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Q9Y5Q8

- TF3C5_HUMAN

UniProt

Q9Y5Q8 - TF3C5_HUMAN

Protein

General transcription factor 3C polypeptide 5

Gene

GTF3C5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
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    Functioni

    Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: HGNC

    GO - Biological processi

    1. 5S class rRNA transcription from RNA polymerase III type 1 promoter Source: HGNC
    2. gene expression Source: Reactome
    3. skeletal muscle cell differentiation Source: Ensembl
    4. transcription, DNA-templated Source: HGNC
    5. transcription from RNA polymerase III promoter Source: HGNC
    6. tRNA transcription from RNA polymerase III promoter Source: HGNC

    Keywords - Biological processi

    Transcription

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor 3C polypeptide 5
    Alternative name(s):
    TF3C-epsilon
    Transcription factor IIIC 63 kDa subunit
    Short name:
    TFIIIC 63 kDa subunit
    Short name:
    TFIIIC63
    Transcription factor IIIC subunit epsilon
    Gene namesi
    Name:GTF3C5
    ORF Names:CDABP0017
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:4668. GTF3C5.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. transcription factor TFIIIC complex Source: HGNC

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29056.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 519518General transcription factor 3C polypeptide 5PRO_0000209715Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine2 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9Y5Q8.
    PaxDbiQ9Y5Q8.
    PRIDEiQ9Y5Q8.

    PTM databases

    PhosphoSiteiQ9Y5Q8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y5Q8.
    BgeeiQ9Y5Q8.
    GenevestigatoriQ9Y5Q8.

    Interactioni

    Subunit structurei

    Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP.2 Publications

    Protein-protein interaction databases

    BioGridi114737. 23 interactions.
    DIPiDIP-50823N.
    IntActiQ9Y5Q8. 4 interactions.
    MINTiMINT-4777347.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y5Q8.
    SMRiQ9Y5Q8. Positions 248-329.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi478 – 51437Glu-richAdd
    BLAST
    Compositional biasi486 – 49914Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TFIIIC subunit 5 family.Curated

    Phylogenomic databases

    eggNOGiNOG311463.
    HOVERGENiHBG058445.
    KOiK15202.
    OMAiDTMSLMI.
    OrthoDBiEOG780RMW.
    PhylomeDBiQ9Y5Q8.
    TreeFamiTF313581.

    Family and domain databases

    InterProiIPR019136. TF_IIIC_su-5.
    [Graphical view]
    PfamiPF09734. Tau95. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y5Q8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAEAADLGL GAAVPVELRR ERRMVCVEYP GVVRDVAKML PTLGGEEGVS    50
    RIYADPTKRL ELYFRPKDPY CHPVCANRFS TSSLLLRIRK RTRRQKGVLG 100
    TEAHSEVTFD MEILGIISTI YKFQGMSDFQ YLAVHTEAGG KHTSMYDKVL 150
    MLRPEKEAFF HQELPLYIPP PIFSRLDAPV DYFYRPETQH REGYNNPPIS 200
    GENLIGLSRA RRPHNAIFVN FEDEEVPKQP LEAAAQTWRR VCTNPVDRKV 250
    EEELRKLFDI RPIWSRNAVK ANISVHPDKL KVLLPFIAYY MITGPWRSLW 300
    IRFGYDPRKN PDAKIYQVLD FRIRCGMKHG YAPSDLPVKA KRSTYNYSLP 350
    ITVKKTSSQL VTMHDLKQGL GPSGTSGARK PASSKYKLKD SVYIFREGAL 400
    PPYRQMFYQL CDLNVEELQK IIHRNDGAEN SCTERDGWCL PKTSDELRDT 450
    MSLMIRQTIR SKRPALFSSS AKADGGKEQL TYESGEDEED EEEEEEEEED 500
    FKPSDGSENE METEILDYV 519
    Length:519
    Mass (Da):59,571
    Last modified:May 24, 2004 - v2
    Checksum:i088B8B6125CEEF36
    GO
    Isoform 2 (identifier: Q9Y5Q8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         56-65: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:509
    Mass (Da):58,266
    Checksum:i58222432D6D3A333
    GO
    Isoform 3 (identifier: Q9Y5Q8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         389-389: K → KVSLQTLR

    Note: No experimental confirmation available.

    Show »
    Length:526
    Mass (Da):60,369
    Checksum:iFAA2A99DF60A0718
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti372 – 3721P → R in AAD41476. (PubMed:10373544)Curated
    Sequence conflicti375 – 3751T → A in BAC04993. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti445 – 4451D → N.
    Corresponds to variant rs637435 [ dbSNP | Ensembl ].
    VAR_053727

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei56 – 6510Missing in isoform 2. 1 PublicationVSP_010355
    Alternative sequencei389 – 3891K → KVSLQTLR in isoform 3. CuratedVSP_035196

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133124 mRNA. Translation: AAD41476.1.
    AY007123 mRNA. Translation: AAG01991.1.
    AK055092 mRNA. Translation: BAG51466.1.
    AK097295 mRNA. Translation: BAC04993.1.
    AL162417 Genomic DNA. Translation: CAI13406.1.
    AL162417 Genomic DNA. Translation: CAI13407.1.
    CH471090 Genomic DNA. Translation: EAW88026.1.
    CH471090 Genomic DNA. Translation: EAW88029.1.
    BC009741 mRNA. Translation: AAH09741.2.
    BC011355 mRNA. Translation: AAH11355.1.
    BC017337 mRNA. Translation: AAH17337.1.
    BC030157 mRNA. Translation: AAH30157.2.
    CCDSiCCDS48050.1. [Q9Y5Q8-3]
    CCDS6958.1. [Q9Y5Q8-1]
    RefSeqiNP_001116295.1. NM_001122823.1. [Q9Y5Q8-3]
    NP_001273638.1. NM_001286709.1.
    NP_036219.2. NM_012087.3. [Q9Y5Q8-1]
    UniGeneiHs.495417.

