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Protein

Zinc finger protein 706

Gene

ZNF706

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transcription repressor involved in the exit of embryonic stem cells (ESCs) from self-renewal. Acts by repressing expression of KLF4.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri39 – 6224C2H2-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Translation regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 706Curated
Gene namesi
Name:ZNF706Imported
ORF Names:HSPC038, PNAS-113
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:24992. ZNF706.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670505.

Polymorphism and mutation databases

BioMutaiZNF706.
DMDMi74735296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7676Zinc finger protein 706PRO_0000047703Add
BLAST

Proteomic databases

EPDiQ9Y5V0.
MaxQBiQ9Y5V0.
PaxDbiQ9Y5V0.
PRIDEiQ9Y5V0.
TopDownProteomicsiQ9Y5V0.

PTM databases

iPTMnetiQ9Y5V0.
PhosphoSiteiQ9Y5V0.

Expressioni

Gene expression databases

BgeeiQ9Y5V0.
CleanExiHS_ZNF706.
ExpressionAtlasiQ9Y5V0. baseline and differential.
GenevisibleiQ9Y5V0. HS.

Organism-specific databases

HPAiHPA042793.

Interactioni

Protein-protein interaction databases

BioGridi119310. 5 interactions.
IntActiQ9Y5V0. 1 interaction.
STRINGi9606.ENSP00000311768.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5V0.
SMRiQ9Y5V0. Positions 4-67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri39 – 6224C2H2-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4118. Eukaryota.
ENOG411234V. LUCA.
GeneTreeiENSGT00390000003465.
HOVERGENiHBG061511.
InParanoidiQ9Y5V0.
OMAiKAQMPDP.
OrthoDBiEOG7C5MCB.
PhylomeDBiQ9Y5V0.
TreeFamiTF315171.

Family and domain databases

Gene3Di4.10.1050.10. 1 hit.
InterProiIPR026939. At2g23090-like.
IPR007513. Uncharacterised_SERF.
[Graphical view]
PANTHERiPTHR21213. PTHR21213. 1 hit.
PfamiPF04419. 4F5. 1 hit.
[Graphical view]
SUPFAMiSSF118359. SSF118359. 1 hit.
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y5V0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGQQKIQS QQKNAKKQAG QKKKQGHDQK AAAKAALIYT CTVCRTQMPD
60 70
PKTFKQHFES KHPKTPLPPE LADVQA
Length:76
Mass (Da):8,498
Last modified:November 1, 1999 - v1
Checksum:i3EDEABD9FFE529FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125099 mRNA. Translation: AAD39916.1.
AF275809 mRNA. Translation: AAG23820.1.
AK290477 mRNA. Translation: BAF83166.1.
CH471060 Genomic DNA. Translation: EAW91831.1.
BC015925 mRNA. Translation: AAH15925.1.
BC068524 mRNA. Translation: AAH68524.1.
CCDSiCCDS6291.1.
RefSeqiNP_001035975.1. NM_001042510.1.
NP_001254637.1. NM_001267708.1.
NP_001254638.1. NM_001267709.1.
NP_057180.1. NM_016096.3.
UniGeneiHs.374485.

Genome annotation databases

EnsembliENST00000311212; ENSP00000311768; ENSG00000120963.
ENST00000517844; ENSP00000428227; ENSG00000120963.
ENST00000518336; ENSP00000428696; ENSG00000120963.
ENST00000519882; ENSP00000428985; ENSG00000120963.
ENST00000520347; ENSP00000430823; ENSG00000120963.
ENST00000520984; ENSP00000427761; ENSG00000120963.
ENST00000521272; ENSP00000430165; ENSG00000120963.
GeneIDi51123.
KEGGihsa:51123.
UCSCiuc003yka.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125099 mRNA. Translation: AAD39916.1.
AF275809 mRNA. Translation: AAG23820.1.
AK290477 mRNA. Translation: BAF83166.1.
CH471060 Genomic DNA. Translation: EAW91831.1.
BC015925 mRNA. Translation: AAH15925.1.
BC068524 mRNA. Translation: AAH68524.1.
CCDSiCCDS6291.1.
RefSeqiNP_001035975.1. NM_001042510.1.
NP_001254637.1. NM_001267708.1.
NP_001254638.1. NM_001267709.1.
NP_057180.1. NM_016096.3.
UniGeneiHs.374485.

3D structure databases

ProteinModelPortaliQ9Y5V0.
SMRiQ9Y5V0. Positions 4-67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119310. 5 interactions.
IntActiQ9Y5V0. 1 interaction.
STRINGi9606.ENSP00000311768.

PTM databases

iPTMnetiQ9Y5V0.
PhosphoSiteiQ9Y5V0.

Polymorphism and mutation databases

BioMutaiZNF706.
DMDMi74735296.

Proteomic databases

EPDiQ9Y5V0.
MaxQBiQ9Y5V0.
PaxDbiQ9Y5V0.
PRIDEiQ9Y5V0.
TopDownProteomicsiQ9Y5V0.

Protocols and materials databases

DNASUi51123.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311212; ENSP00000311768; ENSG00000120963.
ENST00000517844; ENSP00000428227; ENSG00000120963.
ENST00000518336; ENSP00000428696; ENSG00000120963.
ENST00000519882; ENSP00000428985; ENSG00000120963.
ENST00000520347; ENSP00000430823; ENSG00000120963.
ENST00000520984; ENSP00000427761; ENSG00000120963.
ENST00000521272; ENSP00000430165; ENSG00000120963.
GeneIDi51123.
KEGGihsa:51123.
UCSCiuc003yka.4. human.

Organism-specific databases

CTDi51123.
GeneCardsiZNF706.
HGNCiHGNC:24992. ZNF706.
HPAiHPA042793.
neXtProtiNX_Q9Y5V0.
PharmGKBiPA142670505.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4118. Eukaryota.
ENOG411234V. LUCA.
GeneTreeiENSGT00390000003465.
HOVERGENiHBG061511.
InParanoidiQ9Y5V0.
OMAiKAQMPDP.
OrthoDBiEOG7C5MCB.
PhylomeDBiQ9Y5V0.
TreeFamiTF315171.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF706. human.
GenomeRNAii51123.
PROiQ9Y5V0.

Gene expression databases

BgeeiQ9Y5V0.
CleanExiHS_ZNF706.
ExpressionAtlasiQ9Y5V0. baseline and differential.
GenevisibleiQ9Y5V0. HS.

Family and domain databases

Gene3Di4.10.1050.10. 1 hit.
InterProiIPR026939. At2g23090-like.
IPR007513. Uncharacterised_SERF.
[Graphical view]
PANTHERiPTHR21213. PTHR21213. 1 hit.
PfamiPF04419. 4F5. 1 hit.
[Graphical view]
SUPFAMiSSF118359. SSF118359. 1 hit.
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  2. "Human acute promyelocytic leukemia cell line NB4's apoptosis related genes."
    Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Promyelocytic leukemia.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Uterus.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZN706_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5V0
Secondary accession number(s): A8K362
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: November 1, 1999
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.