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Q9Y5W8

- SNX13_HUMAN

UniProt

Q9Y5W8 - SNX13_HUMAN

Protein

Sorting nexin-13

Gene

SNX13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 4 (25 Oct 2002)
      Previous versions | rss
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    Functioni

    May be involved in several stages of intracellular trafficking. May play a role in endosome homeostasis By similarity. Acts as a GAP for Galphas.By similarity1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei612 – 6121Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei614 – 6141Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei639 – 6391Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei653 – 6531Phosphatidylinositol 3-phosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol binding Source: UniProtKB

    GO - Biological processi

    1. intracellular protein transport Source: UniProtKB
    2. positive regulation of GTPase activity Source: UniProtKB
    3. termination of G-protein coupled receptor signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Signal transduction inhibitor

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-13
    Alternative name(s):
    RGS domain- and PHOX domain-containing protein
    RGS-PX1
    Gene namesi
    Name:SNX13
    Synonyms:KIAA0713
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21335. SNX13.

    Subcellular locationi

    Early endosome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication

    GO - Cellular componenti

    1. early endosome Source: UniProtKB
    2. early endosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA129697240.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 968968Sorting nexin-13PRO_0000213860Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y5W8.
    PaxDbiQ9Y5W8.
    PRIDEiQ9Y5W8.

    PTM databases

    PhosphoSiteiQ9Y5W8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y5W8.
    BgeeiQ9Y5W8.
    CleanExiHS_SNX13.
    GenevestigatoriQ9Y5W8.

    Interactioni

    Protein-protein interaction databases

    BioGridi116773. 6 interactions.
    IntActiQ9Y5W8. 4 interactions.
    STRINGi9606.ENSP00000398789.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5W8.
    SMRiQ9Y5W8. Positions 588-681.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini97 – 284188PXAPROSITE-ProRule annotationAdd
    BLAST
    Domaini373 – 496124RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini570 – 691122PXPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate.1 Publication

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation
    Contains 1 PXA domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG313668.
    HOGENOMiHOG000059640.
    HOVERGENiHBG060026.
    InParanoidiQ9Y5W8.
    KOiK17925.
    OMAiGPFAIFY.
    PhylomeDBiQ9Y5W8.
    TreeFamiTF324055.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    IPR003114. Phox_assoc.
    IPR013996. PX_assoc_Snx13.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR013937. Sorting_nexin_C.
    [Graphical view]
    PfamiPF08628. Nexin_C. 1 hit.
    PF00787. PX. 1 hit.
    PF02194. PXA. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    SMARTiSM00312. PX. 1 hit.
    SM00313. PXA. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    PS51207. PXA. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y5W8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLTEASLSIW GWGSLGIVLF LITFGPFVIF YLTFYILCFV GGGLVVTLLF    50
    GKTNSEKYLE QCEHSFLPPT SPGVPKCLEE MKREARTIKI DRRLTGANII 100
    DEPLQQVIQF SLRDYVQYWY YTLSDDESFL LEIRQTLQNA LIQFATRSKE 150
    IDWQPYFTTR IVDDFGTHLR VFRKAQQKIT EKDDQVKGTA EDLVDTFFEV 200
    EVEMEKEVCR DLVCTSPKDE EGFLRDLCEV LLYLLLPPGD FQNKIMRYFV 250
    REILARGILL PLINQLSDPD YINQYVIWMI RDSNCNYEAF MNIIKLSDNI 300
    GELEAVRDKA AEELQYLRSL DTAGDDINTI KNQINSLLFV KKVCDSRIQR 350
    LQSGKEINTV KLAANFGKLC TVPLDSILVD NVALQFFMDY MQQTGGQAHL 400
    FFWMTVEGYR VTAQQQLEVL LSRQRDGKHQ TNQTKGLLRA AAVGIYEQYL 450
    SEKASPRVTV DDYLVAKLAD TLNHEDPTPE IFDDIQRKVY ELMLRDERFY 500
    PSFRQNALYV RMLAELDMLK DPSFRGSDDG DGESFNGSPT GSINLSLDDL 550
    SNVSSDDSVQ LHAYISDTVY ADYDPYAVAG VCNDHGKTYA LYAITVHRRN 600
    LNSEEMWKTY RRYSDFHDFH MRITEQFESL SSILKLPGKK TFNNMDRDFL 650
    EKRKKDLNAY LQLLLAPEMM KASPALAHYV YDFLENKAYS KGKGDFARKM 700
    DTFVNPLRNS MRNVSNAVKS LPDSLAEGMT KMSDNMGKMS ERLGQDIKQS 750
    FFKVPPLIPK TDSDPEHRRV SAQLDDNVDD NIPLRVMLLL MDEVFDLKER 800
    NQWLRRNIKN LLQQLIRATY GDTINRKIVD HVDWMTSPEQ VADSVKRFRD 850
    AFWPNGILAE AVPCRDKSIR MRTRVAGKTK LLAIMPDELK HIIGAETTRK 900
    GILRVFEMFQ HNQLNRRMVY VFLEGFLETL FPQYKFRELF NKLHSRSKQM 950
    QKYKQKLQTT QAPSLQKR 968
    Length:968
    Mass (Da):112,189
    Last modified:October 25, 2002 - v4
    Checksum:i532994AE0B347FB5
    GO
    Isoform 2 (identifier: Q9Y5W8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         569-579: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.

    Show »
    Length:957
    Mass (Da):110,960
    Checksum:iAC41207BE22F3557
    GO

    Sequence cautioni

    The sequence BAA34433.1 differs from that shown. Reason: Frameshift at position 887.
    The sequence AAH22060.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti638 – 6381G → E in BAA34433. (PubMed:11729322)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti472 – 4721L → S.
    Corresponds to variant rs35113148 [ dbSNP | Ensembl ].
    VAR_057333

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei569 – 57911Missing in isoform 2. 2 PublicationsVSP_006192Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF420470 mRNA. Translation: AAL37728.1.
    AB018256 mRNA. Translation: BAA34433.1. Frameshift.
    AK315135 mRNA. Translation: BAG37586.1.
    AF121862 mRNA. Translation: AAD27835.1.
    CH471073 Genomic DNA. Translation: EAW93690.1.
    BC022060 mRNA. Translation: AAH22060.1. Different initiation.
    CCDSiCCDS47551.1. [Q9Y5W8-2]
    RefSeqiNP_055947.1. NM_015132.4. [Q9Y5W8-2]
    XP_005249729.1. XM_005249672.1. [Q9Y5W8-1]
    UniGeneiHs.487648.

    Genome annotation databases

    EnsembliENST00000428135; ENSP00000398789; ENSG00000071189. [Q9Y5W8-2]
    GeneIDi23161.
    KEGGihsa:23161.
    UCSCiuc003stv.3. human. [Q9Y5W8-2]

    Polymorphism databases

    DMDMi24418867.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF420470 mRNA. Translation: AAL37728.1 .
    AB018256 mRNA. Translation: BAA34433.1 . Frameshift.
    AK315135 mRNA. Translation: BAG37586.1 .
    AF121862 mRNA. Translation: AAD27835.1 .
    CH471073 Genomic DNA. Translation: EAW93690.1 .
    BC022060 mRNA. Translation: AAH22060.1 . Different initiation.
    CCDSi CCDS47551.1. [Q9Y5W8-2 ]
    RefSeqi NP_055947.1. NM_015132.4. [Q9Y5W8-2 ]
    XP_005249729.1. XM_005249672.1. [Q9Y5W8-1 ]
    UniGenei Hs.487648.

    3D structure databases

    ProteinModelPortali Q9Y5W8.
    SMRi Q9Y5W8. Positions 588-681.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116773. 6 interactions.
    IntActi Q9Y5W8. 4 interactions.
    STRINGi 9606.ENSP00000398789.

    PTM databases

    PhosphoSitei Q9Y5W8.

    Polymorphism databases

    DMDMi 24418867.

    Proteomic databases

    MaxQBi Q9Y5W8.
    PaxDbi Q9Y5W8.
    PRIDEi Q9Y5W8.

    Protocols and materials databases

    DNASUi 23161.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000428135 ; ENSP00000398789 ; ENSG00000071189 . [Q9Y5W8-2 ]
    GeneIDi 23161.
    KEGGi hsa:23161.
    UCSCi uc003stv.3. human. [Q9Y5W8-2 ]

    Organism-specific databases

    CTDi 23161.
    GeneCardsi GC07M017798.
    H-InvDB HIX0006501.
    HGNCi HGNC:21335. SNX13.
    MIMi 606589. gene.
    neXtProti NX_Q9Y5W8.
    PharmGKBi PA129697240.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313668.
    HOGENOMi HOG000059640.
    HOVERGENi HBG060026.
    InParanoidi Q9Y5W8.
    KOi K17925.
    OMAi GPFAIFY.
    PhylomeDBi Q9Y5W8.
    TreeFami TF324055.

    Miscellaneous databases

    GeneWikii SNX13.
    GenomeRNAii 23161.
    NextBioi 44535.
    PROi Q9Y5W8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5W8.
    Bgeei Q9Y5W8.
    CleanExi HS_SNX13.
    Genevestigatori Q9Y5W8.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    IPR003114. Phox_assoc.
    IPR013996. PX_assoc_Snx13.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR013937. Sorting_nexin_C.
    [Graphical view ]
    Pfami PF08628. Nexin_C. 1 hit.
    PF00787. PX. 1 hit.
    PF02194. PXA. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    SMARTi SM00312. PX. 1 hit.
    SM00313. PXA. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    PS51207. PXA. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking."
      Zheng B., Ma Y.C., Ostrom R.S., Lavoie C., Gill G.N., Insel P.A., Huang X.Y., Farquhar M.G.
      Science 294:1939-1942(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, INTERACTION WITH G PROTEIN-COUPLED RECEPTORS, DOMAIN PX, SUBCELLULAR LOCATION.
    2. "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "A large family of endosome-localized proteins related to sorting nexin 1."
      Teasdale R.D., Loci D., Houghton F., Karlsson L., Gleeson P.A.
      Biochem. J. 358:7-16(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 607-968.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 651-968.
      Tissue: Placenta.
    7. Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).

    Entry informationi

    Entry nameiSNX13_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5W8
    Secondary accession number(s): B2RCI9
    , O94821, Q8WVZ2, Q8WXH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: October 25, 2002
    Last modified: October 1, 2014
    This is version 129 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3