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Q9Y5X0

- SNX10_HUMAN

UniProt

Q9Y5X0 - SNX10_HUMAN

Protein

Sorting nexin-10

Gene

SNX10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei53 – 531Phosphatidylinositol 3-phosphateCurated
    Binding sitei79 – 791Phosphatidylinositol 3-phosphateCurated
    Binding sitei94 – 941Phosphatidylinositol 3-phosphateCurated

    GO - Molecular functioni

    1. 1-phosphatidylinositol binding Source: UniProtKB
    2. ATPase binding Source: UniProtKB

    GO - Biological processi

    1. cilium assembly Source: UniProtKB
    2. endosome organization Source: UniProtKB
    3. intracellular protein transport Source: RefGenome
    4. osteoclast differentiation Source: UniProtKB
    5. protein localization to centrosome Source: UniProtKB
    6. protein localization to cilium Source: UniProtKB

    Keywords - Biological processi

    Cilium biogenesis/degradation, Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-10
    Gene namesi
    Name:SNX10
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:14974. SNX10.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. extrinsic component of endosome membrane Source: UniProtKB
    3. microtubule organizing center Source: UniProtKB-SubCell
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Endosome, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Osteopetrosis, autosomal recessive 8 (OPTB8) [MIM:615085]: A rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. Osteopetrosis occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Recessive osteopetrosis commonly manifests in early infancy with macrocephaly, feeding difficulties, evolving blindness and deafness, bone marrow failure, severe anemia, and hepatosplenomegaly. Deafness and blindness are generally thought to represent effects of pressure on nerves. OPTB8 is clinically characterized by dense bones with no distinction between outer and inner plates, due to extensive encroachment of cortical bone into the medullary space, increased head circumference, broad open fontanelle, frontal bossing, and hepatosplenomegaly. Osteoclasts number is low and their bone resorptive capacity is impaired.3 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161R → L in OPTB8. 1 Publication
    VAR_069299
    Natural varianti32 – 321Y → S in OPTB8. 1 Publication
    VAR_069300
    Natural varianti51 – 511R → P in OPTB8. 1 Publication
    VAR_069301
    Natural varianti51 – 511R → Q in OPTB8; increased expression, produces extensive cytoplasmic vacuolation and impairs bone resorptive function. 1 Publication
    VAR_069302

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi53 – 531R → A: Abolishes vacuolization induced by overexpression. 1 Publication
    Mutagenesisi79 – 791K → A: Slightly reduced vacuolization induced by overexpression. 1 Publication
    Mutagenesisi94 – 941R → A: Reduced vacuolization induced by overexpression. 1 Publication

    Keywords - Diseasei

    Disease mutation, Osteopetrosis

    Organism-specific databases

    MIMi615085. phenotype.
    Orphaneti667. Autosomal recessive malignant osteopetrosis.
    PharmGKBiPA37950.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 201201Sorting nexin-10PRO_0000213854Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y5X0.
    PaxDbiQ9Y5X0.
    PRIDEiQ9Y5X0.

    PTM databases

    PhosphoSiteiQ9Y5X0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y5X0.
    BgeeiQ9Y5X0.
    CleanExiHS_SNX10.
    GenevestigatoriQ9Y5X0.

    Organism-specific databases

    HPAiHPA015605.

    Interactioni

    Subunit structurei

    Interacts with ATP6V1D; may play a role in ciliogenesis.1 Publication

    Protein-protein interaction databases

    BioGridi118940. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5X0.
    SMRiQ9Y5X0. Positions 9-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 127118PXPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni8 – 125118Required for the interaction with ATP6V1DAdd
    BLAST

