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Q9Y5U5

- TNR18_HUMAN

UniProt

Q9Y5U5 - TNR18_HUMAN

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Protein

Tumor necrosis factor receptor superfamily member 18

Gene

TNFRSF18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

GO - Molecular functioni

  1. tumor necrosis factor-activated receptor activity Source: ProtInc

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. negative regulation of apoptotic process Source: ProtInc
  3. signal transduction Source: ProtInc
  4. tumor necrosis factor-mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 18
Alternative name(s):
Activation-inducible TNFR family receptor
Glucocorticoid-induced TNFR-related protein
CD_antigen: CD357
Gene namesi
Name:TNFRSF18
Synonyms:AITR, GITR
ORF Names:UNQ319/PRO364
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11914. TNFRSF18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 162137ExtracellularSequence AnalysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence AnalysisAdd
BLAST
Topological domaini184 – 24158CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. extracellular region Source: UniProtKB-KW
  3. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 241216Tumor necrosis factor receptor superfamily member 18PRO_0000034595Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 49By similarity
Disulfide bondi74 ↔ 86By similarity
Disulfide bondi81 ↔ 94By similarity
Disulfide bondi115 ↔ 134By similarity
Disulfide bondi128 ↔ 153By similarity
Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y5U5.
PRIDEiQ9Y5U5.

Expressioni

Tissue specificityi

Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

Inductioni

Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

Gene expression databases

BgeeiQ9Y5U5.
CleanExiHS_TNFRSF18.
ExpressionAtlasiQ9Y5U5. baseline and differential.
GenevestigatoriQ9Y5U5.

Organism-specific databases

HPAiHPA008025.

Interactioni

Subunit structurei

Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA.

Protein-protein interaction databases

BioGridi114312. 5 interactions.
DIPiDIP-29883N.
IntActiQ9Y5U5. 1 interaction.
STRINGi9606.ENSP00000328207.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5U5.
SMRiQ9Y5U5. Positions 7-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 7239TNFR-Cys 1Add
BLAST
Repeati74 – 11239TNFR-Cys 2Add
BLAST
Repeati115 – 15339TNFR-Cys 3Add
BLAST

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46178.
GeneTreeiENSGT00730000111424.
HOVERGENiHBG054195.
InParanoidiQ9Y5U5.
KOiK05154.
OMAiEGRCKPW.
OrthoDBiEOG7XH6QM.
PhylomeDBiQ9Y5U5.
TreeFamiTF336151.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022318. TNFR_18.
[Graphical view]
PRINTSiPR01968. TNFACTORR18.
SMARTiSM00208. TNFR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y5U5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQHGAMGAF RALCGLALLC ALSLGQRPTG GPGCGPGRLL LGTGTDARCC
60 70 80 90 100
RVHTTRCCRD YPGEECCSEW DCMCVQPEFH CGDPCCTTCR HHPCPPGQGV
110 120 130 140 150
QSQGKFSFGF QCIDCASGTF SGGHEGHCKP WTDCTQFGFL TVFPGNKTHN
160 170 180 190 200
AVCVPGSPPA EPLGWLTVVL LAVAACVLLL TSAQLGLHIW QLRSQCMWPR
210 220 230 240
ETQLLLEVPP STEDARSCQF PEEERGERSA EEKGRLGDLW V
Length:241
Mass (Da):26,000
Last modified:November 1, 1999 - v1
Checksum:i90DC3B4AA7E82CBE
GO
Isoform 2 (identifier: Q9Y5U5-2) [UniParc]FASTAAdd to Basket

Also known as: GITR-D

The sequence of this isoform differs from the canonical sequence as follows:
     135-241: TQFGFLTVFP...EKGRLGDLWV → CWRCRRRPKT...SLAGPDGVGS

Show »
Length:255
Mass (Da):26,827
Checksum:iC986652AC97AF2CC
GO
Isoform 3 (identifier: Q9Y5U5-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-201: SQCMWPRE → K

Show »
Length:234
Mass (Da):25,110
Checksum:i55DB593CD0B1DB45
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431T → R.
Corresponds to variant rs11466676 [ dbSNP | Ensembl ].
VAR_052354
Natural varianti64 – 641E → K.
Corresponds to variant rs11466687 [ dbSNP | Ensembl ].
VAR_052355
Natural varianti83 – 831D → N.
Corresponds to variant rs11466688 [ dbSNP | Ensembl ].
VAR_052356
Natural varianti173 – 1731V → M.
Corresponds to variant rs11466693 [ dbSNP | Ensembl ].
VAR_052357

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei135 – 241107TQFGF…GDLWV → CWRCRRRPKTPEAASSPRKS GASDRQRRRGGWETCGCEPG RPPGPPTAASPSPGAPQAAG ALRSALGRALLPWQQKWVQE GGSDQRPGPCSSAAAAGPCR RERETQSWPPSSLAGPDGVG S in isoform 2. 1 PublicationVSP_006508Add
BLAST
Alternative sequencei194 – 2018SQCMWPRE → K in isoform 3. 1 PublicationVSP_041021

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125304 mRNA. Translation: AAD22635.1.
AF117297 mRNA. Translation: AAD19694.1.
AF241229 mRNA. Translation: AAF63506.1.
AY358877 mRNA. Translation: AAQ89236.1.
BT019531 mRNA. Translation: AAV38338.1.
BT019532 mRNA. Translation: AAV38339.1.
AL162741 Genomic DNA. Translation: CAI23246.1.
AL162741 Genomic DNA. Translation: CAI23247.1.
CH471183 Genomic DNA. Translation: EAW56282.1.
CH471183 Genomic DNA. Translation: EAW56283.1.
BC152381 mRNA. Translation: AAI52382.1.
CCDSiCCDS10.1. [Q9Y5U5-1]
CCDS30552.1. [Q9Y5U5-3]
CCDS9.1. [Q9Y5U5-2]
RefSeqiNP_004186.1. NM_004195.2. [Q9Y5U5-1]
NP_683699.1. NM_148901.1. [Q9Y5U5-2]
NP_683700.1. NM_148902.1. [Q9Y5U5-3]
UniGeneiHs.212680.

Genome annotation databases

EnsembliENST00000328596; ENSP00000328207; ENSG00000186891. [Q9Y5U5-2]
ENST00000379265; ENSP00000368567; ENSG00000186891. [Q9Y5U5-3]
ENST00000379268; ENSP00000368570; ENSG00000186891. [Q9Y5U5-1]
GeneIDi8784.
KEGGihsa:8784.
UCSCiuc001ada.3. human. [Q9Y5U5-1]
uc001add.3. human. [Q9Y5U5-2]

Polymorphism databases

DMDMi13878830.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125304 mRNA. Translation: AAD22635.1 .
AF117297 mRNA. Translation: AAD19694.1 .
AF241229 mRNA. Translation: AAF63506.1 .
AY358877 mRNA. Translation: AAQ89236.1 .
BT019531 mRNA. Translation: AAV38338.1 .
BT019532 mRNA. Translation: AAV38339.1 .
AL162741 Genomic DNA. Translation: CAI23246.1 .
AL162741 Genomic DNA. Translation: CAI23247.1 .
CH471183 Genomic DNA. Translation: EAW56282.1 .
CH471183 Genomic DNA. Translation: EAW56283.1 .
BC152381 mRNA. Translation: AAI52382.1 .
CCDSi CCDS10.1. [Q9Y5U5-1 ]
CCDS30552.1. [Q9Y5U5-3 ]
CCDS9.1. [Q9Y5U5-2 ]
RefSeqi NP_004186.1. NM_004195.2. [Q9Y5U5-1 ]
NP_683699.1. NM_148901.1. [Q9Y5U5-2 ]
NP_683700.1. NM_148902.1. [Q9Y5U5-3 ]
UniGenei Hs.212680.

3D structure databases

ProteinModelPortali Q9Y5U5.
SMRi Q9Y5U5. Positions 7-154.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114312. 5 interactions.
DIPi DIP-29883N.
IntActi Q9Y5U5. 1 interaction.
STRINGi 9606.ENSP00000328207.

Chemistry

GuidetoPHARMACOLOGYi 1890.

Polymorphism databases

DMDMi 13878830.

Proteomic databases

PaxDbi Q9Y5U5.
PRIDEi Q9Y5U5.

Protocols and materials databases

DNASUi 8784.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328596 ; ENSP00000328207 ; ENSG00000186891 . [Q9Y5U5-2 ]
ENST00000379265 ; ENSP00000368567 ; ENSG00000186891 . [Q9Y5U5-3 ]
ENST00000379268 ; ENSP00000368570 ; ENSG00000186891 . [Q9Y5U5-1 ]
GeneIDi 8784.
KEGGi hsa:8784.
UCSCi uc001ada.3. human. [Q9Y5U5-1 ]
uc001add.3. human. [Q9Y5U5-2 ]

Organism-specific databases

CTDi 8784.
GeneCardsi GC01M001128.
HGNCi HGNC:11914. TNFRSF18.
HPAi HPA008025.
MIMi 603905. gene.
neXtProti NX_Q9Y5U5.
PharmGKBi PA36607.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46178.
GeneTreei ENSGT00730000111424.
HOVERGENi HBG054195.
InParanoidi Q9Y5U5.
KOi K05154.
OMAi EGRCKPW.
OrthoDBi EOG7XH6QM.
PhylomeDBi Q9Y5U5.
TreeFami TF336151.

Miscellaneous databases

GeneWikii TNFRSF18.
GenomeRNAii 8784.
NextBioi 32932.
PROi Q9Y5U5.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y5U5.
CleanExi HS_TNFRSF18.
ExpressionAtlasi Q9Y5U5. baseline and differential.
Genevestigatori Q9Y5U5.

Family and domain databases

InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022318. TNFR_18.
[Graphical view ]
PRINTSi PR01968. TNFACTORR18.
SMARTi SM00208. TNFR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR."
    Gurney A.L., Marsters S.A., Huang R.M., Pitti R.M., Mark D.T., Baldwin D.T., Gray A.M., Dowd A.D., Brush A.D., Heldens A.D., Schow A.D., Goddard A.D., Wood W.I., Baker K.P., Godowski P.J., Ashkenazi A.
    Curr. Biol. 9:215-218(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TRAF1; TRAF2 AND TRAF3.
    Tissue: Bone marrow.
  2. "Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand."
    Kwon B., Yu K.-Y., Ni J., Yu G.-L., Jang I.-K., Kim Y.-J., Xing L., Liu D., Wang S.-X., Kwon B.S.
    J. Biol. Chem. 274:6056-6061(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    Tissue: T-cell.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Thymus.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-40.

Entry informationi

Entry nameiTNR18_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5U5
Secondary accession number(s): B1AME1
, O95851, Q5U0I4, Q9NYJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3