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Protein

Sorting nexin-11

Gene

SNX11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei59Phosphatidylinositol 3-phosphate1
Binding sitei85Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei99Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

  • phosphatidylinositol phosphate binding Source: UniProtKB

GO - Biological processi

  • endocytosis Source: GO_Central
  • intracellular protein transport Source: InterPro
  • vesicle organization Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000002919-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-11
Gene namesi
Name:SNX11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:14975. SNX11.

Subcellular locationi

GO - Cellular componenti

  • endosome Source: UniProtKB
  • extrinsic component of membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi59R → A: Abolishes lipid-binding. 1 Publication1
Mutagenesisi135 – 139IEACV → AAAAA: Impairs function in membrane trafficking. 1 Publication5

Organism-specific databases

OpenTargetsiENSG00000002919.
PharmGKBiPA37951.

Polymorphism and mutation databases

BioMutaiSNX11.
DMDMi14916716.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138561 – 270Sorting nexin-11Add BLAST270

Proteomic databases

EPDiQ9Y5W9.
PaxDbiQ9Y5W9.
PeptideAtlasiQ9Y5W9.
PRIDEiQ9Y5W9.

PTM databases

iPTMnetiQ9Y5W9.
PhosphoSitePlusiQ9Y5W9.
SwissPalmiQ9Y5W9.

Expressioni

Gene expression databases

BgeeiENSG00000002919.
CleanExiHS_SNX11.
ExpressionAtlasiQ9Y5W9. baseline and differential.
GenevisibleiQ9Y5W9. HS.

Organism-specific databases

HPAiHPA044787.
HPA054660.

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ARL6IP1Q150415EBI-10329449,EBI-714543
RABAC1Q9UI145EBI-10329449,EBI-712367

Protein-protein interaction databases

BioGridi118960. 23 interactors.
IntActiQ9Y5W9. 3 interactors.
STRINGi9606.ENSP00000352175.

Structurei

Secondary structure

1270
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi17 – 28Combined sources12
Beta strandi35 – 44Combined sources10
Beta strandi52 – 59Combined sources8
Helixi60 – 73Combined sources14
Beta strandi89 – 91Combined sources3
Helixi92 – 110Combined sources19
Helixi114 – 117Combined sources4
Helixi120 – 127Combined sources8
Helixi132 – 139Combined sources8
Beta strandi143 – 145Combined sources3
Helixi147 – 156Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IKBX-ray1.78A/B7-142[»]
4IKDX-ray1.60A7-170[»]
ProteinModelPortaliQ9Y5W9.
SMRiQ9Y5W9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 132PXPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 139Important for membrane trafficking5

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2527. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000231108.
HOVERGENiHBG054994.
InParanoidiQ9Y5W9.
KOiK17924.
OMAiSCCFLPR.
OrthoDBiEOG091G0NL7.
PhylomeDBiQ9Y5W9.
TreeFamiTF332117.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028655. SNX11.
[Graphical view]
PANTHERiPTHR10555:SF36. PTHR10555:SF36. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5W9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGFWCRMSEN QEQEEVITVR VQDPRVQNEG SWNSYVDYKI FLHTNSKAFT
60 70 80 90 100
AKTSCVRRRY REFVWLRKQL QRNAGLVPVP ELPGKSTFFG TSDEFIEKRR
110 120 130 140 150
QGLQHFLEKV LQSVVLLSDS QLHLFLQSQL SVPEIEACVQ GRSTMTVSDA
160 170 180 190 200
ILRYAMSNCG WAQEERQSSS HLAKGDQPKS CCFLPRSGRR SSPSPPPSEE
210 220 230 240 250
KDHLEVWAPV VDSEVPSLES PTLPPLSSPL CCDFGRPKEG TSTLQSVRRA
260 270
VGGDHAVPLD PGQLETVLEK
Length:270
Mass (Da):30,433
Last modified:July 11, 2001 - v2
Checksum:iE6839B7415F1724F
GO
Isoform 2 (identifier: Q9Y5W9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MGFWCRMSENQEQE → MVCREQ

Note: No experimental confirmation available.
Show »
Length:262
Mass (Da):29,423
Checksum:i4DC0C01993F8151D
GO

Sequence cautioni

The sequence AAD27834 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565941 – 14MGFWC…NQEQE → MVCREQ in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121861 mRNA. Translation: AAD27834.1. Different initiation.
BT006723 mRNA. Translation: AAP35369.1.
AK023932 mRNA. Translation: BAB14732.1.
AK091852 mRNA. Translation: BAG52428.1.
AK298551 mRNA. Translation: BAG60747.1.
AK316374 mRNA. Translation: BAH14745.1.
AC006468 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94754.1.
BC000768 mRNA. Translation: AAH00768.1.
BC103721 mRNA. Translation: AAI03722.1.
CCDSiCCDS11526.1. [Q9Y5W9-1]
CCDS82152.1. [Q9Y5W9-2]
RefSeqiNP_001317249.1. NM_001330320.1.
NP_037455.2. NM_013323.2. [Q9Y5W9-1]
NP_689450.1. NM_152244.1. [Q9Y5W9-1]
XP_005257317.1. XM_005257260.3. [Q9Y5W9-1]
XP_005257319.1. XM_005257262.3. [Q9Y5W9-2]
XP_011522999.1. XM_011524697.2. [Q9Y5W9-1]
UniGeneiHs.15827.

