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Q9Y5W8

- SNX13_HUMAN

UniProt

Q9Y5W8 - SNX13_HUMAN

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Protein
Sorting nexin-13
Gene
SNX13, KIAA0713
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis By similarity. Acts as a GAP for Galphas.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei612 – 6121Phosphatidylinositol 3-phosphate By similarity
Binding sitei614 – 6141Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei639 – 6391Phosphatidylinositol 3-phosphate By similarity
Binding sitei653 – 6531Phosphatidylinositol 3-phosphate By similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: UniProtKB

GO - Biological processi

  1. intracellular protein transport Source: UniProtKB
  2. positive regulation of GTPase activity Source: UniProtKB
  3. termination of G-protein coupled receptor signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-13
Alternative name(s):
RGS domain- and PHOX domain-containing protein
RGS-PX1
Gene namesi
Name:SNX13
Synonyms:KIAA0713
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21335. SNX13.

Subcellular locationi

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side 1 Publication

GO - Cellular componenti

  1. early endosome Source: UniProtKB
  2. early endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA129697240.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 968968Sorting nexin-13
PRO_0000213860Add
BLAST

Proteomic databases

MaxQBiQ9Y5W8.
PaxDbiQ9Y5W8.
PRIDEiQ9Y5W8.

PTM databases

PhosphoSiteiQ9Y5W8.

Expressioni

Gene expression databases

ArrayExpressiQ9Y5W8.
BgeeiQ9Y5W8.
CleanExiHS_SNX13.
GenevestigatoriQ9Y5W8.

Interactioni

Protein-protein interaction databases

BioGridi116773. 6 interactions.
IntActiQ9Y5W8. 4 interactions.
STRINGi9606.ENSP00000398789.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5W8.
SMRiQ9Y5W8. Positions 588-681.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 284188PXA
Add
BLAST
Domaini373 – 496124RGS
Add
BLAST
Domaini570 – 691122PX
Add
BLAST

Domaini

The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.
Contains 1 PXA domain.
Contains 1 RGS domain.

Phylogenomic databases

eggNOGiNOG313668.
HOGENOMiHOG000059640.
HOVERGENiHBG060026.
InParanoidiQ9Y5W8.
KOiK17925.
OMAiGPFAIFY.
PhylomeDBiQ9Y5W8.
TreeFamiTF324055.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
IPR003114. Phox_assoc.
IPR013996. PX_assoc_Snx13.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR013937. Sorting_nexin_C.
[Graphical view]
PfamiPF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y5W8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLTEASLSIW GWGSLGIVLF LITFGPFVIF YLTFYILCFV GGGLVVTLLF    50
GKTNSEKYLE QCEHSFLPPT SPGVPKCLEE MKREARTIKI DRRLTGANII 100
DEPLQQVIQF SLRDYVQYWY YTLSDDESFL LEIRQTLQNA LIQFATRSKE 150
IDWQPYFTTR IVDDFGTHLR VFRKAQQKIT EKDDQVKGTA EDLVDTFFEV 200
EVEMEKEVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD FQNKIMRYFV 250
REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNIIKLSDNI 300
GELEAVRDKA AEELQYLRSL DTAGDDINTI KNQINSLLFV KKVCDSRIQR 350
LQSGKEINTV KLAANFGKLC TVPLDSILVD NVALQFFMDY MQQTGGQAHL 400
FFWMTVEGYR VTAQQQLEVL LSRQRDGKHQ TNQTKGLLRA AAVGIYEQYL 450
SEKASPRVTV DDYLVAKLAD TLNHEDPTPE IFDDIQRKVY ELMLRDERFY 500
PSFRQNALYV RMLAELDMLK DPSFRGSDDG DGESFNGSPT GSINLSLDDL 550
SNVSSDDSVQ LHAYISDTVY ADYDPYAVAG VCNDHGKTYA LYAITVHRRN 600
LNSEEMWKTY RRYSDFHDFH MRITEQFESL SSILKLPGKK TFNNMDRDFL 650
EKRKKDLNAY LQLLLAPEMM KASPALAHYV YDFLENKAYS KGKGDFARKM 700
DTFVNPLRNS MRNVSNAVKS LPDSLAEGMT KMSDNMGKMS ERLGQDIKQS 750
FFKVPPLIPK TDSDPEHRRV SAQLDDNVDD NIPLRVMLLL MDEVFDLKER 800
NQWLRRNIKN LLQQLIRATY GDTINRKIVD HVDWMTSPEQ VADSVKRFRD 850
AFWPNGILAE AVPCRDKSIR MRTRVAGKTK LLAIMPDELK HIIGAETTRK 900
GILRVFEMFQ HNQLNRRMVY VFLEGFLETL FPQYKFRELF NKLHSRSKQM 950
QKYKQKLQTT QAPSLQKR 968
Length:968
Mass (Da):112,189
Last modified:October 25, 2002 - v4
Checksum:i532994AE0B347FB5
GO
Isoform 2 (identifier: Q9Y5W8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     569-579: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

