Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y5W9

- SNX11_HUMAN

UniProt

Q9Y5W9 - SNX11_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sorting nexin-11

Gene

SNX11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei59 – 591Phosphatidylinositol 3-phosphate
Binding sitei85 – 851Phosphatidylinositol 3-phosphateBy similarity
Binding sitei99 – 991Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  1. phosphatidylinositol phosphate binding Source: UniProtKB

GO - Biological processi

  1. intracellular protein transport Source: RefGenome
  2. vesicle organization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-11
Gene namesi
Name:SNX11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:14975. SNX11.

Subcellular locationi

Membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated. Endosome 1 Publication

GO - Cellular componenti

  1. endosome Source: UniProtKB
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi59 – 591R → A: Abolishes lipid-binding. 1 Publication
Mutagenesisi135 – 1395IEACV → AAAAA: Impairs function in membrane trafficking. 1 Publication

Organism-specific databases

PharmGKBiPA37951.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Sorting nexin-11PRO_0000213856Add
BLAST

Proteomic databases

MaxQBiQ9Y5W9.
PaxDbiQ9Y5W9.
PRIDEiQ9Y5W9.

PTM databases

PhosphoSiteiQ9Y5W9.

Expressioni

Gene expression databases

BgeeiQ9Y5W9.
CleanExiHS_SNX11.
ExpressionAtlasiQ9Y5W9. baseline and differential.
GenevestigatoriQ9Y5W9.

Organism-specific databases

HPAiHPA044787.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi118960. 15 interactions.

Structurei

Secondary structure

1
270
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi17 – 2812
Beta strandi35 – 4410
Beta strandi52 – 598
Helixi60 – 7314
Beta strandi89 – 913
Helixi92 – 11019
Helixi114 – 1174
Helixi120 – 1278
Helixi132 – 1398
Beta strandi143 – 1453
Helixi147 – 15610

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IKBX-ray1.78A/B7-142[»]
4IKDX-ray1.60A7-170[»]
ProteinModelPortaliQ9Y5W9.
SMRiQ9Y5W9. Positions 15-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 132117PXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni135 – 1395Important for membrane trafficking

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5391.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000231108.
HOVERGENiHBG054994.
InParanoidiQ9Y5W9.
KOiK17924.
OMAiHLAKGDQ.
PhylomeDBiQ9Y5W9.
TreeFamiTF332117.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028655. SNX11.
[Graphical view]
PANTHERiPTHR10555:SF36. PTHR10555:SF36. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y5W9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFWCRMSEN QEQEEVITVR VQDPRVQNEG SWNSYVDYKI FLHTNSKAFT
60 70 80 90 100
AKTSCVRRRY REFVWLRKQL QRNAGLVPVP ELPGKSTFFG TSDEFIEKRR
110 120 130 140 150
QGLQHFLEKV LQSVVLLSDS QLHLFLQSQL SVPEIEACVQ GRSTMTVSDA
160 170 180 190 200
ILRYAMSNCG WAQEERQSSS HLAKGDQPKS CCFLPRSGRR SSPSPPPSEE
210 220 230 240 250
KDHLEVWAPV VDSEVPSLES PTLPPLSSPL CCDFGRPKEG TSTLQSVRRA
260 270
VGGDHAVPLD PGQLETVLEK
Length:270
Mass (Da):30,433
Last modified:July 11, 2001 - v2
Checksum:iE6839B7415F1724F
GO
Isoform 2 (identifier: Q9Y5W9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGFWCRMSENQEQE → MVCREQ

Note: No experimental confirmation available.

Show »
Length:262
Mass (Da):29,423
Checksum:i4DC0C01993F8151D
GO

Sequence cautioni

The sequence AAD27834.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1414MGFWC…NQEQE → MVCREQ in isoform 2. 1 PublicationVSP_056594Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF121861 mRNA. Translation: AAD27834.1. Different initiation.
BT006723 mRNA. Translation: AAP35369.1.
AK023932 mRNA. Translation: BAB14732.1.
AK091852 mRNA. Translation: BAG52428.1.
AK298551 mRNA. Translation: BAG60747.1.
AK316374 mRNA. Translation: BAH14745.1.
AC006468 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94754.1.
BC000768 mRNA. Translation: AAH00768.1.
BC103721 mRNA. Translation: AAI03722.1.
CCDSiCCDS11526.1. [Q9Y5W9-1]
RefSeqiNP_037455.2. NM_013323.2.
NP_689450.1. NM_152244.1.
XP_005257317.1. XM_005257260.1.
XP_005257318.1. XM_005257261.1.
XP_005257319.1. XM_005257262.1.
UniGeneiHs.15827.

