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Protein

Wnt inhibitory factor 1

Gene

WIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.

GO - Molecular functioni

  • Wnt-protein binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of Wnt signaling pathway Source: ParkinsonsUK-UCL
  • positive regulation of fat cell differentiation Source: Ensembl
  • signal transduction Source: ProtInc
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-201681 TCF dependent signaling in response to WNT
R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists
SignaLinkiQ9Y5W5
SIGNORiQ9Y5W5

Names & Taxonomyi

Protein namesi
Recommended name:
Wnt inhibitory factor 1
Short name:
WIF-1
Gene namesi
Name:WIF1
ORF Names:UNQ191/PRO217
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000156076.9
HGNCiHGNC:18081 WIF1
MIMi605186 gene
neXtProtiNX_Q9Y5W5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi11197
OpenTargetsiENSG00000156076
PharmGKBiPA38291

Polymorphism and mutation databases

BioMutaiWIF1
DMDMi61252765

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000777529 – 379Wnt inhibitory factor 1Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi140 ↔ 1771 Publication
Disulfide bondi182 ↔ 192By similarity
Disulfide bondi186 ↔ 198By similarity
Disulfide bondi200 ↔ 209By similarity
Disulfide bondi214 ↔ 224By similarity
Disulfide bondi218 ↔ 230By similarity
Disulfide bondi232 ↔ 241By similarity
Glycosylationi245N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi246 ↔ 256By similarity
Disulfide bondi250 ↔ 262By similarity
Disulfide bondi278 ↔ 288By similarity
Disulfide bondi282 ↔ 294By similarity
Disulfide bondi296 ↔ 305By similarity
Disulfide bondi310 ↔ 320By similarity
Disulfide bondi314 ↔ 326By similarity
Disulfide bondi328 ↔ 337By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y5W5
PeptideAtlasiQ9Y5W5
PRIDEiQ9Y5W5

PTM databases

iPTMnetiQ9Y5W5
PhosphoSitePlusiQ9Y5W5

Expressioni

Gene expression databases

BgeeiENSG00000156076
CleanExiHS_WIF1
ExpressionAtlasiQ9Y5W5 baseline and differential
GenevisibleiQ9Y5W5 HS

Organism-specific databases

HPAiHPA039104

Interactioni

Subunit structurei

Interacts with MYOC.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • Wnt-protein binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi11636610 interactors.
DIPiDIP-59097N
IntActiQ9Y5W5 15 interactors.
MINTiQ9Y5W5
STRINGi9606.ENSP00000286574

Structurei

Secondary structure

1379
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi36 – 40Combined sources5
Helixi42 – 49Combined sources8
Beta strandi55 – 59Combined sources5
Helixi65 – 67Combined sources3
Beta strandi68 – 70Combined sources3
Helixi74 – 76Combined sources3
Beta strandi85 – 93Combined sources9
Beta strandi95 – 97Combined sources3
Beta strandi99 – 109Combined sources11
Beta strandi111 – 113Combined sources3
Beta strandi118 – 121Combined sources4
Beta strandi123 – 126Combined sources4
Beta strandi131 – 137Combined sources7
Beta strandi146 – 158Combined sources13
Beta strandi163 – 165Combined sources3
Beta strandi173 – 177Combined sources5
Turni206 – 209Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D3JNMR-A32-181[»]
2YGNX-ray1.85A35-178[»]
2YGOX-ray1.85A35-210[»]
2YGPX-ray2.22A35-210[»]
2YGQX-ray3.95A35-346[»]
ProteinModelPortaliQ9Y5W5
SMRiQ9Y5W5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y5W5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 177WIFPROSITE-ProRule annotationAdd BLAST140
Domaini178 – 210EGF-like 1PROSITE-ProRule annotationAdd BLAST33
Domaini211 – 242EGF-like 2PROSITE-ProRule annotationAdd BLAST32
Domaini243 – 271EGF-like 3PROSITE-ProRule annotationAdd BLAST29
Domaini274 – 306EGF-like 4PROSITE-ProRule annotationAdd BLAST33
Domaini307 – 338EGF-like 5PROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IQQ0 Eukaryota
ENOG41104IN LUCA
GeneTreeiENSGT00760000119131
HOVERGENiHBG017335
InParanoidiQ9Y5W5
KOiK01691
OMAiDKGIMAD
OrthoDBiEOG091G08T8
PhylomeDBiQ9Y5W5

Family and domain databases

Gene3Di2.60.40.21701 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR003306 WIF
IPR038677 WIF_sf
IPR013309 Wnt-inh
PfamiView protein in Pfam
PF12661 hEGF, 2 hits
PF02019 WIF, 1 hit
PRINTSiPR01901 WIFPROTEIN
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013948 WIF, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00469 WIF, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 5 hits
PS50814 WIF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y5W5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARRSAFPAA ALWLWSILLC LLALRAEAGP PQEESLYLWI DAHQARVLIG
60 70 80 90 100
FEEDILIVSE GKMAPFTHDF RKAQQRMPAI PVNIHSMNFT WQAAGQAEYF
110 120 130 140 150
YEFLSLRSLD KGIMADPTVN VPLLGTVPHK ASVVQVGFPC LGKQDGVAAF
160 170 180 190 200
EVDVIVMNSE GNTILQTPQN AIFFKTCQQA ECPGGCRNGG FCNERRICEC
210 220 230 240 250
PDGFHGPHCE KALCTPRCMN GGLCVTPGFC ICPPGFYGVN CDKANCSTTC
260 270 280 290 300
FNGGTCFYPG KCICPPGLEG EQCEISKCPQ PCRNGGKCIG KSKCKCSKGY
310 320 330 340 350
QGDLCSKPVC EPGCGAHGTC HEPNKCQCQE GWHGRHCNKR YEASLIHALR
360 370
PAGAQLRQHT PSLKKAEERR DPPESNYIW
Length:379
Mass (Da):41,528
Last modified:March 15, 2005 - v3
Checksum:i32ADFA6644833E9D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti166Q → K in AAH18037 (PubMed:15489334).Curated1
Sequence conflicti178Q → L in AAD25402 (PubMed:10201374).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF122922 mRNA Translation: AAD25402.1
AY358344 mRNA Translation: AAQ88710.1
BC018037 mRNA Translation: AAH18037.1
CCDSiCCDS8971.1
PIRiA59180
RefSeqiNP_009122.2, NM_007191.4
UniGeneiHs.284122

Genome annotation databases

EnsembliENST00000286574; ENSP00000286574; ENSG00000156076
GeneIDi11197
KEGGihsa:11197
UCSCiuc001ssk.4 human

Similar proteinsi

Entry informationi

Entry nameiWIF1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5W5
Secondary accession number(s): Q6UXI1, Q8WVG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 15, 2005
Last modified: April 25, 2018
This is version 163 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome