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Q9Y5X2

- SNX8_HUMAN

UniProt

Q9Y5X2 - SNX8_HUMAN

Protein

Sorting nexin-8

Gene

SNX8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei109 – 1091Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei135 – 1351Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei148 – 1481Phosphatidylinositol 3-phosphateBy similarity

    GO - Molecular functioni

    1. identical protein binding Source: IntAct
    2. phosphatidylinositol binding Source: UniProtKB
    3. protein binding Source: IntAct

    GO - Biological processi

    1. early endosome to Golgi transport Source: UniProtKB
    2. intracellular protein transport Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-8
    Gene namesi
    Name:SNX8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:14972. SNX8.

    Subcellular locationi

    Early endosome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
    Note: Colocalizes with retromer components.

    GO - Cellular componenti

    1. early endosome membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37948.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 465465Sorting nexin-8PRO_0000213851Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei452 – 4521Phosphothreonine1 Publication
    Modified residuei456 – 4561Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y5X2.
    PaxDbiQ9Y5X2.
    PRIDEiQ9Y5X2.

    PTM databases

    PhosphoSiteiQ9Y5X2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y5X2.
    BgeeiQ9Y5X2.
    CleanExiHS_SNX8.
    GenevestigatoriQ9Y5X2.

    Organism-specific databases

    HPAiHPA057296.
    HPA060194.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-1752557,EBI-1752557
    NCK1P163332EBI-1752557,EBI-389883

    Protein-protein interaction databases

    BioGridi118939. 9 interactions.
    IntActiQ9Y5X2. 10 interactions.
    MINTiMINT-3087539.
    STRINGi9606.ENSP00000222990.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5X2.
    SMRiQ9Y5X2. Positions 92-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini73 – 181109PXPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5391.
    HOGENOMiHOG000252992.
    HOVERGENiHBG017827.
    InParanoidiQ9Y5X2.
    KOiK17922.
    OMAiMMSATVQ.
    OrthoDBiEOG77128D.
    PhylomeDBiQ9Y5X2.
    TreeFamiTF314082.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    IPR028662. SNX8.
    [Graphical view]
    PANTHERiPTHR10555:SF15. PTHR10555:SF15. 1 hit.
    PfamiPF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y5X2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTGRAMDPLP AAAVGAAAEA EADEEADPPA SDLPTPQAIE PQAIVQQVPA    50
    PSRMQMPQGN PLLLSHTLQE LLARDTVQVE LIPEKKGLFL KHVEYEVSSQ 100
    RFKSSVYRRY NDFVVFQEML LHKFPYRMVP ALPPKRMLGA DREFIEARRR 150
    ALKRFVNLVA RHPLFSEDVV LKLFLSFSGS DVQNKLKESA QCVGDEFLNC 200
    KLATRAKDFL PADIQAQFAI SRELIRNIYN SFHKLRDRAE RIASRAIDNA 250
    ADLLIFGKEL SAIGSDTTPL PSWAALNSST WGSLKQALKG LSVEFALLAD 300
    KAAQQGKQEE NDVVEKLNLF LDLLQSYKDL CERHEKGVLH KHQRALHKYS 350
    LMKRQMMSAT AQNREPESVE QLESRIVEQE NAIQTMELRN YFSLYCLHQE 400
    TQLIHVYLPL TSHILRAFVN SQIQGHKEMS KVWNDLRPKL SCLFAGPHST 450
    LTPPCSPPED GLCPH 465
    Length:465
    Mass (Da):52,569
    Last modified:November 1, 1999 - v1
    Checksum:i90C5EDB761C31E88
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti147 – 1471A → G in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_036259

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF121858 mRNA. Translation: AAD27831.1.
    CH236953 Genomic DNA. Translation: EAL23950.1.
    CH471144 Genomic DNA. Translation: EAW87235.1.
    BC007785 mRNA. Translation: AAH07785.2.
    BC021565 mRNA. Translation: AAH21565.1.
    CCDSiCCDS5331.1.
    RefSeqiNP_037453.1. NM_013321.2.
    UniGeneiHs.584900.

    Genome annotation databases

    EnsembliENST00000222990; ENSP00000222990; ENSG00000106266.
    GeneIDi29886.
    KEGGihsa:29886.
    UCSCiuc003slw.3. human.

    Polymorphism databases

    DMDMi10720288.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF121858 mRNA. Translation: AAD27831.1 .
    CH236953 Genomic DNA. Translation: EAL23950.1 .
    CH471144 Genomic DNA. Translation: EAW87235.1 .
    BC007785 mRNA. Translation: AAH07785.2 .
    BC021565 mRNA. Translation: AAH21565.1 .
    CCDSi CCDS5331.1.
    RefSeqi NP_037453.1. NM_013321.2.
    UniGenei Hs.584900.

    3D structure databases

    ProteinModelPortali Q9Y5X2.
    SMRi Q9Y5X2. Positions 92-330.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118939. 9 interactions.
    IntActi Q9Y5X2. 10 interactions.
    MINTi MINT-3087539.
    STRINGi 9606.ENSP00000222990.

    PTM databases

    PhosphoSitei Q9Y5X2.

    Polymorphism databases

    DMDMi 10720288.

    Proteomic databases

    MaxQBi Q9Y5X2.
    PaxDbi Q9Y5X2.
    PRIDEi Q9Y5X2.

    Protocols and materials databases

    DNASUi 29886.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222990 ; ENSP00000222990 ; ENSG00000106266 .
    GeneIDi 29886.
    KEGGi hsa:29886.
    UCSCi uc003slw.3. human.

    Organism-specific databases

    CTDi 29886.
    GeneCardsi GC07M002261.
    HGNCi HGNC:14972. SNX8.
    HPAi HPA057296.
    HPA060194.
    MIMi 614905. gene.
    neXtProti NX_Q9Y5X2.
    PharmGKBi PA37948.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5391.
    HOGENOMi HOG000252992.
    HOVERGENi HBG017827.
    InParanoidi Q9Y5X2.
    KOi K17922.
    OMAi MMSATVQ.
    OrthoDBi EOG77128D.
    PhylomeDBi Q9Y5X2.
    TreeFami TF314082.

    Miscellaneous databases

    GenomeRNAii 29886.
    NextBioi 52423.
    PROi Q9Y5X2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5X2.
    Bgeei Q9Y5X2.
    CleanExi HS_SNX8.
    Genevestigatori Q9Y5X2.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    IPR028662. SNX8.
    [Graphical view ]
    PANTHERi PTHR10555:SF15. PTHR10555:SF15. 1 hit.
    Pfami PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A large family of endosome-localized proteins related to sorting nexin 1."
      Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.
      Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney and Lung.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-452 AND SER-456, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: FUNCTION, SUBCELLULAR LOCATION.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-147.

    Entry informationi

    Entry nameiSNX8_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5X2
    Secondary accession number(s): A4D207, Q96I67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3