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Q9Y5W8 (SNX13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sorting nexin-13
Alternative name(s):
RGS domain- and PHOX domain-containing protein
RGS-PX1
Gene names
Name:SNX13
Synonyms:KIAA0713
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length968 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis By similarity. Acts as a GAP for Galphas. Ref.1

Subcellular location

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side Ref.1.

Domain

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate. Ref.1

Sequence similarities

Belongs to the sorting nexin family.

Contains 1 PX (phox homology) domain.

Contains 1 PXA domain.

Contains 1 RGS domain.

Sequence caution

The sequence AAH22060.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA34433.1 differs from that shown. Reason: Frameshift at position 887.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y5W8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y5W8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     569-579: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 968968Sorting nexin-13
PRO_0000213860

Regions

Domain97 – 284188PXA
Domain373 – 496124RGS
Domain570 – 691122PX

Sites

Binding site6121Phosphatidylinositol 3-phosphate By similarity
Binding site6141Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding site6391Phosphatidylinositol 3-phosphate By similarity
Binding site6531Phosphatidylinositol 3-phosphate By similarity

Natural variations

Alternative sequence569 – 57911Missing in isoform 2.
VSP_006192
Natural variant4721L → S.
Corresponds to variant rs35113148 [ dbSNP | Ensembl ].
VAR_057333

Experimental info

Sequence conflict6381G → E in BAA34433. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 25, 2002. Version 4.
Checksum: 532994AE0B347FB5

FASTA968112,189
        10         20         30         40         50         60 
MLTEASLSIW GWGSLGIVLF LITFGPFVIF YLTFYILCFV GGGLVVTLLF GKTNSEKYLE 

        70         80         90        100        110        120 
QCEHSFLPPT SPGVPKCLEE MKREARTIKI DRRLTGANII DEPLQQVIQF SLRDYVQYWY 

       130        140        150        160        170        180 
YTLSDDESFL LEIRQTLQNA LIQFATRSKE IDWQPYFTTR IVDDFGTHLR VFRKAQQKIT 

       190        200        210        220        230        240 
EKDDQVKGTA EDLVDTFFEV EVEMEKEVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD 

       250        260        270        280        290        300 
FQNKIMRYFV REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNIIKLSDNI 

       310        320        330        340        350        360 
GELEAVRDKA AEELQYLRSL DTAGDDINTI KNQINSLLFV KKVCDSRIQR LQSGKEINTV 

       370        380        390        400        410        420 
KLAANFGKLC TVPLDSILVD NVALQFFMDY MQQTGGQAHL FFWMTVEGYR VTAQQQLEVL 

       430        440        450        460        470        480 
LSRQRDGKHQ TNQTKGLLRA AAVGIYEQYL SEKASPRVTV DDYLVAKLAD TLNHEDPTPE 

       490        500        510        520        530        540 
IFDDIQRKVY ELMLRDERFY PSFRQNALYV RMLAELDMLK DPSFRGSDDG DGESFNGSPT 

       550        560        570        580        590        600 
GSINLSLDDL SNVSSDDSVQ LHAYISDTVY ADYDPYAVAG VCNDHGKTYA LYAITVHRRN 

       610        620        630        640        650        660 
LNSEEMWKTY RRYSDFHDFH MRITEQFESL SSILKLPGKK TFNNMDRDFL EKRKKDLNAY 

       670        680        690        700        710        720 
LQLLLAPEMM KASPALAHYV YDFLENKAYS KGKGDFARKM DTFVNPLRNS MRNVSNAVKS 

       730        740        750        760        770        780 
LPDSLAEGMT KMSDNMGKMS ERLGQDIKQS FFKVPPLIPK TDSDPEHRRV SAQLDDNVDD 

       790        800        810        820        830        840 
NIPLRVMLLL MDEVFDLKER NQWLRRNIKN LLQQLIRATY GDTINRKIVD HVDWMTSPEQ 

       850        860        870        880        890        900 
VADSVKRFRD AFWPNGILAE AVPCRDKSIR MRTRVAGKTK LLAIMPDELK HIIGAETTRK 

       910        920        930        940        950        960 
GILRVFEMFQ HNQLNRRMVY VFLEGFLETL FPQYKFRELF NKLHSRSKQM QKYKQKLQTT 


QAPSLQKR 

« Hide

Isoform 2 [UniParc].

