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Q9Y5S1

- TRPV2_HUMAN

UniProt

Q9Y5S1 - TRPV2_HUMAN

Protein

Transient receptor potential cation channel subfamily V member 2

Gene

TRPV2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH.1 Publication

    GO - Molecular functioni

    1. calcium channel activity Source: UniProtKB-KW
    2. cation channel activity Source: MGI
    3. ion channel activity Source: ProtInc
    4. ion transmembrane transporter activity Source: ProtInc

    GO - Biological processi

    1. calcium ion transmembrane transport Source: Reactome
    2. ion transmembrane transport Source: Reactome
    3. positive regulation of axon extension Source: Ensembl
    4. positive regulation of calcium ion import Source: Ensembl
    5. response to heat Source: Ensembl
    6. response to temperature stimulus Source: MGI
    7. sensory perception Source: ProtInc
    8. transmembrane transport Source: Reactome
    9. transport Source: ProtInc

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium

    Enzyme and pathway databases

    ReactomeiREACT_169333. TRP channels.

    Protein family/group databases

    TCDBi1.A.4.2.8. the transient receptor potential ca(2+) channel (trp-cc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transient receptor potential cation channel subfamily V member 2
    Short name:
    TrpV2
    Alternative name(s):
    Osm-9-like TRP channel 2
    Short name:
    OTRPC2
    Vanilloid receptor-like protein 1
    Short name:
    VRL-1
    Gene namesi
    Name:TRPV2
    Synonyms:VRL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:18082. TRPV2.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Cytoplasm By similarity. Melanosome 1 Publication
    Note: Translocates from the cytoplasm to the plasma membrane upon ligand stimulation By similarity. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.By similarity

    GO - Cellular componenti

    1. axonal growth cone Source: Ensembl
    2. cell body Source: Ensembl
    3. cell surface Source: Ensembl
    4. endomembrane system Source: Ensembl
    5. growth cone membrane Source: Ensembl
    6. integral component of plasma membrane Source: ProtInc
    7. melanosome Source: UniProtKB-SubCell
    8. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38292.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 764764Transient receptor potential cation channel subfamily V member 2PRO_0000215342Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
    Modified residuei763 – 7631PhosphoserineBy similarity

    Post-translational modificationi

    N-glycosylated.By similarity
    Phosphorylated by PKA.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y5S1.
    PaxDbiQ9Y5S1.
    PRIDEiQ9Y5S1.

    PTM databases

    PhosphoSiteiQ9Y5S1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y5S1.
    BgeeiQ9Y5S1.
    CleanExiHS_TRPV2.
    GenevestigatoriQ9Y5S1.

    Organism-specific databases

    HPAiHPA044993.

    Interactioni

    Subunit structurei

    Homotetramer Probable. Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation By similarity.By similarityCurated

    Protein-protein interaction databases

    BioGridi119520. 1 interaction.
    STRINGi9606.ENSP00000342222.

    Structurei

    Secondary structure

    1
    764
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi76 – 849
    Helixi88 – 914
    Helixi94 – 1018
    Helixi108 – 1103
    Turni113 – 1153
    Helixi119 – 1257
    Helixi135 – 14511
    Helixi151 – 1533
    Turni159 – 1635
    Helixi166 – 1727
    Helixi176 – 1849
    Helixi196 – 1983
    Helixi212 – 2187
    Helixi222 – 2309
    Helixi248 – 2558
    Helixi260 – 28021
    Helixi286 – 2883
    Helixi297 – 3037
    Helixi307 – 3159

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2F37X-ray1.70A/B69-319[»]
    ProteinModelPortaliQ9Y5S1.
    SMRiQ9Y5S1. Positions 70-681.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y5S1.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 390390CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini412 – 43423ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini456 – 47116CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini493 – 4931ExtracellularSequence Analysis
    Topological domaini515 – 53723CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini643 – 764122CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei572 – 60938Pore-formingSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei391 – 41121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei435 – 45521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei472 – 49221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei494 – 51421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei538 – 55821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei622 – 64221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati72 – 11443ANK 11 PublicationPROSITE-ProRule annotationAdd
    BLAST
    Repeati115 – 16147ANK 21 PublicationPROSITE-ProRule annotationAdd
    BLAST
    Repeati162 – 20746ANK 31 PublicationPROSITE-ProRule annotationAdd
    BLAST
    Repeati208 – 24336ANK 41 PublicationPROSITE-ProRule annotationAdd
    BLAST
    Repeati244 – 29249ANK 51 PublicationPROSITE-ProRule annotationAdd
    BLAST
    Repeati293 – 31927ANK 61 PublicationPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 388388Required for interaction with SLC50A1By similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 6 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG281194.
    HOGENOMiHOG000234630.
    HOVERGENiHBG054085.
    InParanoidiQ9Y5S1.
    KOiK04971.
    OMAiLSQVLCF.
    OrthoDBiEOG7V49XW.
    PhylomeDBiQ9Y5S1.
    TreeFamiTF314711.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR008347. TRPV1-4_channel.
    IPR024865. TRPV2_channel.
    [Graphical view]
    PANTHERiPTHR10582:SF5. PTHR10582:SF5. 1 hit.
    PfamiPF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR01768. TRPVRECEPTOR.
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    TIGRFAMsiTIGR00870. trp. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y5S1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSPSSSPVF RLETLDGGQE DGSEADRGKL DFGSGLPPME SQFQGEDRKF    50
    APQIRVNLNY RKGTGASQPD PNRFDRDRLF NAVSRGVPED LAGLPEYLSK 100
    TSKYLTDSEY TEGSTGKTCL MKAVLNLKDG VNACILPLLQ IDRDSGNPQP 150
    LVNAQCTDDY YRGHSALHIA IEKRSLQCVK LLVENGANVH ARACGRFFQK 200
    GQGTCFYFGE LPLSLAACTK QWDVVSYLLE NPHQPASLQA TDSQGNTVLH 250
    ALVMISDNSA ENIALVTSMY DGLLQAGARL CPTVQLEDIR NLQDLTPLKL 300
    AAKEGKIEIF RHILQREFSG LSHLSRKFTE WCYGPVRVSL YDLASVDSCE 350
    ENSVLEIIAF HCKSPHRHRM VVLEPLNKLL QAKWDLLIPK FFLNFLCNLI 400
    YMFIFTAVAY HQPTLKKQAA PHLKAEVGNS MLLTGHILIL LGGIYLLVGQ 450
    LWYFWRRHVF IWISFIDSYF EILFLFQALL TVVSQVLCFL AIEWYLPLLV 500
    SALVLGWLNL LYYTRGFQHT GIYSVMIQKV ILRDLLRFLL IYLVFLFGFA 550
    VALVSLSQEA WRPEAPTGPN ATESVQPMEG QEDEGNGAQY RGILEASLEL 600
    FKFTIGMGEL AFQEQLHFRG MVLLLLLAYV LLTYILLLNM LIALMSETVN 650
    SVATDSWSIW KLQKAISVLE MENGYWWCRK KQRAGVMLTV GTKPDGSPDE 700
    RWCFRVEEVN WASWEQTLPT LCEDPSGAGV PRTLENPVLA SPPKEDEDGA 750
    SEENYVPVQL LQSN 764
    Length:764
    Mass (Da):85,981
    Last modified:November 1, 1999 - v1
    Checksum:iA73E3696E70F91E9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti52 – 521P → S in AAD41724. 1 PublicationCurated
    Sequence conflicti82 – 821A → V in AAD41724. 1 PublicationCurated
    Sequence conflicti200 – 2001K → N in AAD41724. 1 PublicationCurated
    Sequence conflicti459 – 4591V → L in AAD41724. 1 PublicationCurated
    Sequence conflicti465 – 4662FI → YT in AAD41724. 1 PublicationCurated
    Sequence conflicti477 – 4782QA → HS in AAD41724. 1 PublicationCurated
    Sequence conflicti485 – 4851Q → L in AAD41724. 1 PublicationCurated
    Sequence conflicti491 – 4911A → V in AAD41724. 1 PublicationCurated
    Sequence conflicti535 – 5362LL → MV in AAD41724. 1 PublicationCurated
    Sequence conflicti540 – 5401L → V in AAD41724. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171G → A.
    Corresponds to variant rs3813768 [ dbSNP | Ensembl ].
    VAR_024678
    Natural varianti764 – 7641N → S.
    Corresponds to variant rs8071215 [ dbSNP | Ensembl ].
    VAR_059838

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF129112 mRNA. Translation: AAD26363.1.
    AF103906 mRNA. Translation: AAD41724.1.
    AJ487963 mRNA. Translation: CAD32310.1.
    AK289705 mRNA. Translation: BAF82394.1.
    AC093484 Genomic DNA. No translation available.
    CH471222 Genomic DNA. Translation: EAX04508.1.
    BC018926 mRNA. Translation: AAH18926.1.
    BC051305 mRNA. Translation: AAH51305.1.
    CCDSiCCDS32576.1.
    RefSeqiNP_057197.2. NM_016113.4.
    UniGeneiHs.279746.

    Genome annotation databases

    EnsembliENST00000338560; ENSP00000342222; ENSG00000187688.
    GeneIDi51393.
    KEGGihsa:51393.
    UCSCiuc002gpy.3. human.

    Polymorphism databases

    DMDMi62901477.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF129112 mRNA. Translation: AAD26363.1 .
    AF103906 mRNA. Translation: AAD41724.1 .
    AJ487963 mRNA. Translation: CAD32310.1 .
    AK289705 mRNA. Translation: BAF82394.1 .
    AC093484 Genomic DNA. No translation available.
    CH471222 Genomic DNA. Translation: EAX04508.1 .
    BC018926 mRNA. Translation: AAH18926.1 .
    BC051305 mRNA. Translation: AAH51305.1 .
    CCDSi CCDS32576.1.
    RefSeqi NP_057197.2. NM_016113.4.
    UniGenei Hs.279746.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2F37 X-ray 1.70 A/B 69-319 [» ]
    ProteinModelPortali Q9Y5S1.
    SMRi Q9Y5S1. Positions 70-681.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119520. 1 interaction.
    STRINGi 9606.ENSP00000342222.

    Chemistry

    ChEMBLi CHEMBL5051.
    GuidetoPHARMACOLOGYi 508.

    Protein family/group databases

    TCDBi 1.A.4.2.8. the transient receptor potential ca(2+) channel (trp-cc) family.

    PTM databases

    PhosphoSitei Q9Y5S1.

    Polymorphism databases

    DMDMi 62901477.

    Proteomic databases

    MaxQBi Q9Y5S1.
    PaxDbi Q9Y5S1.
    PRIDEi Q9Y5S1.

    Protocols and materials databases

    DNASUi 51393.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338560 ; ENSP00000342222 ; ENSG00000187688 .
    GeneIDi 51393.
    KEGGi hsa:51393.
    UCSCi uc002gpy.3. human.

    Organism-specific databases

    CTDi 51393.
    GeneCardsi GC17P016318.
    HGNCi HGNC:18082. TRPV2.
    HPAi HPA044993.
    MIMi 606676. gene.
    neXtProti NX_Q9Y5S1.
    PharmGKBi PA38292.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281194.
    HOGENOMi HOG000234630.
    HOVERGENi HBG054085.
    InParanoidi Q9Y5S1.
    KOi K04971.
    OMAi LSQVLCF.
    OrthoDBi EOG7V49XW.
    PhylomeDBi Q9Y5S1.
    TreeFami TF314711.

    Enzyme and pathway databases

    Reactomei REACT_169333. TRP channels.

    Miscellaneous databases

    EvolutionaryTracei Q9Y5S1.
    GeneWikii TRPV2.
    GenomeRNAii 51393.
    NextBioi 54925.
    PROi Q9Y5S1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5S1.
    Bgeei Q9Y5S1.
    CleanExi HS_TRPV2.
    Genevestigatori Q9Y5S1.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR008347. TRPV1-4_channel.
    IPR024865. TRPV2_channel.
    [Graphical view ]
    PANTHERi PTHR10582:SF5. PTHR10582:SF5. 1 hit.
    Pfami PF12796. Ank_2. 1 hit.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR01768. TRPVRECEPTOR.
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    TIGRFAMsi TIGR00870. trp. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A capsaicin-receptor homologue with a high threshold for noxious heat."
      Caterina M.J., Rosen T.A., Tominaga M., Brake A.J., Julius D.
      Nature 398:436-441(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Tissue: Lymphoblast.
    2. "Cloning and functional expression of VRL, a vanilloid receptor-like gene."
      Garcia R.L., Delmas P., Cesare P., England S., Liapi A., Wood J.N.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lymphoblast.
    3. Kelsell R.E.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Melanoma.
    9. "Crystal structure of the human TRPV2 channel ankyrin repeat domain."
      McCleverty C.J., Koesema E., Patapoutian A., Lesley S.A., Kreusch A.
      Protein Sci. 15:2201-2206(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 69-319, ANK REPEATS.

    Entry informationi

    Entry nameiTRPV2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5S1
    Secondary accession number(s): A6NML2, A8K0Z0, Q9Y670
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3