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Q9Y5R6

- DMRT1_HUMAN

UniProt

Q9Y5R6 - DMRT1_HUMAN

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Protein

Doublesex- and mab-3-related transcription factor 1

Gene

DMRT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi72 – 11847DMPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. core promoter proximal region sequence-specific DNA binding Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. cell morphogenesis Source: Ensembl
  2. germ cell migration Source: Ensembl
  3. intracellular signal transduction Source: Ensembl
  4. male germ cell proliferation Source: UniProtKB
  5. male sex determination Source: UniProtKB
  6. male sex differentiation Source: UniProtKB
  7. negative regulation of meiosis Source: UniProtKB
  8. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  9. oocyte development Source: Ensembl
  10. positive regulation of male gonad development Source: Ensembl
  11. positive regulation of meiosis I Source: Ensembl
  12. positive regulation of mitosis Source: UniProtKB
  13. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  14. regulation of nodal signaling pathway Source: Ensembl
  15. Sertoli cell development Source: Ensembl
  16. Sertoli cell differentiation Source: UniProtKB
  17. spermatogenesis Source: Ensembl
  18. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Sexual differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Doublesex- and mab-3-related transcription factor 1
Alternative name(s):
DM domain expressed in testis protein 1
Gene namesi
Name:DMRT1
Synonyms:DMT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:2934. DMRT1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Testicular germ cell tumor (TGCT) [MIM:273300]: A common malignancy in males representing 95% of all testicular neoplasms. TGCTs have various pathologic subtypes including: unclassified intratubular germ cell neoplasia, seminoma (including cases with syncytiotrophoblastic cells), spermatocytic seminoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, and teratoma.1 Publication
Note: The disease may be caused by mutations affecting the gene represented in this entry.
46,XY sex reversal 4 (SRXY4) [MIM:154230]: A condition characterized by male-to-female sex reversal in the presence of a normal 46,XY karyotype. Patients display complete or partial gonadal dysgenesis and a chromosome 9p deletion.3 Publications
Note: The disease may be caused by mutations affecting the gene represented in this entry.

Organism-specific databases

MIMi154230. phenotype.
273300. phenotype.
Orphaneti242. 46,XY complete gonadal dysgenesis.
PharmGKBiPA27381.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 373373Doublesex- and mab-3-related transcription factor 1PRO_0000207042Add
BLAST

Proteomic databases

PaxDbiQ9Y5R6.
PeptideAtlasiQ9Y5R6.
PRIDEiQ9Y5R6.

PTM databases

PhosphoSiteiQ9Y5R6.

Expressioni

Tissue specificityi

Testis-specific. Expressed in prostate cancer (at protein level).2 Publications

Developmental stagei

Expressed in the genital ridges of six-week-old male embryos. Becomes confined to the forming seminiferous tubules (probably Sertoli cells) at seven weeks. Not detected in female embryos.

Gene expression databases

BgeeiQ9Y5R6.
CleanExiHS_DMRT1.
ExpressionAtlasiQ9Y5R6. baseline and differential.
GenevestigatoriQ9Y5R6.

Organism-specific databases

HPAiHPA027850.

Interactioni

Protein-protein interaction databases

BioGridi108101. 2 interactions.
IntActiQ9Y5R6. 1 interaction.
MINTiMINT-7969865.
STRINGi9606.ENSP00000371711.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5R6.
SMRiQ9Y5R6. Positions 70-118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi322 – 34726Pro/Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the DMRT family.Curated
Contains 1 DM DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG271390.
GeneTreeiENSGT00550000074486.
HOGENOMiHOG000059585.
HOVERGENiHBG055845.
InParanoidiQ9Y5R6.
OMAiECEPASE.
OrthoDBiEOG7K3TMG.
PhylomeDBiQ9Y5R6.
TreeFamiTF317837.

Family and domain databases

Gene3Di4.10.1040.10. 1 hit.
InterProiIPR001275. DM_DNA-bd.
IPR026607. DMRT/dsx/mab-3.
IPR022114. DMRT1-like.
[Graphical view]
PANTHERiPTHR12322. PTHR12322. 1 hit.
PfamiPF00751. DM. 1 hit.
PF12374. Dmrt1. 1 hit.
[Graphical view]
SMARTiSM00301. DM. 1 hit.
[Graphical view]
SUPFAMiSSF82927. SSF82927. 1 hit.
PROSITEiPS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y5R6-1) [UniParc]FASTAAdd to Basket

