Skip Header

 
Contribute Send feedback
Read comments (1) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9Y5X1 (SNX9_HUMAN)

Last modified June 16, 2009. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Sorting nexin-9
Alternative name(s):
    SH3 and PX domain-containing protein 1
      Short name=Protein SDP1
    SH3 and PX domain-containing protein 3A
Gene names
Name: SNX9
Synonyms: SH3PX1, SH3PXD3A
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length595 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

Hide | Top

General annotation (Comments)

Function

May be involved in several stages of intracellular trafficking.

Sequence similarities

Belongs to the sorting nexin family.

Contains 1 PX (phox homology) domain.

Contains 1 SH3 domain.

Hide | Top

Ontologies

Keywords
   Biological processProtein transport
Transport
   DomainSH3 domain
   PTMPhosphoprotein
   Technical term3D-structure
Gene Ontology (GO)
   Biological processcell communication

Inferred from electronic annotation. Source: InterPro

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionphosphoinositide binding

Inferred from electronic annotation. Source: InterPro

protein binding Ref.2

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Hide | Top

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ACK2O027422EBI-77848,EBI-457220From a different organism.
MPHOSPH6Q995471EBI-77848,EBI-373187
SOS1Q078892EBI-77848,EBI-297487
SOS2Q078902EBI-77848,EBI-298181

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 595595Sorting nexin-9
PRO_0000213852

Regions

Domain1 – 6262SH3
Domain250 – 361112PX

Amino acid modifications

Modified residue1761Phosphoserine By similarity

Experimental info

Sequence conflict891Q → H in AAH05022. Ref.5

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
Q9Y5X1-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 963892AC1A5A9227

FASTA59566,592
        10         20         30         40         50         60 
MATKARVMYD FAAEPGNNEL TVNEGEIITI TNPDVGGGWL EGRNIKGERG LVPTDYVEIL 

        70         80         90        100        110        120 
PSDGKDQFSC GNSVADQAFL DSLSASTAQA SSSAASNNHQ VGSGNDPWSA WSASKSGNWE 

       130        140        150        160        170        180 
SSEGWGAQPE GAGAQRNTNT PNNWDTAFGH PQAYQGPATG DDDDWDEDWD GPKSSSYFKD 

       190        200        210        220        230        240 
SESADAGGAQ RGNSRASSSS MKIPLNKFPG FAKPGTEQYL LAKQLAKPKE KIPIIVGDYG 

       250        260        270        280        290        300 
PMWVYPTSTF DCVVADPRKG SKMYGLKSYI EYQLTPTNTN RSVNHRYKHF DWLYERLLVK 

       310        320        330        340        350        360 
FGSAIPIPSL PDKQVTGRFE EEFIKMRMER LQAWMTRMCR HPVISESEVF QQFLNFRDEK 

       370        380        390        400        410        420 
EWKTGKRKAE RDELAGVMIF STMEPEAPDL DLVEIEQKCE AVGKFTKAMD DGVKELLTVG 

       430        440        450        460        470        480 
QEHWKRCTGP LPKEYQKIGK ALQSLATVFS SSGYQGETDL NDAITEAGKT YEEIASLVAE 

       490        500        510        520        530        540 
QPKKDLHFLM ECNHEYKGFL GCFPDIIGTH KGAIEKVKES DKLVATSKIT LQDKQNMVKR 

       550        560        570        580        590 
VSIMSYALQA EMNHFHSNRI YDYNSVIRLY LEQQVQFYET IAEKLRQALS RFPVM

« Hide

Hide | Top

References

« Hide 'large scale' references
[1]"A large family of endosome-localized proteins related to sorting nexin 1."
Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.
Biochem. J. 358:7-16(2001) [PubMed: 11485546] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1."
Howard L., Nelson K.K., Maciewicz R.A., Blobel C.P.
J. Biol. Chem. 274:31693-31699(1999) [PubMed: 10531379] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Identification of differentially expressed genes in matched prostate cancer and normal epithelial cell lines."
Zhang J.S., Smith D.I.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed: 14574404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney and Skin.
[6]"Human SDP1."
Ramanathan G., Subramaniam V.N., Hong W.
Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 201-595.
[7]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Hide | Top

Cross-references

Sequence databases

AF121859 mRNA. Translation: AAD27832.1.
AF131214 mRNA. Translation: AAF04473.1.
AF172847 mRNA. Translation: AAL54871.1.
AL035634, AL139330, AL391863 Genomic DNA. Translation: CAI20465.1.
AL139330, AL035634, AL391863 Genomic DNA. Translation: CAI12979.1.
AL391863, AL035634, AL139330 Genomic DNA. Translation: CAI15180.1.
BC001084 mRNA. Translation: AAH01084.3.
BC005022 mRNA. Translation: AAH05022.1.
AF076957 mRNA. Translation: AAD43001.1.
IPIIPI00001883.
RefSeqNP_057308.1.
UniGeneHs.191213

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
2RAIX-ray3.20A/B204-595[»]
2RAJX-ray2.45A204-595[»]
2RAKX-ray3.00A204-595[»]
3DYTX-ray2.08A230-595[»]
3DYUX-ray4.10A/B/C230-595[»]
ModBaseSearch...

Protein-protein interaction databases

IntActQ9Y5X1. 7 interactions.

PTM databases

PhosphoSiteQ9Y5X1.

Proteomic databases

PeptideAtlasQ9Y5X1.
PRIDEQ9Y5X1.

Genome annotation databases

EnsemblENSG00000130340. Homo sapiens. [Contig view]
GeneID51429.
KEGGhsa:51429.

Organism-specific databases

GeneCardsGC06P158110.
H-InvDBHIX0018165.
HGNCHGNC:14973. SNX9.
MIM605952. gene.
PharmGKBPA37949.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9Y5X1.
HOVERGENQ9Y5X1.
OMAQ9Y5X1. PGMEQYL.

Gene expression databases

ArrayExpressQ9Y5X1.
BgeeQ9Y5X1.
CleanExHS_SNX9.
GermOnlineENSG00000130340. Homo sapiens.

Family and domain databases

InterProIPR001683. PX.
IPR001452. SH3_domain.
IPR014536. Snx9.
IPR019497. Sorting_nexin_WASP-bd-dom.
[Graphical view]
Gene3DG3DSA:3.30.1520.10. PX. 1 hit.
PfamPF10456. BAR_3_WASP_bdg. 1 hit.
PF00787. PX. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFPIRSF027744. Snx9. 1 hit.
ProDomPD000066. SH3. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00312. PX. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
PROSITEPS50195. PX. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio54991.
SOURCESearch...

Hide | Top

Entry information

Entry nameSNX9_HUMAN
AccessionPrimary (citable) accession number: Q9Y5X1
Secondary accession number(s): Q9BSI7 expand/collapse secondary AC list , Q9BVM1, Q9UJH6, Q9UP20
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: June 16, 2009
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Hide | Top

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents