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Q9Y5W5

- WIF1_HUMAN

UniProt

Q9Y5W5 - WIF1_HUMAN

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Protein

Wnt inhibitory factor 1

Gene

WIF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. positive regulation of fat cell differentiation Source: Ensembl
  3. signal transduction Source: ProtInc
  4. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
SignaLinkiQ9Y5W5.

Names & Taxonomyi

Protein namesi
Recommended name:
Wnt inhibitory factor 1
Short name:
WIF-1
Gene namesi
Name:WIF1
ORF Names:UNQ191/PRO217
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:18081. WIF1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38291.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 379351Wnt inhibitory factor 1PRO_0000007775Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi140 ↔ 1771 Publication
Disulfide bondi182 ↔ 192By similarity
Disulfide bondi186 ↔ 198By similarity
Disulfide bondi200 ↔ 209By similarity
Disulfide bondi214 ↔ 224By similarity
Disulfide bondi218 ↔ 230By similarity
Disulfide bondi232 ↔ 241By similarity
Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi246 ↔ 256By similarity
Disulfide bondi250 ↔ 262By similarity
Disulfide bondi278 ↔ 288By similarity
Disulfide bondi282 ↔ 294By similarity
Disulfide bondi296 ↔ 305By similarity
Disulfide bondi310 ↔ 320By similarity
Disulfide bondi314 ↔ 326By similarity
Disulfide bondi328 ↔ 337By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y5W5.
PRIDEiQ9Y5W5.

Expressioni

Gene expression databases

BgeeiQ9Y5W5.
CleanExiHS_WIF1.
ExpressionAtlasiQ9Y5W5. baseline and differential.
GenevestigatoriQ9Y5W5.

Organism-specific databases

HPAiHPA039104.

Interactioni

Subunit structurei

Interacts with MYOC.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Wnt3aP274677EBI-3922719,EBI-2899665From a different organism.
Wnt5aP227257EBI-3922719,EBI-1570983From a different organism.

Protein-protein interaction databases

BioGridi116366. 3 interactions.
DIPiDIP-59097N.
IntActiQ9Y5W5. 8 interactions.
MINTiMINT-8389706.
STRINGi9606.ENSP00000286574.

Structurei

Secondary structure

1
379
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi36 – 405Combined sources
Helixi42 – 498Combined sources
Beta strandi55 – 595Combined sources
Helixi65 – 673Combined sources
Helixi70 – 756Combined sources
Beta strandi85 – 939Combined sources
Beta strandi95 – 973Combined sources
Beta strandi99 – 10911Combined sources
Turni111 – 1133Combined sources
Beta strandi118 – 1214Combined sources
Beta strandi123 – 1264Combined sources
Beta strandi132 – 1376Combined sources
Beta strandi142 – 1443Combined sources
Beta strandi146 – 15813Combined sources
Beta strandi163 – 1664Combined sources
Beta strandi173 – 1775Combined sources
Turni206 – 2094Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2D3JNMR-A32-181[»]
2YGNX-ray1.85A35-178[»]
2YGOX-ray1.85A35-210[»]
2YGPX-ray2.22A35-210[»]
2YGQX-ray3.95A35-346[»]
ProteinModelPortaliQ9Y5W5.
SMRiQ9Y5W5. Positions 35-337.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y5W5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 177140WIFPROSITE-ProRule annotationAdd
BLAST
Domaini178 – 21033EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini211 – 24232EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini243 – 27129EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini274 – 30633EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini307 – 33832EGF-like 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 EGF-like domains.PROSITE-ProRule annotation
Contains 1 WIF domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG328460.
GeneTreeiENSGT00760000119131.
HOVERGENiHBG017335.
InParanoidiQ9Y5W5.
KOiK01691.
OMAiDKGIMAD.
OrthoDBiEOG7VQJD2.
PhylomeDBiQ9Y5W5.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR003306. WIF.
IPR013309. Wnt-inh.
[Graphical view]
PfamiPF12661. hEGF. 4 hits.
PF02019. WIF. 1 hit.
[Graphical view]
PRINTSiPR01901. WIFPROTEIN.
ProDomiPD013948. WIF. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00181. EGF. 5 hits.
SM00469. WIF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 5 hits.
PS50814. WIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5W5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARRSAFPAA ALWLWSILLC LLALRAEAGP PQEESLYLWI DAHQARVLIG
60 70 80 90 100
FEEDILIVSE GKMAPFTHDF RKAQQRMPAI PVNIHSMNFT WQAAGQAEYF
110 120 130 140 150
YEFLSLRSLD KGIMADPTVN VPLLGTVPHK ASVVQVGFPC LGKQDGVAAF
160 170 180 190 200
EVDVIVMNSE GNTILQTPQN AIFFKTCQQA ECPGGCRNGG FCNERRICEC
210 220 230 240 250
PDGFHGPHCE KALCTPRCMN GGLCVTPGFC ICPPGFYGVN CDKANCSTTC
260 270 280 290 300
FNGGTCFYPG KCICPPGLEG EQCEISKCPQ PCRNGGKCIG KSKCKCSKGY
310 320 330 340 350
QGDLCSKPVC EPGCGAHGTC HEPNKCQCQE GWHGRHCNKR YEASLIHALR
360 370
PAGAQLRQHT PSLKKAEERR DPPESNYIW
Length:379
Mass (Da):41,528
Last modified:March 15, 2005 - v3
Checksum:i32ADFA6644833E9D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti166 – 1661Q → K in AAH18037. (PubMed:15489334)Curated
Sequence conflicti178 – 1781Q → L in AAD25402. (PubMed:10201374)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF122922 mRNA. Translation: AAD25402.1.
AY358344 mRNA. Translation: AAQ88710.1.
BC018037 mRNA. Translation: AAH18037.1.
CCDSiCCDS8971.1.
PIRiA59180.
RefSeqiNP_009122.2. NM_007191.4.
UniGeneiHs.284122.

Genome annotation databases

EnsembliENST00000286574; ENSP00000286574; ENSG00000156076.
GeneIDi11197.
KEGGihsa:11197.
UCSCiuc001ssk.3. human.

Polymorphism databases

DMDMi61252765.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF122922 mRNA. Translation: AAD25402.1 .
AY358344 mRNA. Translation: AAQ88710.1 .
BC018037 mRNA. Translation: AAH18037.1 .
CCDSi CCDS8971.1.
PIRi A59180.
RefSeqi NP_009122.2. NM_007191.4.
UniGenei Hs.284122.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2D3J NMR - A 32-181 [» ]
2YGN X-ray 1.85 A 35-178 [» ]
2YGO X-ray 1.85 A 35-210 [» ]
2YGP X-ray 2.22 A 35-210 [» ]
2YGQ X-ray 3.95 A 35-346 [» ]
ProteinModelPortali Q9Y5W5.
SMRi Q9Y5W5. Positions 35-337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116366. 3 interactions.
DIPi DIP-59097N.
IntActi Q9Y5W5. 8 interactions.
MINTi MINT-8389706.
STRINGi 9606.ENSP00000286574.

Polymorphism databases

DMDMi 61252765.

Proteomic databases

PaxDbi Q9Y5W5.
PRIDEi Q9Y5W5.

Protocols and materials databases

DNASUi 11197.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000286574 ; ENSP00000286574 ; ENSG00000156076 .
GeneIDi 11197.
KEGGi hsa:11197.
UCSCi uc001ssk.3. human.

Organism-specific databases

CTDi 11197.
GeneCardsi GC12M065444.
HGNCi HGNC:18081. WIF1.
HPAi HPA039104.
MIMi 605186. gene.
neXtProti NX_Q9Y5W5.
PharmGKBi PA38291.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG328460.
GeneTreei ENSGT00760000119131.
HOVERGENi HBG017335.
InParanoidi Q9Y5W5.
KOi K01691.
OMAi DKGIMAD.
OrthoDBi EOG7VQJD2.
PhylomeDBi Q9Y5W5.

Enzyme and pathway databases

Reactomei REACT_200643. negative regulation of TCF-dependent signaling by WNT ligand antagonists.
SignaLinki Q9Y5W5.

Miscellaneous databases

ChiTaRSi WIF1. human.
EvolutionaryTracei Q9Y5W5.
GeneWikii WIF1.
GenomeRNAii 11197.
NextBioi 42617.
PROi Q9Y5W5.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y5W5.
CleanExi HS_WIF1.
ExpressionAtlasi Q9Y5W5. baseline and differential.
Genevestigatori Q9Y5W5.

Family and domain databases

InterProi IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR003306. WIF.
IPR013309. Wnt-inh.
[Graphical view ]
Pfami PF12661. hEGF. 4 hits.
PF02019. WIF. 1 hit.
[Graphical view ]
PRINTSi PR01901. WIFPROTEIN.
ProDomi PD013948. WIF. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00181. EGF. 5 hits.
SM00469. WIF. 1 hit.
[Graphical view ]
PROSITEi PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 5 hits.
PS50814. WIF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A new secreted protein that binds to Wnt proteins and inhibits their activities."
    Hsieh J.-C., Kodjabachian L., Rebbert M.L., Rattner A., Smallwood P.M., Samos C.H., Nusse R., Dawid I.B., Nathans J.
    Nature 398:431-436(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: INTERACTION WITH MYOC.
  5. "NMR structure of the WIF domain of the human Wnt-inhibitory factor-1."
    Liepinsh E., Banyai L., Patthy L., Otting G.
    J. Mol. Biol. 357:942-950(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 32-181, DISULFIDE BOND.

Entry informationi

Entry nameiWIF1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5W5
Secondary accession number(s): Q6UXI1, Q8WVG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 15, 2005
Last modified: November 26, 2014
This is version 133 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3