Genome annotation databases

EnsembliENST00000359238; ENSP00000352175; ENSG00000002919. [Q9Y5W9-1]
ENST00000393405; ENSP00000377059; ENSG00000002919. [Q9Y5W9-1]
ENST00000580219; ENSP00000462188; ENSG00000002919. [Q9Y5W9-2]
ENST00000582104; ENSP00000463948; ENSG00000002919. [Q9Y5W9-2]
GeneIDi29916.
KEGGihsa:29916.
UCSCiuc002inf.1. human. [Q9Y5W9-1]

Polymorphism databases

DMDMi14916716.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF121861 mRNA. Translation: AAD27834.1 . Different initiation.
BT006723 mRNA. Translation: AAP35369.1 .
AK023932 mRNA. Translation: BAB14732.1 .
AK091852 mRNA. Translation: BAG52428.1 .
AK298551 mRNA. Translation: BAG60747.1 .
AK316374 mRNA. Translation: BAH14745.1 .
AC006468 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94754.1 .
BC000768 mRNA. Translation: AAH00768.1 .
BC103721 mRNA. Translation: AAI03722.1 .
CCDSi CCDS11526.1. [Q9Y5W9-1 ]
RefSeqi NP_037455.2. NM_013323.2.
NP_689450.1. NM_152244.1.
XP_005257317.1. XM_005257260.1.
XP_005257318.1. XM_005257261.1.
XP_005257319.1. XM_005257262.1.
UniGenei Hs.15827.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4IKB X-ray 1.78 A/B 7-142 [» ]
4IKD X-ray 1.60 A 7-170 [» ]
ProteinModelPortali Q9Y5W9.
SMRi Q9Y5W9. Positions 15-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118960. 15 interactions.

PTM databases

PhosphoSitei Q9Y5W9.

Polymorphism databases

DMDMi 14916716.

Proteomic databases

MaxQBi Q9Y5W9.
PaxDbi Q9Y5W9.
PRIDEi Q9Y5W9.

Protocols and materials databases

DNASUi 29916.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359238 ; ENSP00000352175 ; ENSG00000002919 . [Q9Y5W9-1 ]
ENST00000393405 ; ENSP00000377059 ; ENSG00000002919 . [Q9Y5W9-1 ]
ENST00000580219 ; ENSP00000462188 ; ENSG00000002919 . [Q9Y5W9-2 ]
ENST00000582104 ; ENSP00000463948 ; ENSG00000002919 . [Q9Y5W9-2 ]
GeneIDi 29916.
KEGGi hsa:29916.
UCSCi uc002inf.1. human. [Q9Y5W9-1 ]

Organism-specific databases

CTDi 29916.
GeneCardsi GC17P046184.
HGNCi HGNC:14975. SNX11.
HPAi HPA044787.
MIMi 614906. gene.
neXtProti NX_Q9Y5W9.
PharmGKBi PA37951.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5391.
GeneTreei ENSGT00650000093174.
HOGENOMi HOG000231108.
HOVERGENi HBG054994.
InParanoidi Q9Y5W9.
KOi K17924.
OMAi HLAKGDQ.
PhylomeDBi Q9Y5W9.
TreeFami TF332117.

Miscellaneous databases

ChiTaRSi SNX11. human.
GenomeRNAii 29916.
NextBioi 35474000.
PROi Q9Y5W9.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y5W9.
CleanExi HS_SNX11.
ExpressionAtlasi Q9Y5W9. baseline and differential.
Genevestigatori Q9Y5W9.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
IPR028655. SNX11.
[Graphical view ]
PANTHERi PTHR10555:SF36. PTHR10555:SF36. 1 hit.
Pfami PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A large family of endosome-localized proteins related to sorting nexin 1."
    Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.
    Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung, Testis and Thyroid.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney and Skin.
  7. "Structure of Sorting Nexin 11 (SNX11) reveals a novel extended PX Domain (PXe Domain) critical for the inhibition of Sorting Nexin 10 (SNX10) induced vacuolation."
    Xu J., Xu T., Wu B., Ye Y., You X., Shu X., Pei D., Liu J.
    J. Biol. Chem. 288:16598-16605(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 7-170, FUNCTION, SUBUNIT, LIPID-BINDING, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-59 AND 135-ILE--VAL-139.

Entry informationi

Entry nameiSNX11_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5W9
Secondary accession number(s): B3KRL6
, B4DPY5, D3DTV0, Q53YC0, Q9H885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 11, 2001
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3