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Q9Y5W9 (SNX11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sorting nexin-11
Gene names
Name:SNX11
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length270 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Ref.6

Subunit structure

Monomer. Ref.6

Subcellular location

Membrane; Peripheral membrane protein; Cytoplasmic side Potential. Endosome Ref.6.

Domain

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate (Ref.6).

Sequence similarities

Belongs to the sorting nexin family.

Contains 1 PX (phox homology) domain.

Sequence caution

The sequence AAD27834.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentEndosome
Membrane
   LigandLipid-binding
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processintracellular protein transport

Inferred from electronic annotation. Source: InterPro

vesicle organization

Inferred from mutant phenotype Ref.6. Source: UniProtKB

   Cellular_componentendosome

Inferred from direct assay Ref.6. Source: UniProtKB

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphatidylinositol phosphate binding

Inferred from direct assay Ref.6. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 270270Sorting nexin-11
PRO_0000213856

Regions

Domain16 – 132117PX
Region135 – 1395Important for membrane trafficking

Sites

Binding site591Phosphatidylinositol 3-phosphate
Binding site851Phosphatidylinositol 3-phosphate By similarity
Binding site991Phosphatidylinositol 3-phosphate By similarity

Experimental info

Mutagenesis591R → A: Abolishes lipid-binding. Ref.6
Mutagenesis135 – 1395IEACV → AAAAA: Impairs function in membrane trafficking. Ref.6

Secondary structure

..................... 270
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9Y5W9 [UniParc].

Last modified July 11, 2001. Version 2.
Checksum: E6839B7415F1724F

FASTA27030,433
        10         20         30         40         50         60 
MGFWCRMSEN QEQEEVITVR VQDPRVQNEG SWNSYVDYKI FLHTNSKAFT AKTSCVRRRY 

        70         80         90        100        110        120 
REFVWLRKQL QRNAGLVPVP ELPGKSTFFG TSDEFIEKRR QGLQHFLEKV LQSVVLLSDS 

       130        140        150        160        170        180 
QLHLFLQSQL SVPEIEACVQ GRSTMTVSDA ILRYAMSNCG WAQEERQSSS HLAKGDQPKS 

       190        200        210        220        230        240 
CCFLPRSGRR SSPSPPPSEE KDHLEVWAPV VDSEVPSLES PTLPPLSSPL CCDFGRPKEG 

       250        260        270 
TSTLQSVRRA VGGDHAVPLD PGQLETVLEK 

« Hide

References

« Hide 'large scale' references
[1]"A large family of endosome-localized proteins related to sorting nexin 1."
Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.
Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung and Thyroid.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney and Skin.
[6]"Structure of Sorting Nexin 11 (SNX11) reveals a novel extended PX Domain (PXe Domain) critical for the inhibition of Sorting Nexin 10 (SNX10) induced vacuolation."
Xu J., Xu T., Wu B., Ye Y., You X., Shu X., Pei D., Liu J.
J. Biol. Chem. 288:16598-16605(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 7-170, FUNCTION, SUBUNIT, LIPID-BINDING, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-59 AND 135-ILE--VAL-139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF121861 mRNA. Translation: AAD27834.1. Different initiation.
AK023932 mRNA. Translation: BAB14732.1.
AK091852 mRNA. Translation: BAG52428.1.
BT006723 mRNA. Translation: AAP35369.1.
CH471109 Genomic DNA. Translation: EAW94754.1.
BC000768 mRNA. Translation: AAH00768.1.
BC103721 mRNA. Translation: AAI03722.1.
RefSeqNP_037455.2. NM_013323.2.
NP_689450.1. NM_152244.1.
XP_005257317.1. XM_005257260.1.
UniGeneHs.15827.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4IKBX-ray1.78A/B7-142[»]
4IKDX-ray1.60A7-170[»]
ProteinModelPortalQ9Y5W9.
SMRQ9Y5W9. Positions 15-142.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118960. 1 interaction.

PTM databases

PhosphoSiteQ9Y5W9.

Polymorphism databases

DMDM14916716.

Proteomic databases

PaxDbQ9Y5W9.
PRIDEQ9Y5W9.

Protocols and materials databases

DNASU29916.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359238; ENSP00000352175; ENSG00000002919.
ENST00000393405; ENSP00000377059; ENSG00000002919.
GeneID29916.
KEGGhsa:29916.
UCSCuc002inf.1. human.

Organism-specific databases

CTD29916.
GeneCardsGC17P046184.
HGNCHGNC:14975. SNX11.
HPAHPA044787.
MIM614906. gene.
neXtProtNX_Q9Y5W9.
PharmGKBPA37951.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5391.
HOGENOMHOG000231108.
HOVERGENHBG054994.
InParanoidQ9Y5W9.
KOK17924.
OMAHLAKGDQ.
PhylomeDBQ9Y5W9.
TreeFamTF332117.

Gene expression databases

ArrayExpressQ9Y5W9.
BgeeQ9Y5W9.
CleanExHS_SNX11.
GenevestigatorQ9Y5W9.

Family and domain databases

Gene3D3.30.1520.10. 1 hit.
InterProIPR001683. Phox.
IPR028655. SNX11.
[Graphical view]
PANTHERPTHR10555:SF36. PTHR10555:SF36. 1 hit.
PfamPF00787. PX. 1 hit.
[Graphical view]
SMARTSM00312. PX. 1 hit.
[Graphical view]
SUPFAMSSF64268. SSF64268. 1 hit.
PROSITEPS50195. PX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSNX11. human.
GenomeRNAi29916.
NextBio52510.
PROQ9Y5W9.
SOURCESearch...

Entry information

Entry nameSNX11_HUMAN
AccessionPrimary (citable) accession number: Q9Y5W9
Secondary accession number(s): B3KRL6 expand/collapse secondary AC list , D3DTV0, Q53YC0, Q9H885
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 11, 2001
Last modified: April 16, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM