Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transient receptor potential cation channel subfamily V member 2

Gene

TRPV2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.1 Publication

GO - Molecular functioni

  • calcium channel activity Source: GO_Central
  • cation channel activity Source: MGI
  • ion channel activity Source: ProtInc
  • ion transmembrane transporter activity Source: ProtInc

GO - Biological processi

  • calcium ion transmembrane transport Source: Reactome
  • positive regulation of axon extension Source: Ensembl
  • positive regulation of calcium ion import Source: Ensembl
  • response to heat Source: InterPro
  • response to temperature stimulus Source: MGI
  • sensory perception Source: ProtInc
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:G66-30851-MONOMER.
ReactomeiR-HSA-3295583. TRP channels.

Protein family/group databases

TCDBi1.A.4.2.8. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 2
Short name:
TrpV2
Alternative name(s):
Osm-9-like TRP channel 2
Short name:
OTRPC2
Vanilloid receptor-like protein 1
Short name:
VRL-1
Gene namesi
Name:TRPV2
Synonyms:VRL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:18082. TRPV2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 390CytoplasmicSequence analysisAdd BLAST390
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 434ExtracellularSequence analysisAdd BLAST23
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21
Topological domaini456 – 471CytoplasmicSequence analysisAdd BLAST16
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493ExtracellularSequence analysis1
Transmembranei494 – 514HelicalSequence analysisAdd BLAST21
Topological domaini515 – 537CytoplasmicSequence analysisAdd BLAST23
Transmembranei538 – 558HelicalSequence analysisAdd BLAST21
Intramembranei572 – 609Pore-formingSequence analysisAdd BLAST38
Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 764CytoplasmicSequence analysisAdd BLAST122

GO - Cellular componenti

  • axonal growth cone Source: Ensembl
  • cell body Source: Ensembl
  • cell surface Source: Ensembl
  • growth cone membrane Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • melanosome Source: UniProtKB-SubCell
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51393.
OpenTargetsiENSG00000187688.
PharmGKBiPA38292.

Chemistry databases

ChEMBLiCHEMBL5051.
GuidetoPHARMACOLOGYi508.

Polymorphism and mutation databases

BioMutaiTRPV2.
DMDMi62901477.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153421 – 764Transient receptor potential cation channel subfamily V member 2Add BLAST764

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Glycosylationi570N-linked (GlcNAc...)Sequence analysis1
Modified residuei751PhosphoserineBy similarity1
Modified residuei763PhosphoserineBy similarity1

Post-translational modificationi

N-glycosylated.By similarity
Phosphorylated by PKA.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9Y5S1.
MaxQBiQ9Y5S1.
PaxDbiQ9Y5S1.
PeptideAtlasiQ9Y5S1.
PRIDEiQ9Y5S1.

PTM databases

iPTMnetiQ9Y5S1.
PhosphoSitePlusiQ9Y5S1.

Expressioni

Gene expression databases

BgeeiENSG00000187688.
CleanExiHS_TRPV2.
ExpressionAtlasiQ9Y5S1. baseline and differential.
GenevisibleiQ9Y5S1. HS.

Organism-specific databases

HPAiHPA044993.

Interactioni

Subunit structurei

Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (By similarity).By similarityCurated

Protein-protein interaction databases

IntActiQ9Y5S1. 7 interactors.
STRINGi9606.ENSP00000342222.

Structurei

Secondary structure

1764
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi76 – 84Combined sources9
Helixi88 – 91Combined sources4
Helixi94 – 101Combined sources8
Helixi108 – 110Combined sources3
Turni113 – 115Combined sources3
Helixi119 – 125Combined sources7
Helixi135 – 145Combined sources11
Helixi151 – 153Combined sources3
Turni159 – 163Combined sources5
Helixi166 – 172Combined sources7
Helixi176 – 184Combined sources9
Helixi196 – 198Combined sources3
Helixi212 – 218Combined sources7
Helixi222 – 230Combined sources9
Helixi248 – 255Combined sources8
Helixi260 – 280Combined sources21
Helixi286 – 288Combined sources3
Helixi297 – 303Combined sources7
Helixi307 – 315Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F37X-ray1.70A/B69-319[»]
ProteinModelPortaliQ9Y5S1.
SMRiQ9Y5S1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y5S1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati72 – 114ANK 1PROSITE-ProRule annotation1 PublicationAdd BLAST43
Repeati115 – 161ANK 2PROSITE-ProRule annotation1 PublicationAdd BLAST47
Repeati162 – 207ANK 3PROSITE-ProRule annotation1 PublicationAdd BLAST46
Repeati208 – 243ANK 4PROSITE-ProRule annotation1 PublicationAdd BLAST36
Repeati244 – 292ANK 5PROSITE-ProRule annotation1 PublicationAdd BLAST49
Repeati293 – 319ANK 6PROSITE-ProRule annotation1 PublicationAdd BLAST27