    Domaini

    The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG315047.
    HOGENOMiHOG000231108.
    HOVERGENiHBG054994.
    InParanoidiQ9Y5X0.
    KOiK17924.
    PhylomeDBiQ9Y5X0.
    TreeFamiTF332117.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    [Graphical view]
    PfamiPF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y5X0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFPEQQKEEF VSVWVRDPRI QKEDFWHSYI DYEICIHTNS MCFTMKTSCV    50
    RRRYREFVWL RQRLQSNALL VQLPELPSKN LFFNMNNRQH VDQRRQGLED 100
    FLRKVLQNAL LLSDSSLHLF LQSHLNSEDI EACVSGQTKY SVEEAIHKFA 150
    LMNRRFPEED EEGKKENDID YDSESSSSGL GHSSDDSSSH GCKVNTAPQE 200
    S 201
    Length:201
    Mass (Da):23,598
    Last modified:September 2, 2008 - v2
    Checksum:i665B80734D5E5C72
    GO
    Isoform 2 (identifier: Q9Y5X0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-84: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:117
    Mass (Da):13,181
    Checksum:i1AE71FD546A428CA
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161R → L in OPTB8. 1 Publication
    VAR_069299
    Natural varianti32 – 321Y → S in OPTB8. 1 Publication
    VAR_069300
    Natural varianti51 – 511R → P in OPTB8. 1 Publication
    VAR_069301
    Natural varianti51 – 511R → Q in OPTB8; increased expression, produces extensive cytoplasmic vacuolation and impairs bone resorptive function. 1 Publication
    VAR_069302
    Natural varianti187 – 1871S → I.1 Publication
    Corresponds to variant rs1053042 [ dbSNP | Ensembl ].
    VAR_046098

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8484Missing in isoform 2. 1 PublicationVSP_045920Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF121860 mRNA. Translation: AAD27833.1.
    AK309162 mRNA. No translation available.
    AK312850 mRNA. Translation: BAG35703.1.
    AC004540 Genomic DNA. No translation available.
    AC010677 Genomic DNA. No translation available.
    AC074295 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24234.1.
    CH471073 Genomic DNA. Translation: EAW93849.1.
    BC034992 mRNA. Translation: AAH34992.1.
    CCDSiCCDS5399.1. [Q9Y5X0-1]
    CCDS56470.1. [Q9Y5X0-2]
    RefSeqiNP_001186764.1. NM_001199835.1. [Q9Y5X0-1]
    NP_001186766.1. NM_001199837.1.
    NP_001186767.1. NM_001199838.1. [Q9Y5X0-2]
    NP_037454.2. NM_013322.2. [Q9Y5X0-1]
    XP_006715773.1. XM_006715710.1. [Q9Y5X0-1]
    XP_006715774.1. XM_006715711.1. [Q9Y5X0-1]
    XP_006715775.1. XM_006715712.1. [Q9Y5X0-1]
    UniGeneiHs.741316.

    Genome annotation databases

    EnsembliENST00000338523; ENSP00000343709; ENSG00000086300. [Q9Y5X0-1]
    ENST00000396376; ENSP00000379661; ENSG00000086300. [Q9Y5X0-1]
    ENST00000409838; ENSP00000386540; ENSG00000086300. [Q9Y5X0-2]
    GeneIDi29887.
    KEGGihsa:29887.
    UCSCiuc003sxx.3. human. [Q9Y5X0-1]

    Polymorphism databases

    DMDMi205371824.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF121860 mRNA. Translation: AAD27833.1 .
    AK309162 mRNA. No translation available.
    AK312850 mRNA. Translation: BAG35703.1 .
    AC004540 Genomic DNA. No translation available.
    AC010677 Genomic DNA. No translation available.
    AC074295 Genomic DNA. No translation available.
    CH236948 Genomic DNA. Translation: EAL24234.1 .
    CH471073 Genomic DNA. Translation: EAW93849.1 .
    BC034992 mRNA. Translation: AAH34992.1 .
    CCDSi CCDS5399.1. [Q9Y5X0-1 ]
    CCDS56470.1. [Q9Y5X0-2 ]
    RefSeqi NP_001186764.1. NM_001199835.1. [Q9Y5X0-1 ]
    NP_001186766.1. NM_001199837.1.
    NP_001186767.1. NM_001199838.1. [Q9Y5X0-2 ]
    NP_037454.2. NM_013322.2. [Q9Y5X0-1 ]
    XP_006715773.1. XM_006715710.1. [Q9Y5X0-1 ]
    XP_006715774.1. XM_006715711.1. [Q9Y5X0-1 ]
    XP_006715775.1. XM_006715712.1. [Q9Y5X0-1 ]
    UniGenei Hs.741316.

    3D structure databases

    ProteinModelPortali Q9Y5X0.
    SMRi Q9Y5X0. Positions 9-132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118940. 2 interactions.

    PTM databases

    PhosphoSitei Q9Y5X0.

    Polymorphism databases

    DMDMi 205371824.

    Proteomic databases

    MaxQBi Q9Y5X0.
    PaxDbi Q9Y5X0.
    PRIDEi Q9Y5X0.

    Protocols and materials databases

    DNASUi 29887.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338523 ; ENSP00000343709 ; ENSG00000086300 . [Q9Y5X0-1 ]
    ENST00000396376 ; ENSP00000379661 ; ENSG00000086300 . [Q9Y5X0-1 ]
    ENST00000409838 ; ENSP00000386540 ; ENSG00000086300 . [Q9Y5X0-2 ]
    GeneIDi 29887.
    KEGGi hsa:29887.
    UCSCi uc003sxx.3. human. [Q9Y5X0-1 ]

    Organism-specific databases

    CTDi 29887.
    GeneCardsi GC07P026331.
    HGNCi HGNC:14974. SNX10.
    HPAi HPA015605.
    MIMi 614780. gene.
    615085. phenotype.
    neXtProti NX_Q9Y5X0.
    Orphaneti 667. Autosomal recessive malignant osteopetrosis.
    PharmGKBi PA37950.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG315047.
    HOGENOMi HOG000231108.
    HOVERGENi HBG054994.
    InParanoidi Q9Y5X0.
    KOi K17924.
    PhylomeDBi Q9Y5X0.
    TreeFami TF332117.

    Miscellaneous databases

    GenomeRNAii 29887.
    NextBioi 52427.
    PROi Q9Y5X0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5X0.
    Bgeei Q9Y5X0.
    CleanExi HS_SNX10.
    Genevestigatori Q9Y5X0.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    [Graphical view ]
    Pfami PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A large family of endosome-localized proteins related to sorting nexin 1."
      Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.
      Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, VARIANT ILE-187.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Kidney and Thalamus.
    3. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    7. "Sorting nexin 10 induces giant vacuoles in mammalian cells."
      Qin B., He M., Chen X., Pei D.
      J. Biol. Chem. 281:36891-36896(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-53; LYS-79 AND ARG-94.
    8. "A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo."
      Chen Y., Wu B., Xu L., Li H., Xia J., Yin W., Li Z., Shi D., Li S., Lin S., Shu X., Pei D.
      Cell Res. 22:333-345(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CILIOGENESIS, INTERACTION WITH ATP6V1D, SUBCELLULAR LOCATION.
    9. "SNX10 is required for osteoclast formation and resorption activity."
      Zhu C.H., Morse L.R., Battaglino R.A.
      J. Cell. Biochem. 113:1608-1615(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    10. "Homozygous stop mutation in the SNX10 gene in a consanguineous Iraqi boy with osteopetrosis and corpus callosum hypoplasia."
      Megarbane A., Pangrazio A., Villa A., Chouery E., Maarawi J., Sabbagh S., Lefranc G., Sobacchi C.
      Eur. J. Med. Genet. 56:32-35(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN OPTB8.
    11. Cited for: VARIANT OPTB8 GLN-51, CHARACTERIZATION OF VARIANT OPTB8 GLN-51, FUNCTION IN BONE RESORPTION.
    12. Cited for: VARIANTS OPTB8 LEU-16; SER-32 AND PRO-51.

    Entry informationi

    Entry nameiSNX10_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5X0
    Secondary accession number(s): E9PFH5, Q8IYT5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3