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Q9Y5R6

- DMRT1_HUMAN

UniProt

Q9Y5R6 - DMRT1_HUMAN

Protein

Doublesex- and mab-3-related transcription factor 1

Gene

DMRT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (10 May 2005)
      Previous versions | rss
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    Functioni

    Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi72 – 11847DMPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. core promoter proximal region sequence-specific DNA binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. cell morphogenesis Source: Ensembl
    2. germ cell migration Source: Ensembl
    3. intracellular signal transduction Source: Ensembl
    4. male germ cell proliferation Source: UniProtKB
    5. male gonad development Source: ProtInc
    6. male sex determination Source: UniProtKB
    7. male sex differentiation Source: UniProtKB
    8. negative regulation of meiosis Source: UniProtKB
    9. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    10. oocyte development Source: Ensembl
    11. positive regulation of male gonad development Source: Ensembl
    12. positive regulation of meiosis I Source: Ensembl
    13. positive regulation of mitosis Source: UniProtKB
    14. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    15. Sertoli cell development Source: Ensembl
    16. Sertoli cell differentiation Source: UniProtKB
    17. sex determination Source: ProtInc
    18. spermatogenesis Source: Ensembl
    19. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Sexual differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Doublesex- and mab-3-related transcription factor 1
    Alternative name(s):
    DM domain expressed in testis protein 1
    Gene namesi
    Name:DMRT1
    Synonyms:DMT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:2934. DMRT1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Testicular germ cell tumor (TGCT) [MIM:273300]: A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma.1 Publication
    Note: The disease may be caused by mutations affecting the gene represented in this entry.
    46,XY sex reversal 4 (SRXY4) [MIM:154230]: A condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype. Patients display complete or partial gonadal dysgenesis and a chromosome 9p deletion.3 Publications
    Note: The disease may be caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi154230. phenotype.
    273300. phenotype.
    Orphaneti242. 46,XY complete gonadal dysgenesis.
    PharmGKBiPA27381.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 373373Doublesex- and mab-3-related transcription factor 1PRO_0000207042Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y5R6.
    PeptideAtlasiQ9Y5R6.
    PRIDEiQ9Y5R6.

    PTM databases

    PhosphoSiteiQ9Y5R6.

    Expressioni

    Tissue specificityi

    Testis-specific. Expressed in prostate cancer (at protein level).2 Publications

    Developmental stagei

    Expressed in the genital ridges of six-week-old male embryos. Becomes confined to the forming seminiferous tubules (probably Sertoli cells) at seven weeks. Not detected in female embryos.

    Gene expression databases

    ArrayExpressiQ9Y5R6.
    BgeeiQ9Y5R6.
    CleanExiHS_DMRT1.
    GenevestigatoriQ9Y5R6.

    Organism-specific databases

    HPAiHPA027850.

    Interactioni

    Protein-protein interaction databases

    BioGridi108101. 2 interactions.
    IntActiQ9Y5R6. 1 interaction.
    MINTiMINT-7969865.
    STRINGi9606.ENSP00000371711.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5R6.
    SMRiQ9Y5R6. Positions 70-118.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi322 – 34726Pro/Ser-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DMRT family.Curated
    Contains 1 DM DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG271390.
    HOGENOMiHOG000059585.
    HOVERGENiHBG055845.
    InParanoidiQ9Y5R6.
    OMAiECEPASE.
    OrthoDBiEOG7K3TMG.
    PhylomeDBiQ9Y5R6.
    TreeFamiTF317837.

    Family and domain databases

    Gene3Di4.10.1040.10. 1 hit.
    InterProiIPR001275. DM_DNA-bd.
    IPR026607. DMRT/dsx/mab-3.
    IPR022114. DMRT1-like.
    [Graphical view]
    PANTHERiPTHR12322. PTHR12322. 1 hit.
    PfamiPF00751. DM. 1 hit.
    PF12374. Dmrt1. 1 hit.
    [Graphical view]
    SMARTiSM00301. DM. 1 hit.
    [Graphical view]
    SUPFAMiSSF82927. SSF82927. 1 hit.
    PROSITEiPS40000. DM_1. 1 hit.
    PS50809. DM_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y5R6-1) [UniParc]FASTAAdd to Basket

