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Q9Y5R8

- TPPC1_HUMAN

UniProt

Q9Y5R8 - TPPC1_HUMAN

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Protein

Trafficking protein particle complex subunit 1

Gene

TRAPPC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Enzyme and pathway databases

SignaLinkiQ9Y5R8.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 1
Alternative name(s):
BET5 homolog
Multiple myeloma protein 2
Short name:
MUM-2
Gene namesi
Name:TRAPPC1
Synonyms:BET5, MUM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:19894. TRAPPC1.

Subcellular locationi

GO - Cellular componenti

  1. cis-Golgi network Source: InterPro
  2. endoplasmic reticulum Source: UniProtKB-KW
  3. Golgi apparatus Source: UniProtKB-KW
  4. TRAPP complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134988492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Trafficking protein particle complex subunit 1PRO_0000211562Add
BLAST

Proteomic databases

MaxQBiQ9Y5R8.
PaxDbiQ9Y5R8.
PRIDEiQ9Y5R8.

PTM databases

PhosphoSiteiQ9Y5R8.

Expressioni

Gene expression databases

BgeeiQ9Y5R8.
CleanExiHS_TRAPPC1.
ExpressionAtlasiQ9Y5R8. baseline and differential.
GenevestigatoriQ9Y5R8.

Organism-specific databases

HPAiHPA052398.

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) complex.1 Publication

Protein-protein interaction databases

BioGridi121815. 10 interactions.
DIPiDIP-48285N.
IntActiQ9Y5R8. 1 interaction.
STRINGi9606.ENSP00000302783.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5R8.
SMRiQ9Y5R8. Positions 2-142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG237222.
GeneTreeiENSGT00510000047863.
HOGENOMiHOG000172118.
HOVERGENiHBG056032.
InParanoidiQ9Y5R8.
OMAiFYETPAN.
OrthoDBiEOG7GXPD7.
PhylomeDBiQ9Y5R8.
TreeFamiTF323681.

Family and domain databases

InterProiIPR011012. Longin-like_dom.
IPR007233. Sybindin.
[Graphical view]
PANTHERiPTHR23249. PTHR23249. 1 hit.
PfamiPF04099. Sybindin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y5R8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVHNLYLFD RNGVCLHYSE WHRKKQAGIP KEEEYKLMYG MLFSIRSFVS
60 70 80 90 100
KMSPLDMKDG FLAFQTSRYK LHYYETPTGI KVVMNTDLGV GPIRDVLHHI
110 120 130 140
YSALYVELVV KNPLCPLGQT VQSELFRSRL DSYVRSLPFF SARAG
Length:145
Mass (Da):16,832
Last modified:November 1, 1999 - v1
Checksum:i7C8C81D3F0E8DCC6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti129 – 1291R → G in a melanoma. 1 Publication
VAR_013028

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129332 Genomic DNA. Translation: AAD44697.1.
CH471108 Genomic DNA. Translation: EAW90109.1.
CH471108 Genomic DNA. Translation: EAW90110.1.
CH471108 Genomic DNA. Translation: EAW90111.1.
BC032717 mRNA. Translation: AAH32717.1.
CCDSiCCDS11125.1.
RefSeqiNP_001160093.1. NM_001166621.1.
NP_067033.1. NM_021210.4.
UniGeneiHs.24379.

Genome annotation databases

EnsembliENST00000303731; ENSP00000302783; ENSG00000170043.
ENST00000540486; ENSP00000441130; ENSG00000170043.
GeneIDi58485.
KEGGihsa:58485.
UCSCiuc002gjo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF129332 Genomic DNA. Translation: AAD44697.1 .
CH471108 Genomic DNA. Translation: EAW90109.1 .
CH471108 Genomic DNA. Translation: EAW90110.1 .
CH471108 Genomic DNA. Translation: EAW90111.1 .
BC032717 mRNA. Translation: AAH32717.1 .
CCDSi CCDS11125.1.
RefSeqi NP_001160093.1. NM_001166621.1.
NP_067033.1. NM_021210.4.
UniGenei Hs.24379.

3D structure databases

ProteinModelPortali Q9Y5R8.
SMRi Q9Y5R8. Positions 2-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121815. 10 interactions.
DIPi DIP-48285N.
IntActi Q9Y5R8. 1 interaction.
STRINGi 9606.ENSP00000302783.

PTM databases

PhosphoSitei Q9Y5R8.

Proteomic databases

MaxQBi Q9Y5R8.
PaxDbi Q9Y5R8.
PRIDEi Q9Y5R8.

Protocols and materials databases

DNASUi 58485.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000303731 ; ENSP00000302783 ; ENSG00000170043 .
ENST00000540486 ; ENSP00000441130 ; ENSG00000170043 .
GeneIDi 58485.
KEGGi hsa:58485.
UCSCi uc002gjo.2. human.

Organism-specific databases

CTDi 58485.
GeneCardsi GC17M007833.
HGNCi HGNC:19894. TRAPPC1.
HPAi HPA052398.
MIMi 610969. gene.
neXtProti NX_Q9Y5R8.
PharmGKBi PA134988492.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG237222.
GeneTreei ENSGT00510000047863.
HOGENOMi HOG000172118.
HOVERGENi HBG056032.
InParanoidi Q9Y5R8.
OMAi FYETPAN.
OrthoDBi EOG7GXPD7.
PhylomeDBi Q9Y5R8.
TreeFami TF323681.

Enzyme and pathway databases

SignaLinki Q9Y5R8.

Miscellaneous databases

ChiTaRSi TRAPPC1. human.
GenomeRNAii 58485.
NextBioi 64938.
PROi Q9Y5R8.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y5R8.
CleanExi HS_TRAPPC1.
ExpressionAtlasi Q9Y5R8. baseline and differential.
Genevestigatori Q9Y5R8.

Family and domain databases

InterProi IPR011012. Longin-like_dom.
IPR007233. Sybindin.
[Graphical view ]
PANTHERi PTHR23249. PTHR23249. 1 hit.
Pfami PF04099. Sybindin. 1 hit.
[Graphical view ]
SUPFAMi SSF64356. SSF64356. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene."
    Chiari R., Foury F., De Plaen E., Baurain J.-F., Thonnard J., Coulie P.G.
    Cancer Res. 59:5785-5792(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT MELANOMA GLY-129.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  4. Cited for: IDENTIFICATION IN TRAPP COMPLEX.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTPPC1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5R8
Secondary accession number(s): D3DTR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3