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Q9Y5Q8 (TF3C5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
General transcription factor 3C polypeptide 5
Alternative name(s):
TF3C-epsilon
Transcription factor IIIC 63 kDa subunit
Short name=TFIIIC 63 kDa subunit
Short name=TFIIIC63
Transcription factor IIIC subunit epsilon
Gene names
Name:GTF3C5
ORF Names:CDABP0017
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length519 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

Subunit structure

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP. Ref.1 Ref.7

Subcellular location

Nucleus.

Sequence similarities

Belongs to the TFIIIC subunit 5 family.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y5Q8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y5Q8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     56-65: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q9Y5Q8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     389-389: K → KVSLQTLR
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.8
Chain2 – 519518General transcription factor 3C polypeptide 5
PRO_0000209715

Regions

Compositional bias478 – 51437Glu-rich
Compositional bias486 – 49914Poly-Glu

Amino acid modifications

Modified residue21N-acetylalanine Ref.8 Ref.10

Natural variations

Alternative sequence56 – 6510Missing in isoform 2.
VSP_010355
Alternative sequence3891K → KVSLQTLR in isoform 3.
VSP_035196
Natural variant4451D → N.
Corresponds to variant rs637435 [ dbSNP | Ensembl ].
VAR_053727

Experimental info

Sequence conflict3721P → R in AAD41476. Ref.1
Sequence conflict3751T → A in BAC04993. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: 088B8B6125CEEF36

FASTA51959,571
        10         20         30         40         50         60 
MAAEAADLGL GAAVPVELRR ERRMVCVEYP GVVRDVAKML PTLGGEEGVS RIYADPTKRL 

        70         80         90        100        110        120 
ELYFRPKDPY CHPVCANRFS TSSLLLRIRK RTRRQKGVLG TEAHSEVTFD MEILGIISTI 

       130        140        150        160        170        180 
YKFQGMSDFQ YLAVHTEAGG KHTSMYDKVL MLRPEKEAFF HQELPLYIPP PIFSRLDAPV 

       190        200        210        220        230        240 
DYFYRPETQH REGYNNPPIS GENLIGLSRA RRPHNAIFVN FEDEEVPKQP LEAAAQTWRR 

       250        260        270        280        290        300 
VCTNPVDRKV EEELRKLFDI RPIWSRNAVK ANISVHPDKL KVLLPFIAYY MITGPWRSLW 

       310        320        330        340        350        360 
IRFGYDPRKN PDAKIYQVLD FRIRCGMKHG YAPSDLPVKA KRSTYNYSLP ITVKKTSSQL 

       370        380        390        400        410        420 
VTMHDLKQGL GPSGTSGARK PASSKYKLKD SVYIFREGAL PPYRQMFYQL CDLNVEELQK 

       430        440        450        460        470        480 
IIHRNDGAEN SCTERDGWCL PKTSDELRDT MSLMIRQTIR SKRPALFSSS AKADGGKEQL 

       490        500        510 
TYESGEDEED EEEEEEEEED FKPSDGSENE METEILDYV 

« Hide

Isoform 2 [UniParc].

Checksum: 58222432D6D3A333
Show »

FASTA50958,266
Isoform 3 [UniParc].

Checksum: FAA2A99DF60A0718
Show »

FASTA52660,369

References

« Hide 'large scale' references
[1]"Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III."
Hsieh Y.-J., Wang Z., Kovelman R., Roeder R.G.
Mol. Cell. Biol. 19:4944-4952(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH BRF1 AND TBP, IDENTIFICATION OF SUBUNITS OF TFIIIC2 COMPLEX.
[2]"Pediatric leukemia cDNA sequencing project."
Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Leukemia.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain and Spleen.
[4]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain, Kidney, Ovary and Skin.
[7]"Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC."
Dumay-Odelot H., Marck C., Durrieu-Gaillard S., Lefebvre O., Jourdain S., Prochazkova M., Pflieger A., Teichmann M.
J. Biol. Chem. 282:17179-17189(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN TFIIIC COMPLEX, INTERACTION WITH GTF3C6.
[8]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF133124 mRNA. Translation: AAD41476.1.
AY007123 mRNA. Translation: AAG01991.1.
AK055092 mRNA. Translation: BAG51466.1.
AK097295 mRNA. Translation: BAC04993.1.
AL162417 Genomic DNA. Translation: CAI13406.1.
AL162417 Genomic DNA. Translation: CAI13407.1.
CH471090 Genomic DNA. Translation: EAW88026.1.
CH471090 Genomic DNA. Translation: EAW88029.1.
BC009741 mRNA. Translation: AAH09741.2.
BC011355 mRNA. Translation: AAH11355.1.
BC017337 mRNA. Translation: AAH17337.1.
BC030157 mRNA. Translation: AAH30157.2.
RefSeqNP_001116295.1. NM_001122823.1.
NP_001273638.1. NM_001286709.1.
NP_036219.2. NM_012087.3.
UniGeneHs.495417.

3D structure databases

ProteinModelPortalQ9Y5Q8.
SMRQ9Y5Q8. Positions 21-132, 213-465.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid114737. 23 interactions.
DIPDIP-50823N.
IntActQ9Y5Q8. 4 interactions.
MINTMINT-4777347.

PTM databases

PhosphoSiteQ9Y5Q8.

Polymorphism databases

DMDM47606222.

Proteomic databases

PaxDbQ9Y5Q8.
PRIDEQ9Y5Q8.

Protocols and materials databases

DNASU9328.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000372097; ENSP00000361169; ENSG00000148308. [Q9Y5Q8-1]
ENST00000372108; ENSP00000361180; ENSG00000148308. [Q9Y5Q8-3]
GeneID9328.
KEGGhsa:9328.
UCSCuc004cci.4. human. [Q9Y5Q8-1]
uc004ccj.4. human. [Q9Y5Q8-3]

Organism-specific databases

CTD9328.
GeneCardsGC09P135906.
HGNCHGNC:4668. GTF3C5.
MIM604890. gene.
neXtProtNX_Q9Y5Q8.
PharmGKBPA29056.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG311463.
HOVERGENHBG058445.
KOK15202.
OMARDTMSLM.
OrthoDBEOG780RMW.
PhylomeDBQ9Y5Q8.
TreeFamTF313581.

Enzyme and pathway databases

ReactomeREACT_1788. Transcription.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9Y5Q8.
BgeeQ9Y5Q8.
GenevestigatorQ9Y5Q8.

Family and domain databases

InterProIPR019136. TF_IIIC_su-5.
[Graphical view]
PfamPF09734. Tau95. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGTF3C5. human.
GeneWikiGTF3C5.
GenomeRNAi9328.
NextBio34939.
PROQ9Y5Q8.
SOURCESearch...

Entry information

Entry nameTF3C5_HUMAN
AccessionPrimary (citable) accession number: Q9Y5Q8
Secondary accession number(s): A6NI44 expand/collapse secondary AC list , A6NJB9, Q5T7U2, Q5T7U3, Q8N2U7, Q8N857, Q96GD9, Q9H4P2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: April 16, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM