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Protein

Sorting nexin-8

Gene

SNX8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. May play a role in intracellular protein transport from early endosomes to the trans-Golgi network.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091Phosphatidylinositol 3-phosphateBy similarity
Binding sitei135 – 1351Phosphatidylinositol 3-phosphateBy similarity
Binding sitei148 – 1481Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  1. identical protein binding Source: IntAct
  2. phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  1. early endosome to Golgi transport Source: UniProtKB
  2. endocytosis Source: GO_Central
  3. intracellular protein transport Source: UniProtKB
  4. vesicle organization Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-8
Gene namesi
Name:SNX8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:14972. SNX8.

Subcellular locationi

  1. Early endosome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

  2. Note: Colocalizes with retromer components.

GO - Cellular componenti

  1. early endosome membrane Source: UniProtKB
  2. extrinsic component of membrane Source: GO_Central
  3. intracellular membrane-bounded organelle Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37948.

Polymorphism and mutation databases

BioMutaiSNX8.
DMDMi10720288.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Sorting nexin-8PRO_0000213851Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei452 – 4521Phosphothreonine1 Publication
Modified residuei456 – 4561Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y5X2.
PaxDbiQ9Y5X2.
PRIDEiQ9Y5X2.

PTM databases

PhosphoSiteiQ9Y5X2.

Expressioni

Gene expression databases

BgeeiQ9Y5X2.
CleanExiHS_SNX8.
ExpressionAtlasiQ9Y5X2. baseline and differential.
GenevestigatoriQ9Y5X2.

Organism-specific databases

HPAiHPA057296.
HPA060194.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1752557,EBI-1752557
NCK1P163332EBI-1752557,EBI-389883

Protein-protein interaction databases

BioGridi118939. 11 interactions.
IntActiQ9Y5X2. 10 interactions.
MINTiMINT-3087539.
STRINGi9606.ENSP00000222990.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5X2.
SMRiQ9Y5X2. Positions 92-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini73 – 181109PXPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5391.
GeneTreeiENSGT00460000041594.
HOGENOMiHOG000252992.
HOVERGENiHBG017827.
InParanoidiQ9Y5X2.
KOiK17922.
OMAiMMSATVQ.
OrthoDBiEOG77128D.
PhylomeDBiQ9Y5X2.
TreeFamiTF314082.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028662. SNX8.
[Graphical view]
PANTHERiPTHR10555:SF15. PTHR10555:SF15. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y5X2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTGRAMDPLP AAAVGAAAEA EADEEADPPA SDLPTPQAIE PQAIVQQVPA
60 70 80 90 100
PSRMQMPQGN PLLLSHTLQE LLARDTVQVE LIPEKKGLFL KHVEYEVSSQ
110 120 130 140 150
RFKSSVYRRY NDFVVFQEML LHKFPYRMVP ALPPKRMLGA DREFIEARRR
160 170 180 190 200
ALKRFVNLVA RHPLFSEDVV LKLFLSFSGS DVQNKLKESA QCVGDEFLNC
210 220 230 240 250
KLATRAKDFL PADIQAQFAI SRELIRNIYN SFHKLRDRAE RIASRAIDNA
260 270 280 290 300
ADLLIFGKEL SAIGSDTTPL PSWAALNSST WGSLKQALKG LSVEFALLAD
310 320 330 340 350
KAAQQGKQEE NDVVEKLNLF LDLLQSYKDL CERHEKGVLH KHQRALHKYS
360 370 380 390 400
LMKRQMMSAT AQNREPESVE QLESRIVEQE NAIQTMELRN YFSLYCLHQE
410 420 430 440 450
TQLIHVYLPL TSHILRAFVN SQIQGHKEMS KVWNDLRPKL SCLFAGPHST
460
LTPPCSPPED GLCPH
Length:465
Mass (Da):52,569
Last modified:November 1, 1999 - v1
Checksum:i90C5EDB761C31E88
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti147 – 1471A → G in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036259

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121858 mRNA. Translation: AAD27831.1.
CH236953 Genomic DNA. Translation: EAL23950.1.
CH471144 Genomic DNA. Translation: EAW87235.1.
BC007785 mRNA. Translation: AAH07785.2.
BC021565 mRNA. Translation: AAH21565.1.
CCDSiCCDS5331.1.
RefSeqiNP_037453.1. NM_013321.3.
UniGeneiHs.584900.

Genome annotation databases

EnsembliENST00000222990; ENSP00000222990; ENSG00000106266.
GeneIDi29886.
KEGGihsa:29886.
UCSCiuc003slw.3. human.

Polymorphism and mutation databases

BioMutaiSNX8.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121858 mRNA. Translation: AAD27831.1.
CH236953 Genomic DNA. Translation: EAL23950.1.
CH471144 Genomic DNA. Translation: EAW87235.1.
BC007785 mRNA. Translation: AAH07785.2.
BC021565 mRNA. Translation: AAH21565.1.
CCDSiCCDS5331.1.
RefSeqiNP_037453.1. NM_013321.3.
UniGeneiHs.584900.

3D structure databases

ProteinModelPortaliQ9Y5X2.
SMRiQ9Y5X2. Positions 92-330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118939. 11 interactions.
IntActiQ9Y5X2. 10 interactions.
MINTiMINT-3087539.
STRINGi9606.ENSP00000222990.

PTM databases

PhosphoSiteiQ9Y5X2.

Polymorphism and mutation databases

BioMutaiSNX8.
DMDMi10720288.

Proteomic databases

MaxQBiQ9Y5X2.
PaxDbiQ9Y5X2.
PRIDEiQ9Y5X2.

Protocols and materials databases

DNASUi29886.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222990; ENSP00000222990; ENSG00000106266.
GeneIDi29886.
KEGGihsa:29886.
UCSCiuc003slw.3. human.

Organism-specific databases

CTDi29886.
GeneCardsiGC07M002261.
HGNCiHGNC:14972. SNX8.
HPAiHPA057296.
HPA060194.
MIMi614905. gene.
neXtProtiNX_Q9Y5X2.
PharmGKBiPA37948.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5391.
GeneTreeiENSGT00460000041594.
HOGENOMiHOG000252992.
HOVERGENiHBG017827.
InParanoidiQ9Y5X2.
KOiK17922.
OMAiMMSATVQ.
OrthoDBiEOG77128D.
PhylomeDBiQ9Y5X2.
TreeFamiTF314082.

Miscellaneous databases

ChiTaRSiSNX8. human.
GenomeRNAii29886.
NextBioi52423.
PROiQ9Y5X2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5X2.
CleanExiHS_SNX8.
ExpressionAtlasiQ9Y5X2. baseline and differential.
GenevestigatoriQ9Y5X2.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028662. SNX8.
[Graphical view]
PANTHERiPTHR10555:SF15. PTHR10555:SF15. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A large family of endosome-localized proteins related to sorting nexin 1."
    Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.
    Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney and Lung.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-452 AND SER-456, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: FUNCTION, SUBCELLULAR LOCATION.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-147.

Entry informationi

Entry nameiSNX8_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5X2
Secondary accession number(s): A4D207, Q96I67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: April 29, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.