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Protein

Sorting nexin-11

Gene

SNX11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei59 – 591Phosphatidylinositol 3-phosphate
Binding sitei85 – 851Phosphatidylinositol 3-phosphateBy similarity
Binding sitei99 – 991Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  1. phosphatidylinositol phosphate binding Source: UniProtKB

GO - Biological processi

  1. endocytosis Source: GO_Central
  2. intracellular protein transport Source: InterPro
  3. vesicle organization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-11
Gene namesi
Name:SNX11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:14975. SNX11.

Subcellular locationi

  1. Membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated
  2. Endosome 1 Publication

GO - Cellular componenti

  1. endosome Source: UniProtKB
  2. extrinsic component of membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi59 – 591R → A: Abolishes lipid-binding. 1 Publication
Mutagenesisi135 – 1395IEACV → AAAAA: Impairs function in membrane trafficking. 1 Publication

Organism-specific databases

PharmGKBiPA37951.

Polymorphism and mutation databases

BioMutaiSNX11.
DMDMi14916716.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Sorting nexin-11PRO_0000213856Add
BLAST

Proteomic databases

MaxQBiQ9Y5W9.
PaxDbiQ9Y5W9.
PRIDEiQ9Y5W9.

PTM databases

PhosphoSiteiQ9Y5W9.

Expressioni

Gene expression databases

BgeeiQ9Y5W9.
CleanExiHS_SNX11.
ExpressionAtlasiQ9Y5W9. baseline and differential.
GenevestigatoriQ9Y5W9.

Organism-specific databases

HPAiHPA044787.
HPA054660.

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL6IP1Q150413EBI-10329449,EBI-714543
RABAC1Q9UI143EBI-10329449,EBI-712367

Protein-protein interaction databases

BioGridi118960. 12 interactions.
IntActiQ9Y5W9. 2 interactions.

Structurei

Secondary structure

1
270
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi17 – 2812Combined sources
Beta strandi35 – 4410Combined sources
Beta strandi52 – 598Combined sources
Helixi60 – 7314Combined sources
Beta strandi89 – 913Combined sources
Helixi92 – 11019Combined sources
Helixi114 – 1174Combined sources
Helixi120 – 1278Combined sources
Helixi132 – 1398Combined sources
Beta strandi143 – 1453Combined sources
Helixi147 – 15610Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IKBX-ray1.78A/B7-142[»]
4IKDX-ray1.60A7-170[»]
ProteinModelPortaliQ9Y5W9.
SMRiQ9Y5W9. Positions 15-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 132117PXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni135 – 1395Important for membrane trafficking

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5391.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000231108.
HOVERGENiHBG054994.
InParanoidiQ9Y5W9.
KOiK17924.
OMAiHLAKGDQ.
PhylomeDBiQ9Y5W9.
TreeFamiTF332117.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028655. SNX11.
[Graphical view]
PANTHERiPTHR10555:SF36. PTHR10555:SF36. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5W9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFWCRMSEN QEQEEVITVR VQDPRVQNEG SWNSYVDYKI FLHTNSKAFT
60 70 80 90 100
AKTSCVRRRY REFVWLRKQL QRNAGLVPVP ELPGKSTFFG TSDEFIEKRR
110 120 130 140 150
QGLQHFLEKV LQSVVLLSDS QLHLFLQSQL SVPEIEACVQ GRSTMTVSDA
160 170 180 190 200
ILRYAMSNCG WAQEERQSSS HLAKGDQPKS CCFLPRSGRR SSPSPPPSEE
210 220 230 240 250
KDHLEVWAPV VDSEVPSLES PTLPPLSSPL CCDFGRPKEG TSTLQSVRRA
260 270
VGGDHAVPLD PGQLETVLEK
Length:270
Mass (Da):30,433
Last modified:July 11, 2001 - v2
Checksum:iE6839B7415F1724F
GO
Isoform 2 (identifier: Q9Y5W9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGFWCRMSENQEQE → MVCREQ

Note: No experimental confirmation available.

Show »
Length:262
Mass (Da):29,423
Checksum:i4DC0C01993F8151D
GO

Sequence cautioni

The sequence AAD27834.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1414MGFWC…NQEQE → MVCREQ in isoform 2. 1 PublicationVSP_056594Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121861 mRNA. Translation: AAD27834.1. Different initiation.
BT006723 mRNA. Translation: AAP35369.1.
AK023932 mRNA. Translation: BAB14732.1.
AK091852 mRNA. Translation: BAG52428.1.
AK298551 mRNA. Translation: BAG60747.1.
AK316374 mRNA. Translation: BAH14745.1.
AC006468 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94754.1.
BC000768 mRNA. Translation: AAH00768.1.
BC103721 mRNA. Translation: AAI03722.1.
CCDSiCCDS11526.1. [Q9Y5W9-1]
RefSeqiNP_037455.2. NM_013323.2. [Q9Y5W9-1]
NP_689450.1. NM_152244.1. [Q9Y5W9-1]
XP_005257317.1. XM_005257260.2. [Q9Y5W9-1]
XP_005257318.1. XM_005257261.2. [Q9Y5W9-2]
XP_005257319.1. XM_005257262.2. [Q9Y5W9-2]
UniGeneiHs.15827.

