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Q9Y5S5 (Q9Y5S5_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length2297 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). RuleBase RU000442

Sequence similarities

Belongs to the DNA polymerase type-B family. RuleBase RU000442

Sequences

Sequence LengthMass (Da)Tools
Q9Y5S5 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 3DD4BBB6C615B3CB

FASTA2,297263,016
        10         20         30         40         50         60 
MSRPLGLKSF PRHKQAPLPL SLTFHGCLLL RRDDGATSSV SALKRLERSQ WTDKMDLRFG 

        70         80         90        100        110        120 
FERLKEPGEK TGWLINMHPT EILDEDKRLG SAVDYYFIQD DGSRFKVALP YKPYFYIATR 

       130        140        150        160        170        180 
KGCEREVSSF LSKKFQGKIA KVETVPKEDL DLPNHLVGLK RNYIRLSFHT VEDLVKVRKE 

       190        200        210        220        230        240 
ISPAVKKNRE QDHASDAYTA LLSSVLQRGG VITDEEETSK KIADQLDNIV DMREYDVPYH 

       250        260        270        280        290        300 
IRLSIDLKIH VAHWYNVRYR GNAFPVEITR RDDLVERPDP VVLAFDIETT KLPLKFPDAE 

       310        320        330        340        350        360 
TDQIMMISYM IDGQGYLITN REIVSEDIED FEFTPKPEYE GPFCVFNEPD EAHLIQRWFE 

       370        380        390        400        410        420 
HVQETKPTIM VTYNGDFFDW PFVEARAAVH GLSMQQEIGF QKDSQGEYKA PQCIHMDCLR 

       430        440        450        460        470        480 
WVKRDSYLPV GSHNLKAAAK AKLGYDPVEL DPEDMCRMAT EQPQTLATYS VSDAVATYYL 

       490        500        510        520        530        540 
YMKYVHPFIF ALCTIIPMEP DEVLRKGSGT LCEALLMVQA FHANIIFPNK QEQEFNKLTD 

       550        560        570        580        590        600 
DGHVLDSETY VGGHVEALES GVFRSDIPCR FRMNPAAFDF LLQRVEKTLR HALEEEEKVP 

       610        620        630        640        650        660 
VEQVTNFEEV CDEIKSKLAS LKDVPSRIEC PLIYHLDVGA MYPNIILTNR LQPSAMVDEA 

       670        680        690        700        710        720 
TCAACDFNKP GANCQRKMAW QWRGEFMPAS RSEYHRIQHQ LESEKFPPLF PEGPARAFHE 

       730        740        750        760        770        780 
LSREEQAKYE KRRLADYCRK AYKKIHITKV EERLTTICQR ENSFYVDTVR AFRDRRYEFK 

       790        800        810        820        830        840 
GLHKVWKKKL SAAVEVGDAA EVKRCKNMEV LYDSLQLAHK CILNSFYGYV MRKGARWYSM 

       850        860        870        880        890        900 
EMAGIVCFTG ANIITQAREL IEQIGRPLEL DTDGIWCVLP NSFPENFVFK TTNVKKPKVT 

       910        920        930        940        950        960 
ISYPGAMLNI MVKEGFTNDQ YQELAEPSSL TYVTRSENSI FFEVDGPYLA MILPASKEEG 

       970        980        990       1000       1010       1020 
KKLKKRYAVF NEDGSLAELK GFEVKRRGEL QLIKIFQSSV FEAFLKGSTL EEVYGSVAKV 

      1030       1040       1050       1060       1070       1080 
ADYWLDVLYS KAANMPDSEL FELISENRSM SRKLEDYGEQ KSTSISTAKR LAEFLGDQMV 

      1090       1100       1110       1120       1130       1140 
KDAGLSCRYI ISRKPEGSPV TERAIPLAIF QAEPTVRKHF LRKWLKSSSL QDFDIRAILD 

      1150       1160       1170       1180       1190       1200 
WDYYIERLGS AIQKIITIPA ALQQVKNPVP RVKHPDWLHK KLLEKNDVYK QKKISELFTL 

      1210       1220       1230       1240       1250       1260 
EGRRQVTMAE ASEDSPRPSA PDMEDFGLVK LPHPAAPVTV KRKRVLWESQ EESQDLTPTV 

      1270       1280       1290       1300       1310       1320 
PWQEILGQPP ALGTSQEEWL VWLRFHKKKW QLQARQRLAR RKRQRLESAE GVLRPGAIRD 

      1330       1340       1350       1360       1370       1380 
GPATGLGSFL RRTARSILDL PWQIVQISET SQAGLFRLWA LVGSDLHCIR LSIPRVFYVN 