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 388Required for interaction with SLC50A1By similarityAdd BLAST388

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3676. Eukaryota.
ENOG4110DG4. LUCA.
GeneTreeiENSGT00550000074425.
HOGENOMiHOG000234630.
HOVERGENiHBG054085.
InParanoidiQ9Y5S1.
KOiK04971.
OMAiICVLEME.
OrthoDBiEOG091G02AF.
PhylomeDBiQ9Y5S1.
TreeFamiTF314711.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008347. TRPV1-4_channel.
IPR024865. TRPV2_channel.
[Graphical view]
PANTHERiPTHR10582:SF5. PTHR10582:SF5. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01768. TRPVRECEPTOR.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y5S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSPSSSPVF RLETLDGGQE DGSEADRGKL DFGSGLPPME SQFQGEDRKF
60 70 80 90 100
APQIRVNLNY RKGTGASQPD PNRFDRDRLF NAVSRGVPED LAGLPEYLSK
110 120 130 140 150
TSKYLTDSEY TEGSTGKTCL MKAVLNLKDG VNACILPLLQ IDRDSGNPQP
160 170 180 190 200
LVNAQCTDDY YRGHSALHIA IEKRSLQCVK LLVENGANVH ARACGRFFQK
210 220 230 240 250
GQGTCFYFGE LPLSLAACTK QWDVVSYLLE NPHQPASLQA TDSQGNTVLH
260 270 280 290 300
ALVMISDNSA ENIALVTSMY DGLLQAGARL CPTVQLEDIR NLQDLTPLKL
310 320 330 340 350
AAKEGKIEIF RHILQREFSG LSHLSRKFTE WCYGPVRVSL YDLASVDSCE
360 370 380 390 400
ENSVLEIIAF HCKSPHRHRM VVLEPLNKLL QAKWDLLIPK FFLNFLCNLI
410 420 430 440 450
YMFIFTAVAY HQPTLKKQAA PHLKAEVGNS MLLTGHILIL LGGIYLLVGQ
460 470 480 490 500
LWYFWRRHVF IWISFIDSYF EILFLFQALL TVVSQVLCFL AIEWYLPLLV
510 520 530 540 550
SALVLGWLNL LYYTRGFQHT GIYSVMIQKV ILRDLLRFLL IYLVFLFGFA
560 570 580 590 600
VALVSLSQEA WRPEAPTGPN ATESVQPMEG QEDEGNGAQY RGILEASLEL
610 620 630 640 650
FKFTIGMGEL AFQEQLHFRG MVLLLLLAYV LLTYILLLNM LIALMSETVN
660 670 680 690 700
SVATDSWSIW KLQKAISVLE MENGYWWCRK KQRAGVMLTV GTKPDGSPDE
710 720 730 740 750
RWCFRVEEVN WASWEQTLPT LCEDPSGAGV PRTLENPVLA SPPKEDEDGA
760
SEENYVPVQL LQSN
Length:764
Mass (Da):85,981
Last modified:November 1, 1999 - v1
Checksum:iA73E3696E70F91E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52P → S in AAD41724 (Ref. 2) Curated1
Sequence conflicti82A → V in AAD41724 (Ref. 2) Curated1
Sequence conflicti200K → N in AAD41724 (Ref. 2) Curated1
Sequence conflicti459V → L in AAD41724 (Ref. 2) Curated1
Sequence conflicti465 – 466FI → YT in AAD41724 (Ref. 2) Curated2
Sequence conflicti477 – 478QA → HS in AAD41724 (Ref. 2) Curated2
Sequence conflicti485Q → L in AAD41724 (Ref. 2) Curated1
Sequence conflicti491A → V in AAD41724 (Ref. 2) Curated1
Sequence conflicti535 – 536LL → MV in AAD41724 (Ref. 2) Curated2
Sequence conflicti540L → V in AAD41724 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02467817G → A.Corresponds to variant rs3813768dbSNPEnsembl.1
Natural variantiVAR_059838764N → S.Corresponds to variant rs8071215dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129112 mRNA. Translation: AAD26363.1.
AF103906 mRNA. Translation: AAD41724.1.
AJ487963 mRNA. Translation: CAD32310.1.
AK289705 mRNA. Translation: BAF82394.1.
AC093484 Genomic DNA. No translation available.
CH471222 Genomic DNA. Translation: EAX04508.1.
BC018926 mRNA. Translation: AAH18926.1.
BC051305 mRNA. Translation: AAH51305.1.
CCDSiCCDS32576.1.
RefSeqiNP_057197.2. NM_016113.4.
UniGeneiHs.279746.

