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Q9Y5S5

- Q9Y5S5_HUMAN

UniProt

Q9Y5S5 - Q9Y5S5_HUMAN

Protein

DNA polymerase

Gene

POLE1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
    3. nucleotide binding Source: InterPro
    4. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replicationUniRule annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
    Gene namesi
    Name:POLE1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: InterPro

    PTM / Processingi

    Proteomic databases

    PRIDEiQ9Y5S5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5S5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA polymerase type-B family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000196287.
    HOVERGENiHBG051398.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    InterProiIPR006172. DNA-dir_DNA_pol_B.
    IPR006133. DNA-dir_DNA_pol_B_exonuc.
    IPR006134. DNA-dir_DNA_pol_B_multi_dom.
    IPR013697. DNA_pol_e_suA_C.
    IPR012337. RNaseH-like_dom.
    [Graphical view]
    PfamiPF00136. DNA_pol_B. 1 hit.
    PF03104. DNA_pol_B_exo1. 1 hit.
    PF08490. DUF1744. 1 hit.
    [Graphical view]
    SMARTiSM00486. POLBc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9Y5S5-1 [UniParc]FASTAAdd to Basket

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    MSRPLGLKSF PRHKQAPLPL SLTFHGCLLL RRDDGATSSV SALKRLERSQ     50
    WTDKMDLRFG FERLKEPGEK TGWLINMHPT EILDEDKRLG SAVDYYFIQD 100
    DGSRFKVALP YKPYFYIATR KGCEREVSSF LSKKFQGKIA KVETVPKEDL 150
    DLPNHLVGLK RNYIRLSFHT VEDLVKVRKE ISPAVKKNRE QDHASDAYTA 200
    LLSSVLQRGG VITDEEETSK KIADQLDNIV DMREYDVPYH IRLSIDLKIH 250
    VAHWYNVRYR GNAFPVEITR RDDLVERPDP VVLAFDIETT KLPLKFPDAE 300
    TDQIMMISYM IDGQGYLITN REIVSEDIED FEFTPKPEYE GPFCVFNEPD 350
    EAHLIQRWFE HVQETKPTIM VTYNGDFFDW PFVEARAAVH GLSMQQEIGF 400
    QKDSQGEYKA PQCIHMDCLR WVKRDSYLPV GSHNLKAAAK AKLGYDPVEL 450
    DPEDMCRMAT EQPQTLATYS VSDAVATYYL YMKYVHPFIF ALCTIIPMEP 500
    DEVLRKGSGT LCEALLMVQA FHANIIFPNK QEQEFNKLTD DGHVLDSETY 550
    VGGHVEALES GVFRSDIPCR FRMNPAAFDF LLQRVEKTLR HALEEEEKVP 600
    VEQVTNFEEV CDEIKSKLAS LKDVPSRIEC PLIYHLDVGA MYPNIILTNR 650
    LQPSAMVDEA TCAACDFNKP GANCQRKMAW QWRGEFMPAS RSEYHRIQHQ 700
    LESEKFPPLF PEGPARAFHE LSREEQAKYE KRRLADYCRK AYKKIHITKV 750
    EERLTTICQR ENSFYVDTVR AFRDRRYEFK GLHKVWKKKL SAAVEVGDAA 800
    EVKRCKNMEV LYDSLQLAHK CILNSFYGYV MRKGARWYSM EMAGIVCFTG 850
    ANIITQAREL IEQIGRPLEL DTDGIWCVLP NSFPENFVFK TTNVKKPKVT 900
    ISYPGAMLNI MVKEGFTNDQ YQELAEPSSL TYVTRSENSI FFEVDGPYLA 950
    MILPASKEEG KKLKKRYAVF NEDGSLAELK GFEVKRRGEL QLIKIFQSSV 1000
    FEAFLKGSTL EEVYGSVAKV ADYWLDVLYS KAANMPDSEL FELISENRSM 1050
    SRKLEDYGEQ KSTSISTAKR LAEFLGDQMV KDAGLSCRYI ISRKPEGSPV 1100
    TERAIPLAIF QAEPTVRKHF LRKWLKSSSL QDFDIRAILD WDYYIERLGS 1150
    AIQKIITIPA ALQQVKNPVP RVKHPDWLHK KLLEKNDVYK QKKISELFTL 1200
    EGRRQVTMAE ASEDSPRPSA PDMEDFGLVK LPHPAAPVTV KRKRVLWESQ 1250
    EESQDLTPTV PWQEILGQPP ALGTSQEEWL VWLRFHKKKW QLQARQRLAR 1300
    RKRQRLESAE GVLRPGAIRD GPATGLGSFL RRTARSILDL PWQIVQISET 1350
    SQAGLFRLWA LVGSDLHCIR LSIPRVFYVN QRVAKAEEGA SYRKVNRVLP 1400
    RSNMVYNLYE YSVPEDMYQE HINEINAELS APDIEGVYET QVPLLFRALV 1450
    HLGCVCVVNK QLVRHLSGWE AETFALEHLE MRSLAQFSYL EPGSIRHIYL 1500
    YHHAQAHKAL FGIFIPSQRR ASVFVLDTVR TDQMPSLGAL YSAEHGLLLE 1550