      1390       1400       1410       1420       1430       1440 
QRVAKAEEGA SYRKVNRVLP RSNMVYNLYE YSVPEDMYQE HINEINAELS APDIEGVYET 

      1450       1460       1470       1480       1490       1500 
QVPLLFRALV HLGCVCVVNK QLVRHLSGWE AETFALEHLE MRSLAQFSYL EPGSIRHIYL 

      1510       1520       1530       1540       1550       1560 
YHHAQAHKAL FGIFIPSQRR ASVFVLDTVR TDQMPSLGAL YSAEHGLLLE KVGPELLPPP 

      1570       1580       1590       1600       1610       1620 
KHTFEVRAET DLKTICRAIQ RFLLAYKEER RGPTLIAVQS SWELKRLASE IPVLEEFPLV 

      1630       1640       1650       1660       1670       1680 
PICVADKINY GVLDWQRHGA RRMIRHYLNL DTCLSQAFEM SRYFHIPIGN LPEDISTFGS 

      1690       1700       1710       1720       1730       1740 
DLFFARHLQR HNHLLWLSPT ARPDLGGKEA DDNCLVMEFD DQATVEINSS GCYSTVCVEL 

      1750       1760       1770       1780       1790       1800 
DLQNLAVNTI LQSHHVNDME GADSMGISFD VIQQASLEDM ITGGQAASAP ASYDETALCS 

      1810       1820       1830       1840       1850       1860 
NTFRILKSMV VGWVKEITQY HNIYADNQVM HFYRWLRSPS SLLHDPALHR TLHNMMKKLF 

      1870       1880       1890       1900       1910       1920 
LQLIAEFKRL GSSVIYANFN RIILCTKKRR VEDAIAYVEY ITSSIHSKET FHSLTISFSR 

      1930       1940       1950       1960       1970       1980 
CWEFLLWMDP SNYGGIKGKV SSRIHCGLQD SQKAGGAEDE QENEDDEEER DGEEEEEAEE 

      1990       2000       2010       2020       2030       2040 
SNVEDLLENN WNILQFLPQA ASCQNYFLMI VSAYIVAVYH CMKDGLRRSA PGSTPVRRRG 

      2050       2060       2070       2080       2090       2100 
ASQLSQEAEG AVGALPGMIT FSQDYVANEL TQSFFTITQK IQKKVTGSRN STELSEMFPV 

      2110       2120       2130       2140       2150       2160 
LPGSHLLLNN PALEFIKYVC KVLSLDTNIT NQVNKLNRDL LRLVDVGEFS EEAQFRDPCR 

      2170       2180       2190       2200       2210       2220 
SYVLPEVICR SCNFCRDLDL CKDSSFSEDG AVLPQWLCSN CQAPYDSSAI EMTLVEVLQK 

      2230       2240       2250       2260       2270       2280 
KLMAFTLQDL VCLKCRGVKE TSMPVYCTCA GDFALTIHTQ VFMEQIGIFR NIAQHYGMSY 

      2290 
LLETLEWLLQ KNPQLGH 

« Hide

References

[1]"Structural organization and splice variants of the POLE1 gene encoding the catalytic subunit of human DNA polymerase epsilon."
Huang D., Pospiech H., Kesti T., Syvaoja J.E.
Biochem. J. 339:657-665(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF127975 expand/collapse EMBL AC list , AF127937, AF127939, AF127940, AF127941, AF127942, AF127943, AF127944, AF127945, AF127946, AF127947, AF127948, AF127949, AF127950, AF127951, AF127952, AF127953, AF127954, AF127955, AF127956, AF127957, AF127958, AF127959, AF127960, AF127961, AF127962, AF127963, AF127964, AF127965, AF127966, AF127967, AF127968, AF127969, AF127970, AF127971, AF127972, AF127973, AF127974 Genomic DNA. Translation: AAD44690.1.
UniGeneHs.524871.

3D structure databases

ProteinModelPortalQ9Y5S5.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9Y5S5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOGENOMHOG000196287.
HOVERGENHBG051398.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
InterProIPR006172. DNA-dir_DNA_pol_B.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR013697. DNA_pol_e_suA_C.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
PF08490. DUF1744. 1 hit.
[Graphical view]
SMARTSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMSSF53098. SSF53098. 2 hits.
ProtoNetSearch...

Other

ChiTaRSPOLE. human.

Entry information

Entry nameQ9Y5S5_HUMAN
AccessionPrimary (citable) accession number: Q9Y5S5
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1999
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.