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Protein

Sorting nexin-8

Gene

SNX8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei135Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei148Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  • early endosome to Golgi transport Source: UniProtKB
  • endocytosis Source: GO_Central
  • intracellular protein transport Source: UniProtKB
  • vesicle organization Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106266-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-8
Gene namesi
Name:SNX8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:14972. SNX8.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106266.
PharmGKBiPA37948.

Polymorphism and mutation databases

BioMutaiSNX8.
DMDMi10720288.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138511 – 465Sorting nexin-8Add BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei452PhosphothreonineCombined sources1
Modified residuei456PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y5X2.
MaxQBiQ9Y5X2.
PaxDbiQ9Y5X2.
PeptideAtlasiQ9Y5X2.
PRIDEiQ9Y5X2.

PTM databases

iPTMnetiQ9Y5X2.
PhosphoSitePlusiQ9Y5X2.

Expressioni

Gene expression databases

BgeeiENSG00000106266.
CleanExiHS_SNX8.
ExpressionAtlasiQ9Y5X2. baseline and differential.
GenevisibleiQ9Y5X2. HS.

Organism-specific databases

HPAiHPA057296.
HPA060194.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1752557,EBI-1752557
NCK1P163332EBI-1752557,EBI-389883

Protein-protein interaction databases

BioGridi118939. 15 interactors.
IntActiQ9Y5X2. 14 interactors.
MINTiMINT-3087539.
STRINGi9606.ENSP00000222990.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5X2.
SMRiQ9Y5X2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini73 – 181PXPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00460000041594.
HOGENOMiHOG000252992.
HOVERGENiHBG017827.
InParanoidiQ9Y5X2.
KOiK17922.
OMAiMMSATVQ.
OrthoDBiEOG091G0NVM.
PhylomeDBiQ9Y5X2.
TreeFamiTF314082.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y5X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGRAMDPLP AAAVGAAAEA EADEEADPPA SDLPTPQAIE PQAIVQQVPA
60 70 80 90 100
PSRMQMPQGN PLLLSHTLQE LLARDTVQVE LIPEKKGLFL KHVEYEVSSQ
110 120 130 140 150
RFKSSVYRRY NDFVVFQEML LHKFPYRMVP ALPPKRMLGA DREFIEARRR
160 170 180 190 200
ALKRFVNLVA RHPLFSEDVV LKLFLSFSGS DVQNKLKESA QCVGDEFLNC
210 220 230 240 250
KLATRAKDFL PADIQAQFAI SRELIRNIYN SFHKLRDRAE RIASRAIDNA
260 270 280 290 300
ADLLIFGKEL SAIGSDTTPL PSWAALNSST WGSLKQALKG LSVEFALLAD
310 320 330 340 350
KAAQQGKQEE NDVVEKLNLF LDLLQSYKDL CERHEKGVLH KHQRALHKYS
360 370 380 390 400
LMKRQMMSAT AQNREPESVE QLESRIVEQE NAIQTMELRN YFSLYCLHQE
410 420 430 440 450
TQLIHVYLPL TSHILRAFVN SQIQGHKEMS KVWNDLRPKL SCLFAGPHST
460
LTPPCSPPED GLCPH
Length:465
Mass (Da):52,569
Last modified:November 1, 1999 - v1
Checksum:i90C5EDB761C31E88
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036259147A → G in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121858 mRNA. Translation: AAD27831.1.
CH236953 Genomic DNA. Translation: EAL23950.1.
CH471144 Genomic DNA. Translation: EAW87235.1.
BC007785 mRNA. Translation: AAH07785.2.
BC021565 mRNA. Translation: AAH21565.1.
CCDSiCCDS5331.1.
RefSeqiNP_037453.1. NM_013321.3.
UniGeneiHs.584900.

Genome annotation databases

EnsembliENST00000222990; ENSP00000222990; ENSG00000106266.
GeneIDi29886.
KEGGihsa:29886.
UCSCiuc003slw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121858 mRNA. Translation: AAD27831.1.
CH236953 Genomic DNA. Translation: EAL23950.1.
CH471144 Genomic DNA. Translation: EAW87235.1.
BC007785 mRNA. Translation: AAH07785.2.
BC021565 mRNA. Translation: AAH21565.1.
CCDSiCCDS5331.1.
RefSeqiNP_037453.1. NM_013321.3.
UniGeneiHs.584900.

3D structure databases

ProteinModelPortaliQ9Y5X2.
SMRiQ9Y5X2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118939. 15 interactors.
IntActiQ9Y5X2. 14 interactors.
MINTiMINT-3087539.
STRINGi9606.ENSP00000222990.

PTM databases

iPTMnetiQ9Y5X2.
PhosphoSitePlusiQ9Y5X2.

Polymorphism and mutation databases

BioMutaiSNX8.
DMDMi10720288.

Proteomic databases

EPDiQ9Y5X2.
MaxQBiQ9Y5X2.
PaxDbiQ9Y5X2.
PeptideAtlasiQ9Y5X2.
PRIDEiQ9Y5X2.

Protocols and materials databases

DNASUi29886.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222990; ENSP00000222990; ENSG00000106266.
GeneIDi29886.
KEGGihsa:29886.
UCSCiuc003slw.3. human.

Organism-specific databases

CTDi29886.
GeneCardsiSNX8.
HGNCiHGNC:14972. SNX8.
HPAiHPA057296.
HPA060194.
MIMi614905. gene.
neXtProtiNX_Q9Y5X2.
OpenTargetsiENSG00000106266.
PharmGKBiPA37948.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2273. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00460000041594.
HOGENOMiHOG000252992.
HOVERGENiHBG017827.
InParanoidiQ9Y5X2.
KOiK17922.
OMAiMMSATVQ.
OrthoDBiEOG091G0NVM.
PhylomeDBiQ9Y5X2.
TreeFamiTF314082.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000106266-MONOMER.

Miscellaneous databases

ChiTaRSiSNX8. human.
GenomeRNAii29886.
PROiQ9Y5X2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106266.
CleanExiHS_SNX8.
ExpressionAtlasiQ9Y5X2. baseline and differential.
GenevisibleiQ9Y5X2. HS.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX8_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5X2
Secondary accession number(s): A4D207, Q96I67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.