    KVGPELLPPP KHTFEVRAET DLKTICRAIQ RFLLAYKEER RGPTLIAVQS 1600
    SWELKRLASE IPVLEEFPLV PICVADKINY GVLDWQRHGA RRMIRHYLNL 1650
    DTCLSQAFEM SRYFHIPIGN LPEDISTFGS DLFFARHLQR HNHLLWLSPT 1700
    ARPDLGGKEA DDNCLVMEFD DQATVEINSS GCYSTVCVEL DLQNLAVNTI 1750
    LQSHHVNDME GADSMGISFD VIQQASLEDM ITGGQAASAP ASYDETALCS 1800
    NTFRILKSMV VGWVKEITQY HNIYADNQVM HFYRWLRSPS SLLHDPALHR 1850
    TLHNMMKKLF LQLIAEFKRL GSSVIYANFN RIILCTKKRR VEDAIAYVEY 1900
    ITSSIHSKET FHSLTISFSR CWEFLLWMDP SNYGGIKGKV SSRIHCGLQD 1950
    SQKAGGAEDE QENEDDEEER DGEEEEEAEE SNVEDLLENN WNILQFLPQA 2000
    ASCQNYFLMI VSAYIVAVYH CMKDGLRRSA PGSTPVRRRG ASQLSQEAEG 2050
    AVGALPGMIT FSQDYVANEL TQSFFTITQK IQKKVTGSRN STELSEMFPV 2100
    LPGSHLLLNN PALEFIKYVC KVLSLDTNIT NQVNKLNRDL LRLVDVGEFS 2150
    EEAQFRDPCR SYVLPEVICR SCNFCRDLDL CKDSSFSEDG AVLPQWLCSN 2200
    CQAPYDSSAI EMTLVEVLQK KLMAFTLQDL VCLKCRGVKE TSMPVYCTCA 2250
    GDFALTIHTQ VFMEQIGIFR NIAQHYGMSY LLETLEWLLQ KNPQLGH 2297
    Length:2,297
    Mass (Da):263,016
    Last modified:November 1, 1999 - v1
    Checksum:i3DD4BBB6C615B3CB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF127975
    , AF127937, AF127939, AF127940, AF127941, AF127942, AF127943, AF127944, AF127945, AF127946, AF127947, AF127948, AF127949, AF127950, AF127951, AF127952, AF127953, AF127954, AF127955, AF127956, AF127957, AF127958, AF127959, AF127960, AF127961, AF127962, AF127963, AF127964, AF127965, AF127966, AF127967, AF127968, AF127969, AF127970, AF127971, AF127972, AF127973, AF127974 Genomic DNA. Translation: AAD44690.1.
    UniGeneiHs.524871.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF127975
    , AF127937 , AF127939 , AF127940 , AF127941 , AF127942 , AF127943 , AF127944 , AF127945 , AF127946 , AF127947 , AF127948 , AF127949 , AF127950 , AF127951 , AF127952 , AF127953 , AF127954 , AF127955 , AF127956 , AF127957 , AF127958 , AF127959 , AF127960 , AF127961 , AF127962 , AF127963 , AF127964 , AF127965 , AF127966 , AF127967 , AF127968 , AF127969 , AF127970 , AF127971 , AF127972 , AF127973 , AF127974 Genomic DNA. Translation: AAD44690.1 .
    UniGenei Hs.524871.

    3D structure databases

    ProteinModelPortali Q9Y5S5.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9Y5S5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOGENOMi HOG000196287.
    HOVERGENi HBG051398.

    Miscellaneous databases

    ChiTaRSi POLE. human.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    InterProi IPR006172. DNA-dir_DNA_pol_B.
    IPR006133. DNA-dir_DNA_pol_B_exonuc.
    IPR006134. DNA-dir_DNA_pol_B_multi_dom.
    IPR013697. DNA_pol_e_suA_C.
    IPR012337. RNaseH-like_dom.
    [Graphical view ]
    Pfami PF00136. DNA_pol_B. 1 hit.
    PF03104. DNA_pol_B_exo1. 1 hit.
    PF08490. DUF1744. 1 hit.
    [Graphical view ]
    SMARTi SM00486. POLBc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Structural organization and splice variants of the POLE1 gene encoding the catalytic subunit of human DNA polymerase epsilon."
      Huang D., Pospiech H., Kesti T., Syvaoja J.E.
      Biochem. J. 339:657-665(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ9Y5S5_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5S5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1999
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.