Also known as: DMRT1a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPNDEAFSKP STPSEAPHAP GVPPQGRAGG FGKASGALVG AASGSSAGGS
60 70 80 90 100
SRGGGSGSGA SDLGAGSKKS PRLPKCARCR NHGYASPLKG HKRFCMWRDC
110 120 130 140 150
QCKKCNLIAE RQRVMAAQVA LRRQQAQEEE LGISHPIPLP SAAELLVKRE
160 170 180 190 200
NNGSNPCLMT ECSGTSQPPP ASVPTTAASE GRMVIQDIPA VTSRGHVENT
210 220 230 240 250
PDLVSDSTYY SSFYQPSLFP YYNNLYNCPQ YSMALAADSA SGEVGNPLGG
260 270 280 290 300
SPVKNSLRGL PGPYVPGQTG NQWQMKNMEN RHAMSSQYRM HSYYPPPSYL
310 320 330 340 350
GQSVPQFFTF EDAPSYPEAR ASVFSPPSSQ DSGLVSLSSS SPISNKSTKA
360 370
VLECEPASEP SSFTVTPVIE EDE
Length:373
Mass (Da):39,473
Last modified:May 10, 2005 - v2
Checksum:i23348B2C4A4733A1
GO
Isoform 2 (identifier: Q9Y5R6-2) [UniParc]FASTAAdd to Basket

Also known as: DMRT1b

The sequence of this isoform differs from the canonical sequence as follows:
     275-275: M → V
     276-373: Missing.

Show »
Length:275
Mass (Da):28,690
Checksum:iE5ED8B07861609D9
GO
Isoform 3 (identifier: Q9Y5R6-3) [UniParc]FASTAAdd to Basket

Also known as: DMRT1c

The sequence of this isoform differs from the canonical sequence as follows:
     120-175: ALRRQQAQEE...SQPPPASVPT → GAGVREPGFS...QAILLPQPPK
     176-373: Missing.

Show »
Length:175
Mass (Da):18,325
Checksum:i9CFD6F98F5F9B54C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti45 – 451S → T.3 Publications
Corresponds to variant rs3739583 [ dbSNP | Ensembl ].
VAR_009954
Natural varianti221 – 2211Y → S.1 Publication
VAR_009955
Natural varianti281 – 2811R → S.1 Publication
VAR_009956
Natural varianti295 – 2951P → L.1 Publication
VAR_009957

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei120 – 17556ALRRQ…ASVPT → GAGVREPGFSLSFFFFFFFF RWSLARLPRLQCSGAILAHC NSASRVQAILLPQPPK in isoform 3. 1 PublicationVSP_042959Add
BLAST
Alternative sequencei176 – 373198Missing in isoform 3. 1 PublicationVSP_042960Add
BLAST
Alternative sequencei275 – 2751M → V in isoform 2. 1 PublicationVSP_042961
Alternative sequencei276 – 37398Missing in isoform 2. 1 PublicationVSP_042962Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF130728 mRNA. Translation: AAD40474.1.
AL162131 mRNA. Translation: CAB82427.1.
AY442914 mRNA. Translation: AAR89619.1.
AY442915 mRNA. Translation: AAR89620.1.
AK313594 mRNA. Translation: BAG36360.1.
AJ276801 mRNA. Translation: CAB82851.1.
AL136365 Genomic DNA. Translation: CAB99335.1.
CH471071 Genomic DNA. Translation: EAW58820.1.
BC040847 mRNA. Translation: AAH40847.1.
CCDSiCCDS6442.1. [Q9Y5R6-1]
RefSeqiNP_068770.2. NM_021951.2. [Q9Y5R6-1]
UniGeneiHs.98586.

Genome annotation databases

EnsembliENST00000382276; ENSP00000371711; ENSG00000137090. [Q9Y5R6-1]
GeneIDi1761.
KEGGihsa:1761.
UCSCiuc003zgu.1. human. [Q9Y5R6-2]
uc003zgv.3. human. [Q9Y5R6-1]

Polymorphism databases

DMDMi83305820.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF130728 mRNA. Translation: AAD40474.1 .
AL162131 mRNA. Translation: CAB82427.1 .
AY442914 mRNA. Translation: AAR89619.1 .
AY442915 mRNA. Translation: AAR89620.1 .
AK313594 mRNA. Translation: BAG36360.1 .
AJ276801 mRNA. Translation: CAB82851.1 .
AL136365 Genomic DNA. Translation: CAB99335.1 .
CH471071 Genomic DNA. Translation: EAW58820.1 .
BC040847 mRNA. Translation: AAH40847.1 .
CCDSi CCDS6442.1. [Q9Y5R6-1 ]
RefSeqi NP_068770.2. NM_021951.2. [Q9Y5R6-1 ]
UniGenei Hs.98586.

3D structure databases

ProteinModelPortali Q9Y5R6.
SMRi Q9Y5R6. Positions 70-118.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108101. 2 interactions.
IntActi Q9Y5R6. 1 interaction.
MINTi MINT-7969865.
STRINGi 9606.ENSP00000371711.

PTM databases

PhosphoSitei Q9Y5R6.

Polymorphism databases

DMDMi 83305820.

Proteomic databases

PaxDbi Q9Y5R6.
PeptideAtlasi Q9Y5R6.
PRIDEi Q9Y5R6.

Protocols and materials databases

DNASUi 1761.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382276 ; ENSP00000371711 ; ENSG00000137090 . [Q9Y5R6-1 ]
GeneIDi 1761.
KEGGi hsa:1761.
UCSCi uc003zgu.1. human. [Q9Y5R6-2 ]
uc003zgv.3. human. [Q9Y5R6-1 ]

Organism-specific databases

CTDi 1761.
GeneCardsi GC09P000831.
HGNCi HGNC:2934. DMRT1.
HPAi HPA027850.
MIMi 154230. phenotype.
273300. phenotype.
602424. gene.
neXtProti NX_Q9Y5R6.
Orphaneti 242. 46,XY complete gonadal dysgenesis.
PharmGKBi PA27381.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG271390.
GeneTreei ENSGT00550000074486.
HOGENOMi HOG000059585.
HOVERGENi HBG055845.
InParanoidi Q9Y5R6.
OMAi ECEPASE.
OrthoDBi EOG7K3TMG.
PhylomeDBi Q9Y5R6.
TreeFami TF317837.

Miscellaneous databases

GeneWikii DMRT1.
GenomeRNAii 1761.
NextBioi 7179.
PROi Q9Y5R6.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y5R6.
CleanExi HS_DMRT1.
ExpressionAtlasi Q9Y5R6. baseline and differential.
Genevestigatori Q9Y5R6.

Family and domain databases

Gene3Di 4.10.1040.10. 1 hit.
InterProi IPR001275. DM_DNA-bd.
IPR026607. DMRT/dsx/mab-3.
IPR022114. DMRT1-like.
[Graphical view ]
PANTHERi PTHR12322. PTHR12322. 1 hit.
Pfami PF00751. DM. 1 hit.
PF12374. Dmrt1. 1 hit.
[Graphical view ]
SMARTi SM00301. DM. 1 hit.
[Graphical view ]
SUPFAMi SSF82927. SSF82927. 1 hit.
PROSITEi PS40000. DM_1. 1 hit.
PS50809. DM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A region of human chromosome 9p required for testis development contains two genes related to known sexual regulators."
    Raymond C.S., Parker E.D., Kettlewell J.R., Brown L.G., Page D.C., Kusz K., Jaruzelska J., Reinberg Y., Flejter W.L., Bardwell V.J., Hirsch B., Zarkower D.
    Hum. Mol. Genet. 8:989-996(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS THR-45; SER-221; SER-281 AND LEU-295.
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-45, TISSUE SPECIFICITY.
    Tissue: Testis.
  3. "Transcriptional diversity of DMRT1 (dsx- and mab3-related transcription factor 1) in human testis."
    Cheng H.H., Ying M., Tian Y.H., Guo Y., McElreavey K., Zhou R.J.
    Cell Res. 16:389-393(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), VARIANT THR-45.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  5. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  8. "A gene involved in XY sex reversal is located on chromosome 9, distal to marker D9S1779."
    Flejter W.L., Fergestad J., Gorski J., Varvill T., Chandrasekharappa S.
    Am. J. Hum. Genet. 63:794-802(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN SRXY4.
  9. "Evidence for evolutionary conservation of sex-determining genes."
    Raymond C.S., Shamu C.E., Shen M.M., Seifert K.J., Hirsch B., Hodgkin J., Zarkower D.
    Nature 391:691-695(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN SRXY4.
  10. Cited for: POSSIBLE INVOLVEMENT IN TGCT.
  11. "Identification of de novo copy number variants associated with human disorders of sexual development."
    Tannour-Louet M., Han S., Corbett S.T., Louet J.F., Yatsenko S., Meyers L., Shaw C.A., Kang S.H., Cheung S.W., Lamb D.J.
    PLoS ONE 5:E15392-E15392(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INVOLVEMENT IN SRXY4.
  12. "Scanning of novel cancer/testis proteins by human testis proteomic analysis."
    Liu M., Hu Z., Qi L., Wang J., Zhou T., Guo Y., Zeng Y., Zheng B., Wu Y., Zhang P., Chen X., Tu W., Zhang T., Zhou Q., Jiang M., Guo X., Zhou Z., Sha J.
    Proteomics 13:1200-1210(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiDMRT1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5R6
Secondary accession number(s): B2R913
, Q6T1H8, Q6T1H9, Q8IW77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 10, 2005
Last modified: October 29, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3