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Protein

Trafficking protein particle complex subunit 1

Gene

TRAPPC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Molecular functioni

  1. Rab guanyl-nucleotide exchange factor activity Source: GO_Central

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: GO_Central
  2. positive regulation of GTPase activity Source: GOC
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Enzyme and pathway databases

SignaLinkiQ9Y5R8.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 1
Alternative name(s):
BET5 homolog
Multiple myeloma protein 2
Short name:
MUM-2
Gene namesi
Name:TRAPPC1
Synonyms:BET5, MUM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:19894. TRAPPC1.

Subcellular locationi

GO - Cellular componenti

  1. cis-Golgi network Source: InterPro
  2. endoplasmic reticulum Source: UniProtKB-SubCell
  3. Golgi apparatus Source: UniProtKB-SubCell
  4. TRAPP complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988492.

Polymorphism and mutation databases

BioMutaiTRAPPC1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Trafficking protein particle complex subunit 1PRO_0000211562Add
BLAST

Proteomic databases

MaxQBiQ9Y5R8.
PaxDbiQ9Y5R8.
PRIDEiQ9Y5R8.

PTM databases

PhosphoSiteiQ9Y5R8.

Expressioni

Gene expression databases

BgeeiQ9Y5R8.
CleanExiHS_TRAPPC1.
ExpressionAtlasiQ9Y5R8. baseline and differential.
GenevestigatoriQ9Y5R8.

Organism-specific databases

HPAiHPA052398.

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) complex.1 Publication

Protein-protein interaction databases

BioGridi121815. 11 interactions.
DIPiDIP-48285N.
IntActiQ9Y5R8. 1 interaction.
STRINGi9606.ENSP00000302783.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5R8.
SMRiQ9Y5R8. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG237222.
GeneTreeiENSGT00510000047863.
HOGENOMiHOG000172118.
HOVERGENiHBG056032.
InParanoidiQ9Y5R8.
OMAiFYETPAN.
OrthoDBiEOG7GXPD7.
PhylomeDBiQ9Y5R8.
TreeFamiTF323681.

Family and domain databases

InterProiIPR011012. Longin-like_dom.
IPR007233. Sybindin.
[Graphical view]
PANTHERiPTHR23249. PTHR23249. 1 hit.
PfamiPF04099. Sybindin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y5R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS
60 70 80 90 100
KMSPLDMKDG FLAFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI
110 120 130 140
YSALYVELVV KNPLCPLGQT VQSELFRSRL DSYVRSLPFF SARAG
Length:145
Mass (Da):16,832
Last modified:November 1, 1999 - v1
Checksum:i7C8C81D3F0E8DCC6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti129 – 1291R → G in a melanoma. 1 Publication
VAR_013028

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129332 Genomic DNA. Translation: AAD44697.1.
CH471108 Genomic DNA. Translation: EAW90109.1.
CH471108 Genomic DNA. Translation: EAW90110.1.
CH471108 Genomic DNA. Translation: EAW90111.1.
BC032717 mRNA. Translation: AAH32717.1.
CCDSiCCDS11125.1.
RefSeqiNP_001160093.1. NM_001166621.1.
NP_067033.1. NM_021210.4.
UniGeneiHs.24379.

Genome annotation databases

EnsembliENST00000303731; ENSP00000302783; ENSG00000170043.
ENST00000540486; ENSP00000441130; ENSG00000170043.
GeneIDi58485.
KEGGihsa:58485.
UCSCiuc002gjo.2. human.

Polymorphism and mutation databases

BioMutaiTRAPPC1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129332 Genomic DNA. Translation: AAD44697.1.
CH471108 Genomic DNA. Translation: EAW90109.1.
CH471108 Genomic DNA. Translation: EAW90110.1.
CH471108 Genomic DNA. Translation: EAW90111.1.
BC032717 mRNA. Translation: AAH32717.1.
CCDSiCCDS11125.1.
RefSeqiNP_001160093.1. NM_001166621.1.
NP_067033.1. NM_021210.4.
UniGeneiHs.24379.

3D structure databases

ProteinModelPortaliQ9Y5R8.
SMRiQ9Y5R8. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121815. 11 interactions.
DIPiDIP-48285N.
IntActiQ9Y5R8. 1 interaction.
STRINGi9606.ENSP00000302783.

PTM databases

PhosphoSiteiQ9Y5R8.

Polymorphism and mutation databases

BioMutaiTRAPPC1.

Proteomic databases

MaxQBiQ9Y5R8.
PaxDbiQ9Y5R8.
PRIDEiQ9Y5R8.

Protocols and materials databases

DNASUi58485.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000303731; ENSP00000302783; ENSG00000170043.
ENST00000540486; ENSP00000441130; ENSG00000170043.
GeneIDi58485.
KEGGihsa:58485.
UCSCiuc002gjo.2. human.

Organism-specific databases

CTDi58485.
GeneCardsiGC17M007833.
HGNCiHGNC:19894. TRAPPC1.
HPAiHPA052398.
MIMi610969. gene.
neXtProtiNX_Q9Y5R8.
PharmGKBiPA134988492.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG237222.
GeneTreeiENSGT00510000047863.
HOGENOMiHOG000172118.
HOVERGENiHBG056032.
InParanoidiQ9Y5R8.
OMAiFYETPAN.
OrthoDBiEOG7GXPD7.
PhylomeDBiQ9Y5R8.
TreeFamiTF323681.

Enzyme and pathway databases

SignaLinkiQ9Y5R8.

Miscellaneous databases

ChiTaRSiTRAPPC1. human.
GenomeRNAii58485.
NextBioi64938.
PROiQ9Y5R8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y5R8.
CleanExiHS_TRAPPC1.
ExpressionAtlasiQ9Y5R8. baseline and differential.
GenevestigatoriQ9Y5R8.

Family and domain databases

InterProiIPR011012. Longin-like_dom.
IPR007233. Sybindin.
[Graphical view]
PANTHERiPTHR23249. PTHR23249. 1 hit.
PfamiPF04099. Sybindin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene."
    Chiari R., Foury F., De Plaen E., Baurain J.-F., Thonnard J., Coulie P.G.
    Cancer Res. 59:5785-5792(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MELANOMA GLY-129.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  4. Cited for: IDENTIFICATION IN TRAPP COMPLEX.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTPPC1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5R8
Secondary accession number(s): D3DTR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: April 29, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.