Q9Y5R8 (TPPC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Trafficking protein particle complex subunit 1

Alternative name(s):
BET5 homolog
Multiple myeloma protein 2
Short name=MUM-2

Gene names

Name:	TRAPPC1
Synonyms:	BET5, MUM2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	145 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Subunit structure	Part of the multisubunit TRAPP (transport protein particle) complex. Ref.4
Subcellular location	Golgi apparatus › cis-Golgi network By similarity. Endoplasmic reticulum By similarity.
Sequence similarities	Belongs to the TRAPP small subunits family. BET5 subfamily.

Ontologies

Keywords
Biological process	ER-Golgi transport Transport
Cellular component	Endoplasmic reticulum Golgi apparatus
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ER to Golgi vesicle-mediated transport Inferred from electronic annotation. Source: InterPro
Cellular_component	TRAPP complex Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 145	145	Trafficking protein particle complex subunit 1		PRO_0000211562
Natural variations
	Natural variant	129	1	R → G in a melanoma. Ref.1		VAR_013028

Sequences

	Sequence		Length	Mass (Da)
	Q9Y5R8 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 7C8C81D3F0E8DCC6	FASTA	145	16,832
	10 20 30 40 50 60 MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS KMSPLDMKDG 70 80 90 100 110 120 FLAFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI YSALYVELVV KNPLCPLGQT 130 140 VQSELFRSRL DSYVRSLPFF SARAG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene." Chiari R., Foury F., De Plaen E., Baurain J.-F., Thonnard J., Coulie P.G. Cancer Res. 59:5785-5792(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MELANOMA GLY-129.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[4]	"Functional organization of the yeast proteome by systematic analysis of protein complexes." Gavin A.-C., Boesche M., Krause R., Grandi P., Marzioch M., Bauer A., Schultz J., Rick J.M., Michon A.-M., Cruciat C.-M., Remor M., Hoefert C., Schelder M., Brajenovic M., Ruffner H., Merino A., Klein K., Hudak M. , Dickson D., Rudi T., Gnau V., Bauch A., Bastuck S., Huhse B., Leutwein C., Heurtier M.-A., Copley R.R., Edelmann A., Querfurth E., Rybin V., Drewes G., Raida M., Bouwmeester T., Bork P., Seraphin B., Kuster B., Neubauer G., Superti-Furga G. Nature 415:141-147(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN TRAPP COMPLEX.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF129332 Genomic DNA. Translation: AAD44697.1. CH471108 Genomic DNA. Translation: EAW90109.1. CH471108 Genomic DNA. Translation: EAW90110.1. CH471108 Genomic DNA. Translation: EAW90111.1. BC032717 mRNA. Translation: AAH32717.1.
IPI	IPI00009654.
RefSeq	NP_001160093.1. NM_001166621.1. NP_067033.1. NM_021210.4.
UniGene	Hs.24379.
3D structure databases
ProteinModelPortal	Q9Y5R8.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48285N.
IntAct	Q9Y5R8. 1 interaction.
STRING	9606.ENSP00000302783.
PTM databases
PhosphoSite	Q9Y5R8.
Polymorphism databases
DMDM	20177848.
Proteomic databases
PaxDb	Q9Y5R8.
PRIDE	Q9Y5R8.
Protocols and materials databases
DNASU	58485.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000303731; ENSP00000302783; ENSG00000170043. ENST00000540486; ENSP00000441130; ENSG00000170043.
GeneID	58485.
KEGG	hsa:58485.
UCSC	uc002gjo.2. human.
Organism-specific databases
CTD	58485.
GeneCards	GC17M007833.
HGNC	HGNC:19894. TRAPPC1.
HPA	HPA052398.
MIM	610969. gene.
neXtProt	NX_Q9Y5R8.
PharmGKB	PA134988492.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG237222.
HOGENOM	HOG000172118.
HOVERGEN	HBG056032.
InParanoid	Q9Y5R8.
OMA	FLYYKTN.
OrthoDB	EOG45HRZS.
Gene expression databases
ArrayExpress	Q9Y5R8.
Bgee	Q9Y5R8.
CleanEx	HS_TRAPPC1.
Genevestigator	Q9Y5R8.
GermOnline	ENSG00000170043. Homo sapiens.
Family and domain databases
InterPro	IPR011012. Longin-like_dom. IPR007233. Sybindin. [Graphical view]
PANTHER	PTHR23249. PTHR23249. 1 hit.
Pfam	PF04099. Sybindin. 1 hit. [Graphical view]
SUPFAM	SSF64356. Longin_like. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	TRAPPC1. human.
GenomeRNAi	58485.
NextBio	64938.
SOURCE	Search...

Entry information

Entry name

TPPC1_HUMAN

Accession

Primary (citable) accession number: Q9Y5R8
Secondary accession number(s): D3DTR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 16, 2002
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.