Genome annotation databases

EnsembliENST00000338560; ENSP00000342222; ENSG00000187688.
GeneIDi51393.
KEGGihsa:51393.
UCSCiuc002gpy.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129112 mRNA. Translation: AAD26363.1.
AF103906 mRNA. Translation: AAD41724.1.
AJ487963 mRNA. Translation: CAD32310.1.
AK289705 mRNA. Translation: BAF82394.1.
AC093484 Genomic DNA. No translation available.
CH471222 Genomic DNA. Translation: EAX04508.1.
BC018926 mRNA. Translation: AAH18926.1.
BC051305 mRNA. Translation: AAH51305.1.
CCDSiCCDS32576.1.
RefSeqiNP_057197.2. NM_016113.4.
UniGeneiHs.279746.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F37X-ray1.70A/B69-319[»]
ProteinModelPortaliQ9Y5S1.
SMRiQ9Y5S1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Y5S1. 7 interactors.
STRINGi9606.ENSP00000342222.

Chemistry databases

ChEMBLiCHEMBL5051.
GuidetoPHARMACOLOGYi508.

Protein family/group databases

TCDBi1.A.4.2.8. the transient receptor potential ca(2+) channel (trp-cc) family.

PTM databases

iPTMnetiQ9Y5S1.
PhosphoSitePlusiQ9Y5S1.

Polymorphism and mutation databases

BioMutaiTRPV2.
DMDMi62901477.

Proteomic databases

EPDiQ9Y5S1.
MaxQBiQ9Y5S1.
PaxDbiQ9Y5S1.
PeptideAtlasiQ9Y5S1.
PRIDEiQ9Y5S1.

Protocols and materials databases

DNASUi51393.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338560; ENSP00000342222; ENSG00000187688.
GeneIDi51393.
KEGGihsa:51393.
UCSCiuc002gpy.3. human.

Organism-specific databases

CTDi51393.
DisGeNETi51393.
GeneCardsiTRPV2.
HGNCiHGNC:18082. TRPV2.
HPAiHPA044993.
MIMi606676. gene.
neXtProtiNX_Q9Y5S1.
OpenTargetsiENSG00000187688.
PharmGKBiPA38292.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3676. Eukaryota.
ENOG4110DG4. LUCA.
GeneTreeiENSGT00550000074425.
HOGENOMiHOG000234630.
HOVERGENiHBG054085.
InParanoidiQ9Y5S1.
KOiK04971.
OMAiICVLEME.
OrthoDBiEOG091G02AF.
PhylomeDBiQ9Y5S1.
TreeFamiTF314711.

Enzyme and pathway databases

BioCyciZFISH:G66-30851-MONOMER.
ReactomeiR-HSA-3295583. TRP channels.

Miscellaneous databases

EvolutionaryTraceiQ9Y5S1.
GeneWikiiTRPV2.
GenomeRNAii51393.
PROiQ9Y5S1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187688.
CleanExiHS_TRPV2.
ExpressionAtlasiQ9Y5S1. baseline and differential.
GenevisibleiQ9Y5S1. HS.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008347. TRPV1-4_channel.
IPR024865. TRPV2_channel.
[Graphical view]
PANTHERiPTHR10582:SF5. PTHR10582:SF5. 2 hits.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01768. TRPVRECEPTOR.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRPV2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5S1
Secondary accession number(s): A6NML2, A8K0Z0, Q9Y670
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 146 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.