Reviewed, UniProtKB/Swiss-Prot Q9Y5U2 (TSSC4_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein TSSC4
Alternative name(s):
    Tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein
    Tumor-suppressing STF cDNA 4 protein

Gene names

Name:

TSSC4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	329 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Expressed in fetal brain, lung, liver and kidney. Widely expressed in adult tissues. Ref.1
Sequence similarities	Belongs to the TSSC4 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y5U2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y5U2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     8-71: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 329	329	Protein TSSC4		PRO_0000076360
Amino acid modifications
	Modified residue	129	1	Phosphoserine Ref.4
	Modified residue	132	1	Phosphoserine Ref.5
	Modified residue	143	1	Phosphoserine Ref.5
	Modified residue	146	1	Phosphoserine Ref.5
	Modified residue	321	1	Phosphoserine Ref.3
Natural variations
	Alternative sequence	8 – 71	64	Missing in isoform 2.		VSP_016561
	Natural variant	17	1	H → P: dbSNP rs2234278.		VAR_057826
	Natural variant	230	1	R → S: dbSNP rs2234280.		VAR_057827
	Natural variant	262	1	G → R: dbSNP rs2234281.		VAR_057828
Experimental info
	Sequence conflict	72	1	L → F in AAD23579. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 20, 2005. Version 2. Checksum: D7C2CDD3D93844E2	FASTA	329	34,285
	10 20 30 40 50 60 MAEAGTGEPS PSVEGEHGTE YDTLPSDTVS LSDSDSDLSL PGGAEVEALS PMGLPGEEDS 70 80 90 100 110 120 GPDEPPSPPS GLLPATVQPF HLRGMSSTFS QRSRDIFDCL EGAARRAPSS VAHTSMSDNG 130 140 150 160 170 180 GFKRPLAPSG RSPVEGLGRA HRSPASPRVP PVPDYVAHPE RWTKYSLEDV TEVSEQSNQA 190 200 210 220 230 240 TALAFLGSQS LAAPTDCVSS FNQDPSSCGE GRVIFTKPVR GVEARHERKR VLGKVGEPGR 250 260 270 280 290 300 GGLGNPATDR GEGPVELAHL AGPGSPEAEE WGSPHGGLQE VEALSGSVHS GSVPGLPPVE 310 320 TVGFHGSRKR SRDHFRNKSS SPEDPGAEV
	Isoform 2. Checksum: 0A81048F74FC24D6	FASTA	265	27,895
	10 20 30 40 50 60 MAEAGTGLLP ATVQPFHLRG MSSTFSQRSR DIFDCLEGAA RRAPSSVAHT SMSDNGGFKR 70 80 90 100 110 120 PLAPSGRSPV EGLGRAHRSP ASPRVPPVPD YVAHPERWTK YSLEDVTEVS EQSNQATALA 130 140 150 160 170 180 FLGSQSLAAP TDCVSSFNQD PSSCGEGRVI FTKPVRGVEA RHERKRVLGK VGEPGRGGLG 190 200 210 220 230 240 NPATDRGEGP VELAHLAGPG SPEAEEWGSP HGGLQEVEAL SGSVHSGSVP GLPPVETVGF 250 260 HGSRKRSRDH FRNKSSSPED PGAEV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting." Lee M.P., Brandenburg S., Landes G.M., Adams M., Miller G., Feinberg A.P. Hum. Mol. Genet. 8:683-690(1999) [PubMed: 10072438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Brain and Lymph.
[3]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321, MASS SPECTROMETRY. Tissue: Epithelium.
[4]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-129, MASS SPECTROMETRY. Tissue: Epithelium.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132; SER-143 AND SER-146, MASS SPECTROMETRY.
[6]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF125568 mRNA. Translation: AAD23579.1. BC006091 mRNA. Translation: AAH06091.1. BC050616 mRNA. Translation: AAH50616.1.
IPI	IPI00305144. IPI00657787.
RefSeq	NP_005697.2.
UniGene	Hs.523424
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y5U2. 2 interactions.
PTM databases
PhosphoSite	Q9Y5U2.
Proteomic databases
PRIDE	Q9Y5U2.
Genome annotation databases
Ensembl	ENSG00000184281. Homo sapiens. [Contig view]
GeneID	10078.
KEGG	hsa:10078.
Organism-specific databases
GeneCards	GC11P002378.
H-InvDB	HIX0009365.
HGNC	HGNC:12386. TSSC4.
MIM	603852. gene.
PharmGKB	PA37054.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y5U2.
HOVERGEN	Q9Y5U2.
Gene expression databases
Bgee	Q9Y5U2.
CleanEx	HS_TSSC4.
GermOnline	ENSG00000184281. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	38103.
SOURCE	Search...

Entry information

Entry name

TSSC4_HUMAN

Accession

Primary (citable) accession number: Q9Y5U2
Secondary accession number(s): Q86VL2, Q9BRS6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	May 26, 2009
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)