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Protein

General transcription factor 3C polypeptide 5

Gene

GTF3C5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters.

GO - Molecular functioni

GO - Biological processi

  • 5S class rRNA transcription from RNA polymerase III type 1 promoter Source: HGNC
  • skeletal muscle cell differentiation Source: Ensembl
  • transcription, DNA-templated Source: HGNC
  • transcription from RNA polymerase III promoter Source: HGNC
  • tRNA transcription from RNA polymerase III promoter Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-HSA-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 5
Alternative name(s):
TF3C-epsilon
Transcription factor IIIC 63 kDa subunit
Short name:
TFIIIC 63 kDa subunit
Short name:
TFIIIC63
Transcription factor IIIC subunit epsilon
Gene namesi
Name:GTF3C5
ORF Names:CDABP0017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:4668. GTF3C5.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • transcription factor TFIIIC complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000148308.
PharmGKBiPA29056.

Polymorphism and mutation databases

BioMutaiGTF3C5.
DMDMi47606222.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002097152 – 519General transcription factor 3C polypeptide 5Add BLAST518

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y5Q8.
PaxDbiQ9Y5Q8.
PeptideAtlasiQ9Y5Q8.
PRIDEiQ9Y5Q8.

PTM databases

iPTMnetiQ9Y5Q8.
PhosphoSitePlusiQ9Y5Q8.

Expressioni

Gene expression databases

BgeeiENSG00000148308.
ExpressionAtlasiQ9Y5Q8. baseline and differential.
GenevisibleiQ9Y5Q8. HS.

Organism-specific databases

HPAiHPA067063.

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6. Interacts with BRF1, GTF3C6 and TBP.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
KRT40Q6A1623EBI-1045409,EBI-10171697
MDFIQ997503EBI-1045409,EBI-724076
NOTCH2NLQ7Z3S93EBI-1045409,EBI-945833

Protein-protein interaction databases

BioGridi114737. 52 interactors.
DIPiDIP-50823N.
IntActiQ9Y5Q8. 29 interactors.
MINTiMINT-4777347.
STRINGi9606.ENSP00000361180.

Structurei

3D structure databases

ProteinModelPortaliQ9Y5Q8.
SMRiQ9Y5Q8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi478 – 514Glu-richAdd BLAST37
Compositional biasi486 – 499Poly-GluAdd BLAST14

Sequence similaritiesi

Belongs to the TFIIIC subunit 5 family.Curated

Phylogenomic databases

eggNOGiKOG2473. Eukaryota.
ENOG4111DXH. LUCA.
GeneTreeiENSGT00390000004458.
HOVERGENiHBG058445.
InParanoidiQ9Y5Q8.
KOiK15202.
OMAiTQHREGY.
OrthoDBiEOG091G0990.
PhylomeDBiQ9Y5Q8.
TreeFamiTF313581.

Family and domain databases

InterProiIPR019136. TF_IIIC_su-5.
[Graphical view]
PfamiPF09734. Tau95. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y5Q8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEAADLGL GAAVPVELRR ERRMVCVEYP GVVRDVAKML PTLGGEEGVS
60 70 80 90 100
RIYADPTKRL ELYFRPKDPY CHPVCANRFS TSSLLLRIRK RTRRQKGVLG
110 120 130 140 150
TEAHSEVTFD MEILGIISTI YKFQGMSDFQ YLAVHTEAGG KHTSMYDKVL
160 170 180 190 200
MLRPEKEAFF HQELPLYIPP PIFSRLDAPV DYFYRPETQH REGYNNPPIS
210 220 230 240 250
GENLIGLSRA RRPHNAIFVN FEDEEVPKQP LEAAAQTWRR VCTNPVDRKV
260 270 280 290 300
EEELRKLFDI RPIWSRNAVK ANISVHPDKL KVLLPFIAYY MITGPWRSLW
310 320 330 340 350
IRFGYDPRKN PDAKIYQVLD FRIRCGMKHG YAPSDLPVKA KRSTYNYSLP
360 370 380 390 400
ITVKKTSSQL VTMHDLKQGL GPSGTSGARK PASSKYKLKD SVYIFREGAL
410 420 430 440 450
PPYRQMFYQL CDLNVEELQK IIHRNDGAEN SCTERDGWCL PKTSDELRDT
460 470 480 490 500
MSLMIRQTIR SKRPALFSSS AKADGGKEQL TYESGEDEED EEEEEEEEED
510
FKPSDGSENE METEILDYV
Length:519
Mass (Da):59,571
Last modified:May 24, 2004 - v2
Checksum:i088B8B6125CEEF36
GO
Isoform 2 (identifier: Q9Y5Q8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-65: Missing.