Checksum: AC41207BE22F3557
Show »

FASTA957110,960

References

« Hide 'large scale' references
[1]"RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking."
Zheng B., Ma Y.C., Ostrom R.S., Lavoie C., Gill G.N., Insel P.A., Huang X.Y., Farquhar M.G.
Science 294:1939-1942(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH G PROTEIN-COUPLED RECEPTORS, DOMAIN PX, SUBCELLULAR LOCATION.
[2]"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"A large family of endosome-localized proteins related to sorting nexin 1."
Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.
Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 607-968.
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 651-968.
Tissue: Placenta.
[7]"An unappreciated role for RNA surveillance."
Hillman R.T., Green R.E., Brenner S.E.
Genome Biol. 5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF420470 mRNA. Translation: AAL37728.1.
AB018256 mRNA. Translation: BAA34433.1. Frameshift.
AK315135 mRNA. Translation: BAG37586.1.
AF121862 mRNA. Translation: AAD27835.1.
CH471073 Genomic DNA. Translation: EAW93690.1.
BC022060 mRNA. Translation: AAH22060.1. Different initiation.
CCDSCCDS47551.1. [Q9Y5W8-2]
RefSeqNP_055947.1. NM_015132.4. [Q9Y5W8-2]
XP_005249729.1. XM_005249672.1. [Q9Y5W8-1]
UniGeneHs.487648.

3D structure databases

ProteinModelPortalQ9Y5W8.
SMRQ9Y5W8. Positions 588-681.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid116773. 6 interactions.
IntActQ9Y5W8. 4 interactions.
STRING9606.ENSP00000398789.

PTM databases

PhosphoSiteQ9Y5W8.

Polymorphism databases

DMDM24418867.

Proteomic databases

MaxQBQ9Y5W8.
PaxDbQ9Y5W8.
PRIDEQ9Y5W8.

Protocols and materials databases

DNASU23161.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000428135; ENSP00000398789; ENSG00000071189. [Q9Y5W8-2]
GeneID23161.
KEGGhsa:23161.
UCSCuc003stv.3. human. [Q9Y5W8-2]

Organism-specific databases

CTD23161.
GeneCardsGC07M017798.
H-InvDBHIX0006501.
HGNCHGNC:21335. SNX13.
MIM606589. gene.
neXtProtNX_Q9Y5W8.
PharmGKBPA129697240.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG313668.
HOGENOMHOG000059640.
HOVERGENHBG060026.
InParanoidQ9Y5W8.
KOK17925.
OMAGPFAIFY.
PhylomeDBQ9Y5W8.
TreeFamTF324055.

Gene expression databases

ArrayExpressQ9Y5W8.
BgeeQ9Y5W8.
CleanExHS_SNX13.
GenevestigatorQ9Y5W8.

Family and domain databases

Gene3D3.30.1520.10. 1 hit.
InterProIPR001683. Phox.
IPR003114. Phox_assoc.
IPR013996. PX_assoc_Snx13.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR013937. Sorting_nexin_C.
[Graphical view]
PfamPF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
SMARTSM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMSSF48097. SSF48097. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEPS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSNX13.
GenomeRNAi23161.
NextBio44535.
PROQ9Y5W8.
SOURCESearch...

Entry information

Entry nameSNX13_HUMAN
AccessionPrimary (citable) accession number: Q9Y5W8
Secondary accession number(s): B2RCI9 expand/collapse secondary AC list , O94821, Q8WVZ2, Q8WXH8
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 25, 2002
Last modified: July 9, 2014
This is version 128 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM