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Q9Y5Q9

- TF3C3_HUMAN

UniProt

Q9Y5Q9 - TF3C3_HUMAN

Protein

General transcription factor 3C polypeptide 3

Gene

GTF3C3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. 5S class rRNA transcription from RNA polymerase III type 1 promoter Source: HGNC
    2. gene expression Source: Reactome
    3. transcription, DNA-templated Source: HGNC
    4. transcription from RNA polymerase III promoter Source: HGNC
    5. tRNA transcription from RNA polymerase III promoter Source: HGNC

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor 3C polypeptide 3
    Alternative name(s):
    Transcription factor IIIC 102 kDa subunit
    Short name:
    TFIIIC 102 kDa subunit
    Short name:
    TFIIIC102
    Transcription factor IIIC subunit gamma
    Short name:
    TF3C-gamma
    Gene namesi
    Name:GTF3C3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:4666. GTF3C3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. transcription factor TFIIIC complex Source: HGNC

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29054.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 886885General transcription factor 3C polypeptide 3PRO_0000106363Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Modified residuei43 – 431Phosphoserine3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y5Q9.
    PaxDbiQ9Y5Q9.
    PeptideAtlasiQ9Y5Q9.
    PRIDEiQ9Y5Q9.

    PTM databases

    PhosphoSiteiQ9Y5Q9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y5Q9.
    BgeeiQ9Y5Q9.
    CleanExiHS_GTF3C3.
    GenevestigatoriQ9Y5Q9.

    Interactioni

    Subunit structurei

    Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1 and TBP.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HTTP428583EBI-1054873,EBI-466029

    Protein-protein interaction databases

    BioGridi114739. 28 interactions.
    IntActiQ9Y5Q9. 12 interactions.
    MINTiMINT-3087357.
    STRINGi9606.ENSP00000263956.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5Q9.
    SMRiQ9Y5Q9. Positions 156-317, 487-516, 748-777.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati149 – 18234TPR 1Add
    BLAST
    Repeati183 – 21634TPR 2Add
    BLAST
    Repeati217 – 25034TPR 3Add
    BLAST
    Repeati252 – 28433TPR 4Add
    BLAST
    Repeati290 – 32334TPR 5Add
    BLAST
    Repeati326 – 36136TPR 6Add
    BLAST
    Repeati421 – 45434TPR 7Add
    BLAST
    Repeati456 – 48934TPR 8Add
    BLAST
    Repeati491 – 52333TPR 9Add
    BLAST
    Repeati733 – 76634TPR 10Add
    BLAST
    Repeati811 – 84434TPR 11Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi92 – 11423Glu-richAdd
    BLAST

    Sequence similaritiesi

    Contains 11 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiNOG275814.
    HOVERGENiHBG057124.
    InParanoidiQ9Y5Q9.
    KOiK15201.
    OMAiIRGPCQE.
    OrthoDBiEOG7JMGCS.
    PhylomeDBiQ9Y5Q9.
    TreeFamiTF105955.

