Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor receptor superfamily member 18

Gene

TNFRSF18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

GO - Molecular functioni

  • tumor necrosis factor-activated receptor activity Source: ProtInc

GO - Biological processi

  • extrinsic apoptotic signaling pathway via death domain receptors Source: GO_Central
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • multicellular organism development Source: GO_Central
  • negative regulation of apoptotic process Source: ProtInc
  • positive regulation of cell adhesion Source: UniProtKB
  • positive regulation of leukocyte migration Source: UniProtKB
  • positive regulation of tyrosine phosphorylation of Stat1 protein Source: UniProtKB
  • regulation of cell proliferation Source: GO_Central
  • response to lipopolysaccharide Source: GO_Central
  • signal transduction Source: ProtInc
  • tumor necrosis factor-mediated signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:G66-31196-MONOMER.
ReactomeiR-HSA-5669034. TNFs bind their physiological receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 18
Alternative name(s):
Activation-inducible TNFR family receptor
Glucocorticoid-induced TNFR-related protein
CD_antigen: CD357
Gene namesi
Name:TNFRSF18
Synonyms:AITR, GITR
ORF Names:UNQ319/PRO364
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11914. TNFRSF18.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 162ExtracellularSequence analysisAdd BLAST137
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 241CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi8784.
OpenTargetsiENSG00000186891.
PharmGKBiPA36607.

Polymorphism and mutation databases

BioMutaiTNFRSF18.
DMDMi13878830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000003459526 – 241Tumor necrosis factor receptor superfamily member 18Add BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 49By similarity
Disulfide bondi74 ↔ 86By similarity
Disulfide bondi81 ↔ 94By similarity
Disulfide bondi115 ↔ 134By similarity
Disulfide bondi128 ↔ 153By similarity
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y5U5.
PeptideAtlasiQ9Y5U5.
PRIDEiQ9Y5U5.
TopDownProteomicsiQ9Y5U5-2. [Q9Y5U5-2]

Expressioni

Tissue specificityi

Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

Inductioni

Up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.

Gene expression databases

BgeeiENSG00000186891.
CleanExiHS_TNFRSF18.
ExpressionAtlasiQ9Y5U5. baseline and differential.
GenevisibleiQ9Y5U5. HS.

Organism-specific databases

HPAiHPA008025.

Interactioni

Subunit structurei

Binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6. Binds through its C-terminus to SIVA1/SIVA.

Protein-protein interaction databases

BioGridi114312. 5 interactors.
DIPiDIP-29883N.
IntActiQ9Y5U5. 2 interactors.
STRINGi9606.ENSP00000328207.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5U5.
SMRiQ9Y5U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati34 – 72TNFR-Cys 1Add BLAST39
Repeati74 – 112TNFR-Cys 2Add BLAST39
Repeati115 – 153TNFR-Cys 3Add BLAST39

Sequence similaritiesi

Contains 3 TNFR-Cys repeats.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J0PX. Eukaryota.
ENOG410YX1D. LUCA.
GeneTreeiENSGT00730000111424.
HOVERGENiHBG054195.
InParanoidiQ9Y5U5.
KOiK05154.
OMAiTHNAVCV.
OrthoDBiEOG091G03XW.
PhylomeDBiQ9Y5U5.
TreeFamiTF336151.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022318. TNFR_18.
[Graphical view]
PANTHERiPTHR23097:SF97. PTHR23097:SF97. 1 hit.
PRINTSiPR01968. TNFACTORR18.
SMARTiSM00208. TNFR. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5U5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQHGAMGAF RALCGLALLC ALSLGQRPTG GPGCGPGRLL LGTGTDARCC
60 70 80 90 100
RVHTTRCCRD YPGEECCSEW DCMCVQPEFH CGDPCCTTCR HHPCPPGQGV
110 120 130 140 150
QSQGKFSFGF QCIDCASGTF SGGHEGHCKP WTDCTQFGFL TVFPGNKTHN
160 170 180 190 200
AVCVPGSPPA EPLGWLTVVL LAVAACVLLL TSAQLGLHIW QLRSQCMWPR
210 220 230 240
ETQLLLEVPP STEDARSCQF PEEERGERSA EEKGRLGDLW V
Length:241
Mass (Da):26,000
Last modified:November 1, 1999 - v1
Checksum:i90DC3B4AA7E82CBE
GO
Isoform 2 (identifier: Q9Y5U5-2) [UniParc]FASTAAdd to basket
Also known as: GITR-D

The sequence of this isoform differs from the canonical sequence as follows:
     135-241: TQFGFLTVFP...EKGRLGDLWV → CWRCRRRPKT...SLAGPDGVGS

Show »
Length:255
Mass (Da):26,827
Checksum:iC986652AC97AF2CC
GO
Isoform 3 (identifier: Q9Y5U5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-201: SQCMWPRE → K