    Genome annotation databases

    EnsembliENST00000372097; ENSP00000361169; ENSG00000148308. [Q9Y5Q8-1]
    ENST00000372108; ENSP00000361180; ENSG00000148308. [Q9Y5Q8-3]
    GeneIDi9328.
    KEGGihsa:9328.
    UCSCiuc004cci.4. human. [Q9Y5Q8-1]
    uc004ccj.4. human. [Q9Y5Q8-3]

    Polymorphism databases

    DMDMi47606222.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133124 mRNA. Translation: AAD41476.1 .
    AY007123 mRNA. Translation: AAG01991.1 .
    AK055092 mRNA. Translation: BAG51466.1 .
    AK097295 mRNA. Translation: BAC04993.1 .
    AL162417 Genomic DNA. Translation: CAI13406.1 .
    AL162417 Genomic DNA. Translation: CAI13407.1 .
    CH471090 Genomic DNA. Translation: EAW88026.1 .
    CH471090 Genomic DNA. Translation: EAW88029.1 .
    BC009741 mRNA. Translation: AAH09741.2 .
    BC011355 mRNA. Translation: AAH11355.1 .
    BC017337 mRNA. Translation: AAH17337.1 .
    BC030157 mRNA. Translation: AAH30157.2 .
    CCDSi CCDS48050.1. [Q9Y5Q8-3 ]
    CCDS6958.1. [Q9Y5Q8-1 ]
    RefSeqi NP_001116295.1. NM_001122823.1. [Q9Y5Q8-3 ]
    NP_001273638.1. NM_001286709.1.
    NP_036219.2. NM_012087.3. [Q9Y5Q8-1 ]
    UniGenei Hs.495417.

    3D structure databases

    ProteinModelPortali Q9Y5Q8.
    SMRi Q9Y5Q8. Positions 248-329.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114737. 23 interactions.
    DIPi DIP-50823N.
    IntActi Q9Y5Q8. 4 interactions.
    MINTi MINT-4777347.

    PTM databases

    PhosphoSitei Q9Y5Q8.

    Polymorphism databases

    DMDMi 47606222.

    Proteomic databases

    MaxQBi Q9Y5Q8.
    PaxDbi Q9Y5Q8.
    PRIDEi Q9Y5Q8.

    Protocols and materials databases

    DNASUi 9328.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372097 ; ENSP00000361169 ; ENSG00000148308 . [Q9Y5Q8-1 ]
    ENST00000372108 ; ENSP00000361180 ; ENSG00000148308 . [Q9Y5Q8-3 ]
    GeneIDi 9328.
    KEGGi hsa:9328.
    UCSCi uc004cci.4. human. [Q9Y5Q8-1 ]
    uc004ccj.4. human. [Q9Y5Q8-3 ]

    Organism-specific databases

    CTDi 9328.
    GeneCardsi GC09P135906.
    HGNCi HGNC:4668. GTF3C5.
    MIMi 604890. gene.
    neXtProti NX_Q9Y5Q8.
    PharmGKBi PA29056.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG311463.
    HOVERGENi HBG058445.
    KOi K15202.
    OMAi DTMSLMI.
    OrthoDBi EOG780RMW.
    PhylomeDBi Q9Y5Q8.
    TreeFami TF313581.

    Enzyme and pathway databases

    Reactomei REACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.

    Miscellaneous databases

    ChiTaRSi GTF3C5. human.
    GeneWikii GTF3C5.
    GenomeRNAii 9328.
    NextBioi 34939.
    PROi Q9Y5Q8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y5Q8.
    Bgeei Q9Y5Q8.
    Genevestigatori Q9Y5Q8.

    Family and domain databases

    InterProi IPR019136. TF_IIIC_su-5.
    [Graphical view ]
    Pfami PF09734. Tau95. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III."
      Hsieh Y.-J., Wang Z., Kovelman R., Roeder R.G.
      Mol. Cell. Biol. 19:4944-4952(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH BRF1 AND TBP, IDENTIFICATION OF SUBUNITS OF TFIIIC2 COMPLEX.
    2. "Pediatric leukemia cDNA sequencing project."
      Zhou J., Yu W., Tang H., Mei G., Tsang Y.T.M., Bouck J., Gibbs R.A., Margolin J.F.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Leukemia.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain and Spleen.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain, Kidney, Ovary and Skin.
    7. "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC."
      Dumay-Odelot H., Marck C., Durrieu-Gaillard S., Lefebvre O., Jourdain S., Prochazkova M., Pflieger A., Teichmann M.
      J. Biol. Chem. 282:17179-17189(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN TFIIIC COMPLEX, INTERACTION WITH GTF3C6.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTF3C5_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y5Q8
    Secondary accession number(s): A6NI44
    , A6NJB9, Q5T7U2, Q5T7U3, Q8N2U7, Q8N857, Q96GD9, Q9H4P2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3