    Family and domain databases

    Gene3Di1.25.40.10. 3 hits.
    InterProiIPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF00515. TPR_1. 1 hit.
    PF13181. TPR_8. 1 hit.
    [Graphical view]
    SMARTiSM00028. TPR. 5 hits.
    [Graphical view]
    PROSITEiPS50005. TPR. 6 hits.
    PS50293. TPR_REGION. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y5Q9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSGFSPELID YLEGKISFEE FERRREERKT REKKSLQEKG KLSAEENPDD    50
    SEVPSSSGIN STKSQDKDVN EGETSDGVRK SVHKVFASML GENEDDEEEE 100
    EEEEEEEEEE ETPEQPTAGD VFVLEMVLNR ETKKMMKEKR PRSKLPRALR 150
    GLMGEANIRF ARGEREEAIL MCMEIIRQAP LAYEPFSTLA MIYEDQGDME 200
    KSLQFELIAA HLNPSDTEEW VRLAEMSLEQ DNIKQAIFCY TKALKYEPTN 250
    VRYLWERSSL YEQMGDHKMA MDGYRRILNL LSPSDGERFM QLARDMAKSY 300
    YEANDVTSAI NIIDEAFSKH QGLVSMEDVN IAAELYISNK QYDKALEIIT 350
    DFSGIVLEKK TSEEGTSEEN KAPENVTCTI PDGVPIDITV KLMVCLVHLN 400
    ILEPLNPLLT TLVEQNPEDM GDLYLDVAEA FLDVGEYNSA LPLLSALVCS 450
    ERYNLAVVWL RHAECLKALG YMERAAESYG KVVDLAPLHL DARISLSTLQ 500
    QQLGQPEKAL EALEPMYDPD TLAQDANAAQ QELKLLLHRS TLLFSQGKMY 550
    GYVDTLLTML AMLLKVAMNR AQVCLISSSK SGERHLYLIK VSRDKISDSN 600
    DQESANCDAK AIFAVLTSVL TKDDWWNLLL KAIYSLCDLS RFQEAELLVD 650
    SSLEYYSFYD DRQKRKELEY FGLSAAILDK NFRKAYNYIR IMVMENVNKP 700
    QLWNIFNQVT MHSQDVRHHR FCLRLMLKNP ENHALCVLNG HNAFVSGSFK 750
    HALGQYVQAF RTHPDEPLYS FCIGLTFIHM ASQKYVLRRH ALIVQGFSFL 800
    NRYLSLRGPC QESFYNLGRG LHQLGLIHLA IHYYQKALEL PPLVVEGIEL 850
    DQLDLRRDIA YNLSLIYQSS GNTGMAQTLL YTYCSI 886
    Length:886
    Mass (Da):101,272
    Last modified:November 1, 1999 - v1
    Checksum:i9B97269929F9765F
    GO
    Isoform 2 (identifier: Q9Y5Q9-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         407-413: PLLTTLV → VCNKICT
         414-886: Missing.

    Note: May be due to exon skipping.

    Show »
    Length:413
    Mass (Da):47,258
    Checksum:iA1628BC6E182DDCE
    GO

    Sequence cautioni

    The sequence BAB15638.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti412 – 4132LV → HL in AAH15995. (PubMed:15489334)Curated
    Sequence conflicti589 – 5891I → M in BAB15638. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti70 – 701N → S.1 Publication
    Corresponds to variant rs11559078 [ dbSNP | Ensembl ].
    VAR_061902

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei407 – 4137PLLTTLV → VCNKICT in isoform 2. 1 PublicationVSP_010353
    Alternative sequencei414 – 886473Missing in isoform 2. 1 PublicationVSP_010354Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133123 mRNA. Translation: AAD41475.1.
    AF465407 mRNA. Translation: AAL73493.1.
    AK027050 mRNA. Translation: BAB15638.1. Different initiation.
    AK314718 mRNA. Translation: BAG37262.1.
    AC012486 Genomic DNA. Translation: AAX88853.1.
    CH471063 Genomic DNA. Translation: EAW70132.1.
    BC015995 mRNA. Translation: AAH15995.1.
    BC043347 mRNA. Translation: AAH43347.1.
    AL137453 mRNA. Translation: CAB70745.1.
    CCDSiCCDS2316.1. [Q9Y5Q9-1]
    CCDS56153.1. [Q9Y5Q9-2]
    PIRiT46268.
    RefSeqiNP_001193703.1. NM_001206774.1. [Q9Y5Q9-2]
    NP_036218.1. NM_012086.4. [Q9Y5Q9-1]
    UniGeneiHs.470996.
    Hs.737375.