Show »
Length:957
Mass (Da):110,960
Checksum:iAC41207BE22F3557
GO

Sequence cautioni

The sequence BAA34433.1 differs from that shown. Reason: Frameshift at position 887.
The sequence AAH22060.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti472 – 4721L → S.
Corresponds to variant rs35113148 [ dbSNP | Ensembl ].
VAR_057333

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei569 – 57911Missing in isoform 2.
VSP_006192Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti638 – 6381G → E in BAA34433. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF420470 mRNA. Translation: AAL37728.1.
AB018256 mRNA. Translation: BAA34433.1. Frameshift.
AK315135 mRNA. Translation: BAG37586.1.
AF121862 mRNA. Translation: AAD27835.1.
CH471073 Genomic DNA. Translation: EAW93690.1.
BC022060 mRNA. Translation: AAH22060.1. Different initiation.
CCDSiCCDS47551.1. [Q9Y5W8-2]
RefSeqiNP_055947.1. NM_015132.4. [Q9Y5W8-2]
XP_005249729.1. XM_005249672.1. [Q9Y5W8-1]
UniGeneiHs.487648.

Genome annotation databases

EnsembliENST00000428135; ENSP00000398789; ENSG00000071189. [Q9Y5W8-2]
GeneIDi23161.
KEGGihsa:23161.
UCSCiuc003stv.3. human. [Q9Y5W8-2]

Polymorphism databases

DMDMi24418867.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF420470 mRNA. Translation: AAL37728.1 .
AB018256 mRNA. Translation: BAA34433.1 . Frameshift.
AK315135 mRNA. Translation: BAG37586.1 .
AF121862 mRNA. Translation: AAD27835.1 .
CH471073 Genomic DNA. Translation: EAW93690.1 .
BC022060 mRNA. Translation: AAH22060.1 . Different initiation.
CCDSi CCDS47551.1. [Q9Y5W8-2 ]
RefSeqi NP_055947.1. NM_015132.4. [Q9Y5W8-2 ]
XP_005249729.1. XM_005249672.1. [Q9Y5W8-1 ]
UniGenei Hs.487648.

3D structure databases

ProteinModelPortali Q9Y5W8.
SMRi Q9Y5W8. Positions 588-681.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116773. 6 interactions.
IntActi Q9Y5W8. 4 interactions.
STRINGi 9606.ENSP00000398789.

PTM databases

PhosphoSitei Q9Y5W8.

Polymorphism databases

DMDMi 24418867.

Proteomic databases

MaxQBi Q9Y5W8.
PaxDbi Q9Y5W8.
PRIDEi Q9Y5W8.

Protocols and materials databases

DNASUi 23161.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000428135 ; ENSP00000398789 ; ENSG00000071189 . [Q9Y5W8-2 ]
GeneIDi 23161.
KEGGi hsa:23161.
UCSCi uc003stv.3. human. [Q9Y5W8-2 ]

Organism-specific databases

CTDi 23161.
GeneCardsi GC07M017798.
H-InvDB HIX0006501.
HGNCi HGNC:21335. SNX13.
MIMi 606589. gene.
neXtProti NX_Q9Y5W8.
PharmGKBi PA129697240.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313668.
HOGENOMi HOG000059640.
HOVERGENi HBG060026.
InParanoidi Q9Y5W8.
KOi K17925.
OMAi GPFAIFY.
PhylomeDBi Q9Y5W8.
TreeFami TF324055.

Miscellaneous databases

GeneWikii SNX13.
GenomeRNAii 23161.
NextBioi 44535.
PROi Q9Y5W8.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y5W8.
Bgeei Q9Y5W8.
CleanExi HS_SNX13.
Genevestigatori Q9Y5W8.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
IPR003114. Phox_assoc.
IPR013996. PX_assoc_Snx13.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR013937. Sorting_nexin_C.
[Graphical view ]
Pfami PF08628. Nexin_C. 1 hit.
PF00787. PX. 1 hit.
PF02194. PXA. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
SM00313. PXA. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
PS51207. PXA. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking."
    Zheng B., Ma Y.C., Ostrom R.S., Lavoie C., Gill G.N., Insel P.A., Huang X.Y., Farquhar M.G.
    Science 294:1939-1942(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH G PROTEIN-COUPLED RECEPTORS, DOMAIN PX, SUBCELLULAR LOCATION.
  2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "A large family of endosome-localized proteins related to sorting nexin 1."
    Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.
    Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 607-968.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 651-968.
    Tissue: Placenta.
  7. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).

Entry informationi

Entry nameiSNX13_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5W8
Secondary accession number(s): B2RCI9
, O94821, Q8WVZ2, Q8WXH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 25, 2002
Last modified: July 9, 2014
This is version 128 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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