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Q9Y5S5

- Q9Y5S5_HUMAN

UniProt

Q9Y5S5 - Q9Y5S5_HUMAN

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Protein
DNA polymerase
Gene
POLE1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. nucleotide binding Source: InterPro
  4. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replicationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:POLE1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: InterPro
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ9Y5S5.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5S5.

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000196287.
HOVERGENiHBG051398.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR013697. DNA_pol_e_suA_C.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
PF08490. DUF1744. 1 hit.
[Graphical view]
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9Y5S5-1 [UniParc]FASTAAdd to Basket

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MSRPLGLKSF PRHKQAPLPL SLTFHGCLLL RRDDGATSSV SALKRLERSQ     50
WTDKMDLRFG FERLKEPGEK TGWLINMHPT EILDEDKRLG SAVDYYFIQD 100
DGSRFKVALP YKPYFYIATR KGCEREVSSF LSKKFQGKIA KVETVPKEDL 150
DLPNHLVGLK RNYIRLSFHT VEDLVKVRKE ISPAVKKNRE QDHASDAYTA 200
LLSSVLQRGG VITDEEETSK KIADQLDNIV DMREYDVPYH IRLSIDLKIH 250
VAHWYNVRYR GNAFPVEITR RDDLVERPDP VVLAFDIETT KLPLKFPDAE 300
TDQIMMISYM IDGQGYLITN REIVSEDIED FEFTPKPEYE GPFCVFNEPD 350
EAHLIQRWFE HVQETKPTIM VTYNGDFFDW PFVEARAAVH GLSMQQEIGF 400
QKDSQGEYKA PQCIHMDCLR WVKRDSYLPV GSHNLKAAAK AKLGYDPVEL 450
DPEDMCRMAT EQPQTLATYS VSDAVATYYL YMKYVHPFIF ALCTIIPMEP 500
DEVLRKGSGT LCEALLMVQA FHANIIFPNK QEQEFNKLTD DGHVLDSETY 550
VGGHVEALES GVFRSDIPCR FRMNPAAFDF LLQRVEKTLR HALEEEEKVP 600
VEQVTNFEEV CDEIKSKLAS LKDVPSRIEC PLIYHLDVGA MYPNIILTNR 650
LQPSAMVDEA TCAACDFNKP GANCQRKMAW QWRGEFMPAS RSEYHRIQHQ 700
LESEKFPPLF PEGPARAFHE LSREEQAKYE KRRLADYCRK AYKKIHITKV 750
EERLTTICQR ENSFYVDTVR AFRDRRYEFK GLHKVWKKKL SAAVEVGDAA 800
EVKRCKNMEV LYDSLQLAHK CILNSFYGYV MRKGARWYSM EMAGIVCFTG 850
ANIITQAREL IEQIGRPLEL DTDGIWCVLP NSFPENFVFK TTNVKKPKVT 900
ISYPGAMLNI MVKEGFTNDQ YQELAEPSSL TYVTRSENSI FFEVDGPYLA 950
MILPASKEEG KKLKKRYAVF NEDGSLAELK GFEVKRRGEL QLIKIFQSSV 1000
FEAFLKGSTL EEVYGSVAKV ADYWLDVLYS KAANMPDSEL FELISENRSM 1050
SRKLEDYGEQ KSTSISTAKR LAEFLGDQMV KDAGLSCRYI ISRKPEGSPV 1100
TERAIPLAIF QAEPTVRKHF LRKWLKSSSL QDFDIRAILD WDYYIERLGS 1150
AIQKIITIPA ALQQVKNPVP RVKHPDWLHK KLLEKNDVYK QKKISELFTL 1200
EGRRQVTMAE ASEDSPRPSA PDMEDFGLVK LPHPAAPVTV KRKRVLWESQ 1250
EESQDLTPTV PWQEILGQPP ALGTSQEEWL VWLRFHKKKW QLQARQRLAR 1300
RKRQRLESAE GVLRPGAIRD GPATGLGSFL RRTARSILDL PWQIVQISET 1350
SQAGLFRLWA LVGSDLHCIR LSIPRVFYVN QRVAKAEEGA SYRKVNRVLP 1400
RSNMVYNLYE YSVPEDMYQE HINEINAELS APDIEGVYET QVPLLFRALV 1450
HLGCVCVVNK QLVRHLSGWE AETFALEHLE MRSLAQFSYL EPGSIRHIYL 1500
YHHAQAHKAL FGIFIPSQRR ASVFVLDTVR TDQMPSLGAL YSAEHGLLLE 1550
KVGPELLPPP KHTFEVRAET DLKTICRAIQ RFLLAYKEER RGPTLIAVQS 1600
