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Protein

Endothelial lipase

Gene

LIPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin.

Miscellaneous

It is termed endothelial lipase due to the fact that it is synthesized in endothelial cells, a characteristic that distinguishes it from other members of the family. However, this protein is also expressed in other cell types.

Catalytic activityi

Triacylglycerol + H2O = diacylglycerol + a carboxylate.

Enzyme regulationi

Inhibited by serum.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei169NucleophileBy similarity1
Active sitei193Charge relay systemPROSITE-ProRule annotation1
Active sitei274Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

  • heparin binding Source: UniProtKB-KW
  • lipoprotein lipase activity Source: Reactome
  • phosphatidylcholine 1-acylhydrolase activity Source: MGI
  • phospholipase activity Source: BHF-UCL

GO - Biological processi

  • cell proliferation Source: Ensembl
  • cholesterol homeostasis Source: BHF-UCL
  • high-density lipoprotein particle remodeling Source: BHF-UCL
  • lipid metabolic process Source: ProtInc
  • phospholipid catabolic process Source: BHF-UCL
  • phospholipid homeostasis Source: BHF-UCL
  • positive regulation of cholesterol transport Source: BHF-UCL
  • positive regulation of high-density lipoprotein particle clearance Source: BHF-UCL
  • regulation of lipoprotein metabolic process Source: Ensembl
  • response to nutrient Source: Ensembl
  • reverse cholesterol transport Source: BHF-UCL

Keywordsi

Molecular functionHeparin-binding, Hydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-8964058 HDL remodeling

Protein family/group databases

ESTHERihuman-LIPG Lipoprotein_Lipase

Chemistry databases

SwissLipidsiSLP:000000567

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial lipase (EC:3.1.1.3)
Alternative name(s):
Endothelial cell-derived lipase
Short name:
EDL
Short name:
EL
Gene namesi
Name:LIPG
ORF Names:UNQ387/PRO719
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000101670.11
HGNCiHGNC:6623 LIPG
MIMi603684 gene
neXtProtiNX_Q9Y5X9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi9388
OpenTargetsiENSG00000101670
PharmGKBiPA30395

Chemistry databases

ChEMBLiCHEMBL5080
GuidetoPHARMACOLOGYi2591

Polymorphism and mutation databases

BioMutaiLIPG
DMDMi22001808

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001779721 – 500Endothelial lipaseAdd BLAST480

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 77PROSITE-ProRule annotation
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi136N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi252 ↔ 272PROSITE-ProRule annotation
Disulfide bondi297 ↔ 316PROSITE-ProRule annotation
Disulfide bondi308 ↔ 311PROSITE-ProRule annotation
Glycosylationi393N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi463 ↔ 483PROSITE-ProRule annotation
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y5X9
PeptideAtlasiQ9Y5X9
PRIDEiQ9Y5X9

PTM databases

iPTMnetiQ9Y5X9
PhosphoSitePlusiQ9Y5X9

Miscellaneous databases

PMAP-CutDBiQ9Y5X9

Expressioni

Tissue specificityi

High level of expression in the liver, placenta, lung, thyroid, kidney, testis and in the corpus luteum of the ovary. Expressed also in coronary artery endothelial cells, umbilical vein endothelial cells and in hepatocytes and osteosarcoma cell lines. Not detected in heart, brain and muscle.

Gene expression databases

BgeeiENSG00000101670
CleanExiHS_LIPG
ExpressionAtlasiQ9Y5X9 baseline and differential
GenevisibleiQ9Y5X9 HS

Organism-specific databases

HPAiHPA016966

Interactioni

Subunit structurei

Head to tail homodimer.1 Publication

Protein-protein interaction databases

BioGridi114788, 24 interactors
IntActiQ9Y5X9, 2 interactors
STRINGi9606.ENSP00000261292

Chemistry databases

BindingDBiQ9Y5X9

Structurei

3D structure databases

ProteinModelPortaliQ9Y5X9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini347 – 482PLATPROSITE-ProRule annotationAdd BLAST136

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni325 – 337Heparin-bindingBy similarityAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi118 – 121Poly-Val4

Sequence similaritiesi

Belongs to the AB hydrolase superfamily. Lipase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJUA Eukaryota
ENOG4111GMM LUCA
GeneTreeiENSGT00760000119069
HOGENOMiHOG000038553
HOVERGENiHBG002259
InParanoidiQ9Y5X9
KOiK22284
OrthoDBiEOG091G052B
PhylomeDBiQ9Y5X9
TreeFamiTF324997

Family and domain databases

CDDicd00707 Pancreat_lipase_like, 1 hit
Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013818 Lipase/vitellogenin
IPR016272 Lipase_LIPH
IPR033906 Lipase_N
IPR002330 Lipo_Lipase
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
IPR000734 TAG_lipase
PANTHERiPTHR11610 PTHR11610, 1 hit
PfamiView protein in Pfam
PF00151 Lipase, 1 hit
PF01477 PLAT, 1 hit
PIRSFiPIRSF000865 Lipoprotein_lipase_LIPH, 1 hit
PRINTSiPR00822 LIPOLIPASE
PR00821 TAGLIPASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF49723 SSF49723, 1 hit
SSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00120 LIPASE_SER, 1 hit
PS50095 PLAT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5X9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNSVPLLCF WSLCYCFAAG SPVPFGPEGR LEDKLHKPKA TQTEVKPSVR
60 70 80 90 100
FNLRTSKDPE HEGCYLSVGH SQPLEDCSFN MTAKTFFIIH GWTMSGIFEN
110 120 130 140 150
WLHKLVSALH TREKDANVVV VDWLPLAHQL YTDAVNNTRV VGHSIARMLD
160 170 180 190 200
WLQEKDDFSL GNVHLIGYSL GAHVAGYAGN FVKGTVGRIT GLDPAGPMFE
210 220 230 240 250
GADIHKRLSP DDADFVDVLH TYTRSFGLSI GIQMPVGHID IYPNGGDFQP
260 270 280 290 300
GCGLNDVLGS IAYGTITEVV KCEHERAVHL FVDSLVNQDK PSFAFQCTDS
310 320 330 340 350
NRFKKGICLS CRKNRCNSIG YNAKKMRNKR NSKMYLKTRA GMPFRVYHYQ
360 370 380 390 400
MKIHVFSYKN MGEIEPTFYV TLYGTNADSQ TLPLEIVERI EQNATNTFLV
410 420 430 440 450
YTEEDLGDLL KIQLTWEGAS QSWYNLWKEF RSYLSQPRNP GRELNIRRIR
460 470 480 490 500
VKSGETQRKL TFCTEDPENT SISPGRELWF RKCRDGWRMK NETSPTVELP
Length:500
Mass (Da):56,795
Last modified:November 1, 1999 - v1
Checksum:i96EC95125CD2A3FD
GO
Isoform 2 (identifier: Q9Y5X9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     346-354: VYHYQMKIH → GNLQSLECP
     355-500: Missing.

Note: No experimental confirmation available.
Show »
Length:354
Mass (Da):39,362
Checksum:i939A47B18F97B7FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti476R → Q in AAH60825 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03408226G → S. Corresponds to variant dbSNP:rs9963243Ensembl.1
Natural variantiVAR_01702796G → S1 PublicationCorresponds to variant dbSNP:rs150879681Ensembl.1
Natural variantiVAR_017028111T → I1 PublicationCorresponds to variant dbSNP:rs2000813Ensembl.1
Natural variantiVAR_017029312R → H1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013302346 – 354VYHYQMKIH → GNLQSLECP in isoform 2. 1 Publication9
Alternative sequenceiVSP_013303355 – 500Missing in isoform 2. 1 PublicationAdd BLAST146

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF118767 mRNA Translation: AAD30434.1
AY358928 mRNA Translation: AAQ89287.1
EU332856 Genomic DNA Translation: ABY87545.1
CH471096 Genomic DNA Translation: EAW62947.1
BC060825 mRNA Translation: AAH60825.1
CCDSiCCDS11938.1 [Q9Y5X9-1]
RefSeqiNP_001294935.1, NM_001308006.1
NP_006024.1, NM_006033.3 [Q9Y5X9-1]
UniGeneiHs.465102

Genome annotation databases

EnsembliENST00000261292; ENSP00000261292; ENSG00000101670 [Q9Y5X9-1]
ENST00000580036; ENSP00000462420; ENSG00000101670 [Q9Y5X9-2]
GeneIDi9388
KEGGihsa:9388
UCSCiuc002ldu.2 human [Q9Y5X9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLIPE_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5X9
Secondary accession number(s): B0LPG6, Q6P9C8, Q6UW82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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