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Q9Y5W3

- KLF2_HUMAN

UniProt

Q9Y5W3 - KLF2_HUMAN

Protein

Krueppel-like factor 2

Gene

KLF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (23 Jan 2002)
      Previous versions | rss
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    Functioni

    Binds to the CACCC box in the beta-globin gene promoter and activates transcription.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri272 – 29625C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri302 – 32625C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri332 – 35423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. sequence-specific DNA binding Source: Ensembl
    3. sequence-specific DNA binding transcription factor activity Source: Ensembl

    GO - Biological processi

    1. cell morphogenesis Source: Ensembl
    2. cellular response to cycloheximide Source: Ensembl
    3. cellular response to hydrogen peroxide Source: Ensembl
    4. cellular response to interleukin-1 Source: Ensembl
    5. cellular response to laminar fluid shear stress Source: BHF-UCL
    6. cellular response to peptide Source: Ensembl
    7. cellular response to tumor necrosis factor Source: Ensembl
    8. erythrocyte maturation Source: Ensembl
    9. in utero embryonic development Source: Ensembl
    10. multicellular organism growth Source: Ensembl
    11. negative regulation of interleukin-6 production Source: Ensembl
    12. positive regulation of protein metabolic process Source: BHF-UCL
    13. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    14. positive regulation of transcription from RNA polymerase II promoter in response to stress Source: BHF-UCL
    15. transcription, DNA-templated Source: UniProtKB-KW
    16. Type I pneumocyte differentiation Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 2
    Alternative name(s):
    Lung krueppel-like factor
    Gene namesi
    Name:KLF2
    Synonyms:LKLF
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6347. KLF2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30136.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 355355Krueppel-like factor 2PRO_0000047162Add
    BLAST

    Post-translational modificationi

    Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein By similarity.By similarity

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    PaxDbiQ9Y5W3.
    PRIDEiQ9Y5W3.

    PTM databases

    PhosphoSiteiQ9Y5W3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y5W3.
    BgeeiQ9Y5W3.
    CleanExiHS_KLF2.
    GenevestigatoriQ9Y5W3.

    Organism-specific databases

    HPAiHPA055964.

    Interactioni

    Subunit structurei

    Interacts with WWP1.1 Publication

    Protein-protein interaction databases

    BioGridi115645. 8 interactions.
    MINTiMINT-199597.
    STRINGi9606.ENSP00000248071.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5W3.
    SMRiQ9Y5W3. Positions 269-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni111 – 268158Interaction with WWP1By similarityAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi62 – 7110Poly-Pro
    Compositional biasi130 – 1356Poly-Gly
    Compositional biasi167 – 1715Poly-Pro
    Compositional biasi225 – 2317Poly-Ala

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri272 – 29625C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri302 – 32625C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri332 – 35423C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000060173.
    HOVERGENiHBG006220.
    InParanoidiQ9Y5W3.
    KOiK17845.
    OMAiFYYPEPG.
    PhylomeDBiQ9Y5W3.
    TreeFamiTF350556.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y5W3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALSEPILPS FSTFASPCRE RGLQERWPRA EPESGGTDDD LNSVLDFILS    50
    MGLDGLGAEA APEPPPPPPP PAFYYPEPGA PPPYSAPAGG LVSELLRPEL 100
    DAPLGPALHG RFLLAPPGRL VKAEPPEADG GGGYGCAPGL TRGPRGLKRE 150
    GAPGPAASCM RGPGGRPPPP PDTPPLSPDG PARLPAPGPR ASFPPPFGGP 200
    GFGAPGPGLH YAPPAPPAFG LFDDAAAAAA ALGLAPPAAR GLLTPPASPL 250
    ELLEAKPKRG RRSWPRKRTA THTCSYAGCG KTYTKSSHLK AHLRTHTGEK 300
    PYHCNWDGCG WKFARSDELT RHYRKHTGHR PFQCHLCDRA FSRSDHLALH 350
    MKRHM 355
    Length:355
    Mass (Da):37,420
    Last modified:January 23, 2002 - v2
    Checksum:iD5849C831D676AE1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti43 – 431S → N in AAD55891. (PubMed:10458913)Curated
    Sequence conflicti175 – 1751P → S in AAD55891. (PubMed:10458913)Curated
    Sequence conflicti184 – 1841L → M in AAD55891. (PubMed:10458913)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti104 – 1041L → P.3 Publications
    Corresponds to variant rs3745318 [ dbSNP | Ensembl ].
    VAR_038830
    Natural varianti145 – 1451R → P.1 Publication
    Corresponds to variant rs45586032 [ dbSNP | Ensembl ].
    VAR_038831

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF123344 Genomic DNA. Translation: AAD25076.1.
    AF134053 mRNA. Translation: AAD55891.1.
    AF205849 mRNA. Translation: AAF13295.1.
    EF078888 Genomic DNA. Translation: ABK41959.1.
    BC071983 mRNA. Translation: AAH71983.1.
    CCDSiCCDS12343.1.
    RefSeqiNP_057354.1. NM_016270.2.
    UniGeneiHs.744182.

    Genome annotation databases

    EnsembliENST00000248071; ENSP00000248071; ENSG00000127528.
    GeneIDi10365.
    KEGGihsa:10365.
    UCSCiuc002ndw.3. human.

    Polymorphism databases

    DMDMi20141620.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF123344 Genomic DNA. Translation: AAD25076.1 .
    AF134053 mRNA. Translation: AAD55891.1 .
    AF205849 mRNA. Translation: AAF13295.1 .
    EF078888 Genomic DNA. Translation: ABK41959.1 .
    BC071983 mRNA. Translation: AAH71983.1 .
    CCDSi CCDS12343.1.
    RefSeqi NP_057354.1. NM_016270.2.
    UniGenei Hs.744182.

    3D structure databases

    ProteinModelPortali Q9Y5W3.
    SMRi Q9Y5W3. Positions 269-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115645. 8 interactions.
    MINTi MINT-199597.
    STRINGi 9606.ENSP00000248071.

    PTM databases

    PhosphoSitei Q9Y5W3.

    Polymorphism databases

    DMDMi 20141620.

    Proteomic databases

    PaxDbi Q9Y5W3.
    PRIDEi Q9Y5W3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248071 ; ENSP00000248071 ; ENSG00000127528 .
    GeneIDi 10365.
    KEGGi hsa:10365.
    UCSCi uc002ndw.3. human.

    Organism-specific databases

    CTDi 10365.
    GeneCardsi GC19P016435.
    HGNCi HGNC:6347. KLF2.
    HPAi HPA055964.
    MIMi 602016. gene.
    neXtProti NX_Q9Y5W3.
    PharmGKBi PA30136.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000060173.
    HOVERGENi HBG006220.
    InParanoidi Q9Y5W3.
    KOi K17845.
    OMAi FYYPEPG.
    PhylomeDBi Q9Y5W3.
    TreeFami TF350556.

    Miscellaneous databases

    ChiTaRSi KLF2. human.
    GeneWikii KLF2.
    GenomeRNAii 10365.
    NextBioi 39291.
    PROi Q9Y5W3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5W3.
    Bgeei Q9Y5W3.
    CleanExi HS_KLF2.
    Genevestigatori Q9Y5W3.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the human CpG-island-containing lung Kruppel-like factor (LKLF) gene and its location in chromosome 19p13.11-13 locus."
      Kozyrev S.V., Hansen L.L., Poltaraus A.B., Domninsky D.A., Kisselev L.L.
      FEBS Lett. 448:149-152(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT PRO-104.
      Tissue: Lung.
    2. "cDNA isolation, genomic structure, regulation, and chromosomal localization of human lung kruppel-like factor."
      Wani M.A., Conkright M.D., Jeffries S., Hughes M.J., Lingrel J.B.
      Genomics 60:78-86(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    3. "A catalogue of genes in the human dermal papilla cells as identified by expressed sequence tags."
      Lee H.J., Kim M.K., Kim Y.H., Seo J.M., Lee H.M., Chung H.J., Sohn M.Y., Hwang S.Y., Im S.U., Jung E.J., Kim J.C.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hair follicle dermal papilla.
    4. SeattleSNPs variation discovery resource
      Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PRO-104 AND PRO-145.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT PRO-104.
      Tissue: Spleen.
    6. "Lung Krueppel-like factor contains an autoinhibitory domain that regulates its transcriptional activation by binding WWP1, an E3 ubiquitin ligase."
      Conkright M.D., Wani M.A., Lingrel J.B.
      J. Biol. Chem. 276:29299-29306(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH WWP1.

    Entry informationi

    Entry nameiKLF2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5W3
    Secondary accession number(s): Q6IPC4, Q9UJS5, Q9UKR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2002
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3