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Q9Y5W9

- SNX11_HUMAN

UniProt

Q9Y5W9 - SNX11_HUMAN

Protein

Sorting nexin-11

Gene

SNX11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (11 Jul 2001)
      Previous versions | rss
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    Functioni

    Phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei59 – 591Phosphatidylinositol 3-phosphate
    Binding sitei85 – 851Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei99 – 991Phosphatidylinositol 3-phosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol phosphate binding Source: UniProtKB

    GO - Biological processi

    1. intracellular protein transport Source: RefGenome
    2. vesicle organization Source: UniProtKB

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-11
    Gene namesi
    Name:SNX11
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:14975. SNX11.

    Subcellular locationi

    Membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated. Endosome 1 Publication

    GO - Cellular componenti

    1. endosome Source: UniProtKB
    2. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi59 – 591R → A: Abolishes lipid-binding. 1 Publication
    Mutagenesisi135 – 1395IEACV → AAAAA: Impairs function in membrane trafficking.

    Organism-specific databases

    PharmGKBiPA37951.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Sorting nexin-11PRO_0000213856Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y5W9.
    PaxDbiQ9Y5W9.
    PRIDEiQ9Y5W9.

    PTM databases

    PhosphoSiteiQ9Y5W9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y5W9.
    BgeeiQ9Y5W9.
    CleanExiHS_SNX11.
    GenevestigatoriQ9Y5W9.

    Organism-specific databases

    HPAiHPA044787.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    BioGridi118960. 1 interaction.

    Structurei

    Secondary structure

    1
    270
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi17 – 2812
    Beta strandi35 – 4410
    Beta strandi52 – 598
    Helixi60 – 7314
    Beta strandi89 – 913
    Helixi92 – 11019
    Helixi114 – 1174
    Helixi120 – 1278
    Helixi132 – 1398
    Beta strandi143 – 1453
    Helixi147 – 15610

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4IKBX-ray1.78A/B7-142[»]
    4IKDX-ray1.60A7-170[»]
    ProteinModelPortaliQ9Y5W9.
    SMRiQ9Y5W9. Positions 15-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini16 – 132117PXPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni135 – 1395Important for membrane trafficking

    Domaini

    The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.1 Publication

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5391.
    HOGENOMiHOG000231108.
    HOVERGENiHBG054994.
    InParanoidiQ9Y5W9.
    KOiK17924.
    OMAiHLAKGDQ.
    PhylomeDBiQ9Y5W9.
    TreeFamiTF332117.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    IPR028655. SNX11.
    [Graphical view]
    PANTHERiPTHR10555:SF36. PTHR10555:SF36. 1 hit.
    PfamiPF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y5W9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGFWCRMSEN QEQEEVITVR VQDPRVQNEG SWNSYVDYKI FLHTNSKAFT    50
    AKTSCVRRRY REFVWLRKQL QRNAGLVPVP ELPGKSTFFG TSDEFIEKRR 100
    QGLQHFLEKV LQSVVLLSDS QLHLFLQSQL SVPEIEACVQ GRSTMTVSDA 150
    ILRYAMSNCG WAQEERQSSS HLAKGDQPKS CCFLPRSGRR SSPSPPPSEE 200
    KDHLEVWAPV VDSEVPSLES PTLPPLSSPL CCDFGRPKEG TSTLQSVRRA 250
    VGGDHAVPLD PGQLETVLEK 270
    Length:270
    Mass (Da):30,433
    Last modified:July 11, 2001 - v2
    Checksum:iE6839B7415F1724F
    GO
    Isoform 2 (identifier: Q9Y5W9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-14: MGFWCRMSENQEQE → MVCREQ

    Note: No experimental confirmation available.

    Show »
    Length:262
    Mass (Da):29,423
    Checksum:i4DC0C01993F8151D
    GO

    Sequence cautioni

    The sequence AAD27834.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1414MGFWC…NQEQE → MVCREQ in isoform 2. 1 PublicationVSP_056594Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF121861 mRNA. Translation: AAD27834.1. Different initiation.
    BT006723 mRNA. Translation: AAP35369.1.
    AK023932 mRNA. Translation: BAB14732.1.
    AK091852 mRNA. Translation: BAG52428.1.
    AK298551 mRNA. Translation: BAG60747.1.
    AK316374 mRNA. Translation: BAH14745.1.
    AC006468 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94754.1.
    BC000768 mRNA. Translation: AAH00768.1.
    BC103721 mRNA. Translation: AAI03722.1.
    CCDSiCCDS11526.1.
    RefSeqiNP_037455.2. NM_013323.2.
    NP_689450.1. NM_152244.1.
    XP_005257317.1. XM_005257260.1.
    XP_005257318.1. XM_005257261.1.
    UniGeneiHs.15827.

    Genome annotation databases

    EnsembliENST00000359238; ENSP00000352175; ENSG00000002919.
    ENST00000393405; ENSP00000377059; ENSG00000002919.
    ENST00000580219; ENSP00000462188; ENSG00000002919.
    GeneIDi29916.
    KEGGihsa:29916.
    UCSCiuc002inf.1. human.

    Polymorphism databases

    DMDMi14916716.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF121861 mRNA. Translation: AAD27834.1 . Different initiation.
    BT006723 mRNA. Translation: AAP35369.1 .
    AK023932 mRNA. Translation: BAB14732.1 .
    AK091852 mRNA. Translation: BAG52428.1 .
    AK298551 mRNA. Translation: BAG60747.1 .
    AK316374 mRNA. Translation: BAH14745.1 .
    AC006468 Genomic DNA. No translation available.
    CH471109 Genomic DNA. Translation: EAW94754.1 .
    BC000768 mRNA. Translation: AAH00768.1 .
    BC103721 mRNA. Translation: AAI03722.1 .
    CCDSi CCDS11526.1.
    RefSeqi NP_037455.2. NM_013323.2.
    NP_689450.1. NM_152244.1.
    XP_005257317.1. XM_005257260.1.
    XP_005257318.1. XM_005257261.1.
    UniGenei Hs.15827.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4IKB X-ray 1.78 A/B 7-142 [» ]
    4IKD X-ray 1.60 A 7-170 [» ]
    ProteinModelPortali Q9Y5W9.
    SMRi Q9Y5W9. Positions 15-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118960. 1 interaction.

    PTM databases

    PhosphoSitei Q9Y5W9.

    Polymorphism databases

    DMDMi 14916716.

    Proteomic databases

    MaxQBi Q9Y5W9.
    PaxDbi Q9Y5W9.
    PRIDEi Q9Y5W9.

    Protocols and materials databases

    DNASUi 29916.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359238 ; ENSP00000352175 ; ENSG00000002919 .
    ENST00000393405 ; ENSP00000377059 ; ENSG00000002919 .
    ENST00000580219 ; ENSP00000462188 ; ENSG00000002919 .
    GeneIDi 29916.
    KEGGi hsa:29916.
    UCSCi uc002inf.1. human.

    Organism-specific databases

    CTDi 29916.
    GeneCardsi GC17P046184.
    HGNCi HGNC:14975. SNX11.
    HPAi HPA044787.
    MIMi 614906. gene.
    neXtProti NX_Q9Y5W9.
    PharmGKBi PA37951.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5391.
    HOGENOMi HOG000231108.
    HOVERGENi HBG054994.
    InParanoidi Q9Y5W9.
    KOi K17924.
    OMAi HLAKGDQ.
    PhylomeDBi Q9Y5W9.
    TreeFami TF332117.

    Miscellaneous databases

    ChiTaRSi SNX11. human.
    GenomeRNAii 29916.
    NextBioi 52510.
    PROi Q9Y5W9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5W9.
    Bgeei Q9Y5W9.
    CleanExi HS_SNX11.
    Genevestigatori Q9Y5W9.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    IPR028655. SNX11.
    [Graphical view ]
    PANTHERi PTHR10555:SF36. PTHR10555:SF36. 1 hit.
    Pfami PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A large family of endosome-localized proteins related to sorting nexin 1."
      Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.
      Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Lung, Testis and Thyroid.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney and Skin.
    7. "Structure of Sorting Nexin 11 (SNX11) reveals a novel extended PX Domain (PXe Domain) critical for the inhibition of Sorting Nexin 10 (SNX10) induced vacuolation."
      Xu J., Xu T., Wu B., Ye Y., You X., Shu X., Pei D., Liu J.
      J. Biol. Chem. 288:16598-16605(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 7-170, FUNCTION, SUBUNIT, LIPID-BINDING, SUBCELLULAR LOCATION, MUTAGENESIS OF ARG-59 AND 135-ILE--VAL-139.

    Entry informationi

    Entry nameiSNX11_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5W9
    Secondary accession number(s): B3KRL6
    , B4DPY5, D3DTV0, Q53YC0, Q9H885
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: July 11, 2001
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3