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Q9Y5X2 (SNX8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sorting nexin-8
Gene names
Name:SNX8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length465 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network. Ref.6

Subcellular location

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note: Colocalizes with retromer components. Ref.6

Sequence similarities

Belongs to the sorting nexin family.

Contains 1 PX (phox homology) domain.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentEndosome
Membrane
   Coding sequence diversityPolymorphism
   LigandLipid-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processearly endosome to Golgi transport

Inferred from mutant phenotype Ref.6. Source: UniProtKB

intracellular protein transport

Inferred from mutant phenotype Ref.6. Source: UniProtKB

   Cellular_componentearly endosome membrane

Inferred from direct assay Ref.6. Source: UniProtKB

   Molecular_functionidentical protein binding

Inferred from physical interaction PubMed 23085988. Source: IntAct

phosphatidylinositol binding

Inferred from mutant phenotype Ref.6. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

itself2EBI-1752557,EBI-1752557
NCK1P163332EBI-1752557,EBI-389883

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 465465Sorting nexin-8
PRO_0000213851

Regions

Domain73 – 181109PX

Sites

Binding site1091Phosphatidylinositol 3-phosphate By similarity
Binding site1351Phosphatidylinositol 3-phosphate By similarity
Binding site1481Phosphatidylinositol 3-phosphate By similarity

Amino acid modifications

Modified residue4521Phosphothreonine Ref.5
Modified residue4561Phosphoserine Ref.5

Natural variations

Natural variant1471A → G in a colorectal cancer sample; somatic mutation. Ref.8
VAR_036259

Sequences

Sequence LengthMass (Da)Tools
Q9Y5X2 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 90C5EDB761C31E88

FASTA46552,569
        10         20         30         40         50         60 
MTGRAMDPLP AAAVGAAAEA EADEEADPPA SDLPTPQAIE PQAIVQQVPA PSRMQMPQGN 

        70         80         90        100        110        120 
PLLLSHTLQE LLARDTVQVE LIPEKKGLFL KHVEYEVSSQ RFKSSVYRRY NDFVVFQEML 

       130        140        150        160        170        180 
LHKFPYRMVP ALPPKRMLGA DREFIEARRR ALKRFVNLVA RHPLFSEDVV LKLFLSFSGS 

       190        200        210        220        230        240 
DVQNKLKESA QCVGDEFLNC KLATRAKDFL PADIQAQFAI SRELIRNIYN SFHKLRDRAE 

       250        260        270        280        290        300 
RIASRAIDNA ADLLIFGKEL SAIGSDTTPL PSWAALNSST WGSLKQALKG LSVEFALLAD 

       310        320        330        340        350        360 
KAAQQGKQEE NDVVEKLNLF LDLLQSYKDL CERHEKGVLH KHQRALHKYS LMKRQMMSAT 

       370        380        390        400        410        420 
AQNREPESVE QLESRIVEQE NAIQTMELRN YFSLYCLHQE TQLIHVYLPL TSHILRAFVN 

       430        440        450        460 
SQIQGHKEMS KVWNDLRPKL SCLFAGPHST LTPPCSPPED GLCPH 

« Hide

References

« Hide 'large scale' references
[1]"A large family of endosome-localized proteins related to sorting nexin 1."
Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.
Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney and Lung.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-452 AND SER-456, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Sorting nexin 8 regulates endosome-to-Golgi transport."
Dyve A.B., Bergan J., Utskarpen A., Sandvig K.
Biochem. Biophys. Res. Commun. 390:109-114(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-147.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF121858 mRNA. Translation: AAD27831.1.
CH236953 Genomic DNA. Translation: EAL23950.1.
CH471144 Genomic DNA. Translation: EAW87235.1.
BC007785 mRNA. Translation: AAH07785.2.
BC021565 mRNA. Translation: AAH21565.1.
RefSeqNP_037453.1. NM_013321.2.
UniGeneHs.584900.

3D structure databases

ProteinModelPortalQ9Y5X2.
SMRQ9Y5X2. Positions 92-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118939. 7 interactions.
IntActQ9Y5X2. 10 interactions.
MINTMINT-3087539.
STRING9606.ENSP00000222990.

PTM databases

PhosphoSiteQ9Y5X2.

Polymorphism databases

DMDM10720288.

Proteomic databases

PaxDbQ9Y5X2.
PRIDEQ9Y5X2.

Protocols and materials databases

DNASU29886.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000222990; ENSP00000222990; ENSG00000106266.
GeneID29886.
KEGGhsa:29886.
UCSCuc003slw.3. human.

Organism-specific databases

CTD29886.
GeneCardsGC07M002261.
HGNCHGNC:14972. SNX8.
HPAHPA057296.
HPA060194.
MIM614905. gene.
neXtProtNX_Q9Y5X2.
PharmGKBPA37948.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5391.
HOGENOMHOG000252992.
HOVERGENHBG017827.
InParanoidQ9Y5X2.
KOK17922.
OMAMMSATVQ.
OrthoDBEOG77128D.
PhylomeDBQ9Y5X2.
TreeFamTF314082.

Gene expression databases

ArrayExpressQ9Y5X2.
BgeeQ9Y5X2.
CleanExHS_SNX8.
GenevestigatorQ9Y5X2.

Family and domain databases

Gene3D3.30.1520.10. 1 hit.
InterProIPR001683. Phox.
IPR028662. SNX8.
[Graphical view]
PANTHERPTHR10555:SF15. PTHR10555:SF15. 1 hit.
PfamPF00787. PX. 1 hit.
[Graphical view]
SMARTSM00312. PX. 1 hit.
[Graphical view]
SUPFAMSSF64268. SSF64268. 1 hit.
PROSITEPS50195. PX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi29886.
NextBio52423.
PROQ9Y5X2.
SOURCESearch...

Entry information

Entry nameSNX8_HUMAN
AccessionPrimary (citable) accession number: Q9Y5X2
Secondary accession number(s): A4D207, Q96I67
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM