ID   DMRT2_HUMAN             Reviewed;         226 AA.
AC   Q9Y5R5;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   13-OCT-2009, entry version 67.
DE   RecName: Full=Doublesex- and mab-3-related transcription factor 2;
DE   AltName: Full=Doublesex-like 2 protein;
DE            Short=DSXL-2;
GN   Name=DMRT2; Synonyms=DSXL2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   MEDLINE=99265914; PubMed=10332030; DOI=10.1093/hmg/8.6.989;
RA   Raymond C.S., Parker E.D., Kettlewell J.R., Brown L.G., Page D.C.,
RA   Kusz K., Jaruzelska J., Reinberg Y., Flejter W.L., Bardwell V.J.,
RA   Hirsch B., Zarkower D.;
RT   "A region of human chromosome 9p required for testis development
RT   contains two genes related to known sexual regulators.";
RL   Hum. Mol. Genet. 8:989-996(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney;
RX   MEDLINE=20195628; PubMed=10729224; DOI=10.1006/geno.2000.6120;
RA   Ottolenghi C., Veitia R., Barbieri M., Fellous M., McElreavey K.;
RT   "The human doublesex-related gene, DMRT2, is homologous to a gene
RT   involved in somitogenesis and encodes a potential bicistronic
RT   transcript.";
RL   Genomics 64:179-186(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Kidney;
RX   MEDLINE=20313887; PubMed=10857744; DOI=10.1006/geno.2000.6160;
RA   Calvari V., Bertini V., De Grandi A., Peverali G., Zuffardi O.,
RA   Ferguson-Smith M., Knudtzon J., Camerino G., Borsani G., Guioli S.;
RT   "A new submicroscopic deletion that refines the 9p region for sex
RT   reversal.";
RL   Genomics 65:203-212(2000).
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- TISSUE SPECIFICITY: Expressed in testis, kidney and skeletal
CC       muscle.
CC   -!- SIMILARITY: Belongs to the DMRT family.
CC   -!- SIMILARITY: Contains 1 DM DNA-binding domain.
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DR   EMBL; AF130729; AAD40475.1; -; mRNA.
DR   EMBL; Y19052; CAB59891.1; -; mRNA.
DR   EMBL; AF284223; AAF86291.1; -; mRNA.
DR   EMBL; AF284224; AAF86293.1; -; mRNA.
DR   IPI; IPI00001732; -.
DR   RefSeq; NP_001124337.1; -.
DR   RefSeq; NP_006548.1; -.
DR   RefSeq; NP_870987.2; -.
DR   UniGene; Hs.59506; -.
DR   HSSP; P23023; 1LPV.
DR   STRING; Q9Y5R5; -.
DR   PRIDE; Q9Y5R5; -.
DR   Ensembl; ENST00000259622; ENSP00000259622; ENSG00000173253; Homo sapiens.
DR   Ensembl; ENST00000302441; ENSP00000305785; ENSG00000173253; Homo sapiens.
DR   Ensembl; ENST00000358146; ENSP00000350865; ENSG00000173253; Homo sapiens.
DR   Ensembl; ENST00000382251; ENSP00000371686; ENSG00000173253; Homo sapiens.
DR   Ensembl; ENST00000382255; ENSP00000371690; ENSG00000173253; Homo sapiens.
DR   Ensembl; ENST00000412350; ENSP00000397494; ENSG00000173253; Homo sapiens.
DR   GeneID; 10655; -.
DR   KEGG; hsa:10655; -.
DR   UCSC; uc003zhb.2; human.
DR   CTD; 10655; -.
DR   GeneCards; GC09P001040; -.
DR   H-InvDB; HIX0025707; -.
DR   HGNC; HGNC:2935; DMRT2.
DR   MIM; 604935; gene.
DR   Orphanet; 242; Gonadal dysgenesis, XY female type.
DR   PharmGKB; PA27382; -.
DR   HOVERGEN; Q9Y5R5; -.
DR   NextBio; 40507; -.
DR   ArrayExpress; Q9Y5R5; -.
DR   Bgee; Q9Y5R5; -.
DR   CleanEx; HS_DMRT2; -.
DR   Genevestigator; Q9Y5R5; -.
DR   GermOnline; ENSG00000173253; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:transcription factor activity; TAS:ProtInc.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008584; P:male gonad development; TAS:ProtInc.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro.
DR   GO; GO:0007530; P:sex determination; TAS:ProtInc.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001275; DM_DNA_bd.
DR   Gene3D; G3DSA:4.10.1040.10; DM_DNA_bd; 1.
DR   Pfam; PF00751; DM; 1.
DR   SMART; SM00301; DM; 1.
DR   PROSITE; PS40000; DM_1; 1.
DR   PROSITE; PS50809; DM_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN         1    226       Doublesex- and mab-3-related
FT                                transcription factor 2.
FT                                /FTId=PRO_0000207048.
FT   DNA_BIND    119    165       DM.
SQ   SEQUENCE   226 AA;  24469 MW;  D6DE6CB7EF5EDD43 CRC64;
     MADPQAGSAA GDWEIDVESL ELEEDVCGAP RSTPPGPSPP PADGDCEDDE DDDGVDEDAE
     EEGDGEEAGA SPGMPGQPEQ RGGPQPRPPL APQASPAGTG PRERCTPAGG GAEPRKLSRT
     PKCARCRNHG VVSCLKGHKR FCRWRDCQCA NCLLVVERQR VMAAQVALRR QQATEDKKGL
     SGKQNNFERK AVYQRQVRAP SLLAKSILEV LLGLFYSYYV YIMNHL
//