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Q9Y5R8 (TPPC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Trafficking protein particle complex subunit 1
Alternative name(s):
BET5 homolog
Multiple myeloma protein 2
Short name=MUM-2
Gene names
Name:TRAPPC1
Synonyms:BET5, MUM2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length145 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Subunit structure

Part of the multisubunit TRAPP (transport protein particle) complex. Ref.4

Subcellular location

Golgi apparatuscis-Golgi network By similarity. Endoplasmic reticulum By similarity.

Sequence similarities

Belongs to the TRAPP small subunits family. BET5 subfamily.

Ontologies

Keywords
   Biological processER-Golgi transport
Transport
   Cellular componentEndoplasmic reticulum
Golgi apparatus
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processER to Golgi vesicle-mediated transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

TRAPP complex

Inferred from electronic annotation. Source: Ensembl

cis-Golgi network

Inferred from electronic annotation. Source: InterPro

endoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 145145Trafficking protein particle complex subunit 1
PRO_0000211562

Natural variations

Natural variant1291R → G in a melanoma. Ref.1
VAR_013028

Sequences

Sequence LengthMass (Da)Tools
Q9Y5R8 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 7C8C81D3F0E8DCC6

FASTA14516,832
        10         20         30         40         50         60 
MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS KMSPLDMKDG 

        70         80         90        100        110        120 
FLAFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI YSALYVELVV KNPLCPLGQT 

       130        140 
VQSELFRSRL DSYVRSLPFF SARAG 

« Hide

References

« Hide 'large scale' references
[1]"Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene."
Chiari R., Foury F., De Plaen E., Baurain J.-F., Thonnard J., Coulie P.G.
Cancer Res. 59:5785-5792(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MELANOMA GLY-129.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[4]"Functional organization of the yeast proteome by systematic analysis of protein complexes."
Gavin A.-C., Boesche M., Krause R., Grandi P., Marzioch M., Bauer A., Schultz J., Rick J.M., Michon A.-M., Cruciat C.-M., Remor M., Hoefert C., Schelder M., Brajenovic M., Ruffner H., Merino A., Klein K., Hudak M. expand/collapse author list , Dickson D., Rudi T., Gnau V., Bauch A., Bastuck S., Huhse B., Leutwein C., Heurtier M.-A., Copley R.R., Edelmann A., Querfurth E., Rybin V., Drewes G., Raida M., Bouwmeester T., Bork P., Seraphin B., Kuster B., Neubauer G., Superti-Furga G.
Nature 415:141-147(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN TRAPP COMPLEX.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF129332 Genomic DNA. Translation: AAD44697.1.
CH471108 Genomic DNA. Translation: EAW90109.1.
CH471108 Genomic DNA. Translation: EAW90110.1.
CH471108 Genomic DNA. Translation: EAW90111.1.
BC032717 mRNA. Translation: AAH32717.1.
CCDSCCDS11125.1.
RefSeqNP_001160093.1. NM_001166621.1.
NP_067033.1. NM_021210.4.
UniGeneHs.24379.

3D structure databases

ProteinModelPortalQ9Y5R8.
SMRQ9Y5R8. Positions 2-142.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121815. 7 interactions.
DIPDIP-48285N.
IntActQ9Y5R8. 1 interaction.
STRING9606.ENSP00000302783.

PTM databases

PhosphoSiteQ9Y5R8.

Proteomic databases

MaxQBQ9Y5R8.
PaxDbQ9Y5R8.
PRIDEQ9Y5R8.

Protocols and materials databases

DNASU58485.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000303731; ENSP00000302783; ENSG00000170043.
ENST00000540486; ENSP00000441130; ENSG00000170043.
GeneID58485.
KEGGhsa:58485.
UCSCuc002gjo.2. human.

Organism-specific databases

CTD58485.
GeneCardsGC17M007833.
HGNCHGNC:19894. TRAPPC1.
HPAHPA052398.
MIM610969. gene.
neXtProtNX_Q9Y5R8.
PharmGKBPA134988492.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG237222.
HOGENOMHOG000172118.
HOVERGENHBG056032.
InParanoidQ9Y5R8.
OMAFYETPAN.
OrthoDBEOG7GXPD7.
PhylomeDBQ9Y5R8.
TreeFamTF323681.

Enzyme and pathway databases

SignaLinkQ9Y5R8.

Gene expression databases

ArrayExpressQ9Y5R8.
BgeeQ9Y5R8.
CleanExHS_TRAPPC1.
GenevestigatorQ9Y5R8.

Family and domain databases

InterProIPR011012. Longin-like_dom.
IPR007233. Sybindin.
[Graphical view]
PANTHERPTHR23249. PTHR23249. 1 hit.
PfamPF04099. Sybindin. 1 hit.
[Graphical view]
SUPFAMSSF64356. SSF64356. 1 hit.
ProtoNetSearch...

Other

ChiTaRSTRAPPC1. human.
GenomeRNAi58485.
NextBio64938.
PROQ9Y5R8.
SOURCESearch...

Entry information

Entry nameTPPC1_HUMAN
AccessionPrimary (citable) accession number: Q9Y5R8
Secondary accession number(s): D3DTR0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM