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Protein

General transcription factor 3C polypeptide 3

Gene

GTF3C3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

GO - Molecular functioni

GO - Biological processi

  • 5S class rRNA transcription from RNA polymerase III type 1 promoter Source: HGNC
  • transcription, DNA-templated Source: HGNC
  • transcription from RNA polymerase III promoter Source: HGNC
  • tRNA transcription from RNA polymerase III promoter Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119041-MONOMER.
ReactomeiR-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-HSA-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 3
Alternative name(s):
Transcription factor IIIC 102 kDa subunit
Short name:
TFIIIC 102 kDa subunit
Short name:
TFIIIC102
Transcription factor IIIC subunit gamma
Short name:
TF3C-gamma
Gene namesi
Name:GTF3C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4666. GTF3C3.

Subcellular locationi

GO - Cellular componenti

  • nuclear membrane Source: HPA
  • nucleolus Source: HPA
  • nucleoplasm Source: Reactome
  • nucleus Source: HPA
  • transcription factor TFIIIC complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119041.
PharmGKBiPA29054.

Polymorphism and mutation databases

BioMutaiGTF3C3.
DMDMi47606223.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001063632 – 886General transcription factor 3C polypeptide 3Add BLAST885

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei43PhosphoserineCombined sources1
Modified residuei282PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y5Q9.
PaxDbiQ9Y5Q9.
PeptideAtlasiQ9Y5Q9.
PRIDEiQ9Y5Q9.

PTM databases

iPTMnetiQ9Y5Q9.
PhosphoSitePlusiQ9Y5Q9.

Expressioni

Gene expression databases

BgeeiENSG00000119041.
CleanExiHS_GTF3C3.
ExpressionAtlasiQ9Y5Q9. baseline and differential.
GenevisibleiQ9Y5Q9. HS.

Organism-specific databases

HPAiHPA069179.

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1 and TBP.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428583EBI-1054873,EBI-466029

Protein-protein interaction databases

BioGridi114739. 64 interactors.
IntActiQ9Y5Q9. 27 interactors.
MINTiMINT-3087357.
STRINGi9606.ENSP00000263956.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5Q9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati149 – 182TPR 1Add BLAST34
Repeati183 – 216TPR 2Add BLAST34
Repeati217 – 250TPR 3Add BLAST34
Repeati252 – 284TPR 4Add BLAST33
Repeati290 – 323TPR 5Add BLAST34
Repeati326 – 361TPR 6Add BLAST36
Repeati421 – 454TPR 7Add BLAST34
Repeati456 – 489TPR 8Add BLAST34
Repeati491 – 523TPR 9Add BLAST33
Repeati733 – 766TPR 10Add BLAST34
Repeati811 – 844TPR 11Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi92 – 114Glu-richAdd BLAST23

Sequence similaritiesi

Contains 11 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG2076. Eukaryota.
ENOG410XNW8. LUCA.
GeneTreeiENSGT00390000016929.
HOVERGENiHBG057124.
InParanoidiQ9Y5Q9.
KOiK15201.
OMAiGNTGMAQ.
OrthoDBiEOG091G01VE.
PhylomeDBiQ9Y5Q9.
TreeFamiTF105955.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 4 hits.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5Q9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGFSPELID YLEGKISFEE FERRREERKT REKKSLQEKG KLSAEENPDD
60 70 80 90 100
SEVPSSSGIN STKSQDKDVN EGETSDGVRK SVHKVFASML GENEDDEEEE
110 120 130 140 150
EEEEEEEEEE ETPEQPTAGD VFVLEMVLNR ETKKMMKEKR PRSKLPRALR
160 170 180 190 200
GLMGEANIRF ARGEREEAIL MCMEIIRQAP LAYEPFSTLA MIYEDQGDME
210 220 230 240 250
KSLQFELIAA HLNPSDTEEW VRLAEMSLEQ DNIKQAIFCY TKALKYEPTN
260 270 280 290 300
VRYLWERSSL YEQMGDHKMA MDGYRRILNL LSPSDGERFM QLARDMAKSY
310 320 330 340 350
YEANDVTSAI NIIDEAFSKH QGLVSMEDVN IAAELYISNK QYDKALEIIT
360 370 380 390 400
DFSGIVLEKK TSEEGTSEEN KAPENVTCTI PDGVPIDITV KLMVCLVHLN
410 420 430 440 450
ILEPLNPLLT TLVEQNPEDM GDLYLDVAEA FLDVGEYNSA LPLLSALVCS
460 470 480 490 500
ERYNLAVVWL RHAECLKALG YMERAAESYG KVVDLAPLHL DARISLSTLQ
510 520 530 540 550
QQLGQPEKAL EALEPMYDPD TLAQDANAAQ QELKLLLHRS TLLFSQGKMY
560 570 580 590 600
GYVDTLLTML AMLLKVAMNR AQVCLISSSK SGERHLYLIK VSRDKISDSN
610 620 630 640 650
DQESANCDAK AIFAVLTSVL TKDDWWNLLL KAIYSLCDLS RFQEAELLVD
660 670 680 690 700
SSLEYYSFYD DRQKRKELEY FGLSAAILDK NFRKAYNYIR IMVMENVNKP
710 720 730 740 750
QLWNIFNQVT MHSQDVRHHR FCLRLMLKNP ENHALCVLNG HNAFVSGSFK
760 770 780 790 800
HALGQYVQAF RTHPDEPLYS FCIGLTFIHM ASQKYVLRRH ALIVQGFSFL
810 820 830 840 850
NRYLSLRGPC QESFYNLGRG LHQLGLIHLA IHYYQKALEL PPLVVEGIEL
860 870 880
DQLDLRRDIA YNLSLIYQSS GNTGMAQTLL YTYCSI
Length:886
Mass (Da):101,272
Last modified:November 1, 1999 - v1
Checksum:i9B97269929F9765F
GO
Isoform 2 (identifier: Q9Y5Q9-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     407-413: PLLTTLV → VCNKICT
     414-886: Missing.

