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Q9Y5S5

- Q9Y5S5_HUMAN

UniProt

Q9Y5S5 - Q9Y5S5_HUMAN

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Protein

DNA polymerase

Gene

POLE1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. DNA repair Source: InterPro
  2. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replicationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:POLE1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. epsilon DNA polymerase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ9Y5S5.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5S5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000196287.
HOVERGENiHBG051398.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR013697. DNA_pol_e_suA_C.
IPR029703. POL2.
IPR012337. RNaseH-like_dom.
[Graphical view]
PANTHERiPTHR10670:SF0. PTHR10670:SF0. 1 hit.
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
PF08490. DUF1744. 1 hit.
[Graphical view]
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9Y5S5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRPLGLKSF PRHKQAPLPL SLTFHGCLLL RRDDGATSSV SALKRLERSQ
60 70 80 90 100
WTDKMDLRFG FERLKEPGEK TGWLINMHPT EILDEDKRLG SAVDYYFIQD
110 120 130 140 150
DGSRFKVALP YKPYFYIATR KGCEREVSSF LSKKFQGKIA KVETVPKEDL
160 170 180 190 200
DLPNHLVGLK RNYIRLSFHT VEDLVKVRKE ISPAVKKNRE QDHASDAYTA
210 220 230 240 250
LLSSVLQRGG VITDEEETSK KIADQLDNIV DMREYDVPYH IRLSIDLKIH
260 270 280 290 300
VAHWYNVRYR GNAFPVEITR RDDLVERPDP VVLAFDIETT KLPLKFPDAE
310 320 330 340 350
TDQIMMISYM IDGQGYLITN REIVSEDIED FEFTPKPEYE GPFCVFNEPD
360 370 380 390 400
EAHLIQRWFE HVQETKPTIM VTYNGDFFDW PFVEARAAVH GLSMQQEIGF
410 420 430 440 450
QKDSQGEYKA PQCIHMDCLR WVKRDSYLPV GSHNLKAAAK AKLGYDPVEL
460 470 480 490 500
DPEDMCRMAT EQPQTLATYS VSDAVATYYL YMKYVHPFIF ALCTIIPMEP
510 520 530 540 550
DEVLRKGSGT LCEALLMVQA FHANIIFPNK QEQEFNKLTD DGHVLDSETY
560 570 580 590 600
VGGHVEALES GVFRSDIPCR FRMNPAAFDF LLQRVEKTLR HALEEEEKVP
610 620 630 640 650
VEQVTNFEEV CDEIKSKLAS LKDVPSRIEC PLIYHLDVGA MYPNIILTNR
660 670 680 690 700
LQPSAMVDEA TCAACDFNKP GANCQRKMAW QWRGEFMPAS RSEYHRIQHQ
710 720 730 740 750
LESEKFPPLF PEGPARAFHE LSREEQAKYE KRRLADYCRK AYKKIHITKV
760 770 780 790 800
EERLTTICQR ENSFYVDTVR AFRDRRYEFK GLHKVWKKKL SAAVEVGDAA
810 820 830 840 850
EVKRCKNMEV LYDSLQLAHK CILNSFYGYV MRKGARWYSM EMAGIVCFTG
860 870 880 890 900
ANIITQAREL IEQIGRPLEL DTDGIWCVLP NSFPENFVFK TTNVKKPKVT
910 920 930 940 950
ISYPGAMLNI MVKEGFTNDQ YQELAEPSSL TYVTRSENSI FFEVDGPYLA
960 970 980 990 1000
MILPASKEEG KKLKKRYAVF NEDGSLAELK GFEVKRRGEL QLIKIFQSSV
1010 1020 1030 1040 1050
FEAFLKGSTL EEVYGSVAKV ADYWLDVLYS KAANMPDSEL FELISENRSM
1060 1070 1080 1090 1100
SRKLEDYGEQ KSTSISTAKR LAEFLGDQMV KDAGLSCRYI ISRKPEGSPV
1110 1120 1130 1140 1150
TERAIPLAIF QAEPTVRKHF LRKWLKSSSL QDFDIRAILD WDYYIERLGS
1160 1170 1180 1190 1200
AIQKIITIPA ALQQVKNPVP RVKHPDWLHK KLLEKNDVYK QKKISELFTL
1210 1220 1230 1240 1250
EGRRQVTMAE ASEDSPRPSA PDMEDFGLVK LPHPAAPVTV KRKRVLWESQ
1260 1270 1280 1290 1300
EESQDLTPTV PWQEILGQPP ALGTSQEEWL VWLRFHKKKW QLQARQRLAR
1310 1320 1330 1340 1350
RKRQRLESAE GVLRPGAIRD GPATGLGSFL RRTARSILDL PWQIVQISET
1360 1370 1380 1390 1400
SQAGLFRLWA LVGSDLHCIR LSIPRVFYVN QRVAKAEEGA SYRKVNRVLP
1410 1420 1430 1440 1450
RSNMVYNLYE YSVPEDMYQE HINEINAELS APDIEGVYET QVPLLFRALV
1460 1470 1480 1490 1500
HLGCVCVVNK QLVRHLSGWE AETFALEHLE MRSLAQFSYL EPGSIRHIYL
1510 1520 1530 1540 1550
YHHAQAHKAL FGIFIPSQRR ASVFVLDTVR TDQMPSLGAL YSAEHGLLLE
1560 1570 1580 1590 1600
KVGPELLPPP KHTFEVRAET DLKTICRAIQ RFLLAYKEER RGPTLIAVQS
1610 1620 1630 1640 1650
SWELKRLASE IPVLEEFPLV PICVADKINY GVLDWQRHGA RRMIRHYLNL
1660 1670 1680 1690 1700
DTCLSQAFEM SRYFHIPIGN LPEDISTFGS DLFFARHLQR HNHLLWLSPT
1710 1720 1730 1740 1750
ARPDLGGKEA DDNCLVMEFD DQATVEINSS GCYSTVCVEL DLQNLAVNTI
1760 1770 1780 1790 1800
LQSHHVNDME GADSMGISFD VIQQASLEDM ITGGQAASAP ASYDETALCS
1810 1820 1830 1840 1850
NTFRILKSMV VGWVKEITQY HNIYADNQVM HFYRWLRSPS SLLHDPALHR
1860 1870 1880 1890 1900
TLHNMMKKLF LQLIAEFKRL GSSVIYANFN RIILCTKKRR VEDAIAYVEY
1910 1920 1930 1940 1950
ITSSIHSKET FHSLTISFSR CWEFLLWMDP SNYGGIKGKV SSRIHCGLQD
1960 1970 1980 1990 2000
SQKAGGAEDE QENEDDEEER DGEEEEEAEE SNVEDLLENN WNILQFLPQA
2010 2020 2030 2040 2050
ASCQNYFLMI VSAYIVAVYH CMKDGLRRSA PGSTPVRRRG ASQLSQEAEG
2060 2070 2080 2090 2100
AVGALPGMIT FSQDYVANEL TQSFFTITQK IQKKVTGSRN STELSEMFPV
2110 2120 2130 2140 2150
LPGSHLLLNN PALEFIKYVC KVLSLDTNIT NQVNKLNRDL LRLVDVGEFS
2160 2170 2180 2190 2200
EEAQFRDPCR SYVLPEVICR SCNFCRDLDL CKDSSFSEDG AVLPQWLCSN
2210 2220 2230 2240 2250
CQAPYDSSAI EMTLVEVLQK KLMAFTLQDL VCLKCRGVKE TSMPVYCTCA
2260 2270 2280 2290
GDFALTIHTQ VFMEQIGIFR NIAQHYGMSY LLETLEWLLQ KNPQLGH
Length:2,297
Mass (Da):263,016
Last modified:November 1, 1999 - v1
Checksum:i3DD4BBB6C615B3CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127975
, AF127937, AF127939, AF127940, AF127941, AF127942, AF127943, AF127944, AF127945, AF127946, AF127947, AF127948, AF127949, AF127950, AF127951, AF127952, AF127953, AF127954, AF127955, AF127956, AF127957, AF127958, AF127959, AF127960, AF127961, AF127962, AF127963, AF127964, AF127965, AF127966, AF127967, AF127968, AF127969, AF127970, AF127971, AF127972, AF127973, AF127974 Genomic DNA. Translation: AAD44690.1.
UniGeneiHs.524871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF127975
, AF127937 , AF127939 , AF127940 , AF127941 , AF127942 , AF127943 , AF127944 , AF127945 , AF127946 , AF127947 , AF127948 , AF127949 , AF127950 , AF127951 , AF127952 , AF127953 , AF127954 , AF127955 , AF127956 , AF127957 , AF127958 , AF127959 , AF127960 , AF127961 , AF127962 , AF127963 , AF127964 , AF127965 , AF127966 , AF127967 , AF127968 , AF127969 , AF127970 , AF127971 , AF127972 , AF127973 , AF127974 Genomic DNA. Translation: AAD44690.1 .
UniGenei Hs.524871.

3D structure databases

ProteinModelPortali Q9Y5S5.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9Y5S5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000196287.
HOVERGENi HBG051398.

Miscellaneous databases

ChiTaRSi POLE. human.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
InterProi IPR006172. DNA-dir_DNA_pol_B.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR013697. DNA_pol_e_suA_C.
IPR029703. POL2.
IPR012337. RNaseH-like_dom.
[Graphical view ]
PANTHERi PTHR10670:SF0. PTHR10670:SF0. 1 hit.
Pfami PF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
PF08490. DUF1744. 1 hit.
[Graphical view ]
SMARTi SM00486. POLBc. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Structural organization and splice variants of the POLE1 gene encoding the catalytic subunit of human DNA polymerase epsilon."
    Huang D., Pospiech H., Kesti T., Syvaoja J.E.
    Biochem. J. 339:657-665(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9Y5S5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5S5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.