translation: ABF47096.1.
    CH471100 Genomic DNA. Translation: EAW93374.1.
    BC048312 mRNA. Translation: AAH48312.1.
    CCDSiCCDS1510.1. [Q9Y5Y0-1]
    RefSeqiNP_054772.1. NM_014053.3. [Q9Y5Y0-1]
    UniGeneiHs.7055.

    Genome annotation databases

    EnsembliENST00000366971; ENSP00000355938; ENSG00000162769. [Q9Y5Y0-1]
    GeneIDi28982.
    KEGGihsa:28982.
    UCSCiuc001hjt.3. human. [Q9Y5Y0-1]

    Polymorphism databases

    DMDMi46396053.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF118637 mRNA. Translation: AAD45243.1 .
    AK001419 mRNA. Translation: BAA91679.1 .
    DQ496107 Genomic DNA. Translation: ABF47096.1 .
    CH471100 Genomic DNA. Translation: EAW93374.1 .
    BC048312 mRNA. Translation: AAH48312.1 .
    CCDSi CCDS1510.1. [Q9Y5Y0-1 ]
    RefSeqi NP_054772.1. NM_014053.3. [Q9Y5Y0-1 ]
    UniGenei Hs.7055.

    3D structure databases

    ProteinModelPortali Q9Y5Y0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118803. 1 interaction.
    STRINGi 9606.ENSP00000355938.

    Protein family/group databases

    TCDBi 2.A.1.28.1. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei Q9Y5Y0.

    Polymorphism databases

    DMDMi 46396053.

    Proteomic databases

    MaxQBi Q9Y5Y0.
    PaxDbi Q9Y5Y0.
    PRIDEi Q9Y5Y0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366971 ; ENSP00000355938 ; ENSG00000162769 . [Q9Y5Y0-1 ]
    GeneIDi 28982.
    KEGGi hsa:28982.
    UCSCi uc001hjt.3. human. [Q9Y5Y0-1 ]

    Organism-specific databases

    CTDi 28982.
    GeneCardsi GC01P213031.
    HGNCi HGNC:24682. FLVCR1.
    HPAi HPA046646.
    MIMi 609033. phenotype.
    609144. gene.
    neXtProti NX_Q9Y5Y0.
    Orphaneti 88628. Posterior column ataxia - retinitis pigmentosa.
    PharmGKBi PA162388695.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG297699.
    HOGENOMi HOG000019717.
    HOVERGENi HBG051631.
    InParanoidi Q9Y5Y0.
    KOi K08220.
    OMAi FKEKPQY.
    OrthoDBi EOG7KQ21D.
    PhylomeDBi Q9Y5Y0.
    TreeFami TF314292.

    Enzyme and pathway databases

    Reactomei REACT_25060. Iron uptake and transport.

    Miscellaneous databases

    GeneWikii FLVCR1.
    GenomeRNAii 28982.
    NextBioi 51873.
    PROi Q9Y5Y0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y5Y0.
    CleanExi HS_FLVCR1.
    Genevestigatori Q9Y5Y0.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A putative cell surface receptor for anemia-inducing feline leukemia virus subgroup C is a member of a transporter superfamily."
      Tailor C.S., Willett B.J., Kabat D.
      J. Virol. 73:6500-6505(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, CHARACTERIZATION OF FELV-C RECEPTOR FUNCTION.
      Tissue: Lymphocyte.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. NHLBI resequencing and genotyping service (RS&G)
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS PRO-52 AND MET-544.
      Tissue: Duodenum.
    6. "Genomic structure and evolutionary context of the human feline leukemia virus subgroup C receptor (hFLVCR) gene: evidence for block duplications and de novo gene formation within duplicons of the hFLVCR locus."
      Lipovich L., Hughes A.L., King M.-C., Abkowitz J.L., Quigley J.G.
      Gene 286:203-213(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE STRUCTURE.
    7. "Identification of a human heme exporter that is essential for erythropoiesis."
      Quigley J.G., Yang Z., Worthington M.T., Phillips J.D., Sabo K.M., Sabath D.E., Berg C.L., Sassa S., Wood B.L., Abkowitz J.L.
      Cell 118:757-766(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DEVELOPMENTAL STAGE.
    8. "Comprehensive mapping of receptor-functioning domains in feline leukemia virus subgroup C receptor FLVCR1."
      Brown J.K., Fung C., Tailor C.S.
      J. Virol. 80:1742-1751(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TOPOLOGY, GLYCOSYLATION.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-56, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin."
      Yang Z., Philips J.D., Doty R.T., Giraudi P., Ostrow J.D., Tiribelli C., Smith A., Abkowitz J.L.
      J. Biol. Chem. 285:28874-28882(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH HPX.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: ALTERNATIVE SPLICING (ISOFORM 2), FUNCTION (ISOFORM 2), SUBCELLULAR LOCATION (ISOFORM 2).
    16. Cited for: VARIANTS PCARP ASP-121; ARG-192 AND THR-241.
    17. "Posterior column ataxia with retinitis pigmentosa in a Japanese family with a novel mutation in FLVCR1."
      Ishiura H., Fukuda Y., Mitsui J., Nakahara Y., Ahsan B., Takahashi Y., Ichikawa Y., Goto J., Sakai T., Tsuji S.
      Neurogenetics 12:117-121(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT PCARP ARG-493.

    Entry informationi

    Entry nameiFLVC1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5Y0
    Secondary accession number(s): Q1HE16, Q86XY9, Q9NVR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3