Note: May be due to exon skipping.
Show »
Length:413
Mass (Da):47,258
Checksum:iA1628BC6E182DDCE
GO

Sequence cautioni

The sequence BAB15638 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti412 – 413LV → HL in AAH15995 (PubMed:15489334).Curated2
Sequence conflicti589I → M in BAB15638 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06190270N → S.1 PublicationCorresponds to variant rs11559078dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010353407 – 413PLLTTLV → VCNKICT in isoform 2. 1 Publication7
Alternative sequenceiVSP_010354414 – 886Missing in isoform 2. 1 PublicationAdd BLAST473

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133123 mRNA. Translation: AAD41475.1.
AF465407 mRNA. Translation: AAL73493.1.
AK027050 mRNA. Translation: BAB15638.1. Different initiation.
AK314718 mRNA. Translation: BAG37262.1.
AC012486 Genomic DNA. Translation: AAX88853.1.
CH471063 Genomic DNA. Translation: EAW70132.1.
BC015995 mRNA. Translation: AAH15995.1.
BC043347 mRNA. Translation: AAH43347.1.
AL137453 mRNA. Translation: CAB70745.1.
CCDSiCCDS2316.1. [Q9Y5Q9-1]
CCDS56153.1. [Q9Y5Q9-2]
PIRiT46268.
RefSeqiNP_001193703.1. NM_001206774.1. [Q9Y5Q9-2]
NP_036218.1. NM_012086.4. [Q9Y5Q9-1]
UniGeneiHs.470996.
Hs.737375.

Genome annotation databases

EnsembliENST00000263956; ENSP00000263956; ENSG00000119041. [Q9Y5Q9-1]
ENST00000409364; ENSP00000386465; ENSG00000119041. [Q9Y5Q9-2]
GeneIDi9330.
KEGGihsa:9330.
UCSCiuc002uts.4. human. [Q9Y5Q9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133123 mRNA. Translation: AAD41475.1.
AF465407 mRNA. Translation: AAL73493.1.
AK027050 mRNA. Translation: BAB15638.1. Different initiation.
AK314718 mRNA. Translation: BAG37262.1.
AC012486 Genomic DNA. Translation: AAX88853.1.
CH471063 Genomic DNA. Translation: EAW70132.1.
BC015995 mRNA. Translation: AAH15995.1.
BC043347 mRNA. Translation: AAH43347.1.
AL137453 mRNA. Translation: CAB70745.1.
CCDSiCCDS2316.1. [Q9Y5Q9-1]
CCDS56153.1. [Q9Y5Q9-2]
PIRiT46268.
RefSeqiNP_001193703.1. NM_001206774.1. [Q9Y5Q9-2]
NP_036218.1. NM_012086.4. [Q9Y5Q9-1]
UniGeneiHs.470996.
Hs.737375.

3D structure databases

ProteinModelPortaliQ9Y5Q9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114739. 64 interactors.
IntActiQ9Y5Q9. 27 interactors.
MINTiMINT-3087357.
STRINGi9606.ENSP00000263956.

PTM databases

iPTMnetiQ9Y5Q9.
PhosphoSitePlusiQ9Y5Q9.

Polymorphism and mutation databases

BioMutaiGTF3C3.
DMDMi47606223.

Proteomic databases

EPDiQ9Y5Q9.
PaxDbiQ9Y5Q9.
PeptideAtlasiQ9Y5Q9.
PRIDEiQ9Y5Q9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263956; ENSP00000263956; ENSG00000119041. [Q9Y5Q9-1]
ENST00000409364; ENSP00000386465; ENSG00000119041. [Q9Y5Q9-2]
GeneIDi9330.
KEGGihsa:9330.
UCSCiuc002uts.4. human. [Q9Y5Q9-1]

Organism-specific databases

CTDi9330.
GeneCardsiGTF3C3.
HGNCiHGNC:4666. GTF3C3.
HPAiHPA069179.
MIMi604888. gene.
neXtProtiNX_Q9Y5Q9.
OpenTargetsiENSG00000119041.
PharmGKBiPA29054.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2076. Eukaryota.
ENOG410XNW8. LUCA.
GeneTreeiENSGT00390000016929.
HOVERGENiHBG057124.
InParanoidiQ9Y5Q9.
KOiK15201.
OMAiGNTGMAQ.
OrthoDBiEOG091G01VE.
PhylomeDBiQ9Y5Q9.
TreeFamiTF105955.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000119041-MONOMER.
ReactomeiR-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-HSA-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Miscellaneous databases

ChiTaRSiGTF3C3. human.
GenomeRNAii9330.
PROiQ9Y5Q9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000119041.
CleanExiHS_GTF3C3.
ExpressionAtlasiQ9Y5Q9. baseline and differential.
GenevisibleiQ9Y5Q9. HS.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF13181. TPR_8. 3 hits.
[Graphical view]
SMARTiSM00028. TPR. 6 hits.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 4 hits.
PROSITEiPS50005. TPR. 6 hits.
PS50293. TPR_REGION. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTF3C3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Q9
Secondary accession number(s): Q4ZG48
, Q86XJ8, Q8WX84, Q96B44, Q9H5I8, Q9NT97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.