Show »
Length:234
Mass (Da):25,110
Checksum:i55DB593CD0B1DB45
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05235443T → R.Corresponds to variant rs11466676dbSNPEnsembl.1
Natural variantiVAR_05235564E → K.Corresponds to variant rs11466687dbSNPEnsembl.1
Natural variantiVAR_05235683D → N.Corresponds to variant rs11466688dbSNPEnsembl.1
Natural variantiVAR_052357173V → M.Corresponds to variant rs11466693dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006508135 – 241TQFGF…GDLWV → CWRCRRRPKTPEAASSPRKS GASDRQRRRGGWETCGCEPG RPPGPPTAASPSPGAPQAAG ALRSALGRALLPWQQKWVQE GGSDQRPGPCSSAAAAGPCR RERETQSWPPSSLAGPDGVG S in isoform 2. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_041021194 – 201SQCMWPRE → K in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125304 mRNA. Translation: AAD22635.1.
AF117297 mRNA. Translation: AAD19694.1.
AF241229 mRNA. Translation: AAF63506.1.
AY358877 mRNA. Translation: AAQ89236.1.
BT019531 mRNA. Translation: AAV38338.1.
BT019532 mRNA. Translation: AAV38339.1.
AL162741 Genomic DNA. Translation: CAI23246.1.
AL162741 Genomic DNA. Translation: CAI23247.1.
CH471183 Genomic DNA. Translation: EAW56282.1.
CH471183 Genomic DNA. Translation: EAW56283.1.
BC152381 mRNA. Translation: AAI52382.1.
CCDSiCCDS10.1. [Q9Y5U5-1]
CCDS30552.1. [Q9Y5U5-3]
CCDS9.1. [Q9Y5U5-2]
RefSeqiNP_004186.1. NM_004195.2. [Q9Y5U5-1]
NP_683699.1. NM_148901.1. [Q9Y5U5-2]
NP_683700.1. NM_148902.1. [Q9Y5U5-3]
UniGeneiHs.212680.

Genome annotation databases

EnsembliENST00000328596; ENSP00000328207; ENSG00000186891. [Q9Y5U5-2]
ENST00000379265; ENSP00000368567; ENSG00000186891. [Q9Y5U5-3]
ENST00000379268; ENSP00000368570; ENSG00000186891. [Q9Y5U5-1]
GeneIDi8784.
KEGGihsa:8784.
UCSCiuc001adb.4. human. [Q9Y5U5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125304 mRNA. Translation: AAD22635.1.
AF117297 mRNA. Translation: AAD19694.1.
AF241229 mRNA. Translation: AAF63506.1.
AY358877 mRNA. Translation: AAQ89236.1.
BT019531 mRNA. Translation: AAV38338.1.
BT019532 mRNA. Translation: AAV38339.1.
AL162741 Genomic DNA. Translation: CAI23246.1.
AL162741 Genomic DNA. Translation: CAI23247.1.
CH471183 Genomic DNA. Translation: EAW56282.1.
CH471183 Genomic DNA. Translation: EAW56283.1.
BC152381 mRNA. Translation: AAI52382.1.
CCDSiCCDS10.1. [Q9Y5U5-1]
CCDS30552.1. [Q9Y5U5-3]
CCDS9.1. [Q9Y5U5-2]
RefSeqiNP_004186.1. NM_004195.2. [Q9Y5U5-1]
NP_683699.1. NM_148901.1. [Q9Y5U5-2]
NP_683700.1. NM_148902.1. [Q9Y5U5-3]
UniGeneiHs.212680.

3D structure databases

ProteinModelPortaliQ9Y5U5.
SMRiQ9Y5U5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114312. 5 interactors.
DIPiDIP-29883N.
IntActiQ9Y5U5. 2 interactors.
STRINGi9606.ENSP00000328207.

Polymorphism and mutation databases

BioMutaiTNFRSF18.
DMDMi13878830.

Proteomic databases

PaxDbiQ9Y5U5.
PeptideAtlasiQ9Y5U5.
PRIDEiQ9Y5U5.
TopDownProteomicsiQ9Y5U5-2. [Q9Y5U5-2]

Protocols and materials databases

DNASUi8784.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328596; ENSP00000328207; ENSG00000186891. [Q9Y5U5-2]
ENST00000379265; ENSP00000368567; ENSG00000186891. [Q9Y5U5-3]
ENST00000379268; ENSP00000368570; ENSG00000186891. [Q9Y5U5-1]
GeneIDi8784.
KEGGihsa:8784.
UCSCiuc001adb.4. human. [Q9Y5U5-1]

Organism-specific databases

CTDi8784.
DisGeNETi8784.
GeneCardsiTNFRSF18.
HGNCiHGNC:11914. TNFRSF18.
HPAiHPA008025.
MIMi603905. gene.
neXtProtiNX_Q9Y5U5.
OpenTargetsiENSG00000186891.
PharmGKBiPA36607.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0PX. Eukaryota.
ENOG410YX1D. LUCA.
GeneTreeiENSGT00730000111424.
HOVERGENiHBG054195.
InParanoidiQ9Y5U5.
KOiK05154.
OMAiTHNAVCV.
OrthoDBiEOG091G03XW.
PhylomeDBiQ9Y5U5.
TreeFamiTF336151.

Enzyme and pathway databases

BioCyciZFISH:G66-31196-MONOMER.
ReactomeiR-HSA-5669034. TNFs bind their physiological receptors.

Miscellaneous databases

GeneWikiiTNFRSF18.
GenomeRNAii8784.
PROiQ9Y5U5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186891.
CleanExiHS_TNFRSF18.
ExpressionAtlasiQ9Y5U5. baseline and differential.
GenevisibleiQ9Y5U5. HS.

Family and domain databases

InterProiIPR001368. TNFR/NGFR_Cys_rich_reg.
IPR022318. TNFR_18.
[Graphical view]
PANTHERiPTHR23097:SF97. PTHR23097:SF97. 1 hit.
PRINTSiPR01968. TNFACTORR18.
SMARTiSM00208. TNFR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNR18_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5U5
Secondary accession number(s): B1AME1
, O95851, Q5U0I4, Q9NYJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.