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Protein

Krueppel-like factor 2

Gene

KLF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri272 – 296C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri302 – 326C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri332 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: BHF-UCL
  • DNA binding transcription factor activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: BHF-UCL
  • sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  • cell morphogenesis Source: Ensembl
  • cellular response to cycloheximide Source: Ensembl
  • cellular response to fluid shear stress Source: BHF-UCL
  • cellular response to hydrogen peroxide Source: Ensembl
  • cellular response to interleukin-1 Source: Ensembl
  • cellular response to laminar fluid shear stress Source: BHF-UCL
  • cellular response to peptide Source: Ensembl
  • cellular response to tumor necrosis factor Source: Ensembl
  • cellular stress response to acid chemical Source: BHF-UCL
  • erythrocyte maturation Source: Ensembl
  • in utero embryonic development Source: Ensembl
  • multicellular organism growth Source: Ensembl
  • negative regulation of interleukin-6 production Source: Ensembl
  • negative regulation of sprouting angiogenesis Source: BHF-UCL
  • negative regulation of transcription by RNA polymerase II Source: BHF-UCL
  • positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
  • positive regulation of protein metabolic process Source: BHF-UCL
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • positive regulation of transcription from RNA polymerase II promoter in response to stress Source: BHF-UCL
  • regulation of gene expression, epigenetic Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW
  • Type I pneumocyte differentiation Source: Ensembl

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ9Y5W3

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 2
Alternative name(s):
Lung krueppel-like factor
Gene namesi
Name:KLF2
Synonyms:LKLF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000127528.5
HGNCiHGNC:6347 KLF2
MIMi602016 gene
neXtProtiNX_Q9Y5W3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10365
OpenTargetsiENSG00000127528
PharmGKBiPA30136

Polymorphism and mutation databases

BioMutaiKLF2
DMDMi20141620

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471621 – 355Krueppel-like factor 2Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei173PhosphothreonineBy similarity1
Modified residuei244PhosphothreonineBy similarity1

Post-translational modificationi

Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9Y5W3
PaxDbiQ9Y5W3
PeptideAtlasiQ9Y5W3
PRIDEiQ9Y5W3

PTM databases

iPTMnetiQ9Y5W3
PhosphoSitePlusiQ9Y5W3

Expressioni

Gene expression databases

BgeeiENSG00000127528
CleanExiHS_KLF2
ExpressionAtlasiQ9Y5W3 baseline and differential
GenevisibleiQ9Y5W3 HS

Organism-specific databases

HPAiHPA055964

Interactioni

Subunit structurei

Interacts with WWP1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi115645, 11 interactors
DIPiDIP-41973N
ELMiQ9Y5W3
IntActiQ9Y5W3, 2 interactors
STRINGi9606.ENSP00000248071

Structurei

3D structure databases

ProteinModelPortaliQ9Y5W3
SMRiQ9Y5W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni111 – 268Interaction with WWP1By similarityAdd BLAST158

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 71Poly-Pro10
Compositional biasi130 – 135Poly-Gly6
Compositional biasi167 – 171Poly-Pro5
Compositional biasi225 – 231Poly-Ala7

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri272 – 296C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri302 – 326C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri332 – 354C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000060173
HOVERGENiHBG006220
InParanoidiQ9Y5W3
KOiK17845
OMAiMSFEQPR
OrthoDBiEOG091G1BN0
PhylomeDBiQ9Y5W3
TreeFamiTF350556

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

Q9Y5W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSEPILPS FSTFASPCRE RGLQERWPRA EPESGGTDDD LNSVLDFILS
60 70 80 90 100
MGLDGLGAEA APEPPPPPPP PAFYYPEPGA PPPYSAPAGG LVSELLRPEL
110 120 130 140 150
DAPLGPALHG RFLLAPPGRL VKAEPPEADG GGGYGCAPGL TRGPRGLKRE
160 170 180 190 200
GAPGPAASCM RGPGGRPPPP PDTPPLSPDG PARLPAPGPR ASFPPPFGGP
210 220 230 240 250
GFGAPGPGLH YAPPAPPAFG LFDDAAAAAA ALGLAPPAAR GLLTPPASPL
260 270 280 290 300
ELLEAKPKRG RRSWPRKRTA THTCSYAGCG KTYTKSSHLK AHLRTHTGEK
310 320 330 340 350
PYHCNWDGCG WKFARSDELT RHYRKHTGHR PFQCHLCDRA FSRSDHLALH

MKRHM
Length:355
Mass (Da):37,420
Last modified:January 23, 2002 - v2
Checksum:iD5849C831D676AE1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43S → N in AAD55891 (PubMed:10458913).Curated1
Sequence conflicti175P → S in AAD55891 (PubMed:10458913).Curated1
Sequence conflicti184L → M in AAD55891 (PubMed:10458913).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038830104L → P3 PublicationsCorresponds to variant dbSNP:rs3745318Ensembl.1
Natural variantiVAR_038831145R → P1 PublicationCorresponds to variant dbSNP:rs45586032Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF123344 Genomic DNA Translation: AAD25076.1
AF134053 mRNA Translation: AAD55891.1
AF205849 mRNA Translation: AAF13295.1
EF078888 Genomic DNA Translation: ABK41959.1
BC071983 mRNA Translation: AAH71983.1
CCDSiCCDS12343.1
RefSeqiNP_057354.1, NM_016270.3
UniGeneiHs.685136
Hs.744182

Genome annotation databases

EnsembliENST00000248071; ENSP00000248071; ENSG00000127528
GeneIDi10365
KEGGihsa:10365
UCSCiuc002ndw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKLF2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5W3
Secondary accession number(s): Q6IPC4, Q9UJS5, Q9UKR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 23, 2002
Last modified: April 25, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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