Genome annotation databases

EnsembliENST00000359238; ENSP00000352175; ENSG00000002919. [Q9Y5W9-1]
ENST00000393405; ENSP00000377059; ENSG00000002919. [Q9Y5W9-1]
ENST00000580219; ENSP00000462188; ENSG00000002919. [Q9Y5W9-2]
ENST00000582104; ENSP00000463948; ENSG00000002919. [Q9Y5W9-2]
GeneIDi29916.
KEGGihsa:29916.
UCSCiuc002inf.2. human. [Q9Y5W9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF121861 mRNA. Translation: AAD27834.1. Different initiation.
BT006723 mRNA. Translation: AAP35369.1.
AK023932 mRNA. Translation: BAB14732.1.
AK091852 mRNA. Translation: BAG52428.1.
AK298551 mRNA. Translation: BAG60747.1.
AK316374 mRNA. Translation: BAH14745.1.
AC006468 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94754.1.
BC000768 mRNA. Translation: AAH00768.1.
BC103721 mRNA. Translation: AAI03722.1.
CCDSiCCDS11526.1. [Q9Y5W9-1]
CCDS82152.1. [Q9Y5W9-2]
RefSeqiNP_001317249.1. NM_001330320.1.
NP_037455.2. NM_013323.2. [Q9Y5W9-1]
NP_689450.1. NM_152244.1. [Q9Y5W9-1]
XP_005257317.1. XM_005257260.3. [Q9Y5W9-1]
XP_005257319.1. XM_005257262.3. [Q9Y5W9-2]
XP_011522999.1. XM_011524697.2. [Q9Y5W9-1]
UniGeneiHs.15827.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IKBX-ray1.78A/B7-142[»]
4IKDX-ray1.60A7-170[»]
ProteinModelPortaliQ9Y5W9.
SMRiQ9Y5W9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118960. 23 interactors.
IntActiQ9Y5W9. 3 interactors.
STRINGi9606.ENSP00000352175.

PTM databases

iPTMnetiQ9Y5W9.
PhosphoSitePlusiQ9Y5W9.
SwissPalmiQ9Y5W9.

Polymorphism and mutation databases

BioMutaiSNX11.
DMDMi14916716.

Proteomic databases

EPDiQ9Y5W9.
PaxDbiQ9Y5W9.
PeptideAtlasiQ9Y5W9.
PRIDEiQ9Y5W9.

Protocols and materials databases

DNASUi29916.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359238; ENSP00000352175; ENSG00000002919. [Q9Y5W9-1]
ENST00000393405; ENSP00000377059; ENSG00000002919. [Q9Y5W9-1]
ENST00000580219; ENSP00000462188; ENSG00000002919. [Q9Y5W9-2]
ENST00000582104; ENSP00000463948; ENSG00000002919. [Q9Y5W9-2]
GeneIDi29916.
KEGGihsa:29916.
UCSCiuc002inf.2. human. [Q9Y5W9-1]

Organism-specific databases

CTDi29916.
GeneCardsiSNX11.
HGNCiHGNC:14975. SNX11.
HPAiHPA044787.
HPA054660.
MIMi614906. gene.
neXtProtiNX_Q9Y5W9.
OpenTargetsiENSG00000002919.
PharmGKBiPA37951.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2527. Eukaryota.
COG5391. LUCA.
GeneTreeiENSGT00650000093174.
HOGENOMiHOG000231108.
HOVERGENiHBG054994.
InParanoidiQ9Y5W9.
KOiK17924.
OMAiSCCFLPR.
OrthoDBiEOG091G0NL7.
PhylomeDBiQ9Y5W9.
TreeFamiTF332117.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000002919-MONOMER.

Miscellaneous databases

ChiTaRSiSNX11. human.
GenomeRNAii29916.
PROiQ9Y5W9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000002919.
CleanExiHS_SNX11.
ExpressionAtlasiQ9Y5W9. baseline and differential.
GenevisibleiQ9Y5W9. HS.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR028655. SNX11.
[Graphical view]
PANTHERiPTHR10555:SF36. PTHR10555:SF36. 1 hit.
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX11_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5W9
Secondary accession number(s): B3KRL6
, B4DPY5, D3DTV0, Q53YC0, Q9H885
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 11, 2001
Last modified: November 30, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.