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Protein

Protein TSSC4

Gene

TSSC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TSSC4
Alternative name(s):
Tumor-suppressing STF cDNA 4 protein
Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein
Gene namesi
Name:TSSC4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:12386. TSSC4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37054.

Polymorphism and mutation databases

BioMutaiTSSC4.
DMDMi296453006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Protein TSSC4PRO_0000076360Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601PhosphoserineBy similarity
Modified residuei67 – 671PhosphoserineBy similarity
Modified residuei86 – 861PhosphoserineCombined sources
Modified residuei132 – 1321PhosphoserineCombined sources
Modified residuei143 – 1431PhosphoserineCombined sources
Modified residuei146 – 1461PhosphoserineCombined sources
Modified residuei217 – 2171N6-acetyllysineCombined sources
Modified residuei265 – 2651PhosphoserineCombined sources
Modified residuei321 – 3211PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y5U2.
MaxQBiQ9Y5U2.
PaxDbiQ9Y5U2.
PeptideAtlasiQ9Y5U2.
PRIDEiQ9Y5U2.

PTM databases

iPTMnetiQ9Y5U2.
PhosphoSiteiQ9Y5U2.

Expressioni

Tissue specificityi

Expressed in fetal brain, lung, liver and kidney. Widely expressed in adult tissues.1 Publication

Gene expression databases

BgeeiQ9Y5U2.
CleanExiHS_TSSC4.
ExpressionAtlasiQ9Y5U2. baseline and differential.
GenevisibleiQ9Y5U2. HS.

Organism-specific databases

HPAiHPA041801.
HPA058763.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP76Q8TAP63EBI-717229,EBI-742887
FLJ13057Q53SE73EBI-717229,EBI-10172181
GOLGA2Q083793EBI-717229,EBI-618309
KPNA3Q8IYQ93EBI-717229,EBI-742146
RELQ048643EBI-717229,EBI-307352
RNF31Q96EP0-33EBI-717229,EBI-10225152
TERF2IPQ9NYB02EBI-717229,EBI-750109
TRAF1Q130773EBI-717229,EBI-359224
TRAF2Q129333EBI-717229,EBI-355744

Protein-protein interaction databases

BioGridi115388. 73 interactions.
IntActiQ9Y5U2. 24 interactions.
MINTiMINT-1380986.
STRINGi9606.ENSP00000331087.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5U2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TSSC4 family.Curated

Phylogenomic databases

eggNOGiENOG410IIC0. Eukaryota.
ENOG41120VA. LUCA.
GeneTreeiENSGT00390000011846.
HOGENOMiHOG000154697.
HOVERGENiHBG059835.
InParanoidiQ9Y5U2.
OMAiRDHFRNK.
OrthoDBiEOG7C8GHF.
PhylomeDBiQ9Y5U2.
TreeFamiTF335741.

Family and domain databases

InterProiIPR029338. TSSC4.
[Graphical view]
PfamiPF15264. TSSC4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5U2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEAGTGEPS PSVEGEHGTE YDTLPSDTVS LSDSDSDLSL PGGAEVEALS
60 70 80 90 100
PMGLPGEEDS GPDEPPSPPS GLLPATVQPF HLRGMSSTFS QRSRDIFDCL
110 120 130 140 150
EGAARRAPSS VAHTSMSDNG GFKRPLAPSG RSPVEGLGRA HRSPASPRVP
160 170 180 190 200
PVPDYVAHPE RWTKYSLEDV TEVSEQSNQA TALAFLGSQS LAAPTDCVSS
210 220 230 240 250
FNQDPSSCGE GRVIFTKPVR GVEARHERKR VLGKVGEPGR GGLGNPATDR
260 270 280 290 300
GEGPVELAHL AGPGSPEAEE WGSHHGGLQE VEALSGSVHS GSVPGLPPVE
310 320
TVGFHGSRKR SRDHFRNKSS SPEDPGAEV
Length:329
Mass (Da):34,326
Last modified:May 18, 2010 - v3
Checksum:iAFC2D5CBD93844F0
GO
Isoform 2 (identifier: Q9Y5U2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-71: Missing.

Show »
Length:265
Mass (Da):27,935
Checksum:i72811C9774FC24C4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti72 – 721L → F in AAD23579 (PubMed:10072438).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171H → P.
Corresponds to variant rs2234278 [ dbSNP | Ensembl ].
VAR_057826
Natural varianti124 – 1241R → Q.
Corresponds to variant rs1008265 [ dbSNP | Ensembl ].
VAR_060194
Natural varianti230 – 2301R → S.
Corresponds to variant rs2234280 [ dbSNP | Ensembl ].
VAR_057827
Natural varianti262 – 2621G → R.
Corresponds to variant rs2234281 [ dbSNP | Ensembl ].
VAR_057828
Natural varianti274 – 2741H → P.2 Publications
Corresponds to variant rs2234283 [ dbSNP | Ensembl ].
VAR_063128

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei8 – 7164Missing in isoform 2. 1 PublicationVSP_016561Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125568 mRNA. Translation: AAD23579.1.
AC124057 Genomic DNA. No translation available.
BC006091 mRNA. Translation: AAH06091.1.
BC050616 mRNA. Translation: AAH50616.1.
CCDSiCCDS73241.1. [Q9Y5U2-2]
CCDS7735.1. [Q9Y5U2-1]
RefSeqiNP_001284587.1. NM_001297658.1. [Q9Y5U2-1]
NP_001284588.1. NM_001297659.1. [Q9Y5U2-1]
NP_001284589.1. NM_001297660.1. [Q9Y5U2-1]
NP_001284590.1. NM_001297661.1. [Q9Y5U2-2]
NP_005697.2. NM_005706.3. [Q9Y5U2-1]
XP_006718181.1. XM_006718118.1. [Q9Y5U2-1]
XP_011518132.1. XM_011519830.1. [Q9Y5U2-1]
UniGeneiHs.523424.
Hs.732116.

Genome annotation databases

EnsembliENST00000333256; ENSP00000331087; ENSG00000184281. [Q9Y5U2-1]
ENST00000380996; ENSP00000370384; ENSG00000184281. [Q9Y5U2-2]
ENST00000451491; ENSP00000411224; ENSG00000184281. [Q9Y5U2-1]
GeneIDi10078.
KEGGihsa:10078.
UCSCiuc001lwi.4. human. [Q9Y5U2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125568 mRNA. Translation: AAD23579.1.
AC124057 Genomic DNA. No translation available.
BC006091 mRNA. Translation: AAH06091.1.
BC050616 mRNA. Translation: AAH50616.1.
CCDSiCCDS73241.1. [Q9Y5U2-2]
CCDS7735.1. [Q9Y5U2-1]
RefSeqiNP_001284587.1. NM_001297658.1. [Q9Y5U2-1]
NP_001284588.1. NM_001297659.1. [Q9Y5U2-1]
NP_001284589.1. NM_001297660.1. [Q9Y5U2-1]
NP_001284590.1. NM_001297661.1. [Q9Y5U2-2]
NP_005697.2. NM_005706.3. [Q9Y5U2-1]
XP_006718181.1. XM_006718118.1. [Q9Y5U2-1]
XP_011518132.1. XM_011519830.1. [Q9Y5U2-1]
UniGeneiHs.523424.
Hs.732116.

3D structure databases

ProteinModelPortaliQ9Y5U2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115388. 73 interactions.
IntActiQ9Y5U2. 24 interactions.
MINTiMINT-1380986.
STRINGi9606.ENSP00000331087.

PTM databases

iPTMnetiQ9Y5U2.
PhosphoSiteiQ9Y5U2.

Polymorphism and mutation databases

BioMutaiTSSC4.
DMDMi296453006.

Proteomic databases

EPDiQ9Y5U2.
MaxQBiQ9Y5U2.
PaxDbiQ9Y5U2.
PeptideAtlasiQ9Y5U2.
PRIDEiQ9Y5U2.

Protocols and materials databases

DNASUi10078.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333256; ENSP00000331087; ENSG00000184281. [Q9Y5U2-1]
ENST00000380996; ENSP00000370384; ENSG00000184281. [Q9Y5U2-2]
ENST00000451491; ENSP00000411224; ENSG00000184281. [Q9Y5U2-1]
GeneIDi10078.
KEGGihsa:10078.
UCSCiuc001lwi.4. human. [Q9Y5U2-1]

Organism-specific databases

CTDi10078.
GeneCardsiTSSC4.
H-InvDBHIX0009365.
HGNCiHGNC:12386. TSSC4.
HPAiHPA041801.
HPA058763.
MIMi603852. gene.
neXtProtiNX_Q9Y5U2.
PharmGKBiPA37054.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIC0. Eukaryota.
ENOG41120VA. LUCA.
GeneTreeiENSGT00390000011846.
HOGENOMiHOG000154697.
HOVERGENiHBG059835.
InParanoidiQ9Y5U2.
OMAiRDHFRNK.
OrthoDBiEOG7C8GHF.
PhylomeDBiQ9Y5U2.
TreeFamiTF335741.

Miscellaneous databases

GenomeRNAii10078.
PROiQ9Y5U2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5U2.
CleanExiHS_TSSC4.
ExpressionAtlasiQ9Y5U2. baseline and differential.
GenevisibleiQ9Y5U2. HS.

Family and domain databases

InterProiIPR029338. TSSC4.
[Graphical view]
PfamiPF15264. TSSC4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting."
    Lee M.P., Brandenburg S., Landes G.M., Adams M., Miller G., Feinberg A.P.
    Hum. Mol. Genet. 8:683-690(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT PRO-274.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT PRO-274.
    Tissue: Brain and Lymph.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143 AND SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-217, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143 AND SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-86; SER-132 AND SER-146, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma and Erythroleukemia.
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-265, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiTSSC4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5U2
Secondary accession number(s): C9JS66, Q86VL2, Q9BRS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.