ID   DJC15_HUMAN             Reviewed;         150 AA.
AC   Q9Y5T4; B2R4L0; Q5T219; Q6X963;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 2.
DT   25-JAN-2012, entry version 84.
DE   RecName: Full=DnaJ homolog subfamily C member 15;
DE   AltName: Full=Cell growth-inhibiting gene 22 protein;
DE   AltName: Full=Methylation-controlled J protein;
DE            Short=MCJ;
GN   Name=DNAJC15; Synonyms=DNAJD1; ORFNames=GIG22, HSD18;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND VARIANT GLY-35.
RX   MEDLINE=21257734; PubMed=11358853;
RA   Shridhar V., Bible K.C., Staub J., Avula R., Lee Y.K., Kalli K.,
RA   Huang H., Hartmann L.C., Kaufmann S.H., Smith D.I.;
RT   "Loss of expression of a new member of the DNAJ protein family confers
RT   resistance to chemotherapeutic agents used in the treatment of ovarian
RT   cancer.";
RL   Cancer Res. 61:4258-4265(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RA   Yang C.B., Miao S.Y., Zhang X.D., Qiao Y., Liang G., Wang L.F.;
RT   "A new spermatogenesis-related gene.";
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kim J.W.;
RT   "Identification of a cell growth inhibiting gene.";
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA   Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA   Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA   Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA   Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA   Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA   Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA   Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA   Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA   Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA   Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA   Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA   King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA   Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA   Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA   Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA   Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA   Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA   Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-35.
RC   TISSUE=Skin;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein
CC       (Potential).
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- MISCELLANEOUS: Absent or down-regulated in many advanced cases of
CC       ovarian adenocarcinoma, due to hypermethylation and allelic loss.
CC       Loss of expression correlates with increased resistance to
CC       antineoplastic drugs, such as cisplatin.
CC   -!- SIMILARITY: Contains 1 J domain.
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DR   EMBL; AF126743; AAD38506.1; -; mRNA.
DR   EMBL; AY248898; AAP20049.1; -; mRNA.
DR   EMBL; AY512565; AAS80157.1; -; mRNA.
DR   EMBL; AK311866; BAG34807.1; -; mRNA.
DR   EMBL; AL445217; CAI13480.1; -; Genomic_DNA.
DR   EMBL; CH471075; EAX08688.1; -; Genomic_DNA.
DR   EMBL; BC010910; AAH10910.1; -; mRNA.
DR   EMBL; BC095400; AAH95400.1; -; mRNA.
DR   IPI; IPI00001649; -.
DR   RefSeq; NP_037370.2; NM_013238.2.
DR   UniGene; Hs.438830; -.
DR   ProteinModelPortal; Q9Y5T4; -.
DR   SMR; Q9Y5T4; 83-149.
DR   STRING; Q9Y5T4; -.
DR   PhosphoSite; Q9Y5T4; -.
DR   DMDM; 110808202; -.
DR   PRIDE; Q9Y5T4; -.
DR   Ensembl; ENST00000379221; ENSP00000368523; ENSG00000120675.
DR   GeneID; 29103; -.
DR   KEGG; hsa:29103; -.
DR   NMPDR; fig|9606.3.peg.8795; -.
DR   UCSC; uc001uyy.1; human.
DR   CTD; 29103; -.
DR   GeneCards; GC13P043597; -.
DR   H-InvDB; HIX0011275; -.
DR   HGNC; HGNC:20325; DNAJC15.
DR   HPA; HPA007988; -.
DR   neXtProt; NX_Q9Y5T4; -.
DR   PharmGKB; PA134932264; -.
DR   eggNOG; prNOG20282; -.
DR   GeneTree; ENSGT00390000017303; -.
DR   HOGENOM; HBG526913; -.
DR   HOVERGEN; HBG057483; -.
DR   InParanoid; Q9Y5T4; -.
DR   OMA; RYAFRIW; -.
DR   OrthoDB; EOG4X0MTQ; -.
DR   PhylomeDB; Q9Y5T4; -.
DR   NextBio; 52147; -.
DR   ArrayExpress; Q9Y5T4; -.
DR   Bgee; Q9Y5T4; -.
DR   CleanEx; HS_DNAJC15; -.
DR   Genevestigator; Q9Y5T4; -.
DR   GermOnline; ENSG00000120675; Homo sapiens.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031072; F:heat shock protein binding; IEA:InterPro.
DR   InterPro; IPR001623; DnaJ_N.
DR   Gene3D; G3DSA:1.10.287.110; DnaJ_N; 1.
DR   KO; K09535; -.
DR   Pfam; PF00226; DnaJ; 1.
DR   SMART; SM00271; DnaJ; 1.
DR   SUPFAM; SSF46565; DnaJ_N; 1.
DR   PROSITE; PS00636; DNAJ_1; FALSE_NEG.
DR   PROSITE; PS50076; DNAJ_2; 1.
PE   1: Evidence at protein level;
KW   Chaperone; Complete proteome; Membrane; Phosphoprotein; Polymorphism;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN         1    150       DnaJ homolog subfamily C member 15.
FT                                /FTId=PRO_0000247139.
FT   TRANSMEM     35     57       Helical; (Potential).
FT   DOMAIN       96    150       J.
FT   MOD_RES     104    104       Phosphoserine.
FT   VARIANT      35     35       R -> G (in dbSNP:rs11617079).
FT                                /FTId=VAR_027077.
FT   CONFLICT     34     34       Q -> R (in Ref. 2; AAP20049).
FT   CONFLICT    131    131       P -> S (in Ref. 2; AAP20049).
SQ   SEQUENCE   150 AA;  16383 MW;  988059B686D39967 CRC64;
     MAARGVIAPV GESLRYAEYL QPSAKRPDAD VDQQRLVRSL IAVGLGVAAL AFAGRYAFRI
     WKPLEQVITE TAKKISTPSF SSYYKGGFEQ KMSRREAGLI LGVSPSAGKA KIRTAHRRVM
     ILNHPDKGGS PYVAAKINEA KDLLETTTKH
//