Q9Y5X2 (SNX8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sorting nexin-8

Gene names

Name:

SNX8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	465 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network. Ref.6
Subcellular location	Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note: Colocalizes with retromer components. Ref.6
Sequence similarities	Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Endosome Membrane
Coding sequence diversity	Polymorphism
Ligand	Lipid-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell communication Inferred from electronic annotation. Source: InterPro early endosome to Golgi transport Inferred from mutant phenotype Ref.6. Source: UniProtKB intracellular protein transport Inferred from mutant phenotype Ref.6. Source: UniProtKB
Cellular_component	early endosome membrane Inferred from direct assay Ref.6. Source: UniProtKB
Molecular_function	phosphatidylinositol binding Inferred from mutant phenotype Ref.6. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NCK1	P16333	2	EBI-1752557,EBI-389883

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 465	465	Sorting nexin-8		PRO_0000213851
Regions
	Domain	73 – 181	109	PX
Sites
	Binding site	109	1	Phosphatidylinositol 3-phosphate By similarity
	Binding site	135	1	Phosphatidylinositol 3-phosphate By similarity
	Binding site	148	1	Phosphatidylinositol 3-phosphate By similarity
Amino acid modifications
	Modified residue	452	1	Phosphothreonine Ref.5
	Modified residue	456	1	Phosphoserine Ref.5
Natural variations
	Natural variant	147	1	A → G in a colorectal cancer sample; somatic mutation. Ref.8		VAR_036259

Sequences

	Sequence		Length	Mass (Da)
	Q9Y5X2 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 90C5EDB761C31E88	FASTA	465	52,569
	10 20 30 40 50 60 MTGRAMDPLP AAAVGAAAEA EADEEADPPA SDLPTPQAIE PQAIVQQVPA PSRMQMPQGN 70 80 90 100 110 120 PLLLSHTLQE LLARDTVQVE LIPEKKGLFL KHVEYEVSSQ RFKSSVYRRY NDFVVFQEML 130 140 150 160 170 180 LHKFPYRMVP ALPPKRMLGA DREFIEARRR ALKRFVNLVA RHPLFSEDVV LKLFLSFSGS 190 200 210 220 230 240 DVQNKLKESA QCVGDEFLNC KLATRAKDFL PADIQAQFAI SRELIRNIYN SFHKLRDRAE 250 260 270 280 290 300 RIASRAIDNA ADLLIFGKEL SAIGSDTTPL PSWAALNSST WGSLKQALKG LSVEFALLAD 310 320 330 340 350 360 KAAQQGKQEE NDVVEKLNLF LDLLQSYKDL CERHEKGVLH KHQRALHKYS LMKRQMMSAT 370 380 390 400 410 420 AQNREPESVE QLESRIVEQE NAIQTMELRN YFSLYCLHQE TQLIHVYLPL TSHILRAFVN 430 440 450 460 SQIQGHKEMS KVWNDLRPKL SCLFAGPHST LTPPCSPPED GLCPH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A large family of endosome-localized proteins related to sorting nexin 1." Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A. Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney and Lung.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-452 AND SER-456, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Sorting nexin 8 regulates endosome-to-Golgi transport." Dyve A.B., Bergan J., Utskarpen A., Sandvig K. Biochem. Biophys. Res. Commun. 390:109-114(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-147.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF121858 mRNA. Translation: AAD27831.1. CH236953 Genomic DNA. Translation: EAL23950.1. CH471144 Genomic DNA. Translation: EAW87235.1. BC007785 mRNA. Translation: AAH07785.2. BC021565 mRNA. Translation: AAH21565.1.
IPI	IPI00001885.
RefSeq	NP_037453.1. NM_013321.2.
UniGene	Hs.584900.
3D structure databases
ProteinModelPortal	Q9Y5X2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y5X2. 5 interactions.
MINT	MINT-3087539.
STRING	9606.ENSP00000222990.
PTM databases
PhosphoSite	Q9Y5X2.
Polymorphism databases
DMDM	10720288.
Proteomic databases
PaxDb	Q9Y5X2.
PRIDE	Q9Y5X2.
Protocols and materials databases
DNASU	29886.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000222990; ENSP00000222990; ENSG00000106266.
GeneID	29886.
KEGG	hsa:29886.
UCSC	uc003slw.3. human.
Organism-specific databases
CTD	29886.
GeneCards	GC07M002261.
HGNC	HGNC:14972. SNX8.
MIM	614905. gene.
neXtProt	NX_Q9Y5X2.
PharmGKB	PA37948.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5391.
HOGENOM	HOG000252992.
HOVERGEN	HBG017827.
InParanoid	Q9Y5X2.
OMA	KRQMMSA.
OrthoDB	EOG42JNRD.
PhylomeDB	Q9Y5X2.
Gene expression databases
ArrayExpress	Q9Y5X2.
Bgee	Q9Y5X2.
CleanEx	HS_SNX8.
Genevestigator	Q9Y5X2.
GermOnline	ENSG00000106266. Homo sapiens.
Family and domain databases
Gene3D	3.30.1520.10. 1 hit.
InterPro	IPR001683. Phox. [Graphical view]
Pfam	PF00787. PX. 1 hit. [Graphical view]
SMART	SM00312. PX. 1 hit. [Graphical view]
SUPFAM	SSF64268. PX. 1 hit.
PROSITE	PS50195. PX. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	29886.
NextBio	52423.
SOURCE	Search...

Entry information

Entry name

SNX8_HUMAN

Accession

Primary (citable) accession number: Q9Y5X2
Secondary accession number(s): A4D207, Q96I67

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.