SWELKRLASE IPVLEEFPLV PICVADKINY GVLDWQRHGA RRMIRHYLNL 1650
DTCLSQAFEM SRYFHIPIGN LPEDISTFGS DLFFARHLQR HNHLLWLSPT 1700
ARPDLGGKEA DDNCLVMEFD DQATVEINSS GCYSTVCVEL DLQNLAVNTI 1750
LQSHHVNDME GADSMGISFD VIQQASLEDM ITGGQAASAP ASYDETALCS 1800
NTFRILKSMV VGWVKEITQY HNIYADNQVM HFYRWLRSPS SLLHDPALHR 1850
TLHNMMKKLF LQLIAEFKRL GSSVIYANFN RIILCTKKRR VEDAIAYVEY 1900
ITSSIHSKET FHSLTISFSR CWEFLLWMDP SNYGGIKGKV SSRIHCGLQD 1950
SQKAGGAEDE QENEDDEEER DGEEEEEAEE SNVEDLLENN WNILQFLPQA 2000
ASCQNYFLMI VSAYIVAVYH CMKDGLRRSA PGSTPVRRRG ASQLSQEAEG 2050
AVGALPGMIT FSQDYVANEL TQSFFTITQK IQKKVTGSRN STELSEMFPV 2100
LPGSHLLLNN PALEFIKYVC KVLSLDTNIT NQVNKLNRDL LRLVDVGEFS 2150
EEAQFRDPCR SYVLPEVICR SCNFCRDLDL CKDSSFSEDG AVLPQWLCSN 2200
CQAPYDSSAI EMTLVEVLQK KLMAFTLQDL VCLKCRGVKE TSMPVYCTCA 2250
GDFALTIHTQ VFMEQIGIFR NIAQHYGMSY LLETLEWLLQ KNPQLGH 2297
Length:2,297
Mass (Da):263,016
Last modified:November 1, 1999 - v1
Checksum:i3DD4BBB6C615B3CB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF127975
, AF127937, AF127939, AF127940, AF127941, AF127942, AF127943, AF127944, AF127945, AF127946, AF127947, AF127948, AF127949, AF127950, AF127951, AF127952, AF127953, AF127954, AF127955, AF127956, AF127957, AF127958, AF127959, AF127960, AF127961, AF127962, AF127963, AF127964, AF127965, AF127966, AF127967, AF127968, AF127969, AF127970, AF127971, AF127972, AF127973, AF127974 Genomic DNA. Translation: AAD44690.1.
UniGeneiHs.524871.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF127975
, AF127937 , AF127939 , AF127940 , AF127941 , AF127942 , AF127943 , AF127944 , AF127945 , AF127946 , AF127947 , AF127948 , AF127949 , AF127950 , AF127951 , AF127952 , AF127953 , AF127954 , AF127955 , AF127956 , AF127957 , AF127958 , AF127959 , AF127960 , AF127961 , AF127962 , AF127963 , AF127964 , AF127965 , AF127966 , AF127967 , AF127968 , AF127969 , AF127970 , AF127971 , AF127972 , AF127973 , AF127974 Genomic DNA. Translation: AAD44690.1 .
UniGenei Hs.524871.

3D structure databases

ProteinModelPortali Q9Y5S5.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9Y5S5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000196287.
HOVERGENi HBG051398.

Miscellaneous databases

ChiTaRSi POLE. human.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
InterProi IPR006172. DNA-dir_DNA_pol_B.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR013697. DNA_pol_e_suA_C.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
PF08490. DUF1744. 1 hit.
[Graphical view ]
SMARTi SM00486. POLBc. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Structural organization and splice variants of the POLE1 gene encoding the catalytic subunit of human DNA polymerase epsilon."
    Huang D., Pospiech H., Kesti T., Syvaoja J.E.
    Biochem. J. 339:657-665(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9Y5S5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5S5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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