Q9Y5S5 (Q9Y5S5_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA polymerase RuleBase RU000442
EC=2.7.7.7 RuleBase RU000442

Gene names

Name:

POLE1 EMBL AAD44690.1

Organism

Homo sapiens (Human) EMBL AAD44690.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2297 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). RuleBase RU000442
Sequence similarities	Belongs to the DNA polymerase type-B family. RuleBase RU000442

Ontologies

Keywords
Biological process	DNA replication RuleBase RU000442
Ligand	DNA-binding RuleBase RU000442
Molecular function	DNA-directed DNA polymerase RuleBase RU000442 Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9Y5S5 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 3DD4BBB6C615B3CB	FASTA	2,297	263,016
	10 20 30 40 50 60 MSRPLGLKSF PRHKQAPLPL SLTFHGCLLL RRDDGATSSV SALKRLERSQ WTDKMDLRFG 70 80 90 100 110 120 FERLKEPGEK TGWLINMHPT EILDEDKRLG SAVDYYFIQD DGSRFKVALP YKPYFYIATR 130 140 150 160 170 180 KGCEREVSSF LSKKFQGKIA KVETVPKEDL DLPNHLVGLK RNYIRLSFHT VEDLVKVRKE 190 200 210 220 230 240 ISPAVKKNRE QDHASDAYTA LLSSVLQRGG VITDEEETSK KIADQLDNIV DMREYDVPYH 250 260 270 280 290 300 IRLSIDLKIH VAHWYNVRYR GNAFPVEITR RDDLVERPDP VVLAFDIETT KLPLKFPDAE 310 320 330 340 350 360 TDQIMMISYM IDGQGYLITN REIVSEDIED FEFTPKPEYE GPFCVFNEPD EAHLIQRWFE 370 380 390 400 410 420 HVQETKPTIM VTYNGDFFDW PFVEARAAVH GLSMQQEIGF QKDSQGEYKA PQCIHMDCLR 430 440 450 460 470 480 WVKRDSYLPV GSHNLKAAAK AKLGYDPVEL DPEDMCRMAT EQPQTLATYS VSDAVATYYL 490 500 510 520 530 540 YMKYVHPFIF ALCTIIPMEP DEVLRKGSGT LCEALLMVQA FHANIIFPNK QEQEFNKLTD 550 560 570 580 590 600 DGHVLDSETY VGGHVEALES GVFRSDIPCR FRMNPAAFDF LLQRVEKTLR HALEEEEKVP 610 620 630 640 650 660 VEQVTNFEEV CDEIKSKLAS LKDVPSRIEC PLIYHLDVGA MYPNIILTNR LQPSAMVDEA 670 680 690 700 710 720 TCAACDFNKP GANCQRKMAW QWRGEFMPAS RSEYHRIQHQ LESEKFPPLF PEGPARAFHE 730 740 750 760 770 780 LSREEQAKYE KRRLADYCRK AYKKIHITKV EERLTTICQR ENSFYVDTVR AFRDRRYEFK 790 800 810 820 830 840 GLHKVWKKKL SAAVEVGDAA EVKRCKNMEV LYDSLQLAHK CILNSFYGYV MRKGARWYSM 850 860 870 880 890 900 EMAGIVCFTG ANIITQAREL IEQIGRPLEL DTDGIWCVLP NSFPENFVFK TTNVKKPKVT 910 920 930 940 950 960 ISYPGAMLNI MVKEGFTNDQ YQELAEPSSL TYVTRSENSI FFEVDGPYLA MILPASKEEG 970 980 990 1000 1010 1020 KKLKKRYAVF NEDGSLAELK GFEVKRRGEL QLIKIFQSSV FEAFLKGSTL EEVYGSVAKV 1030 1040 1050 1060 1070 1080 ADYWLDVLYS KAANMPDSEL FELISENRSM SRKLEDYGEQ KSTSISTAKR LAEFLGDQMV 1090 1100 1110 1120 1130 1140 KDAGLSCRYI ISRKPEGSPV TERAIPLAIF QAEPTVRKHF LRKWLKSSSL QDFDIRAILD 1150 1160 1170 1180 1190 1200 WDYYIERLGS AIQKIITIPA ALQQVKNPVP RVKHPDWLHK KLLEKNDVYK QKKISELFTL 1210 1220 1230 1240 1250 1260 EGRRQVTMAE ASEDSPRPSA PDMEDFGLVK LPHPAAPVTV KRKRVLWESQ EESQDLTPTV 1270 1280 1290 1300 1310 1320 PWQEILGQPP ALGTSQEEWL VWLRFHKKKW QLQARQRLAR RKRQRLESAE GVLRPGAIRD 1330 1340 1350 1360 1370 1380 GPATGLGSFL RRTARSILDL PWQIVQISET SQAGLFRLWA LVGSDLHCIR LSIPRVFYVN 1390 1400 1410 1420 1430 1440 QRVAKAEEGA SYRKVNRVLP RSNMVYNLYE YSVPEDMYQE HINEINAELS APDIEGVYET 1450 1460 1470 1480 1490 1500 QVPLLFRALV HLGCVCVVNK QLVRHLSGWE AETFALEHLE MRSLAQFSYL EPGSIRHIYL 1510 1520 1530 1540 1550 1560 YHHAQAHKAL FGIFIPSQRR ASVFVLDTVR TDQMPSLGAL YSAEHGLLLE KVGPELLPPP 1570 1580 1590 1600 1610 1620 KHTFEVRAET DLKTICRAIQ RFLLAYKEER RGPTLIAVQS SWELKRLASE IPVLEEFPLV 1630 1640 1650 1660 1670 1680 PICVADKINY GVLDWQRHGA RRMIRHYLNL DTCLSQAFEM SRYFHIPIGN LPEDISTFGS 1690 1700 1710 1720 1730 1740 DLFFARHLQR HNHLLWLSPT ARPDLGGKEA DDNCLVMEFD DQATVEINSS GCYSTVCVEL 1750 1760 1770 1780 1790 1800 DLQNLAVNTI LQSHHVNDME GADSMGISFD VIQQASLEDM ITGGQAASAP ASYDETALCS 1810 1820 1830 1840 1850 1860 NTFRILKSMV VGWVKEITQY HNIYADNQVM HFYRWLRSPS SLLHDPALHR TLHNMMKKLF 1870 1880 1890 1900 1910 1920 LQLIAEFKRL GSSVIYANFN RIILCTKKRR VEDAIAYVEY ITSSIHSKET FHSLTISFSR 1930 1940 1950 1960 1970 1980 CWEFLLWMDP SNYGGIKGKV SSRIHCGLQD SQKAGGAEDE QENEDDEEER DGEEEEEAEE 1990 2000 2010 2020 2030 2040 SNVEDLLENN WNILQFLPQA ASCQNYFLMI VSAYIVAVYH CMKDGLRRSA PGSTPVRRRG 2050 2060 2070 2080 2090 2100 ASQLSQEAEG AVGALPGMIT FSQDYVANEL TQSFFTITQK IQKKVTGSRN STELSEMFPV 2110 2120 2130 2140 2150 2160 LPGSHLLLNN PALEFIKYVC KVLSLDTNIT NQVNKLNRDL LRLVDVGEFS EEAQFRDPCR 2170 2180 2190 2200 2210 2220 SYVLPEVICR SCNFCRDLDL CKDSSFSEDG AVLPQWLCSN CQAPYDSSAI EMTLVEVLQK 2230 2240 2250 2260 2270 2280 KLMAFTLQDL VCLKCRGVKE TSMPVYCTCA GDFALTIHTQ VFMEQIGIFR NIAQHYGMSY 2290 LLETLEWLLQ KNPQLGH

