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Q9Y5U5

- TNR18_HUMAN

UniProt

Q9Y5U5 - TNR18_HUMAN

Protein

Tumor necrosis factor receptor superfamily member 18

Gene

TNFRSF18

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

    GO - Molecular functioni

    1. tumor necrosis factor-activated receptor activity Source: ProtInc

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. negative regulation of apoptotic process Source: ProtInc
    3. signal transduction Source: ProtInc
    4. tumor necrosis factor-mediated signaling pathway Source: GOC

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 18
    Alternative name(s):
    Activation-inducible TNFR family receptor
    Glucocorticoid-induced TNFR-related protein
    CD_antigen: CD357
    Gene namesi
    Name:TNFRSF18
    Synonyms:AITR, GITR
    ORF Names:UNQ319/PRO364
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11914. TNFRSF18.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular region Source: UniProtKB-SubCell
    3. integral component of plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36607.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 25251 PublicationAdd
    BLAST
    Chaini26 – 241216Tumor necrosis factor receptor superfamily member 18PRO_0000034595Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 49By similarity
    Disulfide bondi74 ↔ 86By similarity
    Disulfide bondi81 ↔ 94By similarity
    Disulfide bondi115 ↔ 134By similarity
    Disulfide bondi128 ↔ 153By similarity
    Glycosylationi146 – 1461N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9Y5U5.
    PRIDEiQ9Y5U5.

    Expressioni

    Tissue specificityi

    Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

    Inductioni

    Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

    Gene expression databases

    ArrayExpressiQ9Y5U5.
    BgeeiQ9Y5U5.
    CleanExiHS_TNFRSF18.
    GenevestigatoriQ9Y5U5.

    Organism-specific databases

    HPAiHPA008025.

    Interactioni

    Subunit structurei

    Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA.

    Protein-protein interaction databases

    BioGridi114312. 5 interactions.
    DIPiDIP-29883N.
    IntActiQ9Y5U5. 1 interaction.
    STRINGi9606.ENSP00000328207.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5U5.
    SMRiQ9Y5U5. Positions 7-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 162137ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini184 – 24158CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei163 – 18321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati34 – 7239TNFR-Cys 1Add
    BLAST
    Repeati74 – 11239TNFR-Cys 2Add
    BLAST
    Repeati115 – 15339TNFR-Cys 3Add
    BLAST

    Sequence similaritiesi

    Contains 3 TNFR-Cys repeats.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46178.
    HOVERGENiHBG054195.
    KOiK05154.
    OMAiEGRCKPW.
    OrthoDBiEOG7XH6QM.
    PhylomeDBiQ9Y5U5.
    TreeFamiTF336151.

    Family and domain databases

    InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022318. TNFR_18.
    [Graphical view]
    PRINTSiPR01968. TNFACTORR18.
    SMARTiSM00208. TNFR. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y5U5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAQHGAMGAF RALCGLALLC ALSLGQRPTG GPGCGPGRLL LGTGTDARCC    50
    RVHTTRCCRD YPGEECCSEW DCMCVQPEFH CGDPCCTTCR HHPCPPGQGV 100
    QSQGKFSFGF QCIDCASGTF SGGHEGHCKP WTDCTQFGFL TVFPGNKTHN 150
    AVCVPGSPPA EPLGWLTVVL LAVAACVLLL TSAQLGLHIW QLRSQCMWPR 200
    ETQLLLEVPP STEDARSCQF PEEERGERSA EEKGRLGDLW V 241
    Length:241
    Mass (Da):26,000
    Last modified:November 1, 1999 - v1
    Checksum:i90DC3B4AA7E82CBE
    GO
    Isoform 2 (identifier: Q9Y5U5-2) [UniParc]FASTAAdd to Basket

    Also known as: GITR-D

    The sequence of this isoform differs from the canonical sequence as follows:
         135-241: TQFGFLTVFP...EKGRLGDLWV → CWRCRRRPKT...SLAGPDGVGS

    Show »
    Length:255
    Mass (Da):26,827
    Checksum:iC986652AC97AF2CC
    GO
    Isoform 3 (identifier: Q9Y5U5-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         194-201: SQCMWPRE → K

    Show »
    Length:234
    Mass (Da):25,110
    Checksum:i55DB593CD0B1DB45
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431T → R.
    Corresponds to variant rs11466676 [ dbSNP | Ensembl ].
    VAR_052354
    Natural varianti64 – 641E → K.
    Corresponds to variant rs11466687 [ dbSNP | Ensembl ].
    VAR_052355
    Natural varianti83 – 831D → N.
    Corresponds to variant rs11466688 [ dbSNP | Ensembl ].
    VAR_052356
    Natural varianti173 – 1731V → M.
    Corresponds to variant rs11466693 [ dbSNP | Ensembl ].
    VAR_052357

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei135 – 241107TQFGF…GDLWV → CWRCRRRPKTPEAASSPRKS GASDRQRRRGGWETCGCEPG RPPGPPTAASPSPGAPQAAG ALRSALGRALLPWQQKWVQE GGSDQRPGPCSSAAAAGPCR RERETQSWPPSSLAGPDGVG S in isoform 2. 1 PublicationVSP_006508Add
    BLAST
    Alternative sequencei194 – 2018SQCMWPRE → K in isoform 3. 1 PublicationVSP_041021

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125304 mRNA. Translation: AAD22635.1.
    AF117297 mRNA. Translation: AAD19694.1.
    AF241229 mRNA. Translation: AAF63506.1.
    AY358877 mRNA. Translation: AAQ89236.1.
    BT019531 mRNA. Translation: AAV38338.1.
    BT019532 mRNA. Translation: AAV38339.1.
    AL162741 Genomic DNA. Translation: CAI23246.1.
    AL162741 Genomic DNA. Translation: CAI23247.1.
    CH471183 Genomic DNA. Translation: EAW56282.1.
    CH471183 Genomic DNA. Translation: EAW56283.1.
    BC152381 mRNA. Translation: AAI52382.1.
    CCDSiCCDS10.1. [Q9Y5U5-1]
    CCDS30552.1. [Q9Y5U5-3]
    CCDS9.1. [Q9Y5U5-2]
    RefSeqiNP_004186.1. NM_004195.2. [Q9Y5U5-1]
    NP_683699.1. NM_148901.1. [Q9Y5U5-2]
    NP_683700.1. NM_148902.1. [Q9Y5U5-3]
    UniGeneiHs.212680.

    Genome annotation databases

    EnsembliENST00000328596; ENSP00000328207; ENSG00000186891. [Q9Y5U5-2]
    ENST00000379265; ENSP00000368567; ENSG00000186891. [Q9Y5U5-3]
    ENST00000379268; ENSP00000368570; ENSG00000186891. [Q9Y5U5-1]
    GeneIDi8784.
    KEGGihsa:8784.
    UCSCiuc001ada.3. human. [Q9Y5U5-1]
    uc001add.3. human. [Q9Y5U5-2]

    Polymorphism databases

    DMDMi13878830.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125304 mRNA. Translation: AAD22635.1 .
    AF117297 mRNA. Translation: AAD19694.1 .
    AF241229 mRNA. Translation: AAF63506.1 .
    AY358877 mRNA. Translation: AAQ89236.1 .
    BT019531 mRNA. Translation: AAV38338.1 .
    BT019532 mRNA. Translation: AAV38339.1 .
    AL162741 Genomic DNA. Translation: CAI23246.1 .
    AL162741 Genomic DNA. Translation: CAI23247.1 .
    CH471183 Genomic DNA. Translation: EAW56282.1 .
    CH471183 Genomic DNA. Translation: EAW56283.1 .
    BC152381 mRNA. Translation: AAI52382.1 .
    CCDSi CCDS10.1. [Q9Y5U5-1 ]
    CCDS30552.1. [Q9Y5U5-3 ]
    CCDS9.1. [Q9Y5U5-2 ]
    RefSeqi NP_004186.1. NM_004195.2. [Q9Y5U5-1 ]
    NP_683699.1. NM_148901.1. [Q9Y5U5-2 ]
    NP_683700.1. NM_148902.1. [Q9Y5U5-3 ]
    UniGenei Hs.212680.

    3D structure databases

    ProteinModelPortali Q9Y5U5.
    SMRi Q9Y5U5. Positions 7-154.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114312. 5 interactions.
    DIPi DIP-29883N.
    IntActi Q9Y5U5. 1 interaction.
    STRINGi 9606.ENSP00000328207.

    Chemistry

    GuidetoPHARMACOLOGYi 1890.

    Polymorphism databases

    DMDMi 13878830.

    Proteomic databases

    PaxDbi Q9Y5U5.
    PRIDEi Q9Y5U5.

    Protocols and materials databases

    DNASUi 8784.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000328596 ; ENSP00000328207 ; ENSG00000186891 . [Q9Y5U5-2 ]
    ENST00000379265 ; ENSP00000368567 ; ENSG00000186891 . [Q9Y5U5-3 ]
    ENST00000379268 ; ENSP00000368570 ; ENSG00000186891 . [Q9Y5U5-1 ]
    GeneIDi 8784.
    KEGGi hsa:8784.
    UCSCi uc001ada.3. human. [Q9Y5U5-1 ]
    uc001add.3. human. [Q9Y5U5-2 ]

    Organism-specific databases

    CTDi 8784.
    GeneCardsi GC01M001128.
    HGNCi HGNC:11914. TNFRSF18.
    HPAi HPA008025.
    MIMi 603905. gene.
    neXtProti NX_Q9Y5U5.
    PharmGKBi PA36607.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46178.
    HOVERGENi HBG054195.
    KOi K05154.
    OMAi EGRCKPW.
    OrthoDBi EOG7XH6QM.
    PhylomeDBi Q9Y5U5.
    TreeFami TF336151.

    Miscellaneous databases

    GeneWikii TNFRSF18.
    GenomeRNAii 8784.
    NextBioi 32932.
    PROi Q9Y5U5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5U5.
    Bgeei Q9Y5U5.
    CleanExi HS_TNFRSF18.
    Genevestigatori Q9Y5U5.

    Family and domain databases

    InterProi IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR022318. TNFR_18.
    [Graphical view ]
    PRINTSi PR01968. TNFACTORR18.
    SMARTi SM00208. TNFR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR."
      Gurney A.L., Marsters S.A., Huang R.M., Pitti R.M., Mark D.T., Baldwin D.T., Gray A.M., Dowd A.D., Brush A.D., Heldens A.D., Schow A.D., Goddard A.D., Wood W.I., Baker K.P., Godowski P.J., Ashkenazi A.
      Curr. Biol. 9:215-218(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TRAF1; TRAF2 AND TRAF3.
      Tissue: Bone marrow.
    2. "Identification of a novel activation-inducible protein of the tumor necrosis factor receptor superfamily and its ligand."
      Kwon B., Yu K.-Y., Ni J., Yu G.-L., Jang I.-K., Kim Y.-J., Xing L., Liu D., Wang S.-X., Kwon B.S.
      J. Biol. Chem. 274:6056-6061(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
      Tissue: T-cell.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Thymus.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    9. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-40.

    Entry informationi

    Entry nameiTNR18_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5U5
    Secondary accession number(s): B1AME1
    , O95851, Q5U0I4, Q9NYJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3