    Also known as: DMRT1a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPNDEAFSKP STPSEAPHAP GVPPQGRAGG FGKASGALVG AASGSSAGGS    50
    SRGGGSGSGA SDLGAGSKKS PRLPKCARCR NHGYASPLKG HKRFCMWRDC 100
    QCKKCNLIAE RQRVMAAQVA LRRQQAQEEE LGISHPIPLP SAAELLVKRE 150
    NNGSNPCLMT ECSGTSQPPP ASVPTTAASE GRMVIQDIPA VTSRGHVENT 200
    PDLVSDSTYY SSFYQPSLFP YYNNLYNCPQ YSMALAADSA SGEVGNPLGG 250
    SPVKNSLRGL PGPYVPGQTG NQWQMKNMEN RHAMSSQYRM HSYYPPPSYL 300
    GQSVPQFFTF EDAPSYPEAR ASVFSPPSSQ DSGLVSLSSS SPISNKSTKA 350
    VLECEPASEP SSFTVTPVIE EDE 373
    Length:373
    Mass (Da):39,473
    Last modified:May 10, 2005 - v2
    Checksum:i23348B2C4A4733A1
    GO
    Isoform 2 (identifier: Q9Y5R6-2) [UniParc]FASTAAdd to Basket

    Also known as: DMRT1b

    The sequence of this isoform differs from the canonical sequence as follows:
         275-275: M → V
         276-373: Missing.

    Show »
    Length:275
    Mass (Da):28,690
    Checksum:iE5ED8B07861609D9
    GO
    Isoform 3 (identifier: Q9Y5R6-3) [UniParc]FASTAAdd to Basket

    Also known as: DMRT1c

    The sequence of this isoform differs from the canonical sequence as follows:
         120-175: ALRRQQAQEE...SQPPPASVPT → GAGVREPGFS...QAILLPQPPK
         176-373: Missing.

    Show »
    Length:175
    Mass (Da):18,325
    Checksum:i9CFD6F98F5F9B54C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451S → T.3 Publications
    Corresponds to variant rs3739583 [ dbSNP | Ensembl ].
    VAR_009954
    Natural varianti221 – 2211Y → S.1 Publication
    VAR_009955
    Natural varianti281 – 2811R → S.1 Publication
    VAR_009956
    Natural varianti295 – 2951P → L.1 Publication
    VAR_009957

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei120 – 17556ALRRQ…ASVPT → GAGVREPGFSLSFFFFFFFF RWSLARLPRLQCSGAILAHC NSASRVQAILLPQPPK in isoform 3. 1 PublicationVSP_042959Add
    BLAST
    Alternative sequencei176 – 373198Missing in isoform 3. 1 PublicationVSP_042960Add
    BLAST
    Alternative sequencei275 – 2751M → V in isoform 2. 1 PublicationVSP_042961
    Alternative sequencei276 – 37398Missing in isoform 2. 1 PublicationVSP_042962Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF130728 mRNA. Translation: AAD40474.1.
    AL162131 mRNA. Translation: CAB82427.1.
    AY442914 mRNA. Translation: AAR89619.1.
    AY442915 mRNA. Translation: AAR89620.1.
    AK313594 mRNA. Translation: BAG36360.1.
    AJ276801 mRNA. Translation: CAB82851.1.
    AL136365 Genomic DNA. Translation: CAB99335.1.
    CH471071 Genomic DNA. Translation: EAW58820.1.
    BC040847 mRNA. Translation: AAH40847.1.
    CCDSiCCDS6442.1. [Q9Y5R6-1]
    RefSeqiNP_068770.2. NM_021951.2. [Q9Y5R6-1]
    UniGeneiHs.98586.

    Genome annotation databases

    EnsembliENST00000382276; ENSP00000371711; ENSG00000137090. [Q9Y5R6-1]
    GeneIDi1761.
    KEGGihsa:1761.
    UCSCiuc003zgu.1. human. [Q9Y5R6-2]
    uc003zgv.3. human. [Q9Y5R6-1]

    Polymorphism databases

    DMDMi83305820.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF130728 mRNA. Translation: AAD40474.1 .
    AL162131 mRNA. Translation: CAB82427.1 .
    AY442914 mRNA. Translation: AAR89619.1 .
    AY442915 mRNA. Translation: AAR89620.1 .
    AK313594 mRNA. Translation: BAG36360.1 .
    AJ276801 mRNA. Translation: CAB82851.1 .
    AL136365 Genomic DNA. Translation: CAB99335.1 .
    CH471071 Genomic DNA. Translation: EAW58820.1 .
    BC040847 mRNA. Translation: AAH40847.1 .
    CCDSi CCDS6442.1. [Q9Y5R6-1 ]
    RefSeqi NP_068770.2. NM_021951.2. [Q9Y5R6-1 ]
    UniGenei Hs.98586.

    3D structure databases

    ProteinModelPortali Q9Y5R6.
    SMRi Q9Y5R6. Positions 70-118.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108101. 2 interactions.
    IntActi Q9Y5R6. 1 interaction.
    MINTi MINT-7969865.
    STRINGi 9606.ENSP00000371711.

    PTM databases

    PhosphoSitei Q9Y5R6.

    Polymorphism databases

    DMDMi 83305820.

    Proteomic databases

    PaxDbi Q9Y5R6.
    PeptideAtlasi Q9Y5R6.
    PRIDEi Q9Y5R6.

    Protocols and materials databases

    DNASUi 1761.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382276 ; ENSP00000371711 ; ENSG00000137090 . [Q9Y5R6-1 ]
    GeneIDi 1761.
    KEGGi hsa:1761.
    UCSCi uc003zgu.1. human. [Q9Y5R6-2 ]
    uc003zgv.3. human. [Q9Y5R6-1 ]

    Organism-specific databases

    CTDi 1761.
    GeneCardsi GC09P000831.
    HGNCi HGNC:2934. DMRT1.
    HPAi HPA027850.
    MIMi 154230. phenotype.
    273300. phenotype.
    602424. gene.
    neXtProti NX_Q9Y5R6.
    Orphaneti 242. 46,XY complete gonadal dysgenesis.
    PharmGKBi PA27381.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG271390.
    HOGENOMi HOG000059585.
    HOVERGENi HBG055845.
    InParanoidi Q9Y5R6.
    OMAi ECEPASE.
    OrthoDBi EOG7K3TMG.
    PhylomeDBi Q9Y5R6.
    TreeFami TF317837.

    Miscellaneous databases

    GeneWikii DMRT1.
    GenomeRNAii 1761.
    NextBioi 7179.
    PROi Q9Y5R6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5R6.
    Bgeei Q9Y5R6.
    CleanExi HS_DMRT1.
    Genevestigatori Q9Y5R6.

    Family and domain databases

    Gene3Di 4.10.1040.10. 1 hit.
    InterProi IPR001275. DM_DNA-bd.
    IPR026607. DMRT/dsx/mab-3.
    IPR022114. DMRT1-like.
    [Graphical view ]
    PANTHERi PTHR12322. PTHR12322. 1 hit.
    Pfami PF00751. DM. 1 hit.
    PF12374. Dmrt1. 1 hit.
    [Graphical view ]
    SMARTi SM00301. DM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82927. SSF82927. 1 hit.
    PROSITEi PS40000. DM_1. 1 hit.
    PS50809. DM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators."
      Raymond C.S., Parker E.D., Kettlewell J.R., Brown L.G., Page D.C., Kusz K., Jaruzelska J., Reinberg Y., Flejter W.L., Bardwell V.J., Hirsch B., Zarkower D.
      Hum. Mol. Genet. 8:989-996(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS THR-45; SER-221; SER-281 AND LEU-295.
      Tissue: Testis.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-45, TISSUE SPECIFICITY.
      Tissue: Testis.
    3. "Transcriptional diversity of DMRT1 (dsx- and mab3-related transcription factor 1) in human testis."
      Cheng H.H., Ying M., Tian Y.H., Guo Y., McElreavey K., Zhou R.J.
      Cell Res. 16:389-393(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT THR-45.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    5. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    8. "A gene involved in XY sex reversal is located on chromosome 9, distal to marker D9S1779."
      Flejter W.L., Fergestad J., Gorski J., Varvill T., Chandrasekharappa S.
      Am. J. Hum. Genet. 63:794-802(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN SRXY4.
    9. "Evidence for evolutionary conservation of sex-determining genes."
      Raymond C.S., Shamu C.E., Shen M.M., Seifert K.J., Hirsch B., Hodgkin J., Zarkower D.
      Nature 391:691-695(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN SRXY4.
    10. Cited for: POSSIBLE INVOLVEMENT IN TGCT.
    11. "Identification of de novo copy number variants associated with human disorders of sexual development."
      Tannour-Louet M., Han S., Corbett S.T., Louet J.F., Yatsenko S., Meyers L., Shaw C.A., Kang S.H., Cheung S.W., Lamb D.J.
      PLoS ONE 5:E15392-E15392(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE INVOLVEMENT IN SRXY4.
    12. "Scanning of novel cancer/testis proteins by human testis proteomic analysis."
      Liu M., Hu Z., Qi L., Wang J., Zhou T., Guo Y., Zeng Y., Zheng B., Wu Y., Zhang P., Chen X., Tu W., Zhang T., Zhou Q., Jiang M., Guo X., Zhou Z., Sha J.
      Proteomics 13:1200-1210(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiDMRT1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5R6
    Secondary accession number(s): B2R913
    , Q6T1H8, Q6T1H9, Q8IW77
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3