References

[1]	"Structural organization and splice variants of the POLE1 gene encoding the catalytic subunit of human DNA polymerase epsilon." Huang D., Pospiech H., Kesti T., Syvaoja J.E. Biochem. J. 339:657-665(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF127975 , AF127937, AF127939, AF127940, AF127941, AF127942, AF127943, AF127944, AF127945, AF127946, AF127947, AF127948, AF127949, AF127950, AF127951, AF127952, AF127953, AF127954, AF127955, AF127956, AF127957, AF127958, AF127959, AF127960, AF127961, AF127962, AF127963, AF127964, AF127965, AF127966, AF127967, AF127968, AF127969, AF127970, AF127971, AF127972, AF127973, AF127974 Genomic DNA. Translation: AAD44690.1.
IPI	IPI01019102.
UniGene	Hs.524871.
3D structure databases
ProteinModelPortal	Q9Y5S5.
ModBase	Search...
Proteomic databases
PRIDE	Q9Y5S5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOGENOM	HOG000196287.
HOVERGEN	HBG051398.
Gene expression databases
ArrayExpress	Q9Y5S5.
Family and domain databases
InterPro	IPR006172. DNA-dir_DNA_pol_B. IPR006133. DNA-dir_DNA_pol_B_exonuc. IPR006134. DNA-dir_DNA_pol_B_multi_dom. IPR013697. DNA_pol_e_suA_C. IPR012337. RNaseH-like_dom. [Graphical view]
Pfam	PF00136. DNA_pol_B. 1 hit. PF03104. DNA_pol_B_exo1. 1 hit. PF08490. DUF1744. 1 hit. [Graphical view]
SMART	SM00486. POLBc. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	POLE. human.

Entry information

Entry name

Q9Y5S5_HUMAN

Accession

Primary (citable) accession number: Q9Y5S5

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1999
Last sequence update:	November 1, 1999
Last modified:	May 29, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.