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Q9Y5W3 (KLF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Krueppel-like factor 2
Alternative name(s):
Lung krueppel-like factor
Gene names
Name:KLF2
Synonyms:LKLF
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length355 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the CACCC box in the beta-globin gene promoter and activates transcription By similarity.

Subunit structure

Interacts with WWP1. Ref.6

Subcellular location

Nucleus By similarity.

Post-translational modification

Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein By similarity.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   PTMUbl conjugation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processType I pneumocyte differentiation

Inferred from electronic annotation. Source: Ensembl

cell morphogenesis

Inferred from electronic annotation. Source: Ensembl

cellular response to cycloheximide

Inferred from electronic annotation. Source: Ensembl

cellular response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

cellular response to interleukin-1

Inferred from electronic annotation. Source: Ensembl

cellular response to laminar fluid shear stress

Inferred from mutant phenotype PubMed 23043106. Source: BHF-UCL

cellular response to peptide

Inferred from electronic annotation. Source: Ensembl

cellular response to tumor necrosis factor

Inferred from electronic annotation. Source: Ensembl

erythrocyte maturation

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

multicellular organism growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein metabolic process

Inferred from genetic interaction PubMed 20551324. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter in response to stress

Inferred from mutant phenotype PubMed 23043106. Source: BHF-UCL

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 355355Krueppel-like factor 2
PRO_0000047162

Regions

Zinc finger272 – 29625C2H2-type 1
Zinc finger302 – 32625C2H2-type 2
Zinc finger332 – 35423C2H2-type 3
Region111 – 268158Interaction with WWP1 By similarity
Compositional bias62 – 7110Poly-Pro
Compositional bias130 – 1356Poly-Gly
Compositional bias167 – 1715Poly-Pro
Compositional bias225 – 2317Poly-Ala

Natural variations

Natural variant1041L → P. Ref.1 Ref.4 Ref.5
Corresponds to variant rs3745318 [ dbSNP | Ensembl ].
VAR_038830
Natural variant1451R → P. Ref.4
Corresponds to variant rs45586032 [ dbSNP | Ensembl ].
VAR_038831

Experimental info

Sequence conflict431S → N in AAD55891. Ref.2
Sequence conflict1751P → S in AAD55891. Ref.2
Sequence conflict1841L → M in AAD55891. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Y5W3 [UniParc].

Last modified January 23, 2002. Version 2.
Checksum: D5849C831D676AE1

FASTA35537,420
        10         20         30         40         50         60 
MALSEPILPS FSTFASPCRE RGLQERWPRA EPESGGTDDD LNSVLDFILS MGLDGLGAEA 

        70         80         90        100        110        120 
APEPPPPPPP PAFYYPEPGA PPPYSAPAGG LVSELLRPEL DAPLGPALHG RFLLAPPGRL 

       130        140        150        160        170        180 
VKAEPPEADG GGGYGCAPGL TRGPRGLKRE GAPGPAASCM RGPGGRPPPP PDTPPLSPDG 

       190        200        210        220        230        240 
PARLPAPGPR ASFPPPFGGP GFGAPGPGLH YAPPAPPAFG LFDDAAAAAA ALGLAPPAAR 

       250        260        270        280        290        300 
GLLTPPASPL ELLEAKPKRG RRSWPRKRTA THTCSYAGCG KTYTKSSHLK AHLRTHTGEK 

       310        320        330        340        350 
PYHCNWDGCG WKFARSDELT RHYRKHTGHR PFQCHLCDRA FSRSDHLALH MKRHM 

« Hide

References

« Hide 'large scale' references
[1]"Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus."
Kozyrev S.V., Hansen L.L., Poltaraus A.B., Domninsky D.A., Kisselev L.L.
FEBS Lett. 448:149-152(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-104.
Tissue: Lung.
[2]"cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung kruppel-like factor."
Wani M.A., Conkright M.D., Jeffries S., Hughes M.J., Lingrel J.B.
Genomics 60:78-86(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
[3]"A catalogue of genes in the human dermal papilla cells as identified by expressed sequence tags."
Lee H.J., Kim M.K., Kim Y.H., Seo J.M., Lee H.M., Chung H.J., Sohn M.Y., Hwang S.Y., Im S.U., Jung E.J., Kim J.C.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hair follicle dermal papilla.
[4]SeattleSNPs variation discovery resource
Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PRO-104 AND PRO-145.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-104.
Tissue: Spleen.
[6]"Lung Krueppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase."
Conkright M.D., Wani M.A., Lingrel J.B.
J. Biol. Chem. 276:29299-29306(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH WWP1.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF123344 Genomic DNA. Translation: AAD25076.1.
AF134053 mRNA. Translation: AAD55891.1.
AF205849 mRNA. Translation: AAF13295.1.
EF078888 Genomic DNA. Translation: ABK41959.1.
BC071983 mRNA. Translation: AAH71983.1.
RefSeqNP_057354.1. NM_016270.2.
UniGeneHs.744182.

3D structure databases

ProteinModelPortalQ9Y5W3.
SMRQ9Y5W3. Positions 216-354.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115645. 8 interactions.
MINTMINT-199597.
STRING9606.ENSP00000248071.

PTM databases

PhosphoSiteQ9Y5W3.

Polymorphism databases

DMDM20141620.

Proteomic databases

PaxDbQ9Y5W3.
PRIDEQ9Y5W3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000248071; ENSP00000248071; ENSG00000127528.
GeneID10365.
KEGGhsa:10365.
UCSCuc002ndw.3. human.

Organism-specific databases

CTD10365.
GeneCardsGC19P016435.
HGNCHGNC:6347. KLF2.
HPAHPA055964.
MIM602016. gene.
neXtProtNX_Q9Y5W3.
PharmGKBPA30136.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000060173.
HOVERGENHBG006220.
InParanoidQ9Y5W3.
KOK17845.
OMAFYYPEPG.
PhylomeDBQ9Y5W3.
TreeFamTF350556.

Gene expression databases

ArrayExpressQ9Y5W3.
BgeeQ9Y5W3.
CleanExHS_KLF2.
GenevestigatorQ9Y5W3.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKLF2. human.
GeneWikiKLF2.
GenomeRNAi10365.
NextBio39291.
PROQ9Y5W3.
SOURCESearch...

Entry information

Entry nameKLF2_HUMAN
AccessionPrimary (citable) accession number: Q9Y5W3
Secondary accession number(s): Q6IPC4, Q9UJS5, Q9UKR6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2002
Last modified: March 19, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM