Q9Y5W3 (KLF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Krueppel-like factor 2

Alternative name(s):
Lung krueppel-like factor

Gene names

Name:	KLF2
Synonyms:	LKLF

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	355 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to the CACCC box in the beta-globin gene promoter and activates transcription By similarity.
Subunit structure	Interacts with WWP1. Ref.6
Subcellular location	Nucleus By similarity.
Post-translational modification	Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein By similarity.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator
PTM	Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell morphogenesis Inferred from electronic annotation. Source: Compara cellular response to hydrogen peroxide Inferred from electronic annotation. Source: Compara cellular response to interleukin-1 Inferred from electronic annotation. Source: Compara cellular response to laminar fluid shear stress Inferred from mutant phenotype PubMed 23043106. Source: BHF-UCL cellular response to tumor necrosis factor Inferred from electronic annotation. Source: Compara erythrocyte maturation Inferred from electronic annotation. Source: Compara in utero embryonic development Inferred from electronic annotation. Source: Compara multicellular organism growth Inferred from electronic annotation. Source: Compara negative regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara positive regulation of protein metabolic process Inferred from genetic interaction PubMed 20551324. Source: BHF-UCL positive regulation of transcription from RNA polymerase II promoter in response to stress Inferred from mutant phenotype PubMed 23043106. Source: BHF-UCL transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Non-traceable author statement. Source: UniProtKB zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 355	355	Krueppel-like factor 2		PRO_0000047162
Regions
	Zinc finger	272 – 296	25	C2H2-type 1
	Zinc finger	302 – 326	25	C2H2-type 2
	Zinc finger	332 – 354	23	C2H2-type 3
	Region	111 – 268	158	Interaction with WWP1 By similarity
	Compositional bias	62 – 71	10	Poly-Pro
	Compositional bias	130 – 135	6	Poly-Gly
	Compositional bias	167 – 171	5	Poly-Pro
	Compositional bias	225 – 231	7	Poly-Ala
Natural variations
	Natural variant	104	1	L → P. Ref.1 Ref.4 Ref.5 Corresponds to variant rs3745318 [ dbSNP | Ensembl ].		VAR_038830
	Natural variant	145	1	R → P. Ref.4 Corresponds to variant rs45586032 [ dbSNP | Ensembl ].		VAR_038831
Experimental info
	Sequence conflict	43	1	S → N in AAD55891. Ref.2
	Sequence conflict	175	1	P → S in AAD55891. Ref.2
	Sequence conflict	184	1	L → M in AAD55891. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9Y5W3 [UniParc]. Last modified January 23, 2002. Version 2. Checksum: D5849C831D676AE1	FASTA	355	37,420
	10 20 30 40 50 60 MALSEPILPS FSTFASPCRE RGLQERWPRA EPESGGTDDD LNSVLDFILS MGLDGLGAEA 70 80 90 100 110 120 APEPPPPPPP PAFYYPEPGA PPPYSAPAGG LVSELLRPEL DAPLGPALHG RFLLAPPGRL 130 140 150 160 170 180 VKAEPPEADG GGGYGCAPGL TRGPRGLKRE GAPGPAASCM RGPGGRPPPP PDTPPLSPDG 190 200 210 220 230 240 PARLPAPGPR ASFPPPFGGP GFGAPGPGLH YAPPAPPAFG LFDDAAAAAA ALGLAPPAAR 250 260 270 280 290 300 GLLTPPASPL ELLEAKPKRG RRSWPRKRTA THTCSYAGCG KTYTKSSHLK AHLRTHTGEK 310 320 330 340 350 PYHCNWDGCG WKFARSDELT RHYRKHTGHR PFQCHLCDRA FSRSDHLALH MKRHM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus." Kozyrev S.V., Hansen L.L., Poltaraus A.B., Domninsky D.A., Kisselev L.L. FEBS Lett. 448:149-152(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-104. Tissue: Lung.
[2]	"cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung kruppel-like factor." Wani M.A., Conkright M.D., Jeffries S., Hughes M.J., Lingrel J.B. Genomics 60:78-86(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
[3]	"A catalogue of genes in the human dermal papilla cells as identified by expressed sequence tags." Lee H.J., Kim M.K., Kim Y.H., Seo J.M., Lee H.M., Chung H.J., Sohn M.Y., Hwang S.Y., Im S.U., Jung E.J., Kim J.C. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Hair follicle dermal papilla.
[4]	SeattleSNPs variation discovery resource Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PRO-104 AND PRO-145.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-104. Tissue: Spleen.
[6]	"Lung Krueppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase." Conkright M.D., Wani M.A., Lingrel J.B. J. Biol. Chem. 276:29299-29306(2001) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH WWP1.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF123344 Genomic DNA. Translation: AAD25076.1. AF134053 mRNA. Translation: AAD55891.1. AF205849 mRNA. Translation: AAF13295.1. EF078888 Genomic DNA. Translation: ABK41959.1. BC071983 mRNA. Translation: AAH71983.1.
IPI	IPI00001862.
RefSeq	NP_057354.1. NM_016270.2.
UniGene	Hs.744182.
3D structure databases
ProteinModelPortal	Q9Y5W3.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-199597.
STRING	9606.ENSP00000248071.
PTM databases
PhosphoSite	Q9Y5W3.
Polymorphism databases
DMDM	20141620.
Proteomic databases
PaxDb	Q9Y5W3.
PRIDE	Q9Y5W3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000248071; ENSP00000248071; ENSG00000127528.
GeneID	10365.
KEGG	hsa:10365.
UCSC	uc002ndw.3. human.
Organism-specific databases
CTD	10365.
GeneCards	GC19P016435.
HGNC	HGNC:6347. KLF2.
MIM	602016. gene.
neXtProt	NX_Q9Y5W3.
PharmGKB	PA30136.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000060173.
HOVERGEN	HBG006220.
InParanoid	Q9Y5W3.
KO	K09204.
OMA	FYYPEPG.
OrthoDB	EOG46HGB1.
PhylomeDB	Q9Y5W3.
Gene expression databases
ArrayExpress	Q9Y5W3.
Bgee	Q9Y5W3.
CleanEx	HS_KLF2.
Genevestigator	Q9Y5W3.
GermOnline	ENSG00000127528. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 3 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 3 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KLF2. human.
GenomeRNAi	10365.
NextBio	39291.
SOURCE	Search...

Entry information

Entry name

KLF2_HUMAN

Accession

Primary (citable) accession number: Q9Y5W3
Secondary accession number(s): Q6IPC4, Q9UJS5, Q9UKR6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	January 23, 2002
Last modified:	May 29, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.