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Q9Y5R8

- TPPC1_HUMAN

UniProt

Q9Y5R8 - TPPC1_HUMAN

Protein

Trafficking protein particle complex subunit 1

Gene

TRAPPC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May play a role in vesicular transport from endoplasmic reticulum to Golgi.

    GO - Biological processi

    1. ER to Golgi vesicle-mediated transport Source: InterPro

    Keywords - Biological processi

    ER-Golgi transport, Transport

    Enzyme and pathway databases

    SignaLinkiQ9Y5R8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trafficking protein particle complex subunit 1
    Alternative name(s):
    BET5 homolog
    Multiple myeloma protein 2
    Short name:
    MUM-2
    Gene namesi
    Name:TRAPPC1
    Synonyms:BET5, MUM2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:19894. TRAPPC1.

    Subcellular locationi

    GO - Cellular componenti

    1. cis-Golgi network Source: InterPro
    2. endoplasmic reticulum Source: UniProtKB-SubCell
    3. Golgi apparatus Source: UniProtKB-SubCell
    4. TRAPP complex Source: Ensembl

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134988492.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 145145Trafficking protein particle complex subunit 1PRO_0000211562Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y5R8.
    PaxDbiQ9Y5R8.
    PRIDEiQ9Y5R8.

    PTM databases

    PhosphoSiteiQ9Y5R8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y5R8.
    BgeeiQ9Y5R8.
    CleanExiHS_TRAPPC1.
    GenevestigatoriQ9Y5R8.

    Organism-specific databases

    HPAiHPA052398.

    Interactioni

    Subunit structurei

    Part of the multisubunit TRAPP (transport protein particle) complex.1 Publication

    Protein-protein interaction databases

    BioGridi121815. 8 interactions.
    DIPiDIP-48285N.
    IntActiQ9Y5R8. 1 interaction.
    STRINGi9606.ENSP00000302783.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5R8.
    SMRiQ9Y5R8. Positions 2-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG237222.
    HOGENOMiHOG000172118.
    HOVERGENiHBG056032.
    InParanoidiQ9Y5R8.
    OMAiFYETPAN.
    OrthoDBiEOG7GXPD7.
    PhylomeDBiQ9Y5R8.
    TreeFamiTF323681.

    Family and domain databases

    InterProiIPR011012. Longin-like_dom.
    IPR007233. Sybindin.
    [Graphical view]
    PANTHERiPTHR23249. PTHR23249. 1 hit.
    PfamiPF04099. Sybindin. 1 hit.
    [Graphical view]
    SUPFAMiSSF64356. SSF64356. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Y5R8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS    50
    KMSPLDMKDG FLAFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI 100
    YSALYVELVV KNPLCPLGQT VQSELFRSRL DSYVRSLPFF SARAG 145
    Length:145
    Mass (Da):16,832
    Last modified:November 1, 1999 - v1
    Checksum:i7C8C81D3F0E8DCC6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti129 – 1291R → G in a melanoma. 1 Publication
    VAR_013028

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF129332 Genomic DNA. Translation: AAD44697.1.
    CH471108 Genomic DNA. Translation: EAW90109.1.
    CH471108 Genomic DNA. Translation: EAW90110.1.
    CH471108 Genomic DNA. Translation: EAW90111.1.
    BC032717 mRNA. Translation: AAH32717.1.
    CCDSiCCDS11125.1.
    RefSeqiNP_001160093.1. NM_001166621.1.
    NP_067033.1. NM_021210.4.
    UniGeneiHs.24379.

    Genome annotation databases

    EnsembliENST00000303731; ENSP00000302783; ENSG00000170043.
    ENST00000540486; ENSP00000441130; ENSG00000170043.
    GeneIDi58485.
    KEGGihsa:58485.
    UCSCiuc002gjo.2. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF129332 Genomic DNA. Translation: AAD44697.1 .
    CH471108 Genomic DNA. Translation: EAW90109.1 .
    CH471108 Genomic DNA. Translation: EAW90110.1 .
    CH471108 Genomic DNA. Translation: EAW90111.1 .
    BC032717 mRNA. Translation: AAH32717.1 .
    CCDSi CCDS11125.1.
    RefSeqi NP_001160093.1. NM_001166621.1.
    NP_067033.1. NM_021210.4.
    UniGenei Hs.24379.

    3D structure databases

    ProteinModelPortali Q9Y5R8.
    SMRi Q9Y5R8. Positions 2-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121815. 8 interactions.
    DIPi DIP-48285N.
    IntActi Q9Y5R8. 1 interaction.
    STRINGi 9606.ENSP00000302783.

    PTM databases

    PhosphoSitei Q9Y5R8.

    Proteomic databases

    MaxQBi Q9Y5R8.
    PaxDbi Q9Y5R8.
    PRIDEi Q9Y5R8.

    Protocols and materials databases

    DNASUi 58485.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000303731 ; ENSP00000302783 ; ENSG00000170043 .
    ENST00000540486 ; ENSP00000441130 ; ENSG00000170043 .
    GeneIDi 58485.
    KEGGi hsa:58485.
    UCSCi uc002gjo.2. human.

    Organism-specific databases

    CTDi 58485.
    GeneCardsi GC17M007833.
    HGNCi HGNC:19894. TRAPPC1.
    HPAi HPA052398.
    MIMi 610969. gene.
    neXtProti NX_Q9Y5R8.
    PharmGKBi PA134988492.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG237222.
    HOGENOMi HOG000172118.
    HOVERGENi HBG056032.
    InParanoidi Q9Y5R8.
    OMAi FYETPAN.
    OrthoDBi EOG7GXPD7.
    PhylomeDBi Q9Y5R8.
    TreeFami TF323681.

    Enzyme and pathway databases

    SignaLinki Q9Y5R8.

    Miscellaneous databases

    ChiTaRSi TRAPPC1. human.
    GenomeRNAii 58485.
    NextBioi 64938.
    PROi Q9Y5R8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5R8.
    Bgeei Q9Y5R8.
    CleanExi HS_TRAPPC1.
    Genevestigatori Q9Y5R8.

    Family and domain databases

    InterProi IPR011012. Longin-like_dom.
    IPR007233. Sybindin.
    [Graphical view ]
    PANTHERi PTHR23249. PTHR23249. 1 hit.
    Pfami PF04099. Sybindin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64356. SSF64356. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene."
      Chiari R., Foury F., De Plaen E., Baurain J.-F., Thonnard J., Coulie P.G.
      Cancer Res. 59:5785-5792(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MELANOMA GLY-129.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    4. Cited for: IDENTIFICATION IN TRAPP COMPLEX.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTPPC1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5R8
    Secondary accession number(s): D3DTR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3