Note: No experimental confirmation available.
Show »
Length:509
Mass (Da):58,266
Checksum:i58222432D6D3A333
GO
Isoform 3 (identifier: Q9Y5Q8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     389-389: K → KVSLQTLR

Note: No experimental confirmation available.
Show »
Length:526
Mass (Da):60,369
Checksum:iFAA2A99DF60A0718
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti372P → R in AAD41476 (PubMed:10373544).Curated1
Sequence conflicti375T → A in BAC04993 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053727445D → N.Corresponds to variant rs637435dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01035556 – 65Missing in isoform 2. 1 Publication10
Alternative sequenceiVSP_035196389K → KVSLQTLR in isoform 3. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133124 mRNA. Translation: AAD41476.1.
AY007123 mRNA. Translation: AAG01991.1.
AK055092 mRNA. Translation: BAG51466.1.
AK097295 mRNA. Translation: BAC04993.1.
AL162417 Genomic DNA. Translation: CAI13406.1.
AL162417 Genomic DNA. Translation: CAI13407.1.
CH471090 Genomic DNA. Translation: EAW88026.1.
CH471090 Genomic DNA. Translation: EAW88029.1.
BC009741 mRNA. Translation: AAH09741.2.
BC011355 mRNA. Translation: AAH11355.1.
BC017337 mRNA. Translation: AAH17337.1.
BC030157 mRNA. Translation: AAH30157.2.
CCDSiCCDS48050.1. [Q9Y5Q8-3]
CCDS6958.1. [Q9Y5Q8-1]
RefSeqiNP_001116295.1. NM_001122823.1. [Q9Y5Q8-3]
NP_001273638.1. NM_001286709.1.
NP_036219.2. NM_012087.3. [Q9Y5Q8-1]
UniGeneiHs.495417.

Genome annotation databases

EnsembliENST00000372097; ENSP00000361169; ENSG00000148308. [Q9Y5Q8-1]
ENST00000372108; ENSP00000361180; ENSG00000148308. [Q9Y5Q8-3]
GeneIDi9328.
KEGGihsa:9328.
UCSCiuc004cci.5. human. [Q9Y5Q8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133124 mRNA. Translation: AAD41476.1.
AY007123 mRNA. Translation: AAG01991.1.
AK055092 mRNA. Translation: BAG51466.1.
AK097295 mRNA. Translation: BAC04993.1.
AL162417 Genomic DNA. Translation: CAI13406.1.
AL162417 Genomic DNA. Translation: CAI13407.1.
CH471090 Genomic DNA. Translation: EAW88026.1.
CH471090 Genomic DNA. Translation: EAW88029.1.
BC009741 mRNA. Translation: AAH09741.2.
BC011355 mRNA. Translation: AAH11355.1.
BC017337 mRNA. Translation: AAH17337.1.
BC030157 mRNA. Translation: AAH30157.2.
CCDSiCCDS48050.1. [Q9Y5Q8-3]
CCDS6958.1. [Q9Y5Q8-1]
RefSeqiNP_001116295.1. NM_001122823.1. [Q9Y5Q8-3]
NP_001273638.1. NM_001286709.1.
NP_036219.2. NM_012087.3. [Q9Y5Q8-1]
UniGeneiHs.495417.

3D structure databases

ProteinModelPortaliQ9Y5Q8.
SMRiQ9Y5Q8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114737. 52 interactors.
DIPiDIP-50823N.
IntActiQ9Y5Q8. 29 interactors.
MINTiMINT-4777347.
STRINGi9606.ENSP00000361180.

PTM databases

iPTMnetiQ9Y5Q8.
PhosphoSitePlusiQ9Y5Q8.

Polymorphism and mutation databases

BioMutaiGTF3C5.
DMDMi47606222.

Proteomic databases

EPDiQ9Y5Q8.
PaxDbiQ9Y5Q8.
PeptideAtlasiQ9Y5Q8.
PRIDEiQ9Y5Q8.

Protocols and materials databases

DNASUi9328.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372097; ENSP00000361169; ENSG00000148308. [Q9Y5Q8-1]
ENST00000372108; ENSP00000361180; ENSG00000148308. [Q9Y5Q8-3]
GeneIDi9328.
KEGGihsa:9328.
UCSCiuc004cci.5. human. [Q9Y5Q8-1]

Organism-specific databases

CTDi9328.
GeneCardsiGTF3C5.
HGNCiHGNC:4668. GTF3C5.
HPAiHPA067063.
MIMi604890. gene.
neXtProtiNX_Q9Y5Q8.
OpenTargetsiENSG00000148308.
PharmGKBiPA29056.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2473. Eukaryota.
ENOG4111DXH. LUCA.
GeneTreeiENSGT00390000004458.
HOVERGENiHBG058445.
InParanoidiQ9Y5Q8.
KOiK15202.
OMAiTQHREGY.
OrthoDBiEOG091G0990.
PhylomeDBiQ9Y5Q8.
TreeFamiTF313581.

Enzyme and pathway databases

ReactomeiR-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-HSA-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.

Miscellaneous databases

ChiTaRSiGTF3C5. human.
GeneWikiiGTF3C5.
GenomeRNAii9328.
PROiQ9Y5Q8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148308.
ExpressionAtlasiQ9Y5Q8. baseline and differential.
GenevisibleiQ9Y5Q8. HS.

Family and domain databases

InterProiIPR019136. TF_IIIC_su-5.
[Graphical view]
PfamiPF09734. Tau95. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTF3C5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y5Q8
Secondary accession number(s): A6NI44
, A6NJB9, Q5T7U2, Q5T7U3, Q8N2U7, Q8N857, Q96GD9, Q9H4P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.