Genome annotation databases

EnsembliENST00000359238; ENSP00000352175; ENSG00000002919. [Q9Y5W9-1]
ENST00000393405; ENSP00000377059; ENSG00000002919. [Q9Y5W9-1]
ENST00000580219; ENSP00000462188; ENSG00000002919. [Q9Y5W9-2]
ENST00000582104; ENSP00000463948; ENSG00000002919. [Q9Y5W9-2]
GeneIDi29916.
KEGGihsa:29916.
UCSCiuc002inf.1. human. [Q9Y5W9-1]
uc010wlg.1. human.

Polymorphism and mutation databases

BioMutaiSNX11.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121861 mRNA. Translation: AAD27834.1. Different initiation.
BT006723 mRNA. Translation: AAP35369.1.
AK023932 mRNA. Translation: BAB14732.1.
AK091852 mRNA. Translation: BAG52428.1.
AK298551 mRNA. Translation: BAG60747.1.
AK316374 mRNA. Translation: BAH14745.1.
AC006468 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94754.1.
BC000768 mRNA. Translation: AAH00768.1.
BC103721 mRNA. Translation: AAI03722.1.
CCDSiCCDS11526.1. [Q9Y5W9-1]
RefSeqiNP_037455.2. NM_013323.2. [Q9Y5W9-1]
NP_689450.1. NM_152244.1. [Q9Y5W9-1]
XP_005257317.1. XM_005257260.2. [Q9Y5W9-1]
XP_005257318.1. XM_005257261.2. [Q9Y5W9-2]
XP_005257319.1. XM_005257262.2. [Q9Y5W9-2]
UniGeneiHs.15827.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4IKBX-ray1.78A/B7-142[»]
4IKDX-ray1.60A7-170[»]
ProteinModelPortaliQ9Y5W9.
SMRiQ9Y5W9. Positions 15-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118960. 12 interactions.
IntActiQ9Y5W9. 2 interactions.

PTM databases

PhosphoSiteiQ9Y5W9.

Polymorphism and mutation databases

BioMutaiSNX11.
DMDMi14916716.

Proteomic databases

MaxQBiQ9Y5W9.
PaxDbiQ9Y5W9.
PRIDEiQ9Y5W9.

Protocols and materials databases

DNASUi29916.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359238; ENSP00000352175; ENSG00000002919. [Q9Y5W9-1]
ENST00000393405; ENSP00000377059; ENSG00000002919. [Q9Y5W9-1]
ENST00000580219; ENSP00000462188; ENSG00000002919. [Q9Y5W9-2]
ENST00000582104; ENSP00000463948; ENSG00000002919. [Q9Y5W9-2]
GeneIDi29916.
KEGGihsa:29916.
UCSCiuc002inf.1. human. [Q9Y5W9-1]
uc010wlg.1. human.

Organism-specific databases

CTDi29916.
GeneCardsiGC17P046184.
HGNCiHGNC:14975. SNX11.
HPAiHPA044787.
HPA054660.
MIMi614906. gene.
neXtProtiNX_Q9Y5W9.
PharmGKBiPA37951.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5391.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000231108.
HOVERGENiHBG054994.
InParanoidiQ9Y5W9.
KOiK17924.
OMAiHLAKGDQ.
PhylomeDBiQ9Y5W9.
TreeFamiTF332117.

Miscellaneous databases

ChiTaRSiSNX11. human.
GenomeRNAii29916.
NextBioi35474000.
PROiQ9Y5W9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5W9.
CleanExiHS_SNX11.
ExpressionAtlasiQ9Y5W9. baseline and differential.
GenevestigatoriQ9Y5W9.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028655. SNX11.
[Graphical view]
PANTHERiPTHR10555:SF36. PTHR10555:SF36. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A large family of endosome-localized proteins related to sorting nexin 1."
    Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.
    Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Lung, Testis and Thyroid.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney and Skin.
  7. "Structure of Sorting Nexin 11 (SNX11) reveals a novel extended PX Domain (PXe Domain) critical for the inhibition of Sorting Nexin 10 (SNX10) induced vacuolation."
    Xu J., Xu T., Wu B., Ye Y., You X., Shu X., Pei D., Liu J.
    J. Biol. Chem. 288:16598-16605(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 7-170, FUNCTION, SUBUNIT, LIPID-BINDING, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-59 AND 135-ILE--VAL-139.

Entry informationi

Entry nameiSNX11_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5W9
Secondary accession number(s): B3KRL6
, B4DPY5, D3DTV0, Q53YC0, Q9H885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 11, 2001
Last modified: April 29, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.