Q9Y5U2 (TSSC4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein TSSC4

Alternative name(s):
Tumor-suppressing STF cDNA 4 protein
Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein

Gene names

Name:

TSSC4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed in fetal brain, lung, liver and kidney. Widely expressed in adult tissues. Ref.1
Sequence similarities	Belongs to the TSSC4 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y5U2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y5U2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     8-71: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Protein TSSC4		PRO_0000076360
Amino acid modifications
	Modified residue	129	1	Phosphoserine Ref.5
	Modified residue	132	1	Phosphoserine Ref.6
	Modified residue	143	1	Phosphoserine Ref.6
	Modified residue	146	1	Phosphoserine Ref.6
	Modified residue	217	1	N6-acetyllysine Ref.9
	Modified residue	321	1	Phosphoserine Ref.4 Ref.7 Ref.8
Natural variations
	Alternative sequence	8 – 71	64	Missing in isoform 2.		VSP_016561
	Natural variant	17	1	H → P. Corresponds to variant rs2234278 [ dbSNP | Ensembl ].		VAR_057826
	Natural variant	124	1	R → Q. Corresponds to variant rs1008265 [ dbSNP | Ensembl ].		VAR_060194
	Natural variant	230	1	R → S. Corresponds to variant rs2234280 [ dbSNP | Ensembl ].		VAR_057827
	Natural variant	262	1	G → R. Corresponds to variant rs2234281 [ dbSNP | Ensembl ].		VAR_057828
	Natural variant	274	1	H → P. Ref.1 Ref.3 Corresponds to variant rs2234283 [ dbSNP | Ensembl ].		VAR_063128
Experimental info
	Sequence conflict	72	1	L → F in AAD23579. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: AFC2D5CBD93844F0	FASTA	329	34,326
	10 20 30 40 50 60 MAEAGTGEPS PSVEGEHGTE YDTLPSDTVS LSDSDSDLSL PGGAEVEALS PMGLPGEEDS 70 80 90 100 110 120 GPDEPPSPPS GLLPATVQPF HLRGMSSTFS QRSRDIFDCL EGAARRAPSS VAHTSMSDNG 130 140 150 160 170 180 GFKRPLAPSG RSPVEGLGRA HRSPASPRVP PVPDYVAHPE RWTKYSLEDV TEVSEQSNQA 190 200 210 220 230 240 TALAFLGSQS LAAPTDCVSS FNQDPSSCGE GRVIFTKPVR GVEARHERKR VLGKVGEPGR 250 260 270 280 290 300 GGLGNPATDR GEGPVELAHL AGPGSPEAEE WGSHHGGLQE VEALSGSVHS GSVPGLPPVE 310 320 TVGFHGSRKR SRDHFRNKSS SPEDPGAEV
	Isoform 2 [UniParc]. Checksum: 72811C9774FC24C4	FASTA	265	27,935
	10 20 30 40 50 60 MAEAGTGLLP ATVQPFHLRG MSSTFSQRSR DIFDCLEGAA RRAPSSVAHT SMSDNGGFKR 70 80 90 100 110 120 PLAPSGRSPV EGLGRAHRSP ASPRVPPVPD YVAHPERWTK YSLEDVTEVS EQSNQATALA 130 140 150 160 170 180 FLGSQSLAAP TDCVSSFNQD PSSCGEGRVI FTKPVRGVEA RHERKRVLGK VGEPGRGGLG 190 200 210 220 230 240 NPATDRGEGP VELAHLAGPG SPEAEEWGSH HGGLQEVEAL SGSVHSGSVP GLPPVETVGF 250 260 HGSRKRSRDH FRNKSSSPED PGAEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting." Lee M.P., Brandenburg S., Landes G.M., Adams M., Miller G., Feinberg A.P. Hum. Mol. Genet. 8:683-690(1999) [PubMed: 10072438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT PRO-274.
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT PRO-274. Tissue: Brain and Lymph.
[4]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-143 AND SER-146, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[8]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[9]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-217, MASS SPECTROMETRY.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF125568 mRNA. Translation: AAD23579.1. AC124057 Genomic DNA. No translation available. BC006091 mRNA. Translation: AAH06091.1. BC050616 mRNA. Translation: AAH50616.1.
IPI	IPI00305144. IPI00657787.
RefSeq	NP_005697.2. NM_005706.2.
UniGene	Hs.523424.
3D structure databases
ProteinModelPortal	Q9Y5U2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y5U2. 3 interactions.
MINT	MINT-1380986.
STRING	Q9Y5U2.
PTM databases
PhosphoSite	Q9Y5U2.
Polymorphism databases
DMDM	296453006.
Proteomic databases
PRIDE	Q9Y5U2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000333256; ENSP00000331087; ENSG00000184281.
GeneID	10078.
KEGG	hsa:10078.
UCSC	uc001lwi.2. human. uc001lwj.1. human.
Organism-specific databases
CTD	10078.
GeneCards	GC11P002421.
H-InvDB	HIX0009365.
HGNC	HGNC:12386. TSSC4.
HPA	HPA041801.
MIM	603852. gene.
neXtProt	NX_Q9Y5U2.
PharmGKB	PA37054.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19882.
GeneTree	ENSGT00390000011846.
HOGENOM	HBG283334.
HOVERGEN	HBG059835.
InParanoid	Q9Y5U2.
OMA	RSRDHFR.
OrthoDB	EOG402WSX.
PhylomeDB	Q9Y5U2.
Gene expression databases
ArrayExpress	Q9Y5U2.
Bgee	Q9Y5U2.
CleanEx	HS_TSSC4.
Genevestigator	Q9Y5U2.
GermOnline	ENSG00000184281. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
NextBio	38103.
SOURCE	Search...

Entry information

Entry name

TSSC4_HUMAN

Accession

Primary (citable) accession number: Q9Y5U2
Secondary accession number(s): C9JS66, Q86VL2, Q9BRS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.