    Genome annotation databases

    EnsembliENST00000263956; ENSP00000263956; ENSG00000119041. [Q9Y5Q9-1]
    ENST00000409364; ENSP00000386465; ENSG00000119041. [Q9Y5Q9-2]
    GeneIDi9330.
    KEGGihsa:9330.
    UCSCiuc002uts.3. human. [Q9Y5Q9-1]
    uc002utu.3. human. [Q9Y5Q9-2]

    Polymorphism databases

    DMDMi47606223.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133123 mRNA. Translation: AAD41475.1 .
    AF465407 mRNA. Translation: AAL73493.1 .
    AK027050 mRNA. Translation: BAB15638.1 . Different initiation.
    AK314718 mRNA. Translation: BAG37262.1 .
    AC012486 Genomic DNA. Translation: AAX88853.1 .
    CH471063 Genomic DNA. Translation: EAW70132.1 .
    BC015995 mRNA. Translation: AAH15995.1 .
    BC043347 mRNA. Translation: AAH43347.1 .
    AL137453 mRNA. Translation: CAB70745.1 .
    CCDSi CCDS2316.1. [Q9Y5Q9-1 ]
    CCDS56153.1. [Q9Y5Q9-2 ]
    PIRi T46268.
    RefSeqi NP_001193703.1. NM_001206774.1. [Q9Y5Q9-2 ]
    NP_036218.1. NM_012086.4. [Q9Y5Q9-1 ]
    UniGenei Hs.470996.
    Hs.737375.

    3D structure databases

    ProteinModelPortali Q9Y5Q9.
    SMRi Q9Y5Q9. Positions 156-317, 487-516, 748-777.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114739. 28 interactions.
    IntActi Q9Y5Q9. 12 interactions.
    MINTi MINT-3087357.
    STRINGi 9606.ENSP00000263956.

    PTM databases

    PhosphoSitei Q9Y5Q9.

    Polymorphism databases

    DMDMi 47606223.

    Proteomic databases

    MaxQBi Q9Y5Q9.
    PaxDbi Q9Y5Q9.
    PeptideAtlasi Q9Y5Q9.
    PRIDEi Q9Y5Q9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263956 ; ENSP00000263956 ; ENSG00000119041 . [Q9Y5Q9-1 ]
    ENST00000409364 ; ENSP00000386465 ; ENSG00000119041 . [Q9Y5Q9-2 ]
    GeneIDi 9330.
    KEGGi hsa:9330.
    UCSCi uc002uts.3. human. [Q9Y5Q9-1 ]
    uc002utu.3. human. [Q9Y5Q9-2 ]

    Organism-specific databases

    CTDi 9330.
    GeneCardsi GC02M197592.
    HGNCi HGNC:4666. GTF3C3.
    MIMi 604888. gene.
    neXtProti NX_Q9Y5Q9.
    PharmGKBi PA29054.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG275814.
    HOVERGENi HBG057124.
    InParanoidi Q9Y5Q9.
    KOi K15201.
    OMAi IRGPCQE.
    OrthoDBi EOG7JMGCS.
    PhylomeDBi Q9Y5Q9.
    TreeFami TF105955.

    Enzyme and pathway databases

    Reactomei REACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

    Miscellaneous databases

    GenomeRNAii 9330.
    NextBioi 34947.
    PROi Q9Y5Q9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5Q9.
    Bgeei Q9Y5Q9.
    CleanExi HS_GTF3C3.
    Genevestigatori Q9Y5Q9.

    Family and domain databases

    Gene3Di 1.25.40.10. 3 hits.
    InterProi IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF00515. TPR_1. 1 hit.
    PF13181. TPR_8. 1 hit.
    [Graphical view ]
    SMARTi SM00028. TPR. 5 hits.
    [Graphical view ]
    PROSITEi PS50005. TPR. 6 hits.
    PS50293. TPR_REGION. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III."
      Hsieh Y.-J., Wang Z., Kovelman R., Roeder R.G.
      Mol. Cell. Biol. 19:4944-4952(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH BRF1 AND TBP, IDENTIFICATION OF SUBUNITS OF TFIIIC2 COMPLEX.
    2. "Identification of a short isoform of hTFIIIC102 subunit."
      Hegde R., Alnemri E.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Hepatoma and Placenta.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-70.
      Tissue: Bone marrow and Lymph.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 166-886 (ISOFORM 1).
      Tissue: Amygdala.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTF3C3_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5Q9
    Secondary accession number(s): Q4ZG48
    , Q86XJ8, Q8WX84, Q96B44, Q